Effect of target gene CpG content on spontaneous mutation in transgenic mice

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 400, Issue 1-2, 1998, Pages 77-88

  Skopek, Thomas ^a   Marino, Deborah ^a   Kort, Kristy ^a   Miller, Judith ^a   Trumbauer, Myrna ^a   Gopal, Shobhna ^a   Chen, Howard ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Big Blue; LacI; Methylation; Mouse; mrkll; Spontaneous; Transgenic

Indexed keywords

5 METHYLCYTOSINE; DNA; MUTAGENIC AGENT;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CPG ISLAND; DNA PACKAGING; GENE TARGETING; MOUSE; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SPONTANEOUS MUTATION; TRANSGENIC MOUSE;

ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; CPG ISLANDS; DNA MUTATIONAL ANALYSIS; ESCHERICHIA COLI PROTEINS; GENE TARGETING; GENES, BACTERIAL; GENETIC VECTORS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; POINT MUTATION; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; TRANSGENES;

EID: 0032565551     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00040-2     Document Type: Article

References (30)

1. [1] N.J. Gorelick, J.C. Mirsalis, A strategy for the application of transgenic rodent mutagenesis assays, Environ. Mol. Mutagen. 28 (1996) 434-442.
2. [2] T. Sofuni, T. Suzuki, M. Hayashi, Initial consideration for use of transgenic rodent mutagenesis assays in a regulatory submission, Environ. Mol. Mutagen. 28 (1996) 443-446.
3. [3] S.W. Kohler, G.S. Provost, A. Fieck, P.L. Kretz, W.O. Bullock, J.A. Sorge, D.L. Putman, J.M. Short, Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice, Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 7958-7962.
4. [4] T.R. Skopek, K.L. Kort, D.R. Marino, Relative sensitivity of the endogenous hprt gene and lacI transgene in ENU-treated Big Blue™ B6C3F1 mice, Environ. Mol. Mutagen. 26 (1995) 9-15.
5. [5] T.R. Skopek, K.L. Kort, D.R. Marino, L.V. Mittal, D.R. Umbenhauer, G.M. Laws, S.P. Adams, Mutagenic response of the endogenous hprt gene and lacI transgene in benzo[a]pyrene-treated Big Blue™ B6C3F1 mice, Environ. Mol. Mutagen. 28 (1996) 376-384.
6. [6] V.E. Walker, N.J. Gorelick, J.L. Andrews, T.R. Craft, J.G. deBoer, B.W. Glickman, T.R. Skopek, Frequency and spectrum of ethylnitrosourea-induced mutation at the hprt and lacI loci in splenic lymphocytes of exposed lacI transgenic mice, Cancer Res. 56 (1996) 4654-4661.
7. [7] V.E. Walker, J.L. Andrews, N.L. Clement, P.B. Upton, J.G. deBoer, H.E. Sussman, N.J. Gorelick, Detection of cyclophosphamide-induced mutations at the hprt but not the lacI locus in splenic lymphocytes of exposed mice. Cancer Res., 1998, in press.
8. [8] V.E. Walker, S.C. Sisk, P.B. Upton, B.A. Wong, L. Recio, In vivo mutagenicity of ethylene oxide at the hprt locus in T-lymphocytes of B6C3F1 lacI transgenic mice following inhalation exposure, Mutation Res. 392 (1998) 211-222.
9. [9] I. Mellon, G. Spivak, P.C. Hanawalt, Selective removal of transcription-blocking DNA damage from the transcribed strand of the mammalian DHFR gene, Cell 51 (1987) 241-249.
10. [10] P.C. Hanawalt, Heterogeneity of DNA repair at the gene level, Mutation Res. 247 (1991) 203-211.
11. [11] M.J. Lippert, H.L. Liber, The effect of transcription level on spontaneous mutation rate in human cells, Mutation Res. 29 (Suppl. 28) (1997) 30.
12. [12] A. Datta, S. Jinks-Robertson, Association of increased spontaneous mutation rates with high levels of transcription in yeast, Science 268 (1995) 1616-1619.
13. [13] P.J. Farabaugh, Sequence of the lacI gene, Nature 274 (1978) 765-769.
14. [14] D.J. Jolly, H. Okayama, P. Berg, A.C. Esty, D. Filpula, P. Bohlen, G.G. Johnson, J.E. Shively, T. Hunkapillar, T. Friedmann, Isolation and characterization of a full-length expressible cDNA for human hypoxanthine phosphoribosyltransferase, Proc. Natl. Acad. Sci. U.S.A. 80 (1983) 477-481.
15. [15] A. Knoll, D.P. Jacobson, H. Hishino, P.L. Kretz, K.S. Lundberg, J.M. Short, S.S. Sommer, Evidence that the pattern of spontaneous somatic mutation can differ dramatically with tissue type, Environ. Mol. Mutagen. 23 (1994) 32, Suppl. 23.
16. [16] G.S. Provost, J.M. Short, Characterization of mutations induced by ethylnitrosourea in seminiferous germ cells of transgenic B6C3F1 mice, Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 6564-6568.
17. [17] J.-C. Shen, W.M. Rideout III, P.A. Jones, The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA, Nucleic Acids Res. 22 (1994) 972-976.
18. [18] B.K. Duncan, J.H. Miller, Mutagenic deamination of cytosine residues in DNA, Nature 287 (1980) 560-561.
19. [19] T.R. Skopek, D.R. Marino, K.L. Kort, J. Miller, T. Pippert, Synthesis of a lacI gene analogue with reduced CpG content, Mutation Res. 349 (1996) 163-172.
20. [20] J. Sambrook, E.F. Fritsch, T. Maniatis, Molecular Cloning, A Laboratory Manual, 2nd edn., Cold Spring Harbor Laboratory Press, 1989.
21. [21] J.E. Dinchuk, K. Kelley, A.L. Boyle, Fluorescence in situ hybridization of interphase nuclei isolated from whole blood of transgenic mice, BioTechniques 17 (1994) 954-959.
22. [22] G.P. Pfeifer, S.D. Steigerwald, R.S. Hansen, S.M. Gartler, A.D. Riggs, Polymerase chain reaction-aided genomic sequencing of an X chromosome-linked CpG island: methylation patterns suggest clonal inheritance, CpG site autonomy, and an explanation of activity state stability, Proc. Natl. Acad. Sci. U.S.A. 87 (1990) 8252-8256.
23. [23] R.P. Ketterling, E. Vielhaber, S.S. Sommer, The rates of G:C → T:A and G:C → C:G transversions at CpG dinucleotides in the human factor IX gene, Am. J. Hum. Genet. 54 (1994) 831-835.
24. [24] J.-C. Shen, W.M. Rideout III, P.A. Jones, High frequency mutagenesis by a DNA methyltransferase, Cell 71 (1992) 1073-1080.
25. [25] M.F. Dennisenko, A. Pao, M.-S. Tang, G.P. Pfeifer, Preferential formation of benzo(a)pyrene adducts at lung cancer mutational hotspots in p53, Science (Washington, DC) 274 (1996) 430-432.
26. [26] S. Tommasi, M.F. Denissenko, G.P. Pfeifer, Sunlight induces pyridmidine dimers preferentially at 5-methylcytosine bases, Cancer Res. 57 (1997) 4727-4730.
27. [27] T. deRojas-Walker, S. Tamir, H. Ji, J.S. Wishnok, S.R. Tannenbaum, Nitric oxide induces oxidative damage in addition to deamination in macrophage DNA, Chem. Res. Toxicol. 8 (1995) 473-477.
28. [28] E.U. Selker, Premeiotic instability of repeated sequences in Neurospora crassa, Annu. Rev. Genet. 24 (1990) 579-613.
29. [29] M.C. Kricker, J.W. Drake, M. Radman, Duplication-targeted DNA methylation and mutagenesis in the evolution of eukaryotic chromosomes, Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 1075-1079.
30. [30] M.J. Dycaico, G.S. Provost, P.L. Kretz, S.L. Ransom, J.C. Moores, J.M. Short, The use of shuttle vectors for mutation analysis in transgenic mice and rats, Mutation Res. 307 (1994) 461-478.