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Volumn 275, Issue 5298, 1997, Pages 391-394

A mouse model with features of familial combined hyperlipidemia

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; APOLIPOPROTEIN C3; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 0031035182     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.275.5298.391     Document Type: Article
Times cited : (128)

References (36)
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    • A. P. Wojciechowski et al., Nature 349, 161 (1991). The genes for apolipoproteins A-I, C-III, and A-IV form a cluster on chromosome 11 [G. A. Bruns, S. K. Karathanasis, J. L. Breslow, Arteriosclerosis 4, 97 (1984)]. These genes encode apoproteins involved in the formation and metabolism of VLDL and HDL.
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    • Bruns, G.A.1    Karathanasis, S.K.2    Breslow, J.L.3
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    • note
    • Analysis of the plasma lipoprotein triglyceride distribution by gel filtration chromatography showed an increase in IDL-LDL triglyceride (858 mg/dl) and HDL triglyceride (57 mg/dl) in LDLR0/C3/CETP mice compared with IDL-LDL triglyceride (350 mg/dl) and HDL triglyceride (10 mg/dl) in LDLR0/C3 mice.
  • 22
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    • M. Dammerman, L. A. Sandkuijl, J. L. Halaas, W. Chung, J. L. Breslow, Proc. Natl. Acad. Sci. U.S.A. 90, 4562 (1993); Q. Zeng et al., Hum. Genet. 95, 371 (1994).
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    • K. A. Kieft, T. M. A. Bocan, B. R. Krause, J. Lipid Res. 32, 859 (1991). Diluted samples of pooled plasma from groups of five or six mice were analyzed by using Superose 6 HR column chromatography to fractionate the lipoproteins. Total cholesterol and triglyceride concentrations were determined by enzymatic assay on total plasma or lipoprotein fractions. Separated lipoproteins in the column eluant were quantified by an online column enzymatic assay for cholesterol or by enzymatic assay of individual fractions. All cholesterol profiles are normalized to represent a constant amount of plasma injected.
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    • note
    • We thank L. Royer for help in quantifying APOA1 in α-HDL and pre-β-HDL. APOB transgenic mice were provided by E. R. Rubin. Supported by NIH grants HL 54591 and HL 21006.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.