메뉴 건너뛰기




Volumn 47, Issue 2, 1997, Pages 113-121

Modified mucoadhesive polymers for the peroral administration of mainly elastase degradable therapeutic (poly)peptides

Author keywords

Elastase; Elastatinal; Luminal degradation; Mucoadhesive polymers; Peroral administration of (poly)peptides

Indexed keywords

CARBOXYMETHYLCELLULOSE; ELASTASE; ELASTATINAL; POLYACRYLIC ACID; POLYMER;

EID: 0030943636     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(97)01627-1     Document Type: Article
Times cited : (32)

References (27)
  • 1
    • 0024327422 scopus 로고
    • Transport of proteins through the membranes of the adult gastro- Intestinal tract - A potential for drug delivery?
    • A. Pusztai, Transport of proteins through the membranes of the adult gastro- intestinal tract - a potential for drug delivery? Adv. Drug Deliv. Rev. 3 (1989) 215-228.
    • (1989) Adv. Drug Deliv. Rev. , vol.3 , pp. 215-228
    • Pusztai, A.1
  • 2
    • 0030318764 scopus 로고    scopus 로고
    • Investigations into the diffusion behaviour of polypeptides in native intestinal mucus with regard to their peroral administration
    • A. Bernkop-Schnürch and R. Fragner, Investigations into the diffusion behaviour of polypeptides in native intestinal mucus with regard to their peroral administration, Pharm. Sci. 2 (1996) 361-363.
    • (1996) Pharm. Sci. , vol.2 , pp. 361-363
    • Bernkop-Schnürch, A.1    Fragner, R.2
  • 3
    • 0028657017 scopus 로고
    • Enzymatic barriers for GI peptide and protein delivery
    • J.F. Woodley, Enzymatic barriers for GI peptide and protein delivery, Crit. Rev. Ther. Drug 11 (1994) 61-95.
    • (1994) Crit. Rev. Ther. Drug , vol.11 , pp. 61-95
    • Woodley, J.F.1
  • 4
    • 0343904410 scopus 로고
    • The current status of therapeutic peptides and proteins
    • R.C. Hider and D. Barlow (Eds.), Ellis Horwood, Chichester, UK
    • A.F. Bristow, The current status of therapeutic peptides and proteins, in: R.C. Hider and D. Barlow (Eds.), Polypeptide and Protein Drugs - Production, Characterization and Formulation, Ellis Horwood, Chichester, UK, 1991, pp. 54-69.
    • (1991) Polypeptide and Protein Drugs - Production, Characterization and Formulation , pp. 54-69
    • Bristow, A.F.1
  • 6
    • 0026789983 scopus 로고
    • Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats
    • I. Morishita, M. Morishita, K. Takayama, Y. Machida and T. Nagai, Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats, Int. J. Pharm. 78 (1992) 9-16.
    • (1992) Int. J. Pharm. , vol.78 , pp. 9-16
    • Morishita, I.1    Morishita, M.2    Takayama, K.3    Machida, Y.4    Nagai, T.5
  • 7
    • 0026796246 scopus 로고
    • Novel oral microspheres of insulin with protease inhibitor protecting from enzymatic degradation
    • M. Morishita, I. Morishita, K. Takayama, Y. Machida and T. Nagai, Novel oral microspheres of insulin with protease inhibitor protecting from enzymatic degradation, Int. J. Pharm. 78 (1992) 1-7.
    • (1992) Int. J. Pharm. , vol.78 , pp. 1-7
    • Morishita, M.1    Morishita, I.2    Takayama, K.3    Machida, Y.4    Nagai, T.5
  • 8
    • 0029092672 scopus 로고
    • Nanoparticles as carriers for oral peptide absorption: Studies on particle uptake and fate
    • A.T. Florence, A.M. Hillery, N. Hussain and P.U. Jani, Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate, J. Control. Release 36 (1995) 39-46.
    • (1995) J. Control. Release , vol.36 , pp. 39-46
    • Florence, A.T.1    Hillery, A.M.2    Hussain, N.3    Jani, P.U.4
  • 11
  • 12
    • 0025133109 scopus 로고
    • Bioadhesive polymer systems for peptide delivery
    • H.E. Junginger, Bioadhesive polymer systems for peptide delivery, Acta Pharm. Technol. 36 (1990) 110-126.
    • (1990) Acta Pharm. Technol. , vol.36 , pp. 110-126
    • Junginger, H.E.1
  • 13
    • 0028609750 scopus 로고
    • Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract
    • C.-M. Lehr, Bioadhesion technologies for the delivery of peptide and protein drugs to the gastrointestinal tract, Crit. Rev. Ther. Drug 11 (1994) 119-160.
    • (1994) Crit. Rev. Ther. Drug , vol.11 , pp. 119-160
    • Lehr, C.-M.1
  • 14
    • 0030581134 scopus 로고    scopus 로고
    • Novel bioadhesive drug delivery system protecting (poly)peptides from gastric enzymatic degradation
    • A. Bernkop-Schnürch and K. Dundalek, Novel bioadhesive drug delivery system protecting (poly)peptides from gastric enzymatic degradation, Int. J. Pharm. 138 (1996) 75-83.
    • (1996) Int. J. Pharm. , vol.138 , pp. 75-83
    • Bernkop-Schnürch, A.1    Dundalek, K.2
  • 15
    • 0019157951 scopus 로고
    • Cytotoxic effects of protease inhibitors on human cells. 2. Effect of elastatinal
    • T. Yagi, K. Ishizaki and H. Takebe, Cytotoxic effects of protease inhibitors on human cells. 2. Effect of elastatinal, Cancer Lett. 10 (1980) 301-307.
    • (1980) Cancer Lett. , vol.10 , pp. 301-307
    • Yagi, T.1    Ishizaki, K.2    Takebe, H.3
  • 16
    • 0027233875 scopus 로고
    • Degradation of proteins by guinea pig intestinal enzymes
    • K. Ikesue, P. Kopeckova and J. Kopecek, Degradation of proteins by guinea pig intestinal enzymes, Int. J. Pharm. 95 (1993) 171-179.
    • (1993) Int. J. Pharm. , vol.95 , pp. 171-179
    • Ikesue, K.1    Kopeckova, P.2    Kopecek, J.3
  • 17
    • 0021963276 scopus 로고
    • Bioadhesive polymers as platforms for oral controlled drug delivery. II: Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers
    • H.S. Chńg, H. Park, P. Kelly and J.R. Robinson, Bioadhesive polymers as platforms for oral controlled drug delivery. II: Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers, J. Pharm. Sci. 74 (1985) 399-405.
    • (1985) J. Pharm. Sci. , vol.74 , pp. 399-405
    • Chńg, H.S.1    Park, H.2    Kelly, P.3    Robinson, J.R.4
  • 18
    • 0022512416 scopus 로고
    • Enhancement by N-hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactions
    • J.V. Staros, R.W. Wright, and D.M. Swingle, Enhancement by N-hydroxysulfosuccinimide of water-soluble carbodiimide-mediated coupling reactions, Anal. Biochem. 156 (1986) 220-222.
    • (1986) Anal. Biochem. , vol.156 , pp. 220-222
    • Staros, J.V.1    Wright, R.W.2    Swingle, D.M.3
  • 19
    • 0028896195 scopus 로고
    • An investigation of some factors influencing the in vitro assessment of mucoadhesion
    • S.A. Mortazavi and J.D. Smart, An investigation of some factors influencing the in vitro assessment of mucoadhesion, Int. J. Pharm. 116 (1995) 223-230.
    • (1995) Int. J. Pharm. , vol.116 , pp. 223-230
    • Mortazavi, S.A.1    Smart, J.D.2
  • 20
    • 0028270565 scopus 로고
    • Metabolites of Pseudevernia furfuracea (L.) Zopf, and their inhibition potential of proteolytic enzymes
    • B. Proksa, J. Adamcova, M. Strudikova and J. Fuska, Metabolites of Pseudevernia furfuracea (L.) Zopf, and their inhibition potential of proteolytic enzymes, Pharmazie 49 (1994) 282-283.
    • (1994) Pharmazie , vol.49 , pp. 282-283
    • Proksa, B.1    Adamcova, J.2    Strudikova, M.3    Fuska, J.4
  • 21
    • 0028788346 scopus 로고
    • Mucoadhesive polymers in the peroral peptide drug delivery: 2. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin
    • H.L. Lueßen, J.C. Verhoef, G. Borchard, C.-M. Lehr, A.G. de Boer and H.E. Junginger, Mucoadhesive polymers in the peroral peptide drug delivery: 2. Carbomer and polycarbophil are potent inhibitors of the intestinal proteolytic enzyme trypsin, Pharm. Res. 12 (1995) 1293-1298.
    • (1995) Pharm. Res. , vol.12 , pp. 1293-1298
    • Lueßen, H.L.1    Verhoef, J.C.2    Borchard, G.3    Lehr, C.-M.4    De Boer, A.G.5    Junginger, H.E.6
  • 22
    • 0029919336 scopus 로고    scopus 로고
    • Effects of polyacrylic polymers on the degradation of insulin and peptide drugs by chymotrypsin and trypsin
    • J.P.F. Bai, L.L. Chang and J.H. Guo, Effects of polyacrylic polymers on the degradation of insulin and peptide drugs by chymotrypsin and trypsin, J. Pharm. Pharmacol. 48 (1996) 17-21.
    • (1996) J. Pharm. Pharmacol. , vol.48 , pp. 17-21
    • Bai, J.P.F.1    Chang, L.L.2    Guo, J.H.3
  • 23
    • 0004155427 scopus 로고
    • W.H. Freeman and Company, New York, NY
    • L. Stryer, Biochemistry, W.H. Freeman and Company, New York, NY, 1988.
    • (1988) Biochemistry
    • Stryer, L.1
  • 24
    • 0021344079 scopus 로고
    • Bioadhesive polymers as platforms for the oral controlled drug delivery: Method to study bioadhesion
    • K. Park and J.R. Robinson, Bioadhesive polymers as platforms for the oral controlled drug delivery: method to study bioadhesion, Int. J. Pharm. 19 (1984) 107-127.
    • (1984) Int. J. Pharm. , vol.19 , pp. 107-127
    • Park, K.1    Robinson, J.R.2
  • 26
    • 0342598658 scopus 로고    scopus 로고
    • Development and analysis of a polymer protecting from luminal enzymatic degradation caused by α-chymotrypsin
    • accepted for publication
    • A. Bernkop-Schnürch and N.C. Göckel, Development and analysis of a polymer protecting from luminal enzymatic degradation caused by α-chymotrypsin, Drug Dev. Ind. Pharm. (1996), accepted for publication.
    • (1996) Drug Dev. Ind. Pharm.
    • Bernkop-Schnürch, A.1    Göckel, N.C.2
  • 27
    • 17344382638 scopus 로고    scopus 로고
    • Mucoadhesive polymers in peroral peptide drug delivery. I. Influence of mucoadhesive excipients on the proteolytic activity of intestinal enzymes
    • H.L. Lueßen, B.J. de Leeuw, D. Pérard, C.-M. Lehr, A.G. de Boer, J.C. Verhoef and H.E. Junginger, Mucoadhesive polymers in peroral peptide drug delivery. I. Influence of mucoadhesive excipients on the proteolytic activity of intestinal enzymes, Eur. J. Pharm. Sci. 4 (1996) 117-128.
    • (1996) Eur. J. Pharm. Sci. , vol.4 , pp. 117-128
    • Lueßen, H.L.1    De Leeuw, B.J.2    Pérard, D.3    Lehr, C.-M.4    De Boer, A.G.5    Verhoef, J.C.6    Junginger, H.E.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.