In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein- sensitive pathway

Journal of Clinical Investigation

Volumn 98, Issue 10, 1996, Pages 2259-2267

  Jong, Miek C ^a   Dahlmans, Vivian E H ^a   Van Gorp, Patrick J J ^b   Van Dijk, Ko Willems ^b   Breuer, Marco L ^b   Hofker, Marten H ^b   Havekes, Louis M ^a  

^a TNO   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

apolipoprorein C1; hyperlipoproteinemia; lipoprotein lipase; low density lipoprotein receptor; low density lipoprotein receptor related protein

Indexed keywords

APOLIPOPROTEIN C1; CHOLESTEROL; LOW DENSITY LIPOPROTEIN RECEPTOR; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL METABOLISM; CONTROLLED STUDY; FEMALE; LIPOPROTEIN METABOLISM; LIVER METABOLISM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; SEX DIFFERENCE; TRANSGENIC MOUSE;

EID: 0029851509     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119036     Document Type: Article

References (40)

1. Shulman, R.S., P.N. Herbert, K. Wehrly, and D.S. Fredrickson. 1975. The complete amino acid sequence of Cl (apo Lp = Ser), an apolipoprotein from human very low density lipoprotein. J. Biol. Chem. 250:182-190.
2. Havel, R.J., C.J. Fielding, T. Olivecrona, V.G. Shore, P.E. Fielding, and T. Egelrud. 1973. Cofactor activity of protein components of human very low density lipoproteins in the hydrolysis of triglycerides by lipoprotein lipase from different sources. Biochemistry. 12:1828-1833.
3. Brown, V., and M.L. Baginsky. 1972. Inhibition of lipoprotein lipase by an apolipoprotein of human very low density lipoprotein. Biochim. Biophys. Acta. 46:375-382.
4. Windler, E., and R.J. Havel. 1985. Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J. Lipid Res. 26:556-565.
5. Quarfordt, S.H., G. Michalopoulos, and B. Schirmer. 1982. The effect of human C apolipoproteins on the in vitro hepatic metabolism of triglyceride emulsions in the rat. J. Biol. Chem. 257:14642-14647.
6. Sehayek, E., and S. Eisenberg. 1991. Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor. J. Biol. Chem. 266:18259-18267.
7. Weisgraber, K.H., R.W. Mahley, R.C. Kowal, J. Herz, J.L. Goldstein, and M.S. Brown. 1990. Apolipoprotein C-1 modulates the interaction of apolipoprotein E with β-migrating very low density lipoproteins (β-VLDL) and inhibits binding of β-VLDL to low density lipoprotein receptor-related protein. J. Biol. Chem. 265:22453-22459.
8. Swaney, J.B., and K.H. Weisgraber. 1994. Effect of apolipoprotein C-1 peptides on the apolipoprotein E content and receptor-binding properties of beta-migrating very low density lipoproteins. J. Lipid Res. 35:134-142.
9. Simonet, W.S., N. Bucay, R.E. Pitas, S.J. Lauer, and J.M. Taylor. 1991. Multiple tissue-specific elements control the apolipoprotein E/C1 gene locus in transgenic mice. J. Biol. Chem. 266:8651-8654.
10. van Ree, J.H., M.H. Hofker, W.J.A.A. van den Broek, J.M.A. van Deursen, H. van der Boom, R.R. Frants, B. Wieringa, and L.M. Havekes. 1995. Increased response to cholesterol feeding in apolipoprotein C-1 deficient mice. Biochem. J. 305:905-911.
11. Hogan, B., F. Costantini, and E. Lacey. 1986. Manipulating the Mouse Embryo: a Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp 253-290.
12. van den Maagdenberg, A.M.J.M., M.H. Hofker, P.J.A. Krimpenfort, I.H. de Bruijn, B.J.M. van Vlijmen, H. van der Boom, L.M. Havekes, and R.R. Frants. 1993. Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia. J. Biol. Chem. 268:10540-10545.
13. Zannis, V.I., J. McPherson, O. Goldberger, S.U. Karathanasis, and J.L. Breslow. 1984. Synthesis, intracellular processing, and signal peptide of human apolipoprotein E. J. Biol. Chem. 259:5495-5499.
14. Hoffer, M.J.V., M.H. van Eck, L.M. Havekes, M.H. Hofker, and R.R. Frants. 1993. The mouse apolipoprotein C1 gene: structure and expression. Genomics. 18:37-42.
15. Horiuchi, K., S. Tajima, M. Menu, and A. Yamamoto. 1989. Structure and expression of mouse apolipoprotein E gene. J. Biochem. 106:98-103.
16. Fort, P., L. Marty, M. Piechaczyk, S.E. Sabrouty, C. Dani, P. Jeanteur, and J.M. Blanchard. 1985. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res. 13:1431-1442.
17. Nishina, P.M., J. Verstuyft, and B. Paigen. 1990. Synthetic low and high fat diets for the study of atherosclerosis in the mouse. J. Lipid Res. 31:859-869.
18. van Vlijmen, B.J.M., A.M.J.M. van den Maagdenberg, M.J.J. Gijbels, H. van der Boom, H. HogenEsch, R.R. Frants, M.H. Hofker, and L.M. Havekes. 1994. Diet-induced hyperlipoproteinemia and atherosclerosis in apolipoprotein E3-Leiden transgenic mice. J. Clin. Invest. 93:1403-1410.
19. van Ree, J.H., J.A.A. van den Broek, V.E.H. Dahlmans, P.H.E. Groot, M. Vidgeon-Hart, R.R. Frants, B. Wieringa, L.M. Havekes, and M.H. Hofker. 1994. Diet-induced hypercholesterolemia and atherosclerosis in heterozygous apolipoprotein E-deficient mice. Atherosclerosis. 111:25-37.
20. Lowry, O.H., N.J. Rosebrough, A.L. Farr, and R.J. Randall. 1951. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:265-275.
21. Bligh, E.G., and W.J. Dyer. 1959. A rapid method of total lipid extraction and purification. Can. J. Biochem. Physiol. 37:911-917.
22. Bernstein, S.E. 1979. Physiological characteristics. In Biology of the Laboratory Mouse. 2nd ed. E.L. Green, editor. Dover publications. Inc., New York. 337-350.
23. Moir, A.M.B., and V.A. Zammit. 1992. Selective labeling of hepatic fatty acids in vivo. Biochem. J. 283:145-149.
24. Aalto-Setala, K., E.A. Fisher, X. Chen, T. Chajek-Shaul, T. Hayek, R. Zechner, A. Walsh, R. Ramakrishnan, H.N. Ginsberg, and J.L. Breslow. 1992. Mechanism of hypertriglyceridemia in human apolipoprotein (Apo) CIII transgenic mice. J. Clin. Invest. 90:1889-1900.
25. Willnow, T.E., Z. Sheng, S. Ishibashi, and J. Herz. 1994. Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist. Science. (Wash. DC). 264:1471-1474.
26. Herz, J., and R.D. Gerard. 1993. Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. Proc. Natl. Acad. Sci. USA. 90:2812-2816.
27. Fallaux, F.J., O. Kranenburg, S.J. Cramer, A. Houweling, H. van Ormondt, R.C. Houben, and A.J. van der Eb. 1996. Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors. Hum. Gene Ther. 7:215-222.
28. 2-macroglobulin by rat liver. Biochem. J. 287:447-455.
29. van Vlijmen, B.J.M., H.B. van 't Hof, M.J.T.M. Mol, H. van der Boom, A. van der Zee, R.R. Frants, M.H. Hofker, and L.M. Havekes. 1996. Modulation of very low density lipoprotein production and clearance contributes to age- and gender-dependent hyperlipoproteinemia in apolipoprotein E3-Leiden transgenic mice. J Clin. Invest. 97:1184-1192.
30. Jong, M.C., V.E.H. Dahlmans, P.J.J. van Gorp, M.L. Breuer, M.J.T.M. Mol, A. van der Zee, R.R. Frants, M.H. Hofker, and L.M. Havekes. 1996. Both lipolysis and hepatic uptake of very low density lipoproteins are impaired in transgenic mice co-expressing human apolipoprotein E*3Leiden and human apolipoprotein C1. Arterioscler. Thromb. Vasc. Biol. 16:934-940.
31. Shachter, N.S., T. Hayek, T. Leff, J.D. Smith, D.W. Rosenberg, A. Walsh, R. Ramakrishnan, I.J. Goldberg, H.N. Ginsberg, and J.L. Breslow. 1994. Overexpression of apolipoprotein CII causes hypertriglyceridemia in transgenic mice. J. Clin. Invest. 93:1683-1690.
32. de Silva, H.V., S.J. Lauer, J. Wang, W.S. Simonet, K.H. Weisgraber, R.W. Mahley, and J.M. Taylor. 1994. Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E. J. Biol. Chem. 269:2324-2335.
33. Choi, S.Y., L.G. Fong, M.J. Kirven, and A.D. Cooper. 1991. Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo. J. Clin. Invest. 88:1173-1181.
34. 2-macroglobulin receptor in chylomicron remnant removal in the mouse in vivo. J. Biol. Chem. 268:15804-15811.
35. Ishibashi, S., M.S. Brown, J.L. Goldstein, R.D. Gerard, R.E. Hammer, and J. Herz. 1993. Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J. Clin. Invest. 92:883-893.
36. Herz, J., and T.E. Wilnow. 1995. Lipoprotein and receptor interactions in vivo. Curr. Opin. Lipidol. 6:97-103.
37. Havel, R.J. 1995. Chylomicron remnants: hepatic receptors and metabolism. Curr. Opin. Lipidol. 6:312-316.
38. Kowal, R.C., J. Herz, J.L. Goldstein, V. Esser, and M.S. Brown. 1989. Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apolipoprotein E-enriched lipoproteins. Proc. Natl. Acad. Sci. USA. 86:5810-5814.
39. Willnow, T.E., S.A. Armstrong, R.E. Hammer, and J. Herz. 1995. Functional expression of low density lipoprotein receptor-related protein is controlled by receptor-associated protein in vivo. Proc. Natl. Acad. Sci. USA. 92: 4537-4541.
40. Shimano, H., Y. Namba, J. Ohsuga, M. Kawamura, K. Yamamoto, M. Shimada, T. Gotoda, K. Harada, Y. Yazaki, and N. Yamamda. 1994. Secretion-recapture process of apolipoprotein E in hepatic uptake of chylomicron remnants in transgenic mice. J. Clin. Invest. 93:2215-2223.