Pharmacokinetic considerations in somatic gene therapy

Advanced Drug Delivery Reviews

Volumn 30, Issue 1-3, 1998, Pages 133-150

  Ledley, Fred D ^a,c   Shapiro Ledley, Tamara ^b  

^a GeneMedicine Inc   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c NONE   (United States)

Author keywords

Gene delivery; Numerical models; Pharmacodynamics; Pharmacokinetics; Somatic gene therapy

Indexed keywords

CELLS; DRUG PRODUCTS; GENES; GENETIC ENGINEERING; MATHEMATICAL MODELS; PHARMACOKINETICS; PHYSIOLOGY; TISSUE;

GENE DELIVERY; SOMATIC GENE THERAPY;

DRUG THERAPY;

GENE PRODUCT; MESSENGER RNA; PLASMID DNA; VIRUS VECTOR;

COMPARTMENT MODEL; DNA DEGRADATION; DRUG CLEARANCE; DRUG DEGRADATION; DRUG UPTAKE; EXPRESSION VECTOR; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; GENE SWITCHING; GENE TARGETING; GENE THERAPY; INHALATIONAL DRUG ADMINISTRATION; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; KINETICS; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0032473482     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(97)00112-9     Document Type: Review

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