Discovery of a novel, potent, and specific family of factor Xa inhibitors via combinatorial chemistry

Biochemistry

Volumn 37, Issue 4, 1998, Pages 1053-1059

  Ostrem, James A ^a   Al Obeidi, Fahad ^a   Safar, Pavel ^a   Safarova, Alena ^a   Stringer, Steven K ^a   Patek, Marcel ^a   Cross, M Todd ^a   Spoonamore, James ^a   LoCascio, Jeff C ^a   Kasireddy, Padmaja ^a   Thorpe, David S ^a   Sepetov, Nikolai ^a   Lebl, Michal ^a   Wildgoose, Peter ^a   Strop, Peter ^a  

^a Selectide Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 10A INHIBITOR;

ANTICOAGULATION; ARTICLE; BLEEDING TIME; COMPETITIVE INHIBITION; DNA LIBRARY; ENZYME MODIFICATION; ENZYME SPECIFICITY; HEMOSTASIS; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; THROMBOCYTE ACTIVATION;

ANTICOAGULANTS; BINDING SITES; CHROMOGENIC COMPOUNDS; DRUG DESIGN; FACTOR XA; MOLECULAR MIMICRY; OLIGOPEPTIDES; PEPTIDE LIBRARY; PROTEIN BINDING; SERINE ENDOPEPTIDASES; SERINE PROTEINASE INHIBITORS; THROMBOPLASTIN;

EID: 0032570258     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971147e     Document Type: Article

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