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For leading references see: (a) Cox, R. J.; Sherwin, W. A.; Lam, L. K. P.; Vederas, J. C. J. Am. Chem. Soc. 1996, 118, 7449-7460. (b) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. (c) Auger, G.; van Heijenoort, J.; Vederas, J. C.; Blanot, D. FEBS Lett. 1996, 391, 171-174. (d) Couper, L.; McKendrick, J. E.; Robins, D. J.; Chrystal, E. J. T. Biorg. Med. Chem. Lett. 1994, 4, 2267-2272. (e) Abbott, S. D.; Lane-Bell, P.; Sidhu, K. P. S.; Vederas, J. C. J. Am. Chem. Soc. 1994, 116, 6513-6520. (f) Song, Y. H.; Niederer, D.; Lane-Bell, P.; Lam, L. K. P.; Crawley, S.; Palcic, M. M.; Pickard, M. A.; Pruess, D. L.; Vederas, J. C. J. Org. Chem. 1994, 59, 5784-5793. (g) Roberts, J. L.; Borgese, J.; Chan, C.; Keith, D. D.; Wei, C.-C. Heterocycles 1993, 35, 115-120.
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For leading references see: (a) Cox, R. J.; Sherwin, W. A.; Lam, L. K. P.; Vederas, J. C. J. Am. Chem. Soc. 1996, 118, 7449-7460. (b) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. (c) Auger, G.; van Heijenoort, J.; Vederas, J. C.; Blanot, D. FEBS Lett. 1996, 391, 171-174. (d) Couper, L.; McKendrick, J. E.; Robins, D. J.; Chrystal, E. J. T. Biorg. Med. Chem. Lett. 1994, 4, 2267-2272. (e) Abbott, S. D.; Lane-Bell, P.; Sidhu, K. P. S.; Vederas, J. C. J. Am. Chem. Soc. 1994, 116, 6513-6520. (f) Song, Y. H.; Niederer, D.; Lane-Bell, P.; Lam, L. K. P.; Crawley, S.; Palcic, M. M.; Pickard, M. A.; Pruess, D. L.; Vederas, J. C. J. Org. Chem. 1994, 59, 5784-5793. (g) Roberts, J. L.; Borgese, J.; Chan, C.; Keith, D. D.; Wei, C.-C. Heterocycles 1993, 35, 115-120.
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For leading references see: (a) Cox, R. J.; Sherwin, W. A.; Lam, L. K. P.; Vederas, J. C. J. Am. Chem. Soc. 1996, 118, 7449-7460. (b) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. (c) Auger, G.; van Heijenoort, J.; Vederas, J. C.; Blanot, D. FEBS Lett. 1996, 391, 171-174. (d) Couper, L.; McKendrick, J. E.; Robins, D. J.; Chrystal, E. J. T. Biorg. Med. Chem. Lett. 1994, 4, 2267-2272. (e) Abbott, S. D.; Lane-Bell, P.; Sidhu, K. P. S.; Vederas, J. C. J. Am. Chem. Soc. 1994, 116, 6513-6520. (f) Song, Y. H.; Niederer, D.; Lane-Bell, P.; Lam, L. K. P.; Crawley, S.; Palcic, M. M.; Pickard, M. A.; Pruess, D. L.; Vederas, J. C. J. Org. Chem. 1994, 59, 5784-5793. (g) Roberts, J. L.; Borgese, J.; Chan, C.; Keith, D. D.; Wei, C.-C. Heterocycles 1993, 35, 115-120.
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Tyler, A.N.2
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For leading references see: (a) Johannsen, L.; Wecke, J.; Obal, F.; Krueger, J. M. Am. J. Physiol. 1991, 260, R126-R133. (b) Johannsen, L. APMIS 1993, 101, 337-344. (c) Luker, K. E.; Tyler, A. N.; Marshall, G. R.; Goldman, W. E. Molec. Microbiol. 1995, 16, 733-743. (d) Takada, H.; Kawabata, Y.; Kawata, S.; Kusumoto, S. Infect. Immun. 1996, 64, 657-659.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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For some examples see: (a) Gelb, M. H.; Lin, Y.; Pickard, M. A.; Song, Y.; Vederas, J. C. J. Am. Chem. Soc. 1990, 112, 4932-4942. (b) Jurgens, J. Tetrahedron Lett. 1992, 33, 4727-4730. (c) Kolodziejczyk, A. M.; Kolodziejczyk, A. S.; Stoev, S. Int. J. Peptide Protein Res. 1992, 39, 382-387. (d) Williams, R. M.; Yuan, C. J. Org. Chem. 1992, 57, 6519-6527. (e) Bold, G.; Allmendinger, T.; Herold, P.; Moesch, L.; Schär, H.-P.; Duthaler, R. O. Helv. Chim. Acta 1992, 75, 865-882. (f) Baldwin, J. E.; Lee, V.; Schofield, C. J. Synth. Lett. 1992, 249-251. (g) Williams, R. M.; Yuan, C. J. Org. Chem. 1994, 59, 6190-6193. (h) Holcomb, R. C.; Schow, S.; Ayral-Kaloustian, S.; Powell, D. Tetrahedron Lett. 1994, 35, 7005-7008. (i) Arakawa, Y.; Goto, T.; Kawase, K.; Yoshifuji. S. Chem. Pharm. Bull. 1995, 43, 535-536. (j) Nadin, A.; Derrer, S.; McGeary, R. P.; Goodman, J. M.; Raithby, P. R.; Holmes, A. B.; O'Hanlon, P. J.; Pearson, N. D. J. Am. Chem. Soc. 1995, 117, 9768-9769. (k) Williams, R. M.; Fegley, G. J.; Gallegos, R.; Schaefer, F.; Pruess, D. L. Tetrahedron 1996, 52, 1149-1164. Jackson, R. F. W.; Turner, D.; Block, M. H. J. Chem. Soc., Perkin Trans. 1 1997, 865-870.
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D-Allylglycine was obtained by resolution of the racemate as previously reported in ref 4a
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D-Allylglycine was obtained by resolution of the racemate as previously reported in ref 4a.
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