Osteoclastic superoxide production and bone resorption: Stimulation and inhibition by modulators of NADPH oxidase

Journal of Bone and Mineral Research

Volumn 11, Issue 5, 1996, Pages 671-675

  Darden, Alix G ^a   Ries, William L ^a   Wolf, William C ^a   Rodriguiz, Ramona Marie ^a   Key Jr , L Lyndon ^a,b  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHENYLIODONIUM SALT; GAMMA INTERFERON; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE;

ANIMAL TISSUE; ARTICLE; BONE REMODELING; CALVARIA; CONTROLLED STUDY; ELECTRON MICROSCOPY; HUMAN; LEUKOCYTE; MOUSE; OSTEOCLAST; OSTEOLYSIS;

EID: 0029864091     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650110515     Document Type: Article

References (23)

1. Key LL, Ries WL, Taylor RG, Hays BD, Pitzer BL 1990 Oxygen derived free radicals in osteoclasts: The specificity and location of the nitroblue tetrazolium reaction. Bone 11:115-119.
2. Garrett IR, Boyce BF, Oreffo ROC, Bonewald L, Poser J, Mundy GR 1990 Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85:632-639.
3. Steinbeck MJ, Appel WH, Verhoeven AJ, Karnovsky MJ 1994 NADPH-oxidase expression and in situ production of superoxide by osteoclasts actively resorbing bone. J Cell Biol 126: 765-772.
4. Key LL, Wolf WC, Gundberg CM, Ries WL 1994 Superoxide and bone resorption. Bone 15:431-436.
5. Segal AW 1989 The electron transport chain of the microbicidal oxidase of phagocytic cells and its involvement in the molecular pathology of chronic granulomatous disease. J Clin Invest 83:1785-1793.
6. Wiktor-Jedrzejczak W, Skelly RR, Ahmed A 1981 Hematopoietic stem cell differentiation and its role in osteopetrosis. In: Gershwin, ME, Merchant, B (eds.) Immunological defects in laboratory animals, Vol 1. Plenum Press, New York, pp. 51-77.
7. Hagenaars CE. van der Kraan AAM, Kawilarang-de Haas EWM, Vissers JWM, Nijweide PJ 1989 Osteoclast formation from cloned pluripotent hemopoietic stem cells. Bone Miner 6:179-189.
8. Cassatella MA, Bazzoni F, Flynn RM, Dusi S, Trinchieri G, Rossi F 1990 Molecular basis of interferon-γ and lipopolysaccharide enhancement of phagocyte respiratory burst capability. J Biol Chem 265:20241-20246.
9. Gowen M, Nedwin GE, Mundy GR 1986 Preferential inhibition of cytokine-stimulated bone resorption by recombinant interferon gamma. J Bone Miner Res 1:469-474.
10. Mundy GR 1993 Role of cytokines in bone resorption. J Cell Biochem 53:296-300.
11. Lerner UH, Ljungrenn O, Ransjo M, Klaushofer K, Peterlik M 1991 Inhibitory effects of gamma-interferon on bradykinin-induced bone resorption and prostaglandin formation in cultured mouse calvarial bones. Agents Actions 32:305-311.
12. Mann GN, Jacobs TW, Buchinsky FJ, Armstrong EC, Li M, Ke HZ, Ma YF, Jee WSS, Epstein S 1994 Interferon-gamma causes loss of bone volume in vivo and fails to ameliorate cyclosporin A-induced osteopenia. Endocrinology 135:1077-1083.
13. Key LL, Ries WL, Rodriguiz RM, Hatcher HC 1992 Recombinant human interferon gamma therapy for osteopetrosis. J Pediatr 121:119-124.
14. Rodriguiz RM, Key LL, Ries WL 1993 Combination macrophage-colony stimulating factor and interferon-gamma administration ameliorates the osteopetrotic condition in microphthalmic (mi/mi) mice. Pediatric Res 33:384-389.
15. O'Donnell VB, Tew DG, Jones OTG, England PJ 1993 Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem J 290:41-49.
16. Ragan CI, Bloxham D 1977 Specific labelling of a constituent polypeptide of bovine heart mitochondrial reduced nicotinamideadenine dinucleotide-ubiquinone reductase by the inhibitor diphenyleneiodonium. Biochem J 163:605-615.
17. 2 generating oxidase of neutrophils by iodonium biphenyl in a cell free system: Effect of the redox state of the oxidase complex. Biochem Biophys Res Commun 175:143-151.
18. Cross AR, Jones TG 1986 The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Biochem J 237:111-116.
19. 2. Arch Biochem Biophys 271:149-156.
20. Segal AW, Abo A 1993 The biochemical basis of the NADPH oxidase of phagocytes. Trends Biol Sci 18:43-47.
21. Cross AR, Jones OTG 1986 The effect of the inhibitor diphenylene iodonium on the superoxide-generating system of neutrophils. Biochem J 237:111-116.
22. -245 is a flavocytochrome containing FAD and the NADPH-binding site of the microbicidal oxidase of phagocytes. Biochem J 284:781-788.
23. 558: The flavin-binding component of the phagocyte NADPH oxidase. Nature 256:1459-1462.