Incomplete gamma carboxylation of human coagulation factor VII: Differential effects on tissue factor binding and enzymatic activity

British Journal of Haematology

Volumn 93, Issue 2, 1996, Pages 445-450

  Clarke, Bryan J ^a,b   Sridhara, Sampath ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY MEDICAL CENTRE   (Canada)

Author keywords

factor VII; GLA; tissue factor; warfarin

Indexed keywords

4 CARBOXYGLUTAMIC ACID; RECOMBINANT BLOOD CLOTTING FACTOR 7; THROMBOPLASTIN; UNCLASSIFIED DRUG; VITAMIN K GROUP; WARFARIN;

ANIMAL CELL; ARTICLE; BLOOD CLOTTING; CARBOXYLATION; CELL LINE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; MONKEY; NONHUMAN; PRIORITY JOURNAL;

EID: 0029982030     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.5141054.x     Document Type: Article

References (33)

1. Bajaj, S.P., Price, P.A. & Russell, W.A. (1982) Decarboxylation of γ-carboxyglutamic acid residues in human prothrombin. Journal of Biological Chemistry, 257, 3726-3731.
2. Berkner, K.L. (1993) Expression of recombinant vitamin K-dependent proteins in mammalian cells: factors IX and VII. Methods in Enzymology, 222, 450-477.
3. Berkner, K.L., Harbeek, M., Ligenfetter, S., Bailey, C., Sanders-Hinck, C. & Suttie, J.W. (1992) Purification and identification of bovine γ-carboxylase, Proceedings of the National Academy of Sciences of the United States of America, 89, 6242-6246.
4. Borowski, M., Furie, B.C., Goldsmith, G.H. & Furie, B. (1985) Metal and phospholipid binding properties of partially carboxylated human prothrombin variants. Journal of Biological Chemistry, 260, 9258-9264.
5. Cerskus, A.L., Ofosu, F.A., Birchall, K.J., Clarke, B.J., Modi, G.J., Johnston, M. & Blajchman, M.A. (1985) The immunodepletion of factor VII from human plasma using a monoclonal antibody. British Journal of Haematology, 61, 467-475.
6. Chaing, S., Clarke, B., Sridhara, S., Chu, K., Friedman, P., Van Dusen, W., Roberts, H.R., Blajchman, M., Monroe, D.M. & High, K.A. (1994) Severe factor VII deficiency caused by mutations abolishing the cleavage site for activation and altering binding to tissue factor. Blood, 83, 3524-3525.
7. Chang, A.C.Y. & Brenner, D.G. (1988) Cationic liposome-mediated transfection: a new method for the introduction of DNA into mammalian cells. Focus, 10, (4), 66-60.
8. 3 into prothrombin. Journal of Biological Chemistry, 250, 4744-4748.
9. Furie, B. & Furie, B.C. (1990) Molecular basis of vitamin K-dependent γ-carboxylation. Blood, 75, 1753-1762.
10. Higashi, S., Nishimura, H., Aita, K. & Iwamiga, S. (1994) Identification of regions of bovine factor VII essential for binding to tissue factor. Journal of Biological Chemistry, 269, 18891-18898.
11. Hirsh, J. (1991) Oral anticoagulant drugs. New England Journal of Medicine, 324, 2855-2875.
12. Hubbard, B.R., Ulrich, M.M.W., Jacobs, M., Vermeer, C., Walsh, C., Furie, B. & Furie, B.C. (1989) Vitamin K-dependenl carhoxylase: affinity puritication from bovine liver by using a synthetic propeptide containing the γ-carboxylation recognition site. Proceedings of the National Academy of Sciences of the United States of America, 86, 6893-6897.
13. Huisse, M.G., Ledercq, M., Belghiti, J., Flejou, J.F., Suttie, J.W., Bezeaud, A., Stafford, D.W. & Guillin, M.C. (1994) Mechanism of the abnormal vitamin K-dependent γ-carboxylation process in human hepatocellular carcinomas. Cancer, 74, 1535-1541.
14. Malhotra, O.P., Nesheim, M.E. & Mann, K.G. (1985) The kinetics of activation of normal and γ-carboxyglutamic acid deficient prothrombins. Journal of Biological Chemistry, 260, 279-287.
15. Morris, D.P., Soute, B., Vermeer, C. & Stafford, D. (1993) Characterization of the purified vitamin K-dependent γ-glutamyl carboxylase. Journal of Biological Chemistry, 268, 8735-8742.
16. Morrissey, J.H., Macik, B.G., Neuenschwander, P.F. & Comp, P.C. (1993) Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood, 81, 734-744.
17. Nelsestuen, G.L. & Suttie, J.W. (1972) The purification and properties of an abnormal prothrombin protein produced by dicoumarol treated cows. Journal of Biological Chemistry, 247, 8176-8182.
18. Neuenschwander, P.F. & Morrissey, J.H. (1994) Roles of the membrane-interactive regions of factor VIIa and tissue factor. Journal of Biological Chemistry, 269, 8007-8013.
19. O'Hara, P.J., Grant, F.J., Haldeman, B.A., Gray, C.L., Insley, M.Y., Hagen, F.S. & Murray, M.J. (1987) Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation. Proceedings of the National Academy of Sciences of the United States of America, 84, 5158-5162.
20. Olsen, R.E. (1982) Vitamin K. Hemostasis and Thrombosis: Basic Principles and Clinical Practice (ed. by R. W. Colman, J. Hirsh, V. J. Mardar and E. W. Salzman), pp. 582-594. J. B. Lippincott Company, Philadelphia.
21. Racchi, M., Watzke, H.H., High, K.A. & Lively, M.O. (1995) Human coagulation factor X deficiency caused by a mutant signal peptide that blocks cleavage by signal peptidase but not targeting and translocation to the endoplasmic reticulum. Journal of Biological Chemistry, 268, 5735-5740.
22. Ratcliffe, J.V., Furie, B. & Furie, B.C. (1995) The importance of specific γ-carboxyglutamic acid residues in prothrombin. Journal of Biological Chemistry, 268, 24339-24345.
23. Rehemtulla, A., Roth, D.A., Wasley, L.C., Kuliopulos, A., Walsh, C.T., Furie, B., Furie, B.C. & Kaufman, R. (1993) In vitro and in vivo functional characterization of bovine vitamin K-dependent γ-carboxylase expressed in Chinese hamster ovary cells. Proceedings of the National Academy of Sciences of the United States of America, 90, 4611-4618.
24. Ruf, W., Kulnik, M.W., Lund-Hanson, T. & Edgington, T.S. (1991) Characterization of factor VII association with tissue factor in solution. Journal of Biological Chemistry, 266, 15719-15725.
25. Sinha, U., Hancock, T.E., Nzerem, J.J., Lin, P.E., Tomlinson, J.E. & Wolf, B.L. (1994) Effect of gamma carboxylation on prothrombinase inhibitory activity of catalytically inactive factor Xa. Thrombosis Research, 75, 427-436.
26. +2 prothrombin fragment 1 including the conformation of the GLA domain. Biochemistry, 28, 6805-6810.
27. Sridhara, S., Clarke, B.J., Ofosu, F.A., High, K.A. & Blajchman, M.A. (1993) The direct binding of human factor VII in plasma to recombinant human tissue factor. Thrombosis Research, 70, 307-316.
28. Suttie, J.W. (1993) Synthesis of vitamin K-dependent proteins. FASEB Journal, 7, 445-452.
29. Suttie, J.W. (1995) The importance of menaquinones in human nutrition. Annual Review of Nutrition. 15, 399-417.
30. Wu, S.M., Cheung, W.F., Frazier, D. & Stafford, D.W. (1991a) Cloning and expression of the cDNA for human gammaglutamyl carboxylase. Science, 254, 1634-1636.
31. Wu, S.M., Morris, D.P. & Stafford, D.W. (1991b) Identification and purification to near homogeneity of the vilamin K-dependent carboxylase. Proceedings of the National Academy of Sciences of the United States of America, 88, 2236-2240.
32. Yan, C.B., Grinnell, B.W. & Wold, F. (1989) Post-translational modifications of proteins: some problems left to solve. Trends in Biochemical Sciences, 14, 264-268.
33. Zhang, L., Jhingan, A. & Castellino, F.J. (1992) Role of individual γ-carboxyglutamic acid residues of activated human protein C in defining its in vitro anticoagulant activity. Blood. 80, 942-952.