메뉴 건너뛰기




Volumn 77, Issue 3, 1997, Pages 793-811

Substance P and enkephalin immunoreactivities in axonal boutons presynaptic to physiologically identified dorsal horn neurons. An ultrastructural multiple-labelling study in the cat

Author keywords

electron microscopy; immunocytochemistry; intracellular recording; nociception; opioid peptide; spinal cord

Indexed keywords

ENKEPHALIN; OPIATE PEPTIDE; SUBSTANCE P;

EID: 0031550618     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(96)00510-6     Document Type: Article
Times cited : (43)

References (90)
  • 1
    • 0024803743 scopus 로고
    • Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo
    • 1. Aimone L. D. and Yaksh T. L. (1989) Opioid modulation of capsaicin-evoked release of substance P from rat spinal cord in vivo. Peptides 10, 1127-1131.
    • (1989) Peptides , vol.10 , pp. 1127-1131
    • Aimone, L.D.1    Yaksh, T.L.2
  • 2
    • 0024500578 scopus 로고
    • Fluorescent histochemical localization of neutral endopeptidase-24.11 (enkephalinase) in the rat spinal cord
    • 2. Back S. A. and Gorenstein C. (1989) Fluorescent histochemical localization of neutral endopeptidase-24.11 (enkephalinase) in the rat spinal cord. J. comp. Neurol. 280, 436-450.
    • (1989) J. Comp. Neurol. , vol.280 , pp. 436-450
    • Back, S.A.1    Gorenstein, C.2
  • 3
    • 0001574292 scopus 로고
    • Functional analysis of the cytochemistry of the spinal dorsal horn
    • eds Fields H. L., Dubner R. and Cervero F., Raven Press, New York
    • 3. Basbaum A. I. (1985) Functional analysis of the cytochemistry of the spinal dorsal horn. In Advances in Pain Research and Therapy, vol. 9. (eds Fields H. L., Dubner R. and Cervero F.), pp. 149-175. Raven Press, New York.
    • (1985) Advances in Pain Research and Therapy , vol.9 , pp. 149-175
    • Basbaum, A.I.1
  • 4
    • 0019504949 scopus 로고
    • Spinal cord layer I neurons with axon collaterals that generate local arbors
    • 4. Bennett G. J., Abdelmoumene M., Hayashi H., Hoffert M. J. and Dubner R. (1981) Spinal cord layer I neurons with axon collaterals that generate local arbors. Brain Res. 209, 421-426.
    • (1981) Brain Res. , vol.209 , pp. 421-426
    • Bennett, G.J.1    Abdelmoumene, M.2    Hayashi, H.3    Hoffert, M.J.4    Dubner, R.5
  • 5
    • 0020079111 scopus 로고
    • Enkephalin immunoreactive stalked cells and lamina IIb islet cells in cat substantia gelatinosa
    • 5. Bennett G. J., Ruda M. A., Gobel S. and Dubner R. (1982) Enkephalin immunoreactive stalked cells and lamina IIb islet cells in cat substantia gelatinosa. Brain Res. 240, 162-166.
    • (1982) Brain Res. , vol.240 , pp. 162-166
    • Bennett, G.J.1    Ruda, M.A.2    Gobel, S.3    Dubner, R.4
  • 6
    • 0025307494 scopus 로고
    • Presynaptic and postsynaptic distribution of mu-opioid, delta-opioid and kappa-opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord
    • 6. Besse D., Lombard M. C., Zajac J. M., Roques B. P. and Besson J. M. (1990) Presynaptic and postsynaptic distribution of mu-opioid, delta-opioid and kappa-opioid receptors in the superficial layers of the cervical dorsal horn of the rat spinal cord. Brain Res. 521, 15-22.
    • (1990) Brain Res. , vol.521 , pp. 15-22
    • Besse, D.1    Lombard, M.C.2    Zajac, J.M.3    Roques, B.P.4    Besson, J.M.5
  • 7
    • 0029027070 scopus 로고
    • Ultrastructural immunolabeling shows prominent presynaptic vesicular localization of d-opioid receptor within both enkephalin- and nonenkephalin-containing axon terminals in the superficial layers of the rat cervical spinal cord
    • 7. Cheng P. Y., Svingos A. L., Wang H., Clarke C. L., Jenab S., Beczkowska I. W., Inturrisi C. E. and Pickel V. M. (1995) Ultrastructural immunolabeling shows prominent presynaptic vesicular localization of d-opioid receptor within both enkephalin- and nonenkephalin-containing axon terminals in the superficial layers of the rat cervical spinal cord. J. Neurosci. 15, 5976-5988.
    • (1995) J. Neurosci. , vol.15 , pp. 5976-5988
    • Cheng, P.Y.1    Svingos, A.L.2    Wang, H.3    Clarke, C.L.4    Jenab, S.5    Beczkowska, I.W.6    Inturrisi, C.E.7    Pickel, V.M.8
  • 8
    • 0023907864 scopus 로고
    • The effects of dorsal rhizotomy and spinal cord isolation on calcitonin gene-related peptide-labeled terminals in the rat lumbar dorsal horn
    • 8. Chung K., Lee W. T. and Carlton S. M. (1988) The effects of dorsal rhizotomy and spinal cord isolation on calcitonin gene-related peptide-labeled terminals in the rat lumbar dorsal horn. Neurosci. Lett. 90, 27-32.
    • (1988) Neurosci. Lett. , vol.90 , pp. 27-32
    • Chung, K.1    Lee, W.T.2    Carlton, S.M.3
  • 9
    • 84990570226 scopus 로고
    • Enkephalinergic trigeminal and spinal neurons projecting to the rat thalamus
    • 9. Coffield J. A. and Miletic V. (1987) Enkephalinergic trigeminal and spinal neurons projecting to the rat thalamus. Soc. Neurosci. Abstr. 13, 522.
    • (1987) Soc. Neurosci. Abstr. , vol.13 , pp. 522
    • Coffield, J.A.1    Miletic, V.2
  • 10
    • 0023572161 scopus 로고
    • Immunoreactive enkephalin is contained within some trigeminal and spinal neurons projecting to the rat medial thalamus
    • 10. Coffield J. A. and Miletic V. (1987) Immunoreactive enkephalin is contained within some trigeminal and spinal neurons projecting to the rat medial thalamus. Brain Res. 425, 380-383.
    • (1987) Brain Res. , vol.425 , pp. 380-383
    • Coffield, J.A.1    Miletic, V.2
  • 11
    • 0025895501 scopus 로고
    • In vivo tonic inhibition of spinal substance P (-like material) release by endogenous opioid(s) acting at d receptors
    • 11. Collin E., Mauborgne A., Bourgoin S., Chantrel D., Hamon M. and Cesselin F. (1991) In vivo tonic inhibition of spinal substance P (-like material) release by endogenous opioid(s) acting at d receptors. Neuroscience 44, 725-731.
    • (1991) Neuroscience , vol.44 , pp. 725-731
    • Collin, E.1    Mauborgne, A.2    Bourgoin, S.3    Chantrel, D.4    Hamon, M.5    Cesselin, F.6
  • 12
    • 0018132799 scopus 로고
    • Spinal and medullary input to the lateral cervical nucleus
    • 12. Craig A. D. (1978) Spinal and medullary input to the lateral cervical nucleus. J. comp. Neurol. 181, 729-744.
    • (1978) J. Comp. Neurol. , vol.181 , pp. 729-744
    • Craig, A.D.1
  • 13
    • 0023700744 scopus 로고
    • An adrenal-mediated, naloxone-reversible increase in reaction time in the tail-flick test following intrathecal administration of substance P at the lower thoracic spinal level in the rat
    • 13. Cridland R. A. and Henry J. L. (1988) An adrenal-mediated, naloxone-reversible increase in reaction time in the tail-flick test following intrathecal administration of substance P at the lower thoracic spinal level in the rat. Neuroscience 26, 243-251.
    • (1988) Neuroscience , vol.26 , pp. 243-251
    • Cridland, R.A.1    Henry, J.L.2
  • 14
    • 0023588142 scopus 로고
    • Intrathecal administration of substance P in the rat: Spinal transection or morphine blocks the behavioural responses but not the facilitation of the tail-flick reflex
    • 14. Cridland R. A. and Henry J. L. (1988) Intrathecal administration of substance P in the rat: spinal transection or morphine blocks the behavioural responses but not the facilitation of the tail-flick reflex. Neurosci. Lett. 84, 203-208.
    • (1988) Neurosci. Lett. , vol.84 , pp. 203-208
    • Cridland, R.A.1    Henry, J.L.2
  • 15
    • 0023794552 scopus 로고
    • Facilitation of the tail-flick reflex by noxious cutaneous stimulation in the rat: Antagonism by a substance P analogue
    • 15. Cridland R. A. and Henry J. L. (1988) Facilitation of the tail-flick reflex by noxious cutaneous stimulation in the rat: antagonism by a substance P analogue. Brain Res. 462, 15-21.
    • (1988) Brain Res. , vol.462 , pp. 15-21
    • Cridland, R.A.1    Henry, J.L.2
  • 16
    • 0020681599 scopus 로고
    • Central distribution of opioid peptides
    • 16. Cuello A. C. (1983) Central distribution of opioid peptides. Br. med. Bull. 39, 11-16.
    • (1983) Br. Med. Bull. , vol.39 , pp. 11-16
    • Cuello, A.C.1
  • 17
    • 0001677317 scopus 로고
    • Preparation and application of conventional and non-conventional monoclonal antibodies
    • ed. Cuello A. C. John Wiley and Sons, Chichester
    • 17. Cuello A. C. and Côté A. (1993) Preparation and application of conventional and non-conventional monoclonal antibodies. In Immunohistochemistry II. (ed. Cuello A. C.), pp. 107-145. John Wiley and Sons, Chichester.
    • (1993) Immunohistochemistry II , pp. 107-145
    • Cuello, A.C.1    Côté, A.2
  • 18
    • 0017665391 scopus 로고
    • Substance P: Localization in synaptic vesicles in rat central nervous system
    • 18. Cuello A. C., Jessell T. M., Kanazawa I. and Iversen L. L. (1977) Substance P: localization in synaptic vesicles in rat central nervous system. J. Neurochem. 29, 747-751.
    • (1977) J. Neurochem. , vol.29 , pp. 747-751
    • Cuello, A.C.1    Jessell, T.M.2    Kanazawa, I.3    Iversen, L.L.4
  • 19
    • 0018102058 scopus 로고
    • The distribution of substance P immunoreactive fibers in the rat central nervous system
    • 19. Cuello A. C. and Kanazawa I. (1978) The distribution of substance P immunoreactive fibers in the rat central nervous system. J. comp. Neurol. 178, 129-156.
    • (1978) J. Comp. Neurol. , vol.178 , pp. 129-156
    • Cuello, A.C.1    Kanazawa, I.2
  • 21
    • 0027220222 scopus 로고
    • Organization of substance P primary sensory neurons: Ultrastructural and physiological correlates
    • 21. Cuello A. C., Ribeiro-da-Silva A., Ma W., De Koninck Y. and Henry J. L. (1993) Organization of substance P primary sensory neurons: ultrastructural and physiological correlates. Regul. Pept. 46, 155-164.
    • (1993) Regul. Pept. , vol.46 , pp. 155-164
    • Cuello, A.C.1    Ribeiro-Da-Silva, A.2    Ma, W.3    De Koninck, Y.4    Henry, J.L.5
  • 22
    • 0026333731 scopus 로고
    • Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation
    • 22. De Koninck Y. and Henry J. L. (1991) Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation. Proc. natn. Acad. Sci. U.S.A. 88, 11344-11348.
    • (1991) Proc. Natn. Acad. Sci. U.S.A. , vol.88 , pp. 11344-11348
    • De Koninck, Y.1    Henry, J.L.2
  • 23
    • 0026787465 scopus 로고
    • Peripheral vibration causes an adenosine-mediated postsynaptic inhibitory potential in dorsal horn neurons of the cat spinal cord
    • 23. De Koninck Y. and Henry J. L. (1992) Peripheral vibration causes an adenosine-mediated postsynaptic inhibitory potential in dorsal horn neurons of the cat spinal cord. Neuroscience 50, 435-443.
    • (1992) Neuroscience , vol.50 , pp. 435-443
    • De Koninck, Y.1    Henry, J.L.2
  • 24
    • 0028179210 scopus 로고
    • A-mediated inhibition following single hair afferent input to single spinal dorsal horn neurones in cats
    • A-mediated inhibition following single hair afferent input to single spinal dorsal horn neurones in cats. J. Physiol., Lond. 476, 89-100.
    • (1994) J. Physiol., Lond. , vol.476 , pp. 89-100
    • De Koninck, Y.1    Henry, J.L.2
  • 25
    • 0026735237 scopus 로고
    • Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts
    • 25. De Koninck Y., Ribeiro-da-Silva A., Henry J. L. and Cuello A. C. (1992) Spinal neurons exhibiting a specific nociceptive response receive abundant substance P-containing synaptic contacts. Proc. natn. Acad. Sci. U.S.A. 89, 5073-5077.
    • (1992) Proc. Natn. Acad. Sci. U.S.A. , vol.89 , pp. 5073-5077
    • De Koninck, Y.1    Ribeiro-Da-Silva, A.2    Henry, J.L.3    Cuello, A.C.4
  • 26
    • 0002434146 scopus 로고
    • Ultrastructural immunocytochemistry combined with intracellular marking of physiologically identified neurons in vivo
    • ed. Cuello A. C. John Wiley and Sons, Chichester
    • 26. De Koninck Y., Ribeiro-da-Silva A. and Henry J. L. and Cuello A. C. (1993) Ultrastructural immunocytochemistry combined with intracellular marking of physiologically identified neurons in vivo. In Immunohistochemistry II (ed. Cuello A. C.), pp. 369-393. John Wiley and Sons, Chichester.
    • (1993) Immunohistochemistry II , pp. 369-393
    • De Koninck, Y.1    Ribeiro-Da-Silva, A.2    Henry, J.L.3    Cuello, A.C.4
  • 27
    • 0019222421 scopus 로고
    • Multiple opiate receptor sites on primary afferent fibres
    • 27. Fields H. L., Emson P. C., Leigh B. K., Gilbert R. F. and Iversen L. L. (1980) Multiple opiate receptor sites on primary afferent fibres. Nature 284, 351-353.
    • (1980) Nature , vol.284 , pp. 351-353
    • Fields, H.L.1    Emson, P.C.2    Leigh, B.K.3    Gilbert, R.F.4    Iversen, L.L.5
  • 28
    • 0024379442 scopus 로고
    • Lumbar dorsal root ganglia of the cat: A quantitative study of peptide immunoreactivity and cell size
    • 28. Garry M. G., Miller K. E. and Seybold V. S. (1989) Lumbar dorsal root ganglia of the cat: a quantitative study of peptide immunoreactivity and cell size. J. comp. Neurol. 284, 36-47.
    • (1989) J. Comp. Neurol. , vol.284 , pp. 36-47
    • Garry, M.G.1    Miller, K.E.2    Seybold, V.S.3
  • 32
    • 0017181611 scopus 로고
    • Effects of substance P on functionally identified units in cat spinal cord
    • 32. Henry J. L. (1976) Effects of substance P on functionally identified units in cat spinal cord. Brain Res. 114, 439-452.
    • (1976) Brain Res. , vol.114 , pp. 439-452
    • Henry, J.L.1
  • 33
    • 0019370056 scopus 로고
    • Diurnal variation in excitation of dorsal horn units by naloxone in the spinal cat suggests a circulating opioid factor
    • 33. Henry J. L. (1981) Diurnal variation in excitation of dorsal horn units by naloxone in the spinal cat suggests a circulating opioid factor. Neuroscience 6, 1935-1942.
    • (1981) Neuroscience , vol.6 , pp. 1935-1942
    • Henry, J.L.1
  • 34
    • 0022557321 scopus 로고
    • Role of circulating opioids in the modulation of pain
    • 34. Henry J. L. (1986) Role of circulating opioids in the modulation of pain. Ann. N. Y. Acad. Sci. 467, 169-181.
    • (1986) Ann. N. Y. Acad. Sci. , vol.467 , pp. 169-181
    • Henry, J.L.1
  • 35
    • 0027203319 scopus 로고
    • Participation of substance P in spinal physiological responses to peripheral aversive stimulation
    • 35. Henry J. L. (1993) Participation of substance P in spinal physiological responses to peripheral aversive stimulation. Regul. Pept. 46, 138-143.
    • (1993) Regul. Pept. , vol.46 , pp. 138-143
    • Henry, J.L.1
  • 36
    • 0016757754 scopus 로고
    • Substance P: Localization in the central nervous system and in some primary sensory neurons
    • 36. Hökfelt T., Kellerth J. O., Nilsson G. and Pernow B. (1975) Substance P: localization in the central nervous system and in some primary sensory neurons. Science 190, 889-890.
    • (1975) Science , vol.190 , pp. 889-890
    • Hökfelt, T.1    Kellerth, J.O.2    Nilsson, G.3    Pernow, B.4
  • 37
    • 0018143252 scopus 로고
    • Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system
    • 37. Hökfelt T., Ljungdahl A., Steinbusch H. W., Verhofstad A. N., Nilsson G., Brodin E., Pernow B. and Goldstein M. (1978) Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system. Neuroscience 3, 517-538.
    • (1978) Neuroscience , vol.3 , pp. 517-538
    • Hökfelt, T.1    Ljungdahl, A.2    Steinbusch, H.W.3    Verhofstad, A.N.4    Nilsson, G.5    Brodin, E.6    Pernow, B.7    Goldstein, M.8
  • 38
    • 0006982482 scopus 로고
    • Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: Enkephalin and substance P
    • 38. Hökfelt T., Ljungdahl A., Terenius L., Elde R. and Nilsson G. (1977) Immunohistochemical analysis of peptide pathways possibly related to pain and analgesia: enkephalin and substance P. Proc. natn. Acad. Sci. U.S.A. 74, 3081-3085.
    • (1977) Proc. Natn. Acad. Sci. U.S.A. , vol.74 , pp. 3081-3085
    • Hökfelt, T.1    Ljungdahl, A.2    Terenius, L.3    Elde, R.4    Nilsson, G.5
  • 39
    • 0019360303 scopus 로고
    • An immunohistochemical study of neuronal populations containing neuropeptides or gamma-aminobutyrate within the superficial layers of the rat dorsal horn
    • 39. Hunt S. P., Kelly J. S., Emson P. C., Kimmel J. R., Miller R. J. and Wu J. -Y. (1981) An immunohistochemical study of neuronal populations containing neuropeptides or gamma-aminobutyrate within the superficial layers of the rat dorsal horn. Neuroscience 6, 1883-1898.
    • (1981) Neuroscience , vol.6 , pp. 1883-1898
    • Hunt, S.P.1    Kelly, J.S.2    Emson, P.C.3    Kimmel, J.R.4    Miller, R.J.5    Wu, J.-Y.6
  • 40
    • 0022578369 scopus 로고
    • Analgesic activity and release of [MET5] enkephalin-Arg6-Gly7-Leu8 from rat spinal cord in vivo
    • 40. Iadarola M. J., Tang J., Costa E. and Yang H. Y. (1986) Analgesic activity and release of [MET5] enkephalin-Arg6-Gly7-Leu8 from rat spinal cord in vivo. Eur. J. Pharmac. 121, 39-48.
    • (1986) Eur. J. Pharmac. , vol.121 , pp. 39-48
    • Iadarola, M.J.1    Tang, J.2    Costa, E.3    Yang, H.Y.4
  • 41
    • 0017622848 scopus 로고
    • Opiate analgesics inhibit substance P release from rat trigeminal nucleus
    • 41. Jessell T. M. and Iversen L. L. (1977) Opiate analgesics inhibit substance P release from rat trigeminal nucleus. Nature 268, 549-551.
    • (1977) Nature , vol.268 , pp. 549-551
    • Jessell, T.M.1    Iversen, L.L.2
  • 42
    • 0023126425 scopus 로고
    • Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells
    • 42. Ju G., Hökfelt T., Brodin E., Fahrenkrug J., Fischer J. A., Frey P., Elde R. P. and Brown J. C. (1987) Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells. Cell Tiss. Res. 247, 417-431.
    • (1987) Cell Tiss. Res. , vol.247 , pp. 417-431
    • Ju, G.1    Hökfelt, T.2    Brodin, E.3    Fahrenkrug, J.4    Fischer, J.A.5    Frey, P.6    Elde, R.P.7    Brown, J.C.8
  • 43
    • 0015820095 scopus 로고
    • A reliable standardized method for ultrastructural electron microscopic radioautography
    • 43. Kopriwa B. M. (1973) A reliable standardized method for ultrastructural electron microscopic radioautography. Histochemistry 37, 1-17.
    • (1973) Histochemistry , vol.37 , pp. 1-17
    • Kopriwa, B.M.1
  • 44
    • 0016825356 scopus 로고
    • A comparison of various procedures for fine grain development in electron microscopic radioautography
    • 44. Kopriwa B. M. (1975) A comparison of various procedures for fine grain development in electron microscopic radioautography. Histochemistry 44, 201-224.
    • (1975) Histochemistry , vol.44 , pp. 201-224
    • Kopriwa, B.M.1
  • 45
    • 0027483422 scopus 로고
    • Substance p markedly potentiates the antinociceptive effects of morphine sulfate administered at the spinal level
    • 45. Kream R. M., Kato T., Shimonaka H., Marchand J. E. and Wurm W. H. (1993) Substance P markedly potentiates the antinociceptive effects of morphine sulfate administered at the spinal level. Proc. natn. Acad. Sci. U.S.A. 90, 3564-3568.
    • (1993) Proc. Natn. Acad. Sci. U.S.A. , vol.90 , pp. 3564-3568
    • Kream, R.M.1    Kato, T.2    Shimonaka, H.3    Marchand, J.E.4    Wurm, W.H.5
  • 46
    • 0017081152 scopus 로고
    • Effects of morphine upon the lamina V type cells activities in the dorsal horn of the decerebrate cat
    • 46. LeBars D., Menetrey D. and Besson J. M. (1976) Effects of morphine upon the lamina V type cells activities in the dorsal horn of the decerebrate cat. Brain Res. 113, 293-310.
    • (1976) Brain Res. , vol.113 , pp. 293-310
    • LeBars, D.1    Menetrey, D.2    Besson, J.M.3
  • 47
    • 0022391328 scopus 로고
    • Distribution of calcitonin gene-related peptide in the rat peripheral nervous sytem with reference to its coexistence with substance P
    • 47. Lee Y., Takami K., Kaway Y., Girgis S., Hillyard C. J., MacIntyre I., Emson P. C. and Tohyama M. (1985) Distribution of calcitonin gene-related peptide in the rat peripheral nervous sytem with reference to its coexistence with substance P. Neuroscience 15, 1227-1237.
    • (1985) Neuroscience , vol.15 , pp. 1227-1237
    • Lee, Y.1    Takami, K.2    Kaway, Y.3    Girgis, S.4    Hillyard, C.J.5    Macintyre, I.6    Emson, P.C.7    Tohyama, M.8
  • 48
    • 0028091385 scopus 로고
    • Synaptic relationship between substance p and the substance P receptor: Light and electron microscopic characterization of the mismatch between neuropeptides and their receptors
    • 48. Liu H., Brown J. L., Jasmin L., Maggio J. E., Vigna S. R., Mantyh P. W. and Basbaum A. I. (1994) Synaptic relationship between substance P and the substance P receptor: Light and electron microscopic characterization of the mismatch between neuropeptides and their receptors. Proc. natn. Acad. Sci. U.S.A. 91, 1009-1013.
    • (1994) Proc. Natn. Acad. Sci. U.S.A. , vol.91 , pp. 1009-1013
    • Liu, H.1    Brown, J.L.2    Jasmin, L.3    Maggio, J.E.4    Vigna, S.R.5    Mantyh, P.W.6    Basbaum, A.I.7
  • 49
    • 0018070087 scopus 로고
    • Distribution of substance P-like immunoreactivity in the central nervous system of the rat - I. Cell bodies and nerve terminals
    • 49. Ljungdahl A., Hökfelt T. and Nilsson G. (1978) Distribution of substance P-like immunoreactivity in the central nervous system of the rat - I. Cell bodies and nerve terminals. Neuroscience 3, 861-943.
    • (1978) Neuroscience , vol.3 , pp. 861-943
    • Ljungdahl, A.1    Hökfelt, T.2    Nilsson, G.3
  • 50
    • 0029853227 scopus 로고    scopus 로고
    • Quantitative analysis of substance P immunoreactive boutons on physiologically characterized dorsal horn neurons in the cat lumbar spinal cord
    • 50. Ma W., Ribeiro-da-Silva A., De Koninck Y., Radhakrishnan V. and Henry J. L. and Cuello A. C. (1996) Quantitative analysis of substance P immunoreactive boutons on physiologically characterized dorsal horn neurons in the cat lumbar spinal cord. J. comp. Neurol. 376, 45-64.
    • (1996) J. Comp. Neurol. , vol.376 , pp. 45-64
    • Ma, W.1    Ribeiro-Da-Silva, A.2    De Koninck, Y.3    Radhakrishnan, V.4    Henry, J.L.5    Cuello, A.C.6
  • 51
    • 0028215823 scopus 로고
    • In situ hybridization study of m- and kappa-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia
    • 51. Maekawa K., Minami M., Yabuuchi K., Toya T., Katao Y., Hosoi Y., Onogi T. and Satoh M. (1994) In situ hybridization study of m- and kappa-opioid receptor mRNAs in the rat spinal cord and dorsal root ganglia. Neurosci. Lett. 168, 97-100.
    • (1994) Neurosci. Lett. , vol.168 , pp. 97-100
    • Maekawa, K.1    Minami, M.2    Yabuuchi, K.3    Toya, T.4    Katao, Y.5    Hosoi, Y.6    Onogi, T.7    Satoh, M.8
  • 52
    • 0025470774 scopus 로고
    • Electron microscopic localization of immunoreactive enkephalinase (EC 3.4.24.11) in the neostriatum of the rat
    • 52. Marcel D., Pollard H., Verroust P., Schwartz J. C. and Beaudet A. (1990) Electron microscopic localization of immunoreactive enkephalinase (EC 3.4.24.11) in the neostriatum of the rat. J. Neurosci. 10, 2804-2817.
    • (1990) J. Neurosci. , vol.10 , pp. 2804-2817
    • Marcel, D.1    Pollard, H.2    Verroust, P.3    Schwartz, J.C.4    Beaudet, A.5
  • 53
    • 0029041881 scopus 로고
    • Double in situ hybridization study on coexistence of m-, d- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia
    • 53. Minami M., Maekawa K., Yabuuchi K. and Satoh M. (1995) Double in situ hybridization study on coexistence of m-, d- and kappa-opioid receptor mRNAs with preprotachykinin A mRNA in the rat dorsal root ganglia. Molec. Brain Res. 30, 203-210.
    • (1995) Molec. Brain Res. , vol.30 , pp. 203-210
    • Minami, M.1    Maekawa, K.2    Yabuuchi, K.3    Satoh, M.4
  • 54
    • 0029102878 scopus 로고
    • Molecular biology of the opioid receptors: Structures, functions and distributions
    • 54. Minami M. and Satoh M. (1995) Molecular biology of the opioid receptors: Structures, functions and distributions. Neurosci. Res. 23, 121-145.
    • (1995) Neurosci. Res. , vol.23 , pp. 121-145
    • Minami, M.1    Satoh, M.2
  • 55
    • 0020024869 scopus 로고
    • The actions of neuropeptides on dorsal horn neurons in the rat spinal cord slice preparation: An intracellular study
    • 55. Murase K., Nedeljkov V. and Randic M. (1982) The actions of neuropeptides on dorsal horn neurons in the rat spinal cord slice preparation: an intracellular study. Brain Res. 234, 170-176.
    • (1982) Brain Res. , vol.234 , pp. 170-176
    • Murase, K.1    Nedeljkov, V.2    Randic, M.3
  • 56
    • 0022459189 scopus 로고
    • Antinociceptive and Met-enkephalin releasing effects of tachykinins and substance P fragments
    • 56. Naranjo J. R., Arnedo A., De Felipe M. C. and Del Rio J. (1986) Antinociceptive and Met-enkephalin releasing effects of tachykinins and substance P fragments. Peptides 7, 419-423.
    • (1986) Peptides , vol.7 , pp. 419-423
    • Naranjo, J.R.1    Arnedo, A.2    De Felipe, M.C.3    Del Rio, J.4
  • 57
    • 0028821053 scopus 로고
    • Mechanisms underlying antinociception provoked by heterosegmental noxious stimulation in the rat tail-flick test
    • 57. Pitcher G. M., Yashpal K., Coderre T. J. and Henry J. L. (1995) Mechanisms underlying antinociception provoked by heterosegmental noxious stimulation in the rat tail-flick test. Neuroscience 65, 273-281.
    • (1995) Neuroscience , vol.65 , pp. 273-281
    • Pitcher, G.M.1    Yashpal, K.2    Coderre, T.J.3    Henry, J.L.4
  • 58
    • 0025613418 scopus 로고
    • Peptide coexistence in axon terminals within the superficial dorsal horn of the rat spinal cord
    • 58. Plenderleith M. B., Haller C. J. and Snow P. J. (1990) Peptide coexistence in axon terminals within the superficial dorsal horn of the rat spinal cord. Synapse 6, 344-350.
    • (1990) Synapse , vol.6 , pp. 344-350
    • Plenderleith, M.B.1    Haller, C.J.2    Snow, P.J.3
  • 59
    • 0024340035 scopus 로고
    • Detailed immunoautoradiographic mapping of enkephalinase (EC 3.4.24.11) in rat central nervous system: Comparison with enkephalins and substance P
    • 59. Pollard H., Bouthenet M. L., Moreau J., Souil E., Verroust P., Ronco P. and Schwartz J. C. (1989) Detailed immunoautoradiographic mapping of enkephalinase (EC 3.4.24.11) in rat central nervous system: Comparison with enkephalins and substance P. Neuroscience 30, 339-376.
    • (1989) Neuroscience , vol.30 , pp. 339-376
    • Pollard, H.1    Bouthenet, M.L.2    Moreau, J.3    Souil, E.4    Verroust, P.5    Ronco, P.6    Schwartz, J.C.7
  • 60
    • 0025945934 scopus 로고
    • Novel substance P antagonist, CP-96345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P
    • 60. Radhakrishnan V. and Henry J. L. (1991) Novel substance P antagonist, CP-96345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P. Neurosci. Lett. 132, 39-43.
    • (1991) Neurosci. Lett. , vol.132 , pp. 39-43
    • Radhakrishnan, V.1    Henry, J.L.2
  • 61
    • 0018125090 scopus 로고
    • Depressant actions of methionine-enkephalin and somatostatin in cat dorsal horn neurones activated by noxious stimuli
    • 61. Randic M. and Miletic V. (1978) Depressant actions of methionine-enkephalin and somatostatin in cat dorsal horn neurones activated by noxious stimuli. Brain Res. 152, 196-202.
    • (1978) Brain Res. , vol.152 , pp. 196-202
    • Randic, M.1    Miletic, V.2
  • 62
    • 0024561822 scopus 로고
    • Distribution of neurons expressing calcitonin gene-related peptide mRNA in the brain stem, spinal cord and dorsal root ganglia of rat and guinea-pig
    • 62. Réthelyi M., Metz C. B. and Lund P. K. (1989) Distribution of neurons expressing calcitonin gene-related peptide mRNA in the brain stem, spinal cord and dorsal root ganglia of rat and guinea-pig. Neuroscience 29, 225-239.
    • (1989) Neuroscience , vol.29 , pp. 225-239
    • Réthelyi, M.1    Metz, C.B.2    Lund, P.K.3
  • 63
    • 0026584274 scopus 로고
    • Enkephalin-immunoreactive nociceptive neurons in the cat spinal cord
    • 63. Ribeiro-da-Silva A., De Koninck Y., Cuello A. C. and Henry J. L. (1992) Enkephalin-immunoreactive nociceptive neurons in the cat spinal cord. NeuroReport 3, 25-28.
    • (1992) Neuroreport , vol.3 , pp. 25-28
    • Ribeiro-Da-Silva, A.1    De Koninck, Y.2    Cuello, A.C.3    Henry, J.L.4
  • 64
    • 0011474017 scopus 로고
    • Co-localization of substance P and enkephalin immunoreactivities in synaptic boutons apposed onto physiologically identified dorsal horn neurones: An ultrastructural multiple-labelling study
    • 64. Ribeiro-da-Silva A., De Koninck Y., Henry J. L. and Cuello A. C. (1991) Co-localization of substance P and enkephalin immunoreactivities in synaptic boutons apposed onto physiologically identified dorsal horn neurones: an ultrastructural multiple-labelling study. Soc. Neurosci. Abstr. 17, 1007.
    • (1991) Soc. Neurosci. Abstr. , vol.17 , pp. 1007
    • Ribeiro-Da-Silva, A.1    De Koninck, Y.2    Henry, J.L.3    Cuello, A.C.4
  • 65
    • 0026046329 scopus 로고
    • Substance p- and enkephalin-like immunoreactivities are colocalized in certain neurons of the substantia gelatinosa of the rat spinal cord. An ultrastructural double-labeling study
    • 65. Ribeiro-da-Silva A., Pioro E. P. and Cuello A. C. (1991) Substance P- and enkephalin-like immunoreactivities are colocalized in certain neurons of the substantia gelatinosa of the rat spinal cord. An ultrastructural double-labeling study. J. Neurosci. 11, 1068-1080.
    • (1991) J. Neurosci. , vol.11 , pp. 1068-1080
    • Ribeiro-Da-Silva, A.1    Pioro, E.P.2    Cuello, A.C.3
  • 66
    • 0000341102 scopus 로고
    • Pre-embedding ultrastructural immunocytochemistry
    • ed. Cuello A. C. John Wiley and Sons, Chichester
    • 66. Ribeiro-da-Silva A. and Priestley J. V. and Cuello A. C. (1993) Pre-embedding ultrastructural immunocytochemistry. In Immunohistochemistry II (ed. Cuello A. C.), pp. 181-227. John Wiley and Sons, Chichester.
    • (1993) Immunohistochemistry II , pp. 181-227
    • Ribeiro-Da-Silva, A.1    Priestley, J.V.2    Cuello, A.C.3
  • 67
    • 0025374430 scopus 로고
    • Neutral endopeptidase-24.11 inhibitors: From analgesics to antihypertensives
    • 67. Roques B. P. and Beaumont A. (1990) Neutral endopeptidase-24.11 inhibitors: From analgesics to antihypertensives. Trends pharmac. Sci. 11, 245-249.
    • (1990) Trends Pharmac. Sci. , vol.11 , pp. 245-249
    • Roques, B.P.1    Beaumont, A.2
  • 68
    • 0020049940 scopus 로고
    • Opiates and pain pathways: Demonstration of enkephalin synapses on dorsal horn projection neurons
    • 68. Ruda M. A. (1982) Opiates and pain pathways: demonstration of enkephalin synapses on dorsal horn projection neurons. Science 215, 1523-1525.
    • (1982) Science , vol.215 , pp. 1523-1525
    • Ruda, M.A.1
  • 69
    • 0021635407 scopus 로고
    • Demonstration of postsynaptic opioid modulation of thalamic projection neurons by the combined techniques of retrograde horseradish peroxidase and enkephalin immunocytochemistry
    • 69. Ruda M. A., Coffield J. and Dubner R. (1984) Demonstration of postsynaptic opioid modulation of thalamic projection neurons by the combined techniques of retrograde horseradish peroxidase and enkephalin immunocytochemistry. J. Neurosci. 4, 2117-2132.
    • (1984) J. Neurosci. , vol.4 , pp. 2117-2132
    • Ruda, M.A.1    Coffield, J.2    Dubner, R.3
  • 70
    • 0025931145 scopus 로고
    • 2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord
    • 2-adrenoceptor agonist suppress nociceptive neurotransmission in neonatal rat spinal cord. Anesthesiology 75, 489-498.
    • (1991) Anesthesiology , vol.75 , pp. 489-498
    • Savola, M.K.T.1    Woodley, S.J.2    Maze, M.3    Kendig, J.J.4
  • 71
    • 0023934774 scopus 로고
    • 8 in the intraspinal neurons of the rat, with special reference to the neurons in the substantia gelatinosa
    • 8 in the intraspinal neurons of the rat, with special reference to the neurons in the substantia gelatinosa. Brain Res. 453, 110-116.
    • (1988) Brain Res. , vol.453 , pp. 110-116
    • Senba, E.1    Yanaihara, C.2    Yanaihara, N.3    Tohyama, M.4
  • 72
    • 0020082162 scopus 로고
    • Neurotensin immunoreactivity in the superficial laminae of the dorsal horn of the rat: I. Light microscopic studies of cell bodies and proximal dendrites
    • 72. Seybold V. S. and Elde R. P. (1982) Neurotensin immunoreactivity in the superficial laminae of the dorsal horn of the rat: I. Light microscopic studies of cell bodies and proximal dendrites. J. comp. Neurol. 205, 89-100.
    • (1982) J. Comp. Neurol. , vol.205 , pp. 89-100
    • Seybold, V.S.1    Elde, R.P.2
  • 73
    • 3543144446 scopus 로고
    • Dendritic organization in the neurons of the visual and motor cortices of the cat
    • 73. Sholl D. A. (1953) Dendritic organization in the neurons of the visual and motor cortices of the cat. J. Anat. 87, 387-406.
    • (1953) J. Anat. , vol.87 , pp. 387-406
    • Sholl, D.A.1
  • 74
    • 0026498790 scopus 로고
    • 5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices
    • 5]enkephalin and morphine inhibits substance P release from trigeminal nucleus slices. Eur. J. Pharmac. 229, 1-7.
    • (1992) Eur. J. Pharmac. , vol.229 , pp. 1-7
    • Suarez-Roca, H.1    Maixner, W.2
  • 75
    • 0022998719 scopus 로고
    • Advantages of bispecific hybridomas in one-step immunocytochemistry and immunoassays
    • 75. Suresh M. R., Cuello A. C. and Milstein C. (1986) Advantages of bispecific hybridomas in one-step immunocytochemistry and immunoassays. Proc. natn. Acad. Sci. U.S.A. 83, 7989-7993.
    • (1986) Proc. Natn. Acad. Sci. U.S.A. , vol.83 , pp. 7989-7993
    • Suresh, M.R.1    Cuello, A.C.2    Milstein, C.3
  • 76
    • 0026075050 scopus 로고
    • Differential effects of acidic and basic fibroblast growth factors on spinal cord cholinergic, GABAergic, and glutamatergic neurons
    • 76. Sweetnam P. M., Sanon H. R., White L. A., Brass B. J., Jaye M. and Whittemore S. R. (1991) Differential effects of acidic and basic fibroblast growth factors on spinal cord cholinergic, GABAergic, and glutamatergic neurons. J. Neurochem. 57, 237-249.
    • (1991) J. Neurochem. , vol.57 , pp. 237-249
    • Sweetnam, P.M.1    Sanon, H.R.2    White, L.A.3    Brass, B.J.4    Jaye, M.5    Whittemore, S.R.6
  • 77
    • 0020510747 scopus 로고
    • Substance P stimulates the release of Met5-enkephalin-Arg6-Phe7 and Met5-enkephalin from rat spinal cord
    • 77. Tang J., Chou J., Yang H. Y. and Costa E. (1983) Substance P stimulates the release of Met5-enkephalin-Arg6-Phe7 and Met5-enkephalin from rat spinal cord. Neuropharmacology 22, 1147-1150.
    • (1983) Neuropharmacology , vol.22 , pp. 1147-1150
    • Tang, J.1    Chou, J.2    Yang, H.Y.3    Costa, E.4
  • 78
    • 0023605954 scopus 로고
    • Immunohistochemical demonstration of coexistence of enkephalin- and substance P-like immunoreactivities in axonal components in the lumbar segments of cat spinal cord
    • 78. Tashiro T., Takahashi O., Satoda T., Matsushima R. and Mizuno N. (1987) Immunohistochemical demonstration of coexistence of enkephalin- and substance P-like immunoreactivities in axonal components in the lumbar segments of cat spinal cord. Brain Res. 424, 391-395.
    • (1987) Brain Res. , vol.424 , pp. 391-395
    • Tashiro, T.1    Takahashi, O.2    Satoda, T.3    Matsushima, R.4    Mizuno, N.5
  • 79
    • 0024447225 scopus 로고
    • Calcitonin gene-related peptide immunoreactivity in the cat lumbosacral spinal cord and the effects of multiple dorsal rhizotomies
    • 79. Traub R. J., Solodkin A. and Ruda M. A. (1989) Calcitonin gene-related peptide immunoreactivity in the cat lumbosacral spinal cord and the effects of multiple dorsal rhizotomies. J. comp. Neurol. 287, 225-237.
    • (1989) J. Comp. Neurol. , vol.287 , pp. 225-237
    • Traub, R.J.1    Solodkin, A.2    Ruda, M.A.3
  • 80
    • 0024581850 scopus 로고
    • A quantitative study of the coexistence of peptides in varicosities within the superficial laminae of the dorsal horn of the rat spinal cord
    • 80. Tuchscherer M. M. and Seybold V. S. (1989) A quantitative study of the coexistence of peptides in varicosities within the superficial laminae of the dorsal horn of the rat spinal cord. J. Neurosci. 9, 195-205.
    • (1989) J. Neurosci. , vol.9 , pp. 195-205
    • Tuchscherer, M.M.1    Seybold, V.S.2
  • 81
    • 0021750080 scopus 로고
    • Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat
    • 81. Wiesenfeld-Hallin Z., Hökfelt T., Lundberg J. M., Forssmann W. G., Reinecke M., Tschopp F. A. and Fischer J. A. (1984) Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat. Neurosci. Lett. 52, 199-204.
    • (1984) Neurosci. Lett. , vol.52 , pp. 199-204
    • Wiesenfeld-Hallin, Z.1    Hökfelt, T.2    Lundberg, J.M.3    Forssmann, W.G.4    Reinecke, M.5    Tschopp, F.A.6    Fischer, J.A.7
  • 82
    • 0019314381 scopus 로고
    • Intrathecal morphine inhibits substance P release from mammalian spinal cord
    • 82. Yaksh T. L., Jessell T. M., Gamse R., Mudge A. W. and Leeman S. E. (1980) Intrathecal morphine inhibits substance P release from mammalian spinal cord. Nature 286, 155-156.
    • (1980) Nature , vol.286 , pp. 155-156
    • Yaksh, T.L.1    Jessell, T.M.2    Gamse, R.3    Mudge, A.W.4    Leeman, S.E.5
  • 83
    • 0020561488 scopus 로고
    • Endorphins mediate overshoot of substance P-induced facilitation of a spinal nociceptive reflex
    • 83. Yashpal K. and Henry J. L. (1983) Endorphins mediate overshoot of substance P-induced facilitation of a spinal nociceptive reflex. Can. J. Physiol. Pharmac. 61, 303-307.
    • (1983) Can. J. Physiol. Pharmac. , vol.61 , pp. 303-307
    • Yashpal, K.1    Henry, J.L.2
  • 84
    • 0027382369 scopus 로고
    • Neural mediation of the cardiovascular responses to intrathecal administration of substance P in the rat: Slowing of the cardioacceleration by an adrenal opioid factor
    • 84. Yashpal K. and Henry J. L. (1993) Neural mediation of the cardiovascular responses to intrathecal administration of substance P in the rat: Slowing of the cardioacceleration by an adrenal opioid factor. Neuropeptides 25, 331-342.
    • (1993) Neuropeptides , vol.25 , pp. 331-342
    • Yashpal, K.1    Henry, J.L.2
  • 85
    • 0027974099 scopus 로고
    • Noxious stimulation decreases substance P binding in rat spinal dorsal horn: Competition by endogenous ligand
    • 85. Yashpal K., Kar S., Quirion R., Hui-Chan C. W. Y. and Henry J. L. (1994) Noxious stimulation decreases substance P binding in rat spinal dorsal horn: Competition by endogenous ligand. NeuroReport 5, 2101-2104.
    • (1994) Neuroreport , vol.5 , pp. 2101-2104
    • Yashpal, K.1    Kar, S.2    Quirion, R.3    Hui-Chan, C.W.Y.4    Henry, J.L.5
  • 86
    • 0028904320 scopus 로고
    • Noxious peripheral stimulation produces antinociception mediated via substance P and opioid mechanisms in the rat tail-flick test
    • 86. Yashpal K., Pitcher G. M. and Henry J. L. (1995) Noxious peripheral stimulation produces antinociception mediated via substance P and opioid mechanisms in the rat tail-flick test. Brain Res. 674, 97-103.
    • (1995) Brain Res. , vol.674 , pp. 97-103
    • Yashpal, K.1    Pitcher, G.M.2    Henry, J.L.3
  • 87
    • 0027397416 scopus 로고
    • CP-96345, but not its stereoisomer, CP-96344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat
    • 87. Yashpal K., Radhakrishnan V., Coderre T. J. and Henry J. L. (1993) CP-96345, but not its stereoisomer, CP-96344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat. Neuroscience 52, 1039-1047.
    • (1993) Neuroscience , vol.52 , pp. 1039-1047
    • Yashpal, K.1    Radhakrishnan, V.2    Coderre, T.J.3    Henry, J.L.4
  • 88
    • 0004252445 scopus 로고
    • Prentice-Hall, Englewood Cliffs, New Jersey
    • 88. Zar J. H. (1984) Biosatistical Analysis. Prentice-Hall, Englewood Cliffs, New Jersey.
    • (1984) Biosatistical Analysis
    • Zar, J.H.1
  • 89
    • 0017170351 scopus 로고
    • The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat
    • 89. Zieglgänsberger W. and Bayerl H. (1976) The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat. Brain Res. 115, 111-128.
    • (1976) Brain Res. , vol.115 , pp. 111-128
    • Zieglgänsberger, W.1    Bayerl, H.2
  • 90
    • 0021158393 scopus 로고
    • Opioid actions on mammalian spinal neurons
    • 90. Zieglgänsberger W. (1984) Opioid actions on mammalian spinal neurons. Int. Rev. Neurobiol. 25, 243-275.
    • (1984) Int. Rev. Neurobiol. , vol.25 , pp. 243-275
    • Zieglgänsberger, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.