-
2
-
-
17644430199
-
Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type k-ras and characteristic histopathology: Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+
-
Goggins M, Offerhaus GJA, Hilgers W, Griffin CA, Shekher M, Tang D, Sohn TA, Yeo CJ, Kern SE, Hruban RH (1998) Pancreatic adenocarcinomas with DNA replication errors (RER+) are associated with wild-type k-ras and characteristic histopathology: Poor differentiation, a syncytial growth pattern, and pushing borders suggest RER+. Am J Pathol 152:1501-1507
-
(1998)
Am J Pathol
, vol.152
, pp. 1501-1507
-
-
Goggins, M.1
Offerhaus, G.J.A.2
Hilgers, W.3
Griffin, C.A.4
Shekher, M.5
Tang, D.6
Sohn, T.A.7
Yeo, C.J.8
Kern, S.E.9
Hruban, R.H.10
-
3
-
-
14444284330
-
Tumor-suppressive pathways in pancreatic carcinoma
-
Rozenblum E, Schutte M, Goggins M, Hahn SA, Panzer S, Zahurak M, Goodman SN, Sohn TA, Hruban RH, Yeo CJ, Kern SE (1997) Tumor-suppressive pathways in pancreatic carcinoma. Cancer Res 57:1731-1734
-
(1997)
Cancer Res
, vol.57
, pp. 1731-1734
-
-
Rozenblum, E.1
Schutte, M.2
Goggins, M.3
Hahn, S.A.4
Panzer, S.5
Zahurak, M.6
Goodman, S.N.7
Sohn, T.A.8
Hruban, R.H.9
Yeo, C.J.10
Kern, S.E.11
-
4
-
-
0027733796
-
K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization
-
Hruban RH, van Mansfeld ADM, Offerhaus GJA, van Weering DHJ, Allison DC, Goodman SN, Kensler TW, Bose KK, Cameron JL, Bos JL (1993) K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization. Am J Pathol 143:545-554
-
(1993)
Am J Pathol
, vol.143
, pp. 545-554
-
-
Hruban, R.H.1
Van Mansfeld, A.D.M.2
Offerhaus, G.J.A.3
Van Weering, D.H.J.4
Allison, D.C.5
Goodman, S.N.6
Kensler, T.W.7
Bose, K.K.8
Cameron, J.L.9
Bos, J.L.10
-
5
-
-
0003070027
-
Tumor suppressor genes
-
Vogelstein B, Kinzler KW (eds) McGraw Hill, New York
-
Fearon ER (1997) Tumor suppressor genes. In: Vogelstein B, Kinzler KW (eds) The genetic basis of human cancer. McGraw Hill, New York, pp 229-236
-
(1997)
The Genetic Basis of Human Cancer
, pp. 229-236
-
-
Fearon, E.R.1
-
6
-
-
0029001472
-
Consistent chromosome abnormalities in adenocarcinoma of the pancreas
-
Griffin CA, Hruban RH, Morsberger L, Ellingham T, Long PP, Jaffee EM, Hauda KM, Bohlander SK, Yeo CJ (1995) Consistent chromosome abnormalities in adenocarcinoma of the pancreas. Cancer Res 55:2394-2399
-
(1995)
Cancer Res
, vol.55
, pp. 2394-2399
-
-
Griffin, C.A.1
Hruban, R.H.2
Morsberger, L.3
Ellingham, T.4
Long, P.P.5
Jaffee, E.M.6
Hauda, K.M.7
Bohlander, S.K.8
Yeo, C.J.9
-
7
-
-
0031035227
-
The structural basis of molecular genetic deletions. An integration of classical cytogenetic and molecular analyses in pancreatic adenocarcinoma
-
Brat DJ, Hahn SA, Griffin CA, Yeo CJ, Kern SE, Hruban RH (1997) The structural basis of molecular genetic deletions. An integration of classical cytogenetic and molecular analyses in pancreatic adenocarcinoma. Am J Pathol 150:383-391
-
(1997)
Am J Pathol
, vol.150
, pp. 383-391
-
-
Brat, D.J.1
Hahn, S.A.2
Griffin, C.A.3
Yeo, C.J.4
Kern, S.E.5
Hruban, R.H.6
-
8
-
-
0027976937
-
Chromosome abnormalities in pancreatic adenocarcinoma
-
Griffin CA, Hruban RH, Long PP, Morsberger LA, Douna-Issa F, Yeo CJ (1994) Chromosome abnormalities in pancreatic adenocarcinoma. Genes, Chromosom Cancer 9:93-100
-
(1994)
Genes, Chromosom Cancer
, vol.9
, pp. 93-100
-
-
Griffin, C.A.1
Hruban, R.H.2
Long, P.P.3
Morsberger, L.A.4
Douna-Issa, F.5
Yeo, C.J.6
-
9
-
-
19444385922
-
Analysis of pancreatic carcinoma cell lines by comparative genomic hybridization
-
Morsberger LA, Griffin CA, Jaffee EM, et al (1997) Analysis of pancreatic carcinoma cell lines by comparative genomic hybridization. Mod Pathol 10:855
-
(1997)
Mod Pathol
, vol.10
, pp. 855
-
-
Morsberger, L.A.1
Griffin, C.A.2
Jaffee, E.M.3
-
10
-
-
0001474910
-
The human genome project and its impact on the study of human disease
-
Vogelstein B, Kinzler KW (eds) McGraw Hill, New York
-
Green ED, Cox DR, Myers RM (1997) The human genome project and its impact on the study of human disease. In: Vogelstein B, Kinzler KW (eds) The genetic basis of human cancer. McGraw Hill, New York, pp 33-64
-
(1997)
The Genetic Basis of Human Cancer
, pp. 33-64
-
-
Green, E.D.1
Cox, D.R.2
Myers, R.M.3
-
11
-
-
0028875562
-
Allelotype of pancreatic adenocarcinoma using xenograft enrichment
-
Hahn SA, Seymour AB, Hoque ATMS, Schutte M, da Costa LT, Redston MS, Caldas C, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE (1995) Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res 55:4670-4675
-
(1995)
Cancer Res
, vol.55
, pp. 4670-4675
-
-
Hahn, S.A.1
Seymour, A.B.2
Hoque, A.T.M.S.3
Schutte, M.4
Da Costa, L.T.5
Redston, M.S.6
Caldas, C.7
Weinstein, C.L.8
Fischer, A.9
Yeo, C.J.10
Hruban, R.H.11
Kern, S.E.12
-
12
-
-
0025815451
-
Identification of p53 as a sequence-specific DNA-binding protein
-
Kern SE, Kinzler KW, Bruskin A, Jarosz D, Friedman P, Prives C, Vogelstein B (1991) Identification of p53 as a sequence-specific DNA-binding protein. Science 252:1708-1711
-
(1991)
Science
, vol.252
, pp. 1708-1711
-
-
Kern, S.E.1
Kinzler, K.W.2
Bruskin, A.3
Jarosz, D.4
Friedman, P.5
Prives, C.6
Vogelstein, B.7
-
13
-
-
0026669469
-
p53 function and dysfunction
-
Vogelstein B, Kinzler KW (1992) p53 function and dysfunction. Cell 70:523-526
-
(1992)
Cell
, vol.70
, pp. 523-526
-
-
Vogelstein, B.1
Kinzler, K.W.2
-
14
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323-331
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
15
-
-
0029670589
-
p53 in signaling checkpoint arrest or apoptosis
-
Bates S, Vousden KH (1996) p53 in signaling checkpoint arrest or apoptosis. Curr Opin Genet Dev 6:12-18
-
(1996)
Curr Opin Genet Dev
, vol.6
, pp. 12-18
-
-
Bates, S.1
Vousden, K.H.2
-
16
-
-
0026801977
-
Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
-
Yin Y, Tainsky MA, Bischoff FZ, Strong LC, Wahl GM (1992) Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70:937-948
-
(1992)
Cell
, vol.70
, pp. 937-948
-
-
Yin, Y.1
Tainsky, M.A.2
Bischoff, F.Z.3
Strong, L.C.4
Wahl, G.M.5
-
17
-
-
0026770424
-
Wild-type p53 activates transcription in vitro
-
Farmer G, Bargonetti J, Zhu H, Friedman P, Prywes R, Prives C (1991) Wild-type p53 activates transcription in vitro. Nature 358:83-86
-
(1991)
Nature
, vol.358
, pp. 83-86
-
-
Farmer, G.1
Bargonetti, J.2
Zhu, H.3
Friedman, P.4
Prywes, R.5
Prives, C.6
-
18
-
-
0028294605
-
1 arrest and apoptosis
-
1 arrest and apoptosis. Cancer Res 54:1169-1174
-
(1994)
Cancer Res
, vol.54
, pp. 1169-1174
-
-
El-Deiry, W.S.1
Harper, J.W.2
O'Connor, P.M.3
Velculescu, V.E.4
Canman, C.E.5
Jackman, J.6
Pietenpol, J.A.7
Burrell, M.8
Hill, D.E.9
Wang, Y.10
Wiman, K.G.11
Mercer, W.E.12
Kastan, M.B.13
Kohn, K.W.14
Elledge, S.J.15
Kinzler, K.W.16
Vogelstein, B.17
-
19
-
-
0027359827
-
WAF1, a potential mediator of p53 tumor suppression
-
El-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW, Vogelstein B (1993) WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825
-
(1993)
Cell
, vol.75
, pp. 817-825
-
-
El-Deiry, W.S.1
Tokino, T.2
Velculescu, V.E.3
Levy, D.B.4
Parsons, R.5
Trent, J.M.6
Lin, D.7
Mercer, W.E.8
Kinzler, K.W.9
Vogelstein, B.10
-
20
-
-
0002056441
-
Molecular genetics of pancreas cancer
-
Sarkar F, Dugan M (eds) Eton, Natick, MA
-
Slebos RJC, Ceba HM, Kern SE, Hruban RH (1998) Molecular genetics of pancreas cancer. In: Sarkar F, Dugan M (eds) Pancreatic cancer. Molecular and clinical management prospects. Eton, Natick, MA pp 65-82
-
(1998)
Pancreatic Cancer. Molecular and Clinical Management Prospects
, pp. 65-82
-
-
Slebos, R.J.C.1
Ceba, H.M.2
Kern, S.E.3
Hruban, R.H.4
-
21
-
-
0030048977
-
p53, ki-ras, and DNA ploidy in human pancreatic ductal adenocarcinomas
-
Weyrer K, Feichtinger H, Haun M, Weiss G, Ofner D, Weger AR, Umlauft F, Grunewald K (1996) p53, ki-ras, and DNA ploidy in human pancreatic ductal adenocarcinomas. Lab Invest 74:279-289
-
(1996)
Lab Invest
, vol.74
, pp. 279-289
-
-
Weyrer, K.1
Feichtinger, H.2
Haun, M.3
Weiss, G.4
Ofner, D.5
Weger, A.R.6
Umlauft, F.7
Grunewald, K.8
-
22
-
-
0027216028
-
p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis
-
Casey G, Yamanaka Y, Friess H, Kobrin MS, Lopez M, Buchler M, Beger HG, Korc M (1993) p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis. Cancer Lett 69:151-160
-
(1993)
Cancer Lett
, vol.69
, pp. 151-160
-
-
Casey, G.1
Yamanaka, Y.2
Friess, H.3
Kobrin, M.S.4
Lopez, M.5
Buchler, M.6
Beger, H.G.7
Korc, M.8
-
23
-
-
0027404269
-
p53 and K-ras alterations in pancreatic epithelial cell lesions
-
Kalthoff H, Schmiegel W, Roeder C, Kasche D, Schmidt A, Lauer G, Thiele H-G, Honold G, Pantel K, Riethmüller G, Scherer E, Maurer J, Maacke H, Deppert W (1993) p53 and K-ras alterations in pancreatic epithelial cell lesions. Oncogene 8:289-298
-
(1993)
Oncogene
, vol.8
, pp. 289-298
-
-
Kalthoff, H.1
Schmiegel, W.2
Roeder, C.3
Kasche, D.4
Schmidt, A.5
Lauer, G.6
Thiele, H.-G.7
Honold, G.8
Pantel, K.9
Riethmüller, G.10
Scherer, E.11
Maurer, J.12
Maacke, H.13
Deppert, W.14
-
24
-
-
0028268635
-
K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions
-
Pellegata NS, Sessa F, Renault B, Bonato MS, Leone BE, Solcia E, Ranzani GN (1994) K-ras and p53 gene mutations in pancreatic cancer: Ductal and nonductal tumors progress through different genetic lesions. Cancer Res 54:1556-1560
-
(1994)
Cancer Res
, vol.54
, pp. 1556-1560
-
-
Pellegata, N.S.1
Sessa, F.2
Renault, B.3
Bonato, M.S.4
Leone, B.E.5
Solcia, E.6
Ranzani, G.N.7
-
25
-
-
0030063636
-
Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma
-
Rall CJN, Yan YX, Graeme-Cook F, Beauchamp R, Yandell DW, Povoski SP, Rustgi AK (1996) Ki-ras and p53 mutations in pancreatic ductal adenocarcinoma. Pancreas 12:10-17
-
(1996)
Pancreas
, vol.12
, pp. 10-17
-
-
Rall, C.J.N.1
Yan, Y.X.2
Graeme-Cook, F.3
Beauchamp, R.4
Yandell, D.W.5
Povoski, S.P.6
Rustgi, A.K.7
-
26
-
-
0028308492
-
p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions
-
Redston MS, Caldas C, Seymour AB, Hruban RH, da Costa L, Yeo CJ, Kern SE (1994) p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopolymer tracts in DNA microdeletions. Cancer Res 54:3025-3033
-
(1994)
Cancer Res
, vol.54
, pp. 3025-3033
-
-
Redston, M.S.1
Caldas, C.2
Seymour, A.B.3
Hruban, R.H.4
Da Costa, L.5
Yeo, C.J.6
Kern, S.E.7
-
27
-
-
0027743438
-
Pancreatic adenocarcinomas frequently show p53 gene mutations
-
Scarpa A, Capelli P, Mukai K, Zamboni G, Oda T, Iacono C, Hirohashi S (1993) Pancreatic adenocarcinomas frequently show p53 gene mutations. Am J Pathol 142:1534-1543
-
(1993)
Am J Pathol
, vol.142
, pp. 1534-1543
-
-
Scarpa, A.1
Capelli, P.2
Mukai, K.3
Zamboni, G.4
Oda, T.5
Iacono, C.6
Hirohashi, S.7
-
28
-
-
0028670932
-
p53 expression in human pancreatic cancer correlates with enhanced biological aggressiveness
-
Yokoyama M, Yamanaka Y, Friess H, Buchler M, Korc M (1994) p53 expression in human pancreatic cancer correlates with enhanced biological aggressiveness. Anticancer Res 14:2477-2483
-
(1994)
Anticancer Res
, vol.14
, pp. 2477-2483
-
-
Yokoyama, M.1
Yamanaka, Y.2
Friess, H.3
Buchler, M.4
Korc, M.5
-
29
-
-
0029917644
-
Prognostic value of immunohistochemical expression of p53 in patients with pancreatic cancer
-
Lundin J, Nordling S, von Boguslawsky K, Roberts PJ, Haglund C (1996) Prognostic value of immunohistochemical expression of p53 in patients with pancreatic cancer. Oncology 53:104-111
-
(1996)
Oncology
, vol.53
, pp. 104-111
-
-
Lundin, J.1
Nordling, S.2
Von Boguslawsky, K.3
Roberts, P.J.4
Haglund, C.5
-
30
-
-
0028152702
-
Expression of p53 protein in precursor lesions and adenocarcinoma of human pancreas
-
Boschman CR, Stryker S, Reddy JK, Rao MS (1994) Expression of p53 protein in precursor lesions and adenocarcinoma of human pancreas. Am J Pathol 145:1291-1295
-
(1994)
Am J Pathol
, vol.145
, pp. 1291-1295
-
-
Boschman, C.R.1
Stryker, S.2
Reddy, J.K.3
Rao, M.S.4
-
31
-
-
0028305095
-
Overexpression of p53 protein in adenocarcinoma of the pancreas
-
DiGiuseppe JA, Hruban RH, Goodman SN, Polak M, van den Berg FM, Allison DC, Cameron JL, Offerhaus GJA (1994) Overexpression of p53 protein in adenocarcinoma of the pancreas. Am J Clin Pathol 101:684-688
-
(1994)
Am J Clin Pathol
, vol.101
, pp. 684-688
-
-
DiGiuseppe, J.A.1
Hruban, R.H.2
Goodman, S.N.3
Polak, M.4
Van Den Berg, F.M.5
Allison, D.C.6
Cameron, J.L.7
Offerhaus, G.J.A.8
-
32
-
-
0029033708
-
Expression of p53 protein in pancreatic adenocarcinoma
-
Lee EU, Cibull ML, O'Daniel-Pierce E, Strodel WE, Jennings CD (1995) Expression of p53 protein in pancreatic adenocarcinoma. Int J Pancreatol 17:237-242
-
(1995)
Int J Pancreatol
, vol.17
, pp. 237-242
-
-
Lee, E.U.1
Cibull, M.L.2
O'Daniel-Pierce, E.3
Strodel, W.E.4
Jennings, C.D.5
-
33
-
-
0027327558
-
Alimentary tract and pancreas. Immunohistochemical demonstration of the p53 tumor suppressor gene product in cancer of the pancreas and chronic pancreatitis
-
Lee CS, Rush M, Charalambous D, Rode J (1993) Alimentary tract and pancreas. Immunohistochemical demonstration of the p53 tumor suppressor gene product in cancer of the pancreas and chronic pancreatitis. J Gastroenterol Hepatol 8:465-469
-
(1993)
J Gastroenterol Hepatol
, vol.8
, pp. 465-469
-
-
Lee, C.S.1
Rush, M.2
Charalambous, D.3
Rode, J.4
-
34
-
-
0000856039
-
Cell cycle control: An overview
-
Vogelstein B, Kinzler KW (eds) McGraw Hill, New York
-
Clurman BE, Roberts JM (1997) Cell cycle control: An overview. In: Vogelstein B, Kinzler KW (eds) The genetic basis of human cancer. McGraw Hill, New York, pp 175-192
-
(1997)
The Genetic Basis of Human Cancer
, pp. 175-192
-
-
Clurman, B.E.1
Roberts, J.M.2
-
35
-
-
0028170806
-
The retinoblastoma protein: More than a tumor suppressor
-
Riley DJ, Lee E, Lee WH (1994) The retinoblastoma protein: More than a tumor suppressor. Annu Rev Cell Biol 10:1-29
-
(1994)
Annu Rev Cell Biol
, vol.10
, pp. 1-29
-
-
Riley, D.J.1
Lee, E.2
Lee, W.H.3
-
36
-
-
0028121279
-
A cell cycle regulator potentially involved in genesis of many tumor types
-
Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day IRS, Johnson BE, Skolnick M (1994) A cell cycle regulator potentially involved in genesis of many tumor types. Science 264:436-440
-
(1994)
Science
, vol.264
, pp. 436-440
-
-
Kamb, A.1
Gruis, N.A.2
Weaver-Feldhaus, J.3
Liu, Q.4
Harshman, K.5
Tavtigian, S.V.6
Stockert, E.7
Day, I.R.S.8
Johnson, B.E.9
Skolnick, M.10
-
37
-
-
16944367477
-
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas
-
Schutte M, Hruban RH, Geradts J, Maynard R, Hilgers W, Rabindran SK, Moskaluk CA, Hahn SA, Schwarte-Waldhoff I, Schmiegel W, Baylin SB, Kern SE, Herman JG (1997) Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas. Cancer Res 57:3126-3130
-
(1997)
Cancer Res
, vol.57
, pp. 3126-3130
-
-
Schutte, M.1
Hruban, R.H.2
Geradts, J.3
Maynard, R.4
Hilgers, W.5
Rabindran, S.K.6
Moskaluk, C.A.7
Hahn, S.A.8
Schwarte-Waldhoff, I.9
Schmiegel, W.10
Baylin, S.B.11
Kern, S.E.12
Herman, J.G.13
-
38
-
-
0028059330
-
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
-
Caldas C, Hahn SA, da Costa LT, Redston MS, Schutte M, Seymour AB, Weinstein CL, Hruban RH, Yeo CJ, Kern SE (1994) Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma. Nat Genet 8:27-32
-
(1994)
Nat Genet
, vol.8
, pp. 27-32
-
-
Caldas, C.1
Hahn, S.A.2
Da Costa, L.T.3
Redston, M.S.4
Schutte, M.5
Seymour, A.B.6
Weinstein, C.L.7
Hruban, R.H.8
Yeo, C.J.9
Kern, S.E.10
-
39
-
-
0029986043
-
Reduced survival in patients with ductal pancreatic adenocarcinoma associated with CDKN2 mutation
-
Bartsch D, Shevlin DW, Callery MP, Norton JA, Wells SA, Goodfellow PJ (1996) Reduced survival in patients with ductal pancreatic adenocarcinoma associated with CDKN2 mutation. J Natl Cancer Inst 88:680-682
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 680-682
-
-
Bartsch, D.1
Shevlin, D.W.2
Callery, M.P.3
Norton, J.A.4
Wells, S.A.5
Goodfellow, P.J.6
-
40
-
-
0028809606
-
Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas
-
Bartsch D, Shevlin DW, Tung WS, Kisker O, Wells SA, Goodfellow PJ (1995) Frequent mutations of CDKN2 in primary pancreatic adenocarcinomas. Genes, Chromosom Cancer 14:189-195
-
(1995)
Genes, Chromosom Cancer
, vol.14
, pp. 189-195
-
-
Bartsch, D.1
Shevlin, D.W.2
Tung, W.S.3
Kisker, O.4
Wells, S.A.5
Goodfellow, P.J.6
-
41
-
-
0030795157
-
Frequent loss of pl6 expression and its correlation with clinicopathological parameters in pancreatic carcinoma
-
Hu YX, Watanabe H, Ohtsubo K, Yamaguchi Y, Ha A, Okai T, Sawabu N (1997) Frequent loss of pl6 expression and its correlation with clinicopathological parameters in pancreatic carcinoma. Clin Cancer Res 3:1473-1477
-
(1997)
Clin Cancer Res
, vol.3
, pp. 1473-1477
-
-
Hu, Y.X.1
Watanabe, H.2
Ohtsubo, K.3
Yamaguchi, Y.4
Ha, A.5
Okai, T.6
Sawabu, N.7
-
42
-
-
0030043385
-
Deletion and mutation analyses of the P16/ MTS-1 tumor-suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas
-
Huang L, Goodrow TL, Zhang S, Klein-Szanto AJP, Chang H, Ruggeri BA (1996) Deletion and mutation analyses of the P16/ MTS-1 tumor-suppressor gene in human ductal pancreatic cancer reveals a higher frequency of abnormalities in tumor-derived cell lines than in primary ductal adenocarcinomas. Cancer Res 56:1137-1141
-
(1996)
Cancer Res
, vol.56
, pp. 1137-1141
-
-
Huang, L.1
Goodrow, T.L.2
Zhang, S.3
Klein-Szanto, A.J.P.4
Chang, H.5
Ruggeri, B.A.6
-
43
-
-
0029880379
-
Frequent codeletion of p16/MTS1 and p15/ MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors
-
Naumann M, Savitskaia N, Eilert C, Schramm A, Kalthoff H, Schmiegel W (1996) Frequent codeletion of p16/MTS1 and p15/ MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors. Gastroenterology 110:1215-1224
-
(1996)
Gastroenterology
, vol.110
, pp. 1215-1224
-
-
Naumann, M.1
Savitskaia, N.2
Eilert, C.3
Schramm, A.4
Kalthoff, H.5
Schmiegel, W.6
-
44
-
-
0029011539
-
5' CpG island methylation is associated with transcriptional silencing of the tumor-suppressor p16/ CDKN2/MTS1 in human cancers
-
Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, Baylin SB, Sidransky D (1995) 5' CpG island methylation is associated with transcriptional silencing of the tumor-suppressor p16/ CDKN2/MTS1 in human cancers. Nature Medicine 1:686-692
-
(1995)
Nature Medicine
, vol.1
, pp. 686-692
-
-
Merlo, A.1
Herman, J.G.2
Mao, L.3
Lee, D.J.4
Gabrielson, E.5
Burger, P.C.6
Baylin, S.B.7
Sidransky, D.8
-
45
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn SA, Schutte M, Hoque ATMS, Moskaluk CA, daCosta LT, Rozenblum E, Weinstein CL, Fischer A, Yeo CJ, Hruban RH, Kern SE (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271:350-353
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
Schutte, M.2
Hoque, A.T.M.S.3
Moskaluk, C.A.4
DaCosta, L.T.5
Rozenblum, E.6
Weinstein, C.L.7
Fischer, A.8
Yeo, C.J.9
Hruban, R.H.10
Kern, S.E.11
-
46
-
-
0032478143
-
Targeted deletion of Smad4 shows it is required for transforming growth factor β and activin signaling in colorectal cancer cells
-
Zhou S, Buckhaults P, Zawel L, Bunz F, Riggins G, Dai JL, Kern SE, Kinzler KW, Vogelstein B (1998) Targeted deletion of Smad4 shows it is required for transforming growth factor β and activin signaling in colorectal cancer cells. Proc Natl Acad Sci USA 95:2412-2416
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 2412-2416
-
-
Zhou, S.1
Buckhaults, P.2
Zawel, L.3
Bunz, F.4
Riggins, G.5
Dai, J.L.6
Kern, S.E.7
Kinzler, K.W.8
Vogelstein, B.9
-
47
-
-
0021845022
-
Mucinous cystic neoplasm of the pancreas with high carcinoembryonic antigen
-
Yu HC, Shetty J (1985) Mucinous cystic neoplasm of the pancreas with high carcinoembryonic antigen. Arch Pathol Lab Med 109:375-377
-
(1985)
Arch Pathol Lab Med
, vol.109
, pp. 375-377
-
-
Yu, H.C.1
Shetty, J.2
-
48
-
-
0029834067
-
Partnership between DPC4 and SMAD proteins in TGFβ signalling pathways
-
Lagna G, Hata A, Hemmati-Brivanlou A, Massagué J (1996) Partnership between DPC4 and SMAD proteins in TGFβ signalling pathways. Nature 383:832-836
-
(1996)
Nature
, vol.383
, pp. 832-836
-
-
Lagna, G.1
Hata, A.2
Hemmati-Brivanlou, A.3
Massagué, J.4
-
49
-
-
0029786212
-
Receptor-associated Mad homologues synergize as effectors of the TGF-β response
-
Zhang Y, Feng XH, Wu RY, Derynck R (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383:168-172
-
(1996)
Nature
, vol.383
, pp. 168-172
-
-
Zhang, Y.1
Feng, X.H.2
Wu, R.Y.3
Derynck, R.4
-
50
-
-
0030460085
-
Cancer gets Mad: DPC4 and other TGF beta; pathway genes in human cancer
-
Moskaluk CA, Kern SE (1996) Cancer gets Mad: DPC4 and other TGF beta; pathway genes in human cancer. Biochim Biophys Acta 1288:M31-M33
-
(1996)
Biochim Biophys Acta
, vol.1288
-
-
Moskaluk, C.A.1
Kern, S.E.2
-
51
-
-
0029868841
-
Negative regulation of cell growth by TGF β
-
Polyak K (1996) Negative regulation of cell growth by TGF β. Biochim Biophys Acta 1242:185-199
-
(1996)
Biochim Biophys Acta
, vol.1242
, pp. 185-199
-
-
Polyak, K.1
-
52
-
-
0032489549
-
Tumor suppressing pathways
-
White RL (1998) Tumor suppressing pathways. Cell 92:591-592
-
(1998)
Cell
, vol.92
, pp. 591-592
-
-
White, R.L.1
-
53
-
-
0032489508
-
Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Ape genes
-
Takaku K, Oshima M, Miyoshi H, Matsui M, Seldin MF, Taketo MM (1998) Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Ape genes. Cell 92:645-656
-
(1998)
Cell
, vol.92
, pp. 645-656
-
-
Takaku, K.1
Oshima, M.2
Miyoshi, H.3
Matsui, M.4
Seldin, M.F.5
Taketo, M.M.6
-
54
-
-
9344223357
-
DPC4 gene in various tumor types
-
Schutte M, Hruban RH, Hedrick L, Cho KR, Nadasdy GM, Weinstein CL, Bova GS, Isaacs WB, Cairns P, Nawroz H, Sidransky D, Casero RA, Meltzer PS, Hahn SA, Kern SE (1996) DPC4 gene in various tumor types. Cancer Res 56:2527-2530
-
(1996)
Cancer Res
, vol.56
, pp. 2527-2530
-
-
Schutte, M.1
Hruban, R.H.2
Hedrick, L.3
Cho, K.R.4
Nadasdy, G.M.5
Weinstein, C.L.6
Bova, G.S.7
Isaacs, W.B.8
Cairns, P.9
Nawroz, H.10
Sidransky, D.11
Casero, R.A.12
Meltzer, P.S.13
Hahn, S.A.14
Kern, S.E.15
-
55
-
-
15844387270
-
Mad-related genes in the human
-
Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz S, Kinzler KW, Vogelstein B (1996) Mad-related genes in the human. Nature Genetics 13:347-349
-
(1996)
Nature Genetics
, vol.13
, pp. 347-349
-
-
Riggins, G.J.1
Thiagalingam, S.2
Rozenblum, E.3
Weinstein, C.L.4
Kern, S.E.5
Hamilton, S.R.6
Willson, J.K.7
Markowitz, S.8
Kinzler, K.W.9
Vogelstein, B.10
-
56
-
-
15844390729
-
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
-
Thiagalingam S, Lengauer C, Leach FS, Schutte M, Hahn SA, Overhauser J, Willson JKV, Markowitz S, Hamilton SR, Kern SE, Kinzler KW, Vogelstein B (1996) Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nature Genetics 13:343-346
-
(1996)
Nature Genetics
, vol.13
, pp. 343-346
-
-
Thiagalingam, S.1
Lengauer, C.2
Leach, F.S.3
Schutte, M.4
Hahn, S.A.5
Overhauser, J.6
Willson, J.K.V.7
Markowitz, S.8
Hamilton, S.R.9
Kern, S.E.10
Kinzler, K.W.11
Vogelstein, B.12
-
57
-
-
0029933642
-
Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers
-
Nagatake M, Takagi Y, Osada H, Uchida K, Mitsudomi T, Saji S, Shimokata K, Takahashi T (1996) Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers. Cancer Res 56:2718-2720
-
(1996)
Cancer Res
, vol.56
, pp. 2718-2720
-
-
Nagatake, M.1
Takagi, Y.2
Osada, H.3
Uchida, K.4
Mitsudomi, T.5
Saji, S.6
Shimokata, K.7
Takahashi, T.8
-
58
-
-
0029808666
-
Somatic alterations of the DPC4 gene in human colorectal cancers in vivo
-
Takagi Y, Kohmura H, Futamura M, Kida H, Tanemura H, Shimokawa K, Saji S (1996) Somatic alterations of the DPC4 gene in human colorectal cancers in vivo. Gastroenterology 111:1369-1372
-
(1996)
Gastroenterology
, vol.111
, pp. 1369-1372
-
-
Takagi, Y.1
Kohmura, H.2
Futamura, M.3
Kida, H.4
Tanemura, H.5
Shimokawa, K.6
Saji, S.7
-
59
-
-
12644253827
-
Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas
-
Goggins M, Schutte M, Lu J, Moskaluk CA, Weinstein CL, Petersen GM, Yeo CJ, Jackson CE, Lynch HT, Hruban RH, Kern SE (1996) Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res 56:5360-5364
-
(1996)
Cancer Res
, vol.56
, pp. 5360-5364
-
-
Goggins, M.1
Schutte, M.2
Lu, J.3
Moskaluk, C.A.4
Weinstein, C.L.5
Petersen, G.M.6
Yeo, C.J.7
Jackson, C.E.8
Lynch, H.T.9
Hruban, R.H.10
Kern, S.E.11
-
60
-
-
0031137173
-
Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients
-
Ozcelik H, Schmocker B, DiNicola N, Shi XH, Langer B, Moore M, Taylor BR, Narod SA, Darlington G, Andrulis IL, Gallinger S, Redston M (1997) Germline BRCA2 6174delT mutations in Ashkenazi Jewish pancreatic cancer patients. Nature Genetics 16:17-18
-
(1997)
Nature Genetics
, vol.16
, pp. 17-18
-
-
Ozcelik, H.1
Schmocker, B.2
DiNicola, N.3
Shi, X.H.4
Langer, B.5
Moore, M.6
Taylor, B.R.7
Narod, S.A.8
Darlington, G.9
Andrulis, I.L.10
Gallinger, S.11
Redston, M.12
-
61
-
-
0029041032
-
Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region
-
Schutte M, daCosta LT, Hahn SA, Moskaluk C, Hoque ATMS, Rozenblum E, Weinstein CL, Meltzer PS, Trent JM, Yeo CJ, Hruban RH, Kern SE (1995) Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region. Proc Natl Acad Sci USA 92:5950-5954
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 5950-5954
-
-
Schutte, M.1
DaCosta, L.T.2
Hahn, S.A.3
Moskaluk, C.4
Hoque, A.T.M.S.5
Rozenblum, E.6
Weinstein, C.L.7
Meltzer, P.S.8
Trent, J.M.9
Yeo, C.J.10
Hruban, R.H.11
Kern, S.E.12
-
62
-
-
0028864588
-
An integrated high-resolution physical map of the DPC/ BRCA2 region at chromosome 13q12
-
Schutte M, Rozenblum E, Moskaluk CA, Guan X, Hoque ATMS, Hahn SA, daCosta LT, deJong PJ, Kern SE (1995) An integrated high-resolution physical map of the DPC/ BRCA2 region at chromosome 13q12. Cancer Res 55:4570-4574
-
(1995)
Cancer Res
, vol.55
, pp. 4570-4574
-
-
Schutte, M.1
Rozenblum, E.2
Moskaluk, C.A.3
Guan, X.4
Hoque, A.T.M.S.5
Hahn, S.A.6
DaCosta, L.T.7
DeJong, P.J.8
Kern, S.E.9
-
63
-
-
0031974516
-
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
-
Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Müller O, Back W, Zimmer M (1998) Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nature Genetics 18:38-43
-
(1998)
Nature Genetics
, vol.18
, pp. 38-43
-
-
Jenne, D.E.1
Reimann, H.2
Nezu, J.3
Friedel, W.4
Loff, S.5
Jeschke, R.6
Müller, O.7
Back, W.8
Zimmer, M.9
-
64
-
-
0023192463
-
Increased risk of cancer in the Peutz-Jeghers syndrome
-
Giardiello FM, Welsh SB, Hamilton SR, Offerhaus GJA, Gittelsohn AM, Booker SV, Krush AJ, Yardley JH, Luk GD (1987) Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med 316:1511-1514
-
(1987)
N Engl J Med
, vol.316
, pp. 1511-1514
-
-
Giardiello, F.M.1
Welsh, S.B.2
Hamilton, S.R.3
Offerhaus, G.J.A.4
Gittelsohn, A.M.5
Booker, S.V.6
Krush, A.J.7
Yardley, J.H.8
Luk, G.D.9
-
65
-
-
0040061124
-
Cytogenetic and fluorescence in situ hybridization analyses of chromosomes 19 aberrations in pancreatic carcinomas: Frequent loss of 19p13.3 and gain of 19q13.1-13.2
-
Höglund M, Gorunova L, Andrén-Sandberg A, Dawiskiba S, Mitelman F, Johansson B (1998) Cytogenetic and fluorescence in situ hybridization analyses of chromosomes 19 aberrations in pancreatic carcinomas: Frequent loss of 19p13.3 and gain of 19q13.1-13.2. Genes Chromosom Cancer 21:8-16
-
(1998)
Genes Chromosom Cancer
, vol.21
, pp. 8-16
-
-
Höglund, M.1
Gorunova, L.2
Andrén-Sandberg, A.3
Dawiskiba, S.4
Mitelman, F.5
Johansson, B.6
-
66
-
-
0032100617
-
Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor-suppressor gene
-
Su GH, Hilgers W, Shekher M, Tang D, Yeo CJ, Hruban RH, Kern SE (1998) Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor-suppressor gene. Cancer Res 58:2339-2342
-
(1998)
Cancer Res
, vol.58
, pp. 2339-2342
-
-
Su, G.H.1
Hilgers, W.2
Shekher, M.3
Tang, D.4
Yeo, C.J.5
Hruban, R.H.6
Kern, S.E.7
-
67
-
-
0031891450
-
Progression of pancreatic intraductal neoplasias (high-grade PanIN) to infiltrating adenocarcinoma of the pancreas
-
Brat DJ, Lillemoe KD, Yeo CJ, Warfield PB, Hruban RH (1998) Progression of pancreatic intraductal neoplasias (high-grade PanIN) to infiltrating adenocarcinoma of the pancreas. Am J Surg Pathol 22:163-169
-
(1998)
Am J Surg Pathol
, vol.22
, pp. 163-169
-
-
Brat, D.J.1
Lillemoe, K.D.2
Yeo, C.J.3
Warfield, P.B.4
Hruban, R.H.5
-
68
-
-
0030988302
-
P16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma
-
Moskaluk CA, Hruban RH, Kern SE (1997) p16 and K-ras gene mutations in the intraductal precursors of human pancreatic adenocarcinoma. Cancer Res 57:2140-2143
-
(1997)
Cancer Res
, vol.57
, pp. 2140-2143
-
-
Moskaluk, C.A.1
Hruban, R.H.2
Kern, S.E.3
-
69
-
-
0344122865
-
Relationship of BRCA2 germline mutation and pancreatic cancer intra-ductal lesions
-
Goggins M, Hruban RH, Kern SE (1997) Relationship of BRCA2 germline mutation and pancreatic cancer intra-ductal lesions. Fourth Annual SPORE Meeting 4:30
-
(1997)
Fourth Annual SPORE Meeting
, vol.4
, pp. 30
-
-
Goggins, M.1
Hruban, R.H.2
Kern, S.E.3
-
70
-
-
0029129816
-
Increased risk of pancreatic cancer in melanoma-prone kindreds with p16(INK4) mutations
-
Goldstein AM, Fraser MC, Struewing JP, Hussussian CJ, Ranade K, Zametkin DP, Fontaine LS, Organic SM, Dracopoli NC, Clark J WH, Tucker MA (1995) Increased risk of pancreatic cancer in melanoma-prone kindreds with p16(INK4) mutations. N Engl J Med 333:970-974
-
(1995)
N Engl J Med
, vol.333
, pp. 970-974
-
-
Goldstein, A.M.1
Fraser, M.C.2
Struewing, J.P.3
Hussussian, C.J.4
Ranade, K.5
Zametkin, D.P.6
Fontaine, L.S.7
Organic, S.M.8
Dracopoli, N.C.9
Clark, J.W.H.10
Tucker, M.A.11
-
71
-
-
0029102927
-
Brief report: A familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene
-
Whelan AJ, Bartsch D, Goodfellow PJ (1995) Brief report: A familial syndrome of pancreatic cancer and melanoma with a mutation in the CDKN2 tumor-suppressor gene. N Engl J Med 333:975-977
-
(1995)
N Engl J Med
, vol.333
, pp. 975-977
-
-
Whelan, A.J.1
Bartsch, D.2
Goodfellow, P.J.3
-
73
-
-
0029680501
-
A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals
-
Berman DB, Costalas J, Schultz DC, Grana G, Daly M, Godwin AK (1996) A common mutation in BRCA2 that predisposes to a variety of cancers is found in both Jewish Ashkenazi and non-Jewish individuals. Cancer Res 56:3409-3414
-
(1996)
Cancer Res
, vol.56
, pp. 3409-3414
-
-
Berman, D.B.1
Costalas, J.2
Schultz, D.C.3
Grana, G.4
Daly, M.5
Godwin, A.K.6
-
74
-
-
0030137718
-
Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families
-
Phelan CM, Lancaster J, Tonin P, Gumbs C, Cochran C, Carter R, Ghadirian P, Perret C, Moslehi R, Dion F, Faucher M, Dole K, Lounis H, Warner E, Goss P (1996) Mutation analysis of the BRCA2 gene in 49 site-specific breast cancer families. Nature Genetics 13:120-122
-
(1996)
Nature Genetics
, vol.13
, pp. 120-122
-
-
Phelan, C.M.1
Lancaster, J.2
Tonin, P.3
Gumbs, C.4
Cochran, C.5
Carter, R.6
Ghadirian, P.7
Perret, C.8
Moslehi, R.9
Dion, F.10
Faucher, M.11
Dole, K.12
Lounis, H.13
Warner, E.14
Goss, P.15
-
75
-
-
0030140026
-
A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes
-
Thorlacius S, Olafsdottir G, Tryggvadottir L, Neuhausen S, Jonasson JG, Tavitigian SV, Tulinius H, Ogmundsdottir HM, Eyfjord JE (1996) A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. Nature Genetics 13:117-119
-
(1996)
Nature Genetics
, vol.13
, pp. 117-119
-
-
Thorlacius, S.1
Olafsdottir, G.2
Tryggvadottir, L.3
Neuhausen, S.4
Jonasson, J.G.5
Tavitigian, S.V.6
Tulinius, H.7
Ogmundsdottir, H.M.8
Eyfjord, J.E.9
|