Endomorphin-2 is an endogenous opioid in primary sensory afferent fibers

Peptides

Volumn 19, Issue 10, 1998, Pages 1783-1789

  Martin Schild, Sheryl ^a   Gerall, Arnold A ^a,b   Kastin, Abba J ^a,c,d   Zadina, James E ^a,c,d  

^a TULANE UNIVERSITY   (United States)

^b Tulane University   (United States)

^c TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; ENDOMORPHIN 2; MU OPIATE RECEPTOR; OPIATE DERIVATIVE; SUBSTANCE P;

ANIMAL TISSUE; ARTICLE; IMMUNOCYTOCHEMISTRY; NONHUMAN; PEPTIDE ANALYSIS; PRIORITY JOURNAL; RAT; RHIZOTOMY; SENSORY NERVE; SPINAL CORD; TRIGEMINAL NUCLEUS;

ANALGESICS, OPIOID; ANIMALS; BRAIN CHEMISTRY; NERVE FIBERS; NEURONS, AFFERENT; NEUROTRANSMITTER AGENTS; OLIGOPEPTIDES; RATS; RECEPTORS, OPIOID, MU; SUBSTANCE P;

ANIMALIA; LAMIINAE;

EID: 0032420958     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(98)00136-3     Document Type: Article

References (28)

1. Arvidsson, U.; Riedl, M.; Charkrabarti, S.; Lee, J.-H.; Nakano, A. H.; Dado, R. J.; Loh, H. H.; Law, P. Y.; Wessendorf, M. W.; Elde, R. Distribution and targeting of a μ-opioid receptor (MOR1) in brain and spinal cord. J. Neurosci. 15:3328-3341; 1995.
2. Basbaum, A. I.; Cruz, L.; Weber, E. Immunoreactive dynorphin B in sacral primary afferent fibers of the cat. J. Neurosci. 6:127-133; 1986.
3. Besse, D.; Lombard, M. C.; Zajac, J. M.; Roques, B. P.; Besson, J. M. Pre- and postsynaptic distribution of μ, δ, and κ opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord. Brain Res. 521:15-22; 1990.
4. Caterina, M. J.; Schumacher, M. A.; Tominaga, M.; Rosen, T. A.; Levine, J. D.; Julius, D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816-824; 1997.
5. 5-enkephalin. Brain Res. 731:141-154; 1996.
6. Cho, H. J.; Basbaum, A. I. Ultrastructural analysis of dynorphin B-immunoreactive cells and terminals in the superifical dorsal horn of the deafferented spinal cord of the rat. J. Comp. Neurol. 281:193-205; 1989.
7. Cooper, B. Y.; Vierck, C. J. J.; Yeomans, D. C. Selective reduction of second pain sensations by systemic morphine in humans. Pain 24:93-116; 1986.
8. Dickenson, A. H. Mechanisms of the analgesic actions of opiates and opioids. Brit. Med. Bull. 47:690-702; 1991.
9. Dickenson, A. H. Spinal cord pharmacology of pain. Brit. J. Anaesthesia 75:193-200; 1995.
10. Dickenson, A. H.; Sullivan, A. F. Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn. Pain 24:211-222; 1986.
11. Ding, Y.-Q.; Kaneko, T.; Nomura, S.; Mizuno, N. Immunohistochemical localization of μ-opioid receptors in the central nervous system of the rat. J. Comp. Neurol. 367:375-402; 1996.
12. Gamse, R.; Leeman, S. E.; Holzer, P.; Lembeck, F. Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat. Naunyn-Schmiedeberg's Arch. Pharmacol. 317:140-148; 1981.
13. Gibbons, I. L.; Furness, J. B.; Costa, M. Pathway-specific patterns of the co-existence of substance P, calcitonin gene-related peptide, cholecystokinin and dynorphin in neurons of the dorsal root ganglia of the guinea-pig. Cell Tissue Res. 248:417-437; 1987.
14. Glazer, E. J.; Basbaum, A. I. Opioid neurons and pain modulation: an ultrastructural analysis of enkephalin in cat superficial dorsal horn. Neuroscience 10:357-376; 1983.
15. Hackler, L.; Zadina, J. E.; Ge, L.-J.; Kastin, A. J. Isolation of relatively large amounts of endomorphin-1 and endomorphin-2 from human brain cortex. Peptides 18:1635-1639; 1997.
16. Holzer, P. Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol. Rev. 42:143-201; 1991.
17. Ma, W.; Ribeiro-da-Silva, A.; De Koninck, Y.; Radhakrishnan, V.; Cuello, A. C.; Henry, J. L. Substance P and enkephalin immunoreactivities in axonal boutons presynaptic to physiologically identified dorsal horn neurons. An ultrastructural multiple-labelling study in the cat. Neuroscience 77:793-811; 1997.
18. Mansour, A.; Fox, C. A.; Burke, S.; Akil, H.; Watson, S. J. Immunohistochemical localization of the cloned μ opioid receptor in the rat CNS. J. Chem. Neuroanat. 8:283-305; 1995.
19. Mansour, A.; Fox, C. A.; Thompson, R. C.; Akil, H.; Watson, S. J. μ-opioid receptor mRNA expression in the rat CNS: comparison to μ-receptor binding. Brain Res. 643:245-265; 1994.
20. Martin-Schild, S.; Zadina, J. E.; Gerall, A. A.; Vigh, S.; Kastin, A. J. Localization of endomorphin-2-like immunoreactivity in the rat medulla and spinal cord. Peptides 18:1641-1649; 1997.
21. Minami, M.; Maekawa, K.; Yabuuchi, K.; Satoh, M. Double in situ hybridization study on coexistence of μ-, δ- and κ-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia. Molec. Brain Res. 30:203-210; 1995.
22. Pierce, T. L.; Grahek, M. D.; Wessendorf, M. W. Immunoreactivity for endomorphin-2 occurs in primary afferents in rats and monkeys. Neuroreport 9:385-389; 1998.
23. 5-enkephalin-, and dynorphin A (1-8)-like materials in the spinal cord and dorsal root ganglia of adult rats: effects of dorsal rhizotomy and neonatal capsaicin. J. Neurochem. 55:1122-1130; 1990.
24. Ribeiro-da-Silva, A.; Pioro, E. P.; Cuello, A. C. Substance P- and enkephalin-like immunoreactivities are colocalized in certain neurons of the substantia gelatinosa of the rat spinal cord: an ultrastructural double-labeling study. J. Neurosci. 11:1068-1080; 1991.
25. Szallasi, A.; Nilsson, S.; Farkas-Szallasi, T.; Blumberg, P. M.; Hökfelt, T.; Lundberg, J. M. Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery, and depletion by systemic vanilloid treatment. Brain Res. 703:175-183; 1995.
26. Tuchscherer, M. M.; Seybold, V. S. A quantitative study of the coexistence of peptides in varicosities within the superficial laminae of the dorsal horn of the rat spinal cord. J. Neurosci. 9:195-205; 1989.
27. Weihe, T.; Hartschuh, W.; Weber, E. Prodynorphin opioid peptides in small somatosensory primary afferents of guinea pig. Neurosci. Lett. 58:347-352; 1985.
28. Zadina, J. E.; Hackler, L.; Ge, L.-J.; Kastin, A. J. A potent and selective endogenous agonist for the μ-opiate receptor. Nature 386:499-502; 1997.