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Volumn 118, Issue 32, 1996, Pages 7449-7460

Synthesis and evaluation of novel substrates and inhibitors of N-succinyl-LL-diaminopimelate aminotransferase (DAP-AT) from Escherichia coli

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; PIMELIC ACID DERIVATIVE; SUCCINYLDIAMINOPIMELATE AMINOTRANSFERASE; UNCLASSIFIED DRUG;

EID: 0029782572     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja960640v     Document Type: Article
Times cited : (46)

References (85)
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    • For a summary of early work on the E. coli L-lysine pathway see: (a) Gilvarg, C. Meth. Enzvmol. 1962, 5, 848-850. (b) Kindler, S. H. Meth. Enzvmol. 1962, 5, 851-853. (c) Peterkofsky, B. Meth. Enzymol 1962, 5, 853-858. (d) Work, E. Meth. Enzymol. 1962, 5, 858-864. (e) Work, E. Meth. Enzymol. 1962, 5, 864-870. (f) Berges, D. A.; DeWolf, W. E.; Dunn, G. L.; Newman. S. J.; Schmidt, J.; Taggart, J.; Gilvarg, C. J. Biol. Chem. 1986, 261, 6160-6167.
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    • For a summary of early work on the E. coli L-lysine pathway see: (a) Gilvarg, C. Meth. Enzvmol. 1962, 5, 848-850. (b) Kindler, S. H. Meth. Enzvmol. 1962, 5, 851-853. (c) Peterkofsky, B. Meth. Enzymol 1962, 5, 853-858. (d) Work, E. Meth. Enzymol. 1962, 5, 858-864. (e) Work, E. Meth. Enzymol. 1962, 5, 864-870. (f) Berges, D. A.; DeWolf, W. E.; Dunn, G. L.; Newman. S. J.; Schmidt, J.; Taggart, J.; Gilvarg, C. J. Biol. Chem. 1986, 261, 6160-6167.
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    • m = 5.20 mM (Tris, pH 8.0, 30 °C).
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    • Literature values for other DAP pathway enzyme purifications: (a) L-THDPA succinyltransferase 1900-fold from E. coli; see ref 8. (b) DAP desuccinylase (EC 3.5.1.18) 7100-fold from E. coli; see ref 10b. (c) DAP epimerase (EC 5.1.1.7) 6000-fold from E. coli; see ref 11. (d) DAP dehydrogenase (EC 1.4.1.16) 290-fold from B. sphaericus, see ref 13b. (d) DAP decarboxylase (EC4.1.1.20) 500-fold from B. sphaericus: Asada, Y.; Tanizawa, K.; Kawabata, Y.; Misono, H.; Soda, K. Agric. Biol. Chem. 1981, 45, 1513-1514. Andersen, Å. B.; Hansen, E. B. Gene 1993, 124, 105-109.
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