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Volumn 16, Issue 12, 1996, Pages 6926-6936

Phosphorylation of tyrosine 720 in the platelet-derived growth factor α receptor is required for binding of Grb2 and SHP-2 but not for activation of Ras or cell proliferation

Author keywords

[No Author keywords available]

Indexed keywords

HYBRID PROTEIN; PHENYLALANINE; PHOSPHOPEPTIDE; PLATELET DERIVED GROWTH FACTOR AA; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE; RAS PROTEIN; TYROSINE;

EID: 0029860951     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.16.12.6926     Document Type: Article
Times cited : (63)

References (71)
  • 3
    • 0028079681 scopus 로고
    • The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with ras-GAP
    • Bazenet, C., and A. Kazlauskas. 1994. The PDGF receptor alpha subunit activates p21ras and triggers DNA synthesis without interacting with ras-GAP. Oncogene 9:517-525.
    • (1994) Oncogene , vol.9 , pp. 517-525
    • Bazenet, C.1    Kazlauskas, A.2
  • 5
    • 0026022620 scopus 로고
    • Human microvascular endothelial cells express receptors for platelet-derived growth factor
    • Beitz, J. G., I.-S. Kim, P. Calabresi, and A. R. J. Frackelton. 1991. Human microvascular endothelial cells express receptors for platelet-derived growth factor. Proc. Natl. Acad. Sci. USA 88:2021-2025.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2021-2025
    • Beitz, J.G.1    Kim, I.-S.2    Calabresi, P.3    Frackelton, A.R.J.4
  • 6
    • 0030049783 scopus 로고    scopus 로고
    • Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression
    • Bennett, A. M., S. F. Hausdorff, A. M. O'Reilly, R. M. Freeman, and B. G. Neel. 1996. Multiple requirements for SHPTP2 in epidermal growth factor-mediated cell cycle progression. Mol. Cell. Biol. 16:1189-1202.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1189-1202
    • Bennett, A.M.1    Hausdorff, S.F.2    O'Reilly, A.M.3    Freeman, R.M.4    Neel, B.G.5
  • 7
    • 0028179013 scopus 로고
    • Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras
    • Bennett, A. M., T. L. Tang, S. Sugimoto, C. T. Walsh, and B. J. Neel. 1994. Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras. Proc. Natl. Acad. Sci. USA 91:7335-7339.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7335-7339
    • Bennett, A.M.1    Tang, T.L.2    Sugimoto, S.3    Walsh, C.T.4    Neel, B.J.5
  • 9
    • 0028589148 scopus 로고
    • Platelet-derived growth factor receptor signals
    • Claesson-Welsh, L. 1994. Platelet-derived growth factor receptor signals. J. Biol. Chem. 269:32023-32026.
    • (1994) J. Biol. Chem. , vol.269 , pp. 32023-32026
    • Claesson-Welsh, L.1
  • 10
    • 0028895654 scopus 로고
    • Modular binding domains in signal transduction proteins
    • Cohen, G. B., R. Ren, and D. Baltimore. 1995. Modular binding domains in signal transduction proteins. Cell 80:237-248.
    • (1995) Cell , vol.80 , pp. 237-248
    • Cohen, G.B.1    Ren, R.2    Baltimore, D.3
  • 12
    • 0022081671 scopus 로고
    • Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation
    • Courtneidge, S. A. 1985. Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation. EMBO J. 4:1471-1477.
    • (1985) EMBO J. , vol.4 , pp. 1471-1477
    • Courtneidge, S.A.1
  • 13
    • 0026647411 scopus 로고
    • Mouse platelet-derived growth factor α receptor: Sequence, tissue-specific expression and correlation with metastatic phenotype
    • Do, M.-S., C. Fitzer-Altas, J. Gubbaj, L. Greenfield, M. Feldman, and L. Eisenbach. 1992. Mouse platelet-derived growth factor α receptor: sequence, tissue-specific expression and correlation with metastatic phenotype. Oncogene 7:1567-1575.
    • (1992) Oncogene , vol.7 , pp. 1567-1575
    • Do, M.-S.1    Fitzer-Altas, C.2    Gubbaj, J.3    Greenfield, L.4    Feldman, M.5    Eisenbach, L.6
  • 14
    • 0027536088 scopus 로고
    • Expression of platelet- derived growth factor (PDGF) and PDGF α- and β-receptors in the peripheral nervous system: An analysis of sciatic nerve and dorsal root ganglia
    • Eccleston, P. A., K. Funa, and C.-H. Heldin. 1993. Expression of platelet- derived growth factor (PDGF) and PDGF α- and β-receptors in the peripheral nervous system: an analysis of sciatic nerve and dorsal root ganglia. Dev. Biol. 155:459-470.
    • (1993) Dev. Biol. , vol.155 , pp. 459-470
    • Eccleston, P.A.1    Funa, K.2    Heldin, C.-H.3
  • 15
    • 0028951440 scopus 로고
    • Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors
    • Eriksson, A., E. Nanberg, L. Ronnstrand, U. Engstrom, U. Hellman, E. Rupp, G. Carpenter, C. H. Heldin, and L. Claesson-Welsh. 1995. Demonstration of functionally different interactions between phospholipase C-gamma and the two types of platelet-derived growth factor receptors. J. Biol. Chem. 270:7773-7781.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7773-7781
    • Eriksson, A.1    Nanberg, E.2    Ronnstrand, L.3    Engstrom, U.4    Hellman, U.5    Rupp, E.6    Carpenter, G.7    Heldin, C.H.8    Claesson-Welsh, L.9
  • 16
    • 0026583942 scopus 로고
    • PDGF α- and β-receptors activate unique and common signal transduction pathways
    • Eriksson, A., A. Siegbahn, B. Westermark, C.-H. Heldin, and L. Claesson-Welsh. 1992. PDGF α- and β-receptors activate unique and common signal transduction pathways. EMBO J. 11:543-550.
    • (1992) EMBO J. , vol.11 , pp. 543-550
    • Eriksson, A.1    Siegbahn, A.2    Westermark, B.3    Heldin, C.-H.4    Claesson-Welsh, L.5
  • 17
    • 0026652899 scopus 로고
    • Distinct phosphotyrosines on a growth factor receptor hind to specific molecules that mediate different signaling pathways
    • Fantl, W. J., J. A. Escobedo, G. A. Martin, C. T. Turck, M. del Rosario, F. McCormick, and L. T. Williams. 1992. Distinct phosphotyrosines on a growth factor receptor hind to specific molecules that mediate different signaling pathways. Cell 69:413-423.
    • (1992) Cell , vol.69 , pp. 413-423
    • Fantl, W.J.1    Escobedo, J.A.2    Martin, G.A.3    Turck, C.T.4    Del Rosario, M.5    McCormick, F.6    Williams, L.T.7
  • 18
    • 0027531637 scopus 로고
    • SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases
    • Feng, G.-S., C.-C. Hui, and T. Pawson. 1993. SH2-containing phosphotyrosine phosphatase as a target of protein-tyrosine kinases. Science 259:1607-1611.
    • (1993) Science , vol.259 , pp. 1607-1611
    • Feng, G.-S.1    Hui, C.-C.2    Pawson, T.3
  • 19
    • 0027535962 scopus 로고
    • Expression of functionally intact PDGF-α receptors in highly metastatic 3LL lewis lung carcinoma cells
    • Fitzer-Attas, C., M. Feldman, and L. Eisenbach. 1993. Expression of functionally intact PDGF-α receptors in highly metastatic 3LL lewis lung carcinoma cells. Int. J. Cancer 53:315-322.
    • (1993) Int. J. Cancer , vol.53 , pp. 315-322
    • Fitzer-Attas, C.1    Feldman, M.2    Eisenbach, L.3
  • 22
    • 0000579617 scopus 로고
    • Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia
    • Heldin, C.-H., B. Westermark, and A. Wasteson. 1981. Specific receptors for platelet-derived growth factor on cells derived from connective tissue and glia. Proc. Natl. Acad. Sci. USA 78:3664-3668.
    • (1981) Proc. Natl. Acad. Sci. USA , vol.78 , pp. 3664-3668
    • Heldin, C.-H.1    Westermark, B.2    Wasteson, A.3
  • 23
    • 0027365546 scopus 로고
    • Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms
    • Henriksen, R., K. Funa, E. Wilander, T. Backstrom, M. Ridderheim, and K. Oberg. 1993. Expression and prognostic significance of platelet-derived growth factor and its receptors in epithelial ovarian neoplasms. Cancer Res. 53:4550-4554.
    • (1993) Cancer Res. , vol.53 , pp. 4550-4554
    • Henriksen, R.1    Funa, K.2    Wilander, E.3    Backstrom, T.4    Ridderheim, M.5    Oberg, K.6
  • 24
    • 85088671971 scopus 로고    scopus 로고
    • Expression of PDGF, VEGF and their receptors in non-small cell lung tumor cell lines
    • in press
    • Holm, C., D. Gineitis, G. S. McConville, and A. Kazlauskas. Expression of PDGF, VEGF and their receptors in non-small cell lung tumor cell lines. Int. J. Oncol., in press.
    • Int. J. Oncol.
    • Holm, C.1    Gineitis, D.2    McConville, G.S.3    Kazlauskas, A.4
  • 25
    • 0028077899 scopus 로고
    • Differences in signal transduction between platelet-derived growth factor (PDGF) alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesis
    • Inui, H., Y. Kitami, M. Tani, T. Kondo, and T. Inagami. 1994. Differences in signal transduction between platelet-derived growth factor (PDGF) alpha and beta receptors in vascular smooth muscle cells. PDGF-BB is a potent mitogen, but PDGF-AA promotes only protein synthesis without activation of DNA synthesis. J. Biol. Chem. 269:30546-30552.
    • (1994) J. Biol. Chem. , vol.269 , pp. 30546-30552
    • Inui, H.1    Kitami, Y.2    Tani, M.3    Kondo, T.4    Inagami, T.5
  • 26
    • 0026557517 scopus 로고
    • Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo
    • Kashishian, A., A. Kazlauskas, and J. A. Cooper. 1992. Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo. EMBO J. 11:1373-1382.
    • (1992) EMBO J. , vol.11 , pp. 1373-1382
    • Kashishian, A.1    Kazlauskas, A.2    Cooper, J.A.3
  • 27
    • 0028084335 scopus 로고
    • Receptor tyrosine kinases and their targets
    • Kazlauskas, A. 1994. Receptor tyrosine kinases and their targets. Curr. Opin. Genet. Dev. 4:5-14.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 5-14
    • Kazlauskas, A.1
  • 28
    • 0024434183 scopus 로고
    • Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
    • Kazlauskas, A., and J. A. Cooper. 1989. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell 58:1121-1133.
    • (1989) Cell , vol.58 , pp. 1121-1133
    • Kazlauskas, A.1    Cooper, J.A.2
  • 29
    • 0025042770 scopus 로고
    • Phosphorylation of the PDGF receptor β subunit creates a tight binding site for phosphatidylinositol 3 kinase
    • Kazlauskas, A., and J. A. Cooper. 1990. Phosphorylation of the PDGF receptor β subunit creates a tight binding site for phosphatidylinositol 3 kinase. EMBO J. 9:3279-3266.
    • (1990) EMBO J. , vol.9 , pp. 3279-13266
    • Kazlauskas, A.1    Cooper, J.A.2
  • 30
    • 0027179869 scopus 로고
    • The 64-kDa protein that associates with the platelet-derived growth factor receptor β subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp
    • Kazlauskas, A., G.-S. Feng, T. Pawson, and M. Valius. 1993. The 64-kDa protein that associates with the platelet-derived growth factor receptor β subunit via Tyr-1009 is the SH2-containing phosphotyrosine phosphatase Syp. Proc. Natl. Acad. Sci. USA 90:6939-6942.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6939-6942
    • Kazlauskas, A.1    Feng, G.-S.2    Pawson, T.3    Valius, M.4
  • 31
    • 0026664293 scopus 로고
    • GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor β subunit
    • Kazlauskas, A., A. Kashishian, J. A. Cooper, and M. Valius. 1992. GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor β subunit. Mol. Cell. Biol. 12:2534-2544.
    • (1992) Mol. Cell. Biol. , vol.12 , pp. 2534-2544
    • Kazlauskas, A.1    Kashishian, A.2    Cooper, J.A.3    Valius, M.4
  • 32
    • 0029085194 scopus 로고
    • Identification of a putative Syp substrate, the PDGF beta receptor
    • Klinghoffer, A. R., and A. Kazlauskas. 1995. Identification of a putative Syp substrate, the PDGF beta receptor. J. Biol. Chem. 270:22208-22217.
    • (1995) J. Biol. Chem. , vol.270 , pp. 22208-22217
    • Klinghoffer, A.R.1    Kazlauskas, A.2
  • 33
    • 0027490590 scopus 로고
    • Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2
    • Lechleider, R. J., R. M. J. Freeman, and B. G. Neel. 1993. Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2. J. Biol. Chem. 268:13434-13438.
    • (1993) J. Biol. Chem. , vol.268 , pp. 13434-13438
    • Lechleider, R.J.1    Freeman, R.M.J.2    Neel, B.G.3
  • 34
    • 0027987263 scopus 로고
    • Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins
    • Li, N., J. Schlessinger, and B. Margolis. 1994. Autophosphorylation mutants of the EGF-receptor signal through auxiliary mechanisms involving SH2 domain proteins. Oncogene 9:3457-3465.
    • (1994) Oncogene , vol.9 , pp. 3457-3465
    • Li, N.1    Schlessinger, J.2    Margolis, B.3
  • 36
    • 0028136280 scopus 로고
    • Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin
    • Milarski, K. L., and A. R. Saltiel. 1994. Expression of catalytically inactive Syp phosphatase in 3T3 cells blocks stimulation of mitogen-activated protein kinase by insulin. J. Biol. Chem. 269:21239-21243.
    • (1994) J. Biol. Chem. , vol.269 , pp. 21239-21243
    • Milarski, K.L.1    Saltiel, A.R.2
  • 37
  • 38
    • 0026663734 scopus 로고
    • A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells
    • Morrison-Graham, K., G. C. Schatteman, T. Bork, D. F. Bowen-Pope, and J. A. Weston. 1992. A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells. Development 115:133-143.
    • (1992) Development , vol.115 , pp. 133-143
    • Morrison-Graham, K.1    Schatteman, G.C.2    Bork, T.3    Bowen-Pope, D.F.4    Weston, J.A.5
  • 39
    • 0023747564 scopus 로고
    • Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-α and their receptors in human malignant glioma cell lines
    • Nister, M., T. A. Libermann, C. Betsholtz, M. Pettersson, L. Claesson-Welsh, C.-H. Heldin, J. Schlessinger, and B. Westermark. 1988. Expression of messenger RNAs for platelet-derived growth factor and transforming growth factor-α and their receptors in human malignant glioma cell lines. Cancer Res. 48:3910-3918.
    • (1988) Cancer Res. , vol.48 , pp. 3910-3918
    • Nister, M.1    Libermann, T.A.2    Betsholtz, C.3    Pettersson, M.4    Claesson-Welsh, L.5    Heldin, C.-H.6    Schlessinger, J.7    Westermark, B.8
  • 40
    • 0026045167 scopus 로고
    • Differential expression ot platelet-derived growth factor receptors in human malignant glioma cell lines
    • Nister, M. L., L. Claesson-Welsh, A. Eriksson, C. H. Heldin, and B. Westermark. 1991. Differential expression ot platelet-derived growth factor receptors in human malignant glioma cell lines. J. Biol. Chem. 266:16755-16763.
    • (1991) J. Biol. Chem. , vol.266 , pp. 16755-16763
    • Nister, M.L.1    Claesson-Welsh, L.2    Eriksson, A.3    Heldin, C.H.4    Westermark, B.5
  • 41
    • 0024282573 scopus 로고
    • PDGF promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell
    • Noble, M., K. Murray, P. Stroobant, M. D. Waterfield, and P. Riddle. 1988. PDGF promotes division and motility and inhibits premature differentiation of the oligodendrocyte/type-2 astrocyte progenitor cell. Nature (London) 333:560-562.
    • (1988) Nature (London) , vol.333 , pp. 560-562
    • Noble, M.1    Murray, K.2    Stroobant, P.3    Waterfield, M.D.4    Riddle, P.5
  • 42
    • 0027103825 scopus 로고
    • Expression of mouse PDGF-A and PDGF α-receptor genes during pre- and post-implantation development: Evidence for a developmental shift from an autocrine to a paracrine mode of action
    • Palmieri, S. L., J. Payne, C. D. Stiles, J. D. Biggers, and M. Mercola. 1992. Expression of mouse PDGF-A and PDGF α-receptor genes during pre- and post-implantation development: evidence for a developmental shift from an autocrine to a paracrine mode of action. Mech. Dev. 39:181-191.
    • (1992) Mech. Dev. , vol.39 , pp. 181-191
    • Palmieri, S.L.1    Payne, J.2    Stiles, C.D.3    Biggers, J.D.4    Mercola, M.5
  • 43
    • 0028859279 scopus 로고
    • Protein modules and signaling networks
    • Pawson, T. 1995. Protein modules and signaling networks. Nature (London) 373:573-578.
    • (1995) Nature (London) , vol.373 , pp. 573-578
    • Pawson, T.1
  • 45
    • 0024282594 scopus 로고
    • Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture
    • Raff, M. C., L. E. Lillien, W. D. Richardson, J. F. Burne, and M. D. Noble. 1988. Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture. Nature (London) 333:562-565.
    • (1988) Nature (London) , vol.333 , pp. 562-565
    • Raff, M.C.1    Lillien, L.E.2    Richardson, W.D.3    Burne, J.F.4    Noble, M.D.5
  • 46
    • 0023947394 scopus 로고
    • A role for platelet-derived growth factor in normal gliogenesis in the central nervous system
    • Richardson, W. D., N. Pringle, M. J. Mosley, B. Westermark, and M. Dubois-Dalcq. 1988. A role for platelet-derived growth factor in normal gliogenesis in the central nervous system. Cell 53:309-319.
    • (1988) Cell , vol.53 , pp. 309-319
    • Richardson, W.D.1    Pringle, N.2    Mosley, M.J.3    Westermark, B.4    Dubois-Dalcq, M.5
  • 50
    • 0027418984 scopus 로고
    • PDGF-AB requires PDGF receptor α-subunits for high-affinity, but not for low-affinity, binding and signal transduction
    • Seifert, R. A., A. van Koppen, and D. F. Bowen-Pope. 1993. PDGF-AB requires PDGF receptor α-subunits for high-affinity, but not for low-affinity, binding and signal transduction. J. Biol. Chem. 268:4473-4480.
    • (1993) J. Biol. Chem. , vol.268 , pp. 4473-4480
    • Seifert, R.A.1    Van Koppen, A.2    Bowen-Pope, D.F.3
  • 51
    • 0027361809 scopus 로고
    • Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells
    • Shamah, S. M., C. D. Stiles, and A. Guhu. 1993. Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells. Mol. Cell. Biol. 13:7203-7212.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7203-7212
    • Shamah, S.M.1    Stiles, C.D.2    Guhu, A.3
  • 52
    • 0025913156 scopus 로고
    • Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF β-type receptors and respond to PDGF
    • Smits, A., M. Kato, B. Westermark, M. Nister, C.-H. Heldin, and K. Funa. 1991. Neurotrophic activity of platelet-derived growth factor (PDGF): rat neuronal cells possess functional PDGF β-type receptors and respond to PDGF. Proc. Natl. Acad. Sci. USA 88:8159-8163.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 8159-8163
    • Smits, A.1    Kato, M.2    Westermark, B.3    Nister, M.4    Heldin, C.-H.5    Funa, K.6
  • 53
    • 0028237504 scopus 로고
    • Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites
    • Soler, C., C. V. Alvarez, L. Beguinot, and G. Carpenter. 1994. Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites. Oncogene 9:2207-2215.
    • (1994) Oncogene , vol.9 , pp. 2207-2215
    • Soler, C.1    Alvarez, C.V.2    Beguinot, L.3    Carpenter, G.4
  • 56
    • 0028059309 scopus 로고
    • Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice
    • Soriano, P. 1994. Abnormal kidney development and hematological disorders in PDGF β-receptor mutant mice. Genes Dev. 8:1888-1896.
    • (1994) Genes Dev. , vol.8 , pp. 1888-1896
    • Soriano, P.1
  • 58
    • 0026130677 scopus 로고
    • 1-Histidinol provides effective selection of retrovirus-vector-transduced keratinocytes without impairing their proliferative potential
    • Stockschlaeder, M. A., R. Storb, W. R. Osborne, and A. D. Miller. 1991. 1-Histidinol provides effective selection of retrovirus-vector-transduced keratinocytes without impairing their proliferative potential. Hum. Gene Ther. 2:33-39.
    • (1991) Hum. Gene Ther. , vol.2 , pp. 33-39
    • Stockschlaeder, M.A.1    Storb, R.2    Osborne, W.R.3    Miller, A.D.4
  • 59
    • 0028878979 scopus 로고
    • The SH2-containing protein tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development
    • Tang, T. L., R. M. J. Freeman, A. M. O'Reilly, B. G. Neel, and S. Y. Sokol. 1995. The SH2-containing protein tyrosine phosphatase SH-PTP2 is required upstream of MAP kinase for early Xenopus development. Cell 80: 473-483.
    • (1995) Cell , vol.80 , pp. 473-483
    • Tang, T.L.1    Freeman, R.M.J.2    O'Reilly, A.M.3    Neel, B.G.4    Sokol, S.Y.5
  • 60
    • 0027506762 scopus 로고
    • Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor β subunit and are required for binding of phospholipase Cγ and a 64-kilodalton protein, respectively
    • Valius, M., C. Bazenet, and A. Kazlauskas. 1993. Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor β subunit and are required for binding of phospholipase Cγ and a 64-kilodalton protein, respectively. Mol. Cell. Biol. 13:133-143.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 133-143
    • Valius, M.1    Bazenet, C.2    Kazlauskas, A.3
  • 61
    • 0027211693 scopus 로고
    • Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
    • Valius, M., and A. Kazlauskas. 1993. Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 73:321-334.
    • (1993) Cell , vol.73 , pp. 321-334
    • Valius, M.1    Kazlauskas, A.2
  • 62
    • 0027159221 scopus 로고
    • Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant
    • Vassbotn, F. S., M. Andersson, B. Westermark, C.-H. Heldin, and A. Östman. 1993. Reversion of autocrine transformation by a dominant negative platelet-derived growth factor mutant. Mol. Cell. Biol. 13:4066-4076.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 4066-4076
    • Vassbotn, F.S.1    Andersson, M.2    Westermark, B.3    Heldin, C.-H.4    Östman, A.5
  • 63
    • 0026753688 scopus 로고
    • Neomycin is a platelet-derived growth factor (PDGF) antagonist that allows discrimination of PDGF alpha- and beta-receptor signals in cells expressing both receptor types
    • Vassbotn, F. S., A. Ostman, S. Siegbahn, H. Holmsen, and C.-H. Heldin. 1992. Neomycin is a platelet-derived growth factor (PDGF) antagonist that allows discrimination of PDGF alpha- and beta-receptor signals in cells expressing both receptor types. J. Biol. Chem. 267:15635-15641.
    • (1992) J. Biol. Chem. , vol.267 , pp. 15635-15641
    • Vassbotn, F.S.1    Ostman, A.2    Siegbahn, S.3    Holmsen, H.4    Heldin, C.-H.5
  • 64
    • 0027399168 scopus 로고
    • Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation
    • Vogel, W., R. Lammers, J. Huang, and A. Ulrich. 1993. Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. Science 259:1611-1614.
    • (1993) Science , vol.259 , pp. 1611-1614
    • Vogel, W.1    Lammers, R.2    Huang, J.3    Ulrich, A.4
  • 67
    • 0026012736 scopus 로고
    • PDGF A-chain gene is expressed by mammalian neurons during development and in maturity
    • Yen, H.-J., K. G. Ruit, Y.-X. Wang, W. C. Parks, W. D. Snider, and T. F. Deuel. 1991. PDGF A-chain gene is expressed by mammalian neurons during development and in maturity. Cell 64:209-216.
    • (1991) Cell , vol.64 , pp. 209-216
    • Yen, H.-J.1    Ruit, K.G.2    Wang, Y.-X.3    Parks, W.C.4    Snider, W.D.5    Deuel, T.F.6
  • 68
    • 0027512554 scopus 로고
    • Developmental expression of the platelet-derived growth factor alpha-receptor gene in the mammalian central nervous system
    • Yen, H. J., I. Silos-Santiago, Y. X. Wang, R. J. George, W. D. Snider, and T. F. Deuel. 1993. Developmental expression of the platelet-derived growth factor alpha-receptor gene in the mammalian central nervous system. Proc. Natl. Acad. Sci. USA 90:1952-1956.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1952-1956
    • Yen, H.J.1    Silos-Santiago, I.2    Wang, Y.X.3    George, R.J.4    Snider, W.D.5    Deuel, T.F.6
  • 69
    • 0028043846 scopus 로고
    • Biological function of PDGF-induced PI-3 kinases activity: Its role in alpha PDGF receptor-mediated mitogenic or chemotactic signaling
    • Yu, J.-C., J. S. Gutkind, D. Mahadevan, W. Li, K. A. Meyers, J. H. Pierce, and M. A. Heidaran. 1994. Biological function of PDGF-induced PI-3 kinases activity: its role in alpha PDGF receptor-mediated mitogenic or chemotactic signaling. J. Cell Biol. 127:479-487.
    • (1994) J. Cell Biol. , vol.127 , pp. 479-487
    • Yu, J.-C.1    Gutkind, J.S.2    Mahadevan, D.3    Li, W.4    Meyers, K.A.5    Pierce, J.H.6    Heidaran, M.A.7
  • 70
    • 0025735518 scopus 로고
    • Tyrosine mutations within the α platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction
    • Yu, J.-C., M. A. Heidaran, J. H. Pierce, J. S. Gutkind, D. Lombardi, M. Ruggiero, and S. A. Aaronson. 1991. Tyrosine mutations within the α platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction. Mol. Cell. Biol. 11:3780-3785.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 3780-3785
    • Yu, J.-C.1    Heidaran, M.A.2    Pierce, J.H.3    Gutkind, J.S.4    Lombardi, D.5    Ruggiero, M.6    Aaronson, S.A.7
  • 71
    • 0028930121 scopus 로고
    • Differential requirement of a motif within the carboxyl-terminal domain of the alpha-platelet-derived growth factor (alphaPDGF) receptor for PDGF focus forming activity, chemotaxis or growth
    • Yu, J.-C., W. Li, L.-M. Wang, A. Uren, J. H. Pierce, and M. A. Heidaran. 1995. Differential requirement of a motif within the carboxyl-terminal domain of the alpha-platelet-derived growth factor (alphaPDGF) receptor for PDGF focus forming activity, chemotaxis or growth. J. Biol. Chem. 270: 7033-7036.
    • (1995) J. Biol. Chem. , vol.270 , pp. 7033-7036
    • Yu, J.-C.1    Li, W.2    Wang, L.-M.3    Uren, A.4    Pierce, J.H.5    Heidaran, M.A.6


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