Design of low molecular weight hematoregulatory agents from the structure-activity relationship of a dimeric pentapeptide

Journal of Medicinal Chemistry

Volumn 40, Issue 18, 1997, Pages 2876-2882

  Cuthbertson, Alan S ^a   Husbyn, Mette ^a   Engebretsen, May ^a   Hartmann, Michael ^a   Lange, Meinolf ^a   Sandosham, Jessie ^a   Fischer, Peter M ^a   Fjerdingstad, Hege ^a   Løvhaug, Dagfinn ^a  

^a NYCOMED IMAGING AS   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMATOPOIETIC SYNERGISTIC FACTOR; PENTAPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DIMERIZATION; DISULFIDE BOND; HEMATOPOIESIS; IMMUNOREGULATION; MOLECULAR WEIGHT; MOUSE; NONHUMAN; PEPTIDE ANALYSIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; BONE MARROW CELLS; CELL LINE; CELLS, CULTURED; COLONY-FORMING UNITS ASSAY; CULTURE MEDIA, CONDITIONED; DIMERIZATION; GRANULOCYTES; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; INDICATORS AND REAGENTS; L CELLS (CELL LINE); MACROPHAGES; MICE; MICE, INBRED C57BL; MOLECULAR WEIGHT; OLIGOPEPTIDES; STEREOISOMERISM; STROMAL CELLS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030868650     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9702443     Document Type: Article

References (22)

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17. Peptide 13 was analyzed by coinjection with peptide 12 on analytical HPLC (Vydac 218TP54, 0.46 × 25 cm column). Following elution with a linear gradient of increasing 0.1% TFA/ MeCN (0-30% over 20 min) at a flow rate of 1 mL/min, two peaks were observed corresponding to compound 13 at 11.3 min and compound 12 at 11.7 min.
18. D = -9.2, c = 0.32.
19. The C6.4 cell line and anti-KC antibody were supplied by A. King, SmithKline Beecham Pharmaceuticals, King of Prussia, PA.
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