Induction of anergy in human T helper 0 cells by stimulation with altered T cell antigen receptor ligands

Journal of Immunology

Volumn 156, Issue 8, 1996, Pages 2801-2808

  Tsitoura, Daphne C ^a   Holtet, Wolfgang ^b   Cerwenka, Adelheid ^b   Gelder, Colin M ^a   Lamb, Jonathan R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b CHILDREN'S CANCER RESEARCH INSTITUTE   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GAMMA INTERFERON; INTERLEUKIN 4; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR; PEPTIDE FRAGMENT; VIRUS HEMAGGLUTININ;

AMINO ACID SEQUENCE; ARTICLE; BIOSYNTHESIS; CELL COMMUNICATION; CHEMISTRY; CLONAL ANERGY; DRUG EFFECT; HELPER CELL; HUMAN; IMMUNOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; METABOLISM; MOLECULAR GENETICS; ORTHOMYXOVIRUS; PHYSIOLOGY;

AMINO ACID SEQUENCE; AMINO ACIDS; CELL COMMUNICATION; CLONAL ANERGY; HEMAGGLUTININS, VIRAL; HUMANS; IMMUNOPHENOTYPING; INTERFERON TYPE II; INTERLEUKIN-4; LIGANDS; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; ORTHOMYXOVIRIDAE; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0030584803     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Babbitt, B. P., P. M. Allen, G. Matsueda, E. Haber, and E. R Unanue. 1985. Binding of immunogenic peptides to Ia histocompatibility molecules Nature 317:359.
2. Schwartz. R. H. 1985. T lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu. Rev. Immunol. 4:205.
3. Moller, G 1987 Antigen requirements for activation of MHC restricted responses. Immunol Rev 98:1.
4. Mueller, D. L., M. K. Jenkins, and R. H. Schwartz. 1989. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev Immunol 7:445.
5. Lamb, J. R, B. J. Skidmore, N. Green, J. M. Chiller, and M. Feldmann. 1983. Induction of tolerance m influenza virus immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin. J. Exp. Med 157:1434.
6. Jenkins, M. K , and R. H. Schwartz. 1987 Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J. Exp. Med. 165-302.
7. Gajewski, T R, D. W. Lancki, R. Stack, and F. W. Fitch. 1994. "Anergy" of Th0 helper T lymphocytes induces a downregulation of Th1 characteristics and a transition to Th2 phenotype. J Exp. Med. 179:481.
8. Williams, M. E., A. II. Lichtman, and A. K. Abbas. 1990. Anti-CD3 antibody induces unresponsiveness to IL-2 in Th1 clones but not in Th2 clones. J. Immunol. 144:1208.
9. Sloan-Lancaster, J., B. D. Evavold, and P. M. Allen. 1993. Induction of T cell anergy by altered T cell receptor ligand on live antigen-presenting cells. Nature 363:156.
10. Sloan-Lancaster, J., B. D. Evavold, and P, M. Allen. 1994 Th2 clonal anergy as a consequence of partial activation. J. Exp. Med. 180:1195.
11. Schall, T. J., R. E. O'Hehir, D V. Goeddel, and J. R. Lamb. 1992. Uncoupling of cytokine mRNA expression and protein secretion during the induction phase of T cell anergy. J. Immunol. 148.381.
12. O'Hehir, R. E , H. Yssel, S. Verma, J E de Vries, H. Spits, and J. R. Lamb. 1991. Clonal analysis of differential lymphokine secretion in peptide and superantigen induced anergy. Int Immunol. 3:819.
13. Gilbert, K. M , K D. Hoang, and W O. Weigle 1990. Th1 and Th2 clones differ in their response to a tolerogenic signal. J Immunol. 144:2063.
14. Williams, M. E., C. M Shea. A. H. Lichtman. and A. K Abbas. 1992. Antigen-receptor mediated anergy in resting T lymphocytes and T cell clones: correlation with lymphokine secretion patterns. J. Immunol 149:1921.
15. Evavold, B. D., and P M. Allen. 1991. Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand. Science 252.1308.
16. Evavold, B. D., J. Sloan-Lancaster, and P. M Allen. 1993 Tickling the TCR: selective T-cell functions stimulated by altered peptide ligand. Immunol. Today 14.602.
17. Stem, L. I, J H Brown, T. S. Jardetzky, and D. C Wiley. 1994 Crystal structure of the human class 11 MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368:215.
18. Stem, L. J., and D. C. Wiley. 1994. Antigen peptide binding by class I and class II histocompatibility proteins Structure 2:245.
19. Busch R , and .T. B. Rothbard. 1990. Detection of peptide-MHC class II complexes on the surface of intact cells J. Immunol. Methods 134:1.
20. O'Sullivan, D., T. Arrhemus, J. Sidney, M -F Del Guercio, M. Albertson, M. Wall, C Oseroff, S. Southwood, S. Colon, F. C. A. Gaeta. and A. Sette 1991 On the interaction of promiscuous antigenic peptides with different DR alleles: identification of common structural motifs. J. Immunol. 147:2663.
21. Lamb. J. R, D. Eckels, P. Lake, J. Woody, and N. Green. 1982. Human T-cell clones recognise chemically synthesised peptides of influenza haemagglutinra. Nature 300:66.
22. Wraith, D. C., B. Bruun, and P. J. Fairchild. 1992. Cross-reactive antigen recognition by an encephalitogenic T cell receptor J. Immunol. 149:3765.
23. Holier, W., O. Majdic, F. S. Kalthoff, and W Knapp. 1992. Regulation of interleukin-4 production in human mononuclear cells. Eur. J. Immunol. 22 2765
24. O'Hehir, R. E., and J. R. Lamb. 1990. Induction of specific clonal anergy in human T lymphocytes by Stapliylococcus aureus enterotoxins. Proc. Natl. Acad Sci. USA 87.8884.
25. Rothbard, J. B , R. Lechler, K Howland, V. Bal, D. Eckels, R. Sekaly, E. Long, W. Taylor. and J. R. Lamb. 1988. Structural model of HLA-DR1 restricted T cell antigen recognition. Cell 52:515.
26. Evavold, B D , S. G. Williams, J S. Chen, and P. M. Allen. 1991. T cell inducing determinants contain hierarchy of residues contacting the T cell receptor. Semin. Immunol. 3:225.
27. Lamb, J. R., J. A. Higgins, C. Hetzel, J. D. Hayball, R. A. Lake, and R. E. O'Hehir. 1995. The effects of changes at peptide residues contacting MHC class II or TCR on antigen recognition and human Th0 cell effector function Immunology 85:447.
28. Ria, F, B M. Chan, M T Scherer, J. A. Smith, and M. L. Gefter. 1990. Immunological activity of covalently linked T cell epitopes Nature 343:381.
29. Liu, G. Y., and D C. Wraith. 1995 Affinity for class II MHC determines the extent to which soluble peptides tolerise autoreactive T cells in naive and primed adult mice implications for autoimmunity Int Immunol 7:1255.
30. Yssel, H., S. Fasler, J Lamb, and J. E. de Vries. 1994 Induction of nonresponsiveness in human allergen-specific type 2 helper cells. Curr. Opin. Immunol. 6:847.
31. Wedderburn. L. R , S. J M. Searle, A. R. Rees, J. R. Lamb, and M. J. Owen 1995. Mapping T cell recognition: the identification of a T cell receptor residue critical to the specific interaction with an influenza haemagglutirun peptide Eur J. Immunol. 25:1654.
32. Racioppi L., F. Ronchese, L. A. Matis, and R. N. Germain. 1993. Peptide-major histocompatibility complexes with mixed agonist/antagonist properties provide evidence for ligand-related differences in T cell receptor-dependent intracellular signalling. J. Exp. Med. 177.1047.
33. Sloan-Lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994 Partial T cell signaling altered phospho-ζ and lack of ZAP-70 recruitment in APL-induced T cell anergy. Cell 79.913.
34. Madrenas, J., R. L. Wange. J. L. Wang. N. Isakov, L. E. Samelson, and R N Germain. 1995 Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists Science 267:515
35. Betz, M , and B. S. Fox. 1991. Prostaglandin E2 inhibits production of Th1 but not Th2 lymphokines J. Immunol 146:108.
36. Lee, H. J , N Koyano-Nakagawa, Y Naito, J. Nishida, N. Arai, K. I. Arai, and T. Yokcota. 1993. cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4. J. Immunol. 151.6135
37. Neumann. M., T Grieshammer, S. Chuvpilo, B Kneitz, M. Lohoff, A. Sehimpl, B. R. Franza, and E. Serffing. 1995. RelA/p65 is a molecular target for the immunosuppressivc action of protein kinase A. EMBO J. 14:1991
38. Franco, A , S Southwood, T Arrhenius, V. K. Kuchroo, H. M. Grey, A Sette, and G Y. Ishioka 1994. T cell receptor antagonist peptides are highly effective inhibitors of experimental allergic encephalomyehus. Eur. J Immunol. 24.940.
39. Hetzel, C., and J. R. Lamb. 1994. CD4+ T cell targeted immunomudulation and the therapy of allergic disease. Clin. Immunol. Immunopathol. 73:1
40. Sloan-Lancaster, J , and P M. Allen 1995. Significance of T cell stimulation by altered peptide ligands in T cell biology. Curr Opin. Immunol 7:103.