Presence and characterization of nociceptin (orphanin FQ) receptor binding in adult rat and human fetal hypothalamus

Brain Research

Volumn 762, Issue 1-2, 1997, Pages 247-250

  Makman, Maynard H ^a   Lyman, William D ^a   Dvorkin, B ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Dynorphin A; Hypothalamus; Nociceptin; Opioid; Orphanin FQ; Receptor

Indexed keywords

BENZOMORPHAN DERIVATIVE; DYNORPHIN A; DYNORPHIN A DERIVATIVE; DYNORPHIN[1-8]; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE DERIVATIVE; GUANYLATE CYCLASE; IODINE 125; MORPHINE; NALOXONE; NEUROPEPTIDE; NOCICEPTIN; OPIATE RECEPTOR; SODIUM ION;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; FEMALE; FETUS; HUMAN; HUMAN TISSUE; HYPOTHALAMUS; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING;

ANIMALS; BINDING, COMPETITIVE; FEMALE; FETUS; GTP-BINDING PROTEINS; HUMANS; HYPOTHALAMUS; IODINE RADIOISOTOPES; MALE; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID;

EID: 0030789790     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00503-9     Document Type: Article

References (15)

1. Birnbaumer L. G proteins in signal transduction. Annu. Rev. Pharmacol. Toxicol. 30:1990;675-705.
2. Bunzow J.R., Saez C., Mortrud M., Bouvier C., Williams J.T., Low M., Grandy D.K. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid rceptor type. FEBS Lett. 347:1994;284-288.
3. Chen Y., Fan Y., Liu J., Mestek A., Tian M., Kozak C.A., Yu L. Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family. FEBS Lett. 347:1994;279-283.
4. Cruciani R.A., Dvorkin B., Morris S.A., Crain S.M., Makman M.H. Direct coupling of opioid receptors to both stimulatory and inhibitory guanine nucleotide-binding proteins in F-11 neuroblastoma-sensory neuron hybrid cells. Proc. Natl. Acad. Sci. USA. 90:1993;3019-3023.
5. 3 receptor in mammalian microglia, astrocytes and Kupffer cells. Brain Res. 686:1995;239-248.
6. Fukada K., Kato S., Mori K., Nishi M., Takeshima H., Iwabe N., Miyata T., Houtani T., Sugimoto T. cDNA cloning and regional distribution of a novel member of the opioid receptor family. FEBS Lett. 343:1994;42-46.
7. Lachowicz J.E., Shen Y., Monsma F.J., Sibley D.R. Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family. J. Neurochem. 64:1995;34-40.
8. 1 receptor. Nature. 377:1995;532-535.
9. Mollereau C., Parmentier M., Mailleux P., Butour J.-L., Moisand C., Chalon P., Caput D., Vassart G., Meunier J.-C. ORL1, a novel member of the opioid receptor family-cloning, functional expression and localization. FEBS Lett. 341:1994;33-88.
10. Mollereau C., Simons M.-J., Soularue P., Liners G., Vassart G., Meunier J.-C., Parmentier M. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene. Proc. Natl. Acad. Sci. USA. 93:1996;8666-8670.
11. Nothacker H.-P., Reinscheid R.K., Mansour A., Henningsen R.A., Ardati A.H., Monsma F.J. Jr., Watson S.J., Civelli O. Primary Structure and tissue distribution of the orphanin FQ precursor. Proc. Natl. Acad. Sci. USA. 93:1996;8672-8677.
12. Reinscheid R.K., Nothacker H.-P., Bourson A., Ardati A., Henningsen R.A., Bunzow J.R., Grandy D.K., Langen H., Monsma F.J. Jr., Civelli O. Orphanin FQ: a neuropeptide that activates an opioid-like G protein-coupled receptor. Science. 270:1995;792-794.
13. Wang J.B., Johnson P.S., Imai Y., Persico A.M., Ozenberger B.A., Eppler C.M., Uhl G.R. cDNA cloning of an orphan opiate gene family member and its splice variant. FEBS Lett. 348:1994;75-79.
14. Wick M.J., Minnerath S.R., Roy S., Ramakrishnan S., Loh H.H. Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ and κ opioid receptors. Mol. Brain Res. 32:1995;342-347.
15. Zhang S., Yu L. Identification of dynorphins as endogenous ligands for an opioid receptor-like orphan receptor. J. Biol. Chem. 270:1995;22772-22776.