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Volumn 157, Issue 10, 1996, Pages 4341-4346

Deletion in HCDR3 Rescues T15 Antibody Mutants from a Secretion Defect Caused by Mutations in HCDR2

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; PHOSPHOLIPID ANTIBODY; PHOSPHORYLCHOLINE;

EID: 0030588683     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (10)

References (42)
  • 1
    • 0024461745 scopus 로고
    • Protein oligomerization in the endoplasmic reticulum
    • Hurtley, S. M., and A. Helenius. 1989. Protein oligomerization in the endoplasmic reticulum. Annu. Rev. Cell Biol. 5:277.
    • (1989) Annu. Rev. Cell Biol. , vol.5 , pp. 277
    • Hurtley, S.M.1    Helenius, A.2
  • 2
    • 0015702537 scopus 로고
    • The synthesis, assembly, and secretion of immunoglobulin: A biochemical and genetic approach
    • Scharff, M. D. 1975. The synthesis, assembly, and secretion of immunoglobulin: a biochemical and genetic approach. Harvey Lect. 69:125.
    • (1975) Harvey Lect. , vol.69 , pp. 125
    • Scharff, M.D.1
  • 3
    • 0025134871 scopus 로고
    • A single amino acid substitution in the variable region of the light chain specifically blocks immunoglobulin secretion
    • Dul, J. L., and Y. Argon. 1990. A single amino acid substitution in the variable region of the light chain specifically blocks immunoglobulin secretion. Proc. Natl. Acad. Sci. USA 87:8135.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 8135
    • Dul, J.L.1    Argon, Y.2
  • 4
    • 0026768470 scopus 로고
    • A conditional secretory mutant in an Ig L chain is caused by replacement of tyrosine/phenylalanine 87 with histidine
    • Dul, J. L., O. R. Burrone, and Y. Argon. 1992. A conditional secretory mutant in an Ig L chain is caused by replacement of tyrosine/phenylalanine 87 with histidine. J. Immunol. 149:1927.
    • (1992) J. Immunol. , vol.149 , pp. 1927
    • Dul, J.L.1    Burrone, O.R.2    Argon, Y.3
  • 5
    • 0026334511 scopus 로고
    • Immunoglobulin transport in B cell development
    • Pillai, S. 1991. Immunoglobulin transport in B cell development. Int. Rev. Cytol. 130:1.
    • (1991) Int. Rev. Cytol. , vol.130 , pp. 1
    • Pillai, S.1
  • 6
    • 0019787187 scopus 로고
    • Ig biosynthesis in a human pre-B cell line
    • McCune, J. M., and S. M. Fu. 1981. Ig biosynthesis in a human pre-B cell line. J. Immunol. 127:2609.
    • (1981) J. Immunol. , vol.127 , pp. 2609
    • McCune, J.M.1    Fu, S.M.2
  • 7
    • 0022556376 scopus 로고
    • Gene transfer of immunoglobulin light chain restores heavy chain secretion
    • Pepe, V. H., G. E. Sonenshein, M. I. Yoshimura, and M. J. Shulman. 1986. Gene transfer of immunoglobulin light chain restores heavy chain secretion. J. Immunol. 137:2367.
    • (1986) J. Immunol. , vol.137 , pp. 2367
    • Pepe, V.H.1    Sonenshein, G.E.2    Yoshimura, M.I.3    Shulman, M.J.4
  • 8
    • 0016640704 scopus 로고
    • Heavy chain-producing variants of a mouse myeloma cell line
    • Morrison, S. L., and M. D. Scharff. 1975. Heavy chain-producing variants of a mouse myeloma cell line. J. Immunol. 114:655.
    • (1975) J. Immunol. , vol.114 , pp. 655
    • Morrison, S.L.1    Scharff, M.D.2
  • 9
    • 0026569212 scopus 로고
    • Interaction of BiP with newly synthesized immunoglobulin light chain molecules: Cycles of sequential binding and release
    • Knittler, M. R., and I. G. Haas 1992. Interaction of BiP with newly synthesized immunoglobulin light chain molecules: cycles of sequential binding and release. EMBO J. 11:1573.
    • (1992) EMBO J. , vol.11 , pp. 1573
    • Knittler, M.R.1    Haas, I.G.2
  • 10
    • 0020641571 scopus 로고
    • Secretion of a λ2 immunoglobulin chain is prevented by a single amino acid substitution in its variable region
    • Wu, G. E., N. Hozumi, and H. Murialdo. 1983. Secretion of a λ2 immunoglobulin chain is prevented by a single amino acid substitution in its variable region. Cell 33:77.
    • (1983) Cell , vol.33 , pp. 77
    • Wu, G.E.1    Hozumi, N.2    Murialdo, H.3
  • 11
    • 0029022591 scopus 로고
    • Coordination of immunoglobulin chain folding and immunoglobulin chain assembly is essential for the formation of functional IgG
    • Kaloff, C. R., and I. G. Haas. 1995. Coordination of immunoglobulin chain folding and immunoglobulin chain assembly is essential for the formation of functional IgG. Immunity 2:629.
    • (1995) Immunity , vol.2 , pp. 629
    • Kaloff, C.R.1    Haas, I.G.2
  • 12
    • 0023096246 scopus 로고
    • Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein
    • Hendershot, L., D. Bole, G. Köhler, and J. F. Kearney. 1987. Assembly and secretion of heavy chains that do not associate posttranslationally with immunoglobulin heavy chain-binding protein. J. Cell Biol. 104:761.
    • (1987) J. Cell Biol. , vol.104 , pp. 761
    • Hendershot, L.1    Bole, D.2    Köhler, G.3    Kearney, J.F.4
  • 13
    • 0022536233 scopus 로고
    • Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas
    • Bole, D. G., L. M. Hendershot, and J. F. Kearny. 1986. Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas. J. Cell Biol. 102:1558.
    • (1986) J. Cell Biol. , vol.102 , pp. 1558
    • Bole, D.G.1    Hendershot, L.M.2    Kearny, J.F.3
  • 16
    • 0028357638 scopus 로고
    • Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementary determining region 2
    • Chen, C., T. M. Martin, S. Stevens, and M. B. Rittenberg. 1994. Defective secretion of an immunoglobulin caused by mutations in the heavy chain complementary determining region 2. J. Exp. Med. 180:577.
    • (1994) J. Exp. Med. , vol.180 , pp. 577
    • Chen, C.1    Martin, T.M.2    Stevens, S.3    Rittenberg, M.B.4
  • 18
    • 0026782875 scopus 로고
    • Generation and analysis of random point mutations in an antibody CDR2 sequence: Many mutated antibodies lose their ability to bind antigen
    • Chen, C., V. A. Roberts, and M. B. Rittenberg. 1992. Generation and analysis of random point mutations in an antibody CDR2 sequence: Many mutated antibodies lose their ability to bind antigen. J. Exp. Med. 176:855.
    • (1992) J. Exp. Med. , vol.176 , pp. 855
    • Chen, C.1    Roberts, V.A.2    Rittenberg, M.B.3
  • 19
    • 0014943022 scopus 로고
    • Variability in the lambda light chain sequences of mouse antibody
    • Weigert, M. G., I. M. Cesari, S. J. Yonkovich, and M. Cohn. 1970. Variability in the lambda light chain sequences of mouse antibody. Nature 228:1045.
    • (1970) Nature , vol.228 , pp. 1045
    • Weigert, M.G.1    Cesari, I.M.2    Yonkovich, S.J.3    Cohn, M.4
  • 20
    • 0026537575 scopus 로고
    • Immunologic memory to phosphocholine keyhole limpet hemocyanin. Recurrent mutations in the lambda I light chain increase affinity for antigen
    • Brown, M., M. P. Stenzel-Poore, S. Stevens, S. K. Kondoleon, J. Ng, H. P. Bachinger, and M. B. Rittenberg. 1992. Immunologic memory to phosphocholine keyhole limpet hemocyanin. Recurrent mutations in the lambda I light chain increase affinity for antigen. J. Immunol. 148:339.
    • (1992) J. Immunol. , vol.148 , pp. 339
    • Brown, M.1    Stenzel-Poore, M.P.2    Stevens, S.3    Kondoleon, S.K.4    Ng, J.5    Bachinger, H.P.6    Rittenberg, M.B.7
  • 21
    • 0024349257 scopus 로고
    • Molecular analysis and fine specificity of antibodies against an organophosphorus hapten
    • Buenafe, A., and M. B. Rittenberg. 1989. Molecular analysis and fine specificity of antibodies against an organophosphorus hapten. J. Immunol. 143:539.
    • (1989) J. Immunol. , vol.143 , pp. 539
    • Buenafe, A.1    Rittenberg, M.B.2
  • 22
    • 0023796143 scopus 로고
    • RNA isolation: A mini-prep method
    • Wilkinson, M. 1988. RNA isolation: a mini-prep method. Nucleic Acids Res. 16:10933.
    • (1988) Nucleic Acids Res. , vol.16 , pp. 10933
    • Wilkinson, M.1
  • 23
    • 0018843979 scopus 로고
    • An immunoglobulin heavy chain variable region is generated from three segments of DNA: VH, D and JH
    • Early, P., H. Huang, M. Davis, K. Calame, and L. Hood. 1980. An immunoglobulin heavy chain variable region is generated from three segments of DNA: VH, D and JH. Cell 19:981.
    • (1980) Cell , vol.19 , pp. 981
    • Early, P.1    Huang, H.2    Davis, M.3    Calame, K.4    Hood, L.5
  • 24
    • 0019498437 scopus 로고
    • Nucleic acid and protein sequences of phosphocholine-binding light chains
    • Kwan, S. P., S. Rudikoff, J. G. Seidman, P. Leder, and M. D. Scharff. 1981. Nucleic acid and protein sequences of phosphocholine-binding light chains. J. Exp. Med. 153:1366.
    • (1981) J. Exp. Med. , vol.153 , pp. 1366
    • Kwan, S.P.1    Rudikoff, S.2    Seidman, J.G.3    Leder, P.4    Scharff, M.D.5
  • 25
    • 0024820854 scopus 로고
    • Clonal diversity, somatic mutation, and immune memory to phosphocholine-keyhole limpet homocyanin
    • Stenzel-Poore, M. P., and M. B. Rittenberg. 1989. Clonal diversity, somatic mutation, and immune memory to phosphocholine-keyhole limpet homocyanin. J. Immunol. 143:4123.
    • (1989) J. Immunol. , vol.143 , pp. 4123
    • Stenzel-Poore, M.P.1    Rittenberg, M.B.2
  • 26
    • 0018507639 scopus 로고
    • Production of mRNA in Chinese hamster cells: Relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences
    • Harpold, M. M., R. M. Evans, M. S. Salditt-Georgieff, and J. E. Darnell. 1979. Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell 17:1025.
    • (1979) Cell , vol.17 , pp. 1025
    • Harpold, M.M.1    Evans, R.M.2    Salditt-Georgieff, M.S.3    Darnell, J.E.4
  • 27
    • 0020064743 scopus 로고
    • Immunologic memory to phosphorylcholine. II. PC-KLH induces two antibody populations that dominate different isotypes
    • Chang, S. P., M. Brown, and M. B. Rittenberg. 1982. Immunologic memory to phosphorylcholine. II. PC-KLH induces two antibody populations that dominate different isotypes. J. Immunol. 128:702.
    • (1982) J. Immunol. , vol.128 , pp. 702
    • Chang, S.P.1    Brown, M.2    Rittenberg, M.B.3
  • 28
    • 0030009781 scopus 로고    scopus 로고
    • Tolerance to single, but not multiple, amino acid replacements in antibody VH CDR2: A means of minimizing B cell wastage from somatic hypermutation?
    • Brown, M., M. B. Rittenberg, C. Chen, and V. A. Roberts. 1996. Tolerance to single, but not multiple, amino acid replacements in antibody VH CDR2: a means of minimizing B cell wastage from somatic hypermutation? J. Immunol. 156: 3285.
    • (1996) J. Immunol. , vol.156 , pp. 3285
    • Brown, M.1    Rittenberg, M.B.2    Chen, C.3    Roberts, V.A.4
  • 31
    • 0028966985 scopus 로고
    • Engineered turns of a recombinant antibody improve its in vivo folding
    • Knappik, A., and A. Plückthun. 1995. Engineered turns of a recombinant antibody improve its in vivo folding. Protein Eng. 8:81.
    • (1995) Protein Eng. , vol.8 , pp. 81
    • Knappik, A.1    Plückthun, A.2
  • 32
    • 0028289241 scopus 로고
    • Anatomy of the antibody molecule
    • Padlan, E. A. 1994. Anatomy of the antibody molecule. Mol. Immunol. 31:169.
    • (1994) Mol. Immunol. , vol.31 , pp. 169
    • Padlan, E.A.1
  • 34
    • 0022339938 scopus 로고
    • Domain association in immunoglobulin molecules: The packing of variable domains
    • Chothia, C., J. Novotny, R. Bruccoleri, and M. Karplus. 1985. Domain association in immunoglobulin molecules: the packing of variable domains. J. Mol. Biol. 186:651.
    • (1985) J. Mol. Biol. , vol.186 , pp. 651
    • Chothia, C.1    Novotny, J.2    Bruccoleri, R.3    Karplus, M.4
  • 36
    • 0029047689 scopus 로고
    • Enhancement and destruction of antibody function by somatic mutation: Unequal occurrence is controlled by V gene combinatorial associations
    • Chen, C., V. A. Roberts, S. Stevens, M. Brown, M. P. Stenzel-Poore, and M. B. Rittenberg. 1995. Enhancement and destruction of antibody function by somatic mutation: unequal occurrence is controlled by V gene combinatorial associations. EMBO J. 14:2784.
    • (1995) EMBO J. , vol.14 , pp. 2784
    • Chen, C.1    Roberts, V.A.2    Stevens, S.3    Brown, M.4    Stenzel-Poore, M.P.5    Rittenberg, M.B.6
  • 37
    • 0023278330 scopus 로고
    • Canonical structures for the hypervariable regions of immunoglobulins
    • Chothia, C., and A. M. Lesk. 1987. Canonical structures for the hypervariable regions of immunoglobulins. J. Mol. Biol. 196:901.
    • (1987) J. Mol. Biol. , vol.196 , pp. 901
    • Chothia, C.1    Lesk, A.M.2
  • 38
    • 0027335509 scopus 로고
    • Role of mouse VH10 and VL gene segments in the specific binding of antibody to Z-DNA, analyzed with recombinant single chain Fv molecules
    • Brigido, M. M., M. Polymenis, and B. D. Stollar. 1993. Role of mouse VH10 and VL gene segments in the specific binding of antibody to Z-DNA, analyzed with recombinant single chain Fv molecules. J. Immunol. 150:469.
    • (1993) J. Immunol. , vol.150 , pp. 469
    • Brigido, M.M.1    Polymenis, M.2    Stollar, B.D.3
  • 39
    • 0027254941 scopus 로고
    • Differences in heavy chain amino acid sequences affecting the specificity of antibodies for variants of cytochrome c
    • Jemmerson, R., C. Mueller, and D. Flaa. 1993. Differences in heavy chain amino acid sequences affecting the specificity of antibodies for variants of cytochrome c. Mol. Immunol. 30:1107.
    • (1993) Mol. Immunol. , vol.30 , pp. 1107
    • Jemmerson, R.1    Mueller, C.2    Flaa, D.3
  • 40
    • 0027057707 scopus 로고
    • Nucleotide sequence of messenger RNA encoding VHDJH and VKJK of a highly conserved idiotype-defined primary response anti-hapten antibody
    • Lou, S. C., D. Winter, G. L. Mayers, and R. B. Bankert. 1992. Nucleotide sequence of messenger RNA encoding VHDJH and VKJK of a highly conserved idiotype-defined primary response anti-hapten antibody. J. Immunol. 149:3944.
    • (1992) J. Immunol. , vol.149 , pp. 3944
    • Lou, S.C.1    Winter, D.2    Mayers, G.L.3    Bankert, R.B.4
  • 41
    • 0025823716 scopus 로고
    • Identical V region amino acid sequences and segments of sequences in antibodies of different specificities: Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites
    • Kabat, E. A., and T. T. Wu. 1991. Identical V region amino acid sequences and segments of sequences in antibodies of different specificities: Relative contributions of VH and VL genes, minigenes, and complementarity-determining regions to binding of antibody-combining sites. J. Immunol. 147:1709.
    • (1991) J. Immunol. , vol.147 , pp. 1709
    • Kabat, E.A.1    Wu, T.T.2
  • 42
    • 0026610941 scopus 로고
    • VH-related idiotopes detected by site-directed mutagenesis: A study induced by the failure to find CD4 anti-idiotypic antibodies mimicking the cellular receptor of HIV
    • Weissenhorn, W., Y.-H. Chen, G. Riethmüller, E. P. Rieber, and E. H. Weiss. 1992. VH-related idiotopes detected by site-directed mutagenesis: a study induced by the failure to find CD4 anti-idiotypic antibodies mimicking the cellular receptor of HIV. J. Immunol. 149:1237.
    • (1992) J. Immunol. , vol.149 , pp. 1237
    • Weissenhorn, W.1    Chen, Y.-H.2    Riethmüller, G.3    Rieber, E.P.4    Weiss, E.H.5


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