Coagulation factor VII Gln100 → Arg. Amino acid substitution at the epidermal growth factor 2-protease domain interface results in severely reduced tissue factor binding and procoagulant function

Journal of Biological Chemistry

Volumn 273, Issue 14, 1998, Pages 8516-8521

  Kemball Cook, Geoffrey ^a   Johnson, Daniel J D ^a   Takamiya, Osamu ^b   Banner, David W ^c   McVey, John H ^a   Tuddenham, Edward G D ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b SHINSHU UNIVERSITY   (Japan)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 7;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BLOOD CLOTTING; MOLECULAR CLONING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; BLOOD COAGULATION; FACTOR VII; FACTOR VII DEFICIENCY; GLYCINE; HUMANS; MUTATION; RECOMBINANT PROTEINS; THROMBOPLASTIN;

MAMMALIA;

EID: 0032478622     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.14.8516     Document Type: Article

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