Perspectives on multiple sclerosis

American Journal of Neuroradiology

Volumn 19, Issue 7, 1998, Pages 1251-1265

  Grossman, Robert I ^a   McGowan, Joseph C ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

N ACETYLASPARTIC ACID;

BRAIN INJURY; CHRONIC INFLAMMATION; CLINICAL FEATURE; CONTRAST ENHANCEMENT; DIAGNOSTIC IMAGING; DIFFERENTIAL DIAGNOSIS; HUMAN; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; REVIEW; SPINAL CORD DISEASE;

ADOLESCENT; ADULT; BRAIN DISEASES; CHILD; CONTRAST MEDIA; DIAGNOSIS, DIFFERENTIAL; DIFFUSION; HUMANS; IMAGE ENHANCEMENT; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MIDDLE AGED; MULTIPLE SCLEROSIS; SPINAL CORD DISEASES;

EID: 0032231335     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (190)

1. Paty DW, Asbury AK, Herndon RM, et al. Use of magnetic resonance imaging in the diagnosis of multiple sclerosis: policy statement. Neurology 1989;39:151-153
2. Lublin FD, Reingold RC. Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996;46: 907-911
3. Giang DW, Grow VM, Mooney C, et al. Clinical diagnosis of multiple sclerosis: the impact of magnetic resonance imaging and ancillary testing. Rochester-Toronto Magnetic Resonance Study Group. Arch Neurol 1994;51:61-66
4. Isaac C, Li DK, Genton M, et al. Multiple sclerosis: a serial study using MRI in relapsing patients. Neurology 1988;38:1511-1515
5. Koopmans RA, Li DK, Oger JJ, et al. The lesion of multiple sclerosis: imaging of acute and chronic stages. Neurology 1989;39: 959-963
6. Goodkin DE, Rudick RA, Ross JS. The use of brain magnetic resonance imaging in multiple sclerosis. Arch Neurol 1994;51:505-516
7. Truyen L, Gheuens J, Parizel PM, et al. Long term follow-up of multiple sclerosis by standardized, non-contrast-enhanced magnetic resonance imaging. J Neurol Sci 1991;106:35-40
8. Willoughby EW, Grochowski E, Li DK, et al. Serial magnetic resonance scanning in multiple sclerosis: a second prospective study in relapsing patients. Ann Neurol 1989;25:43-49
9. Muller R. Course and prognosis of disseminated sclerosis in relation to age of onset. Arch Neurol Psychiatry 1951;66:561-570
10. Ghezzi A, Deplano V, Faroni J, et al. Multiple sclerosis in childhood: clinical reatures of 149 cases. Multiple Sclerosis 1997;3: 43-46
11. Duquette P, et al. Multiple sclerosis in childhood: clinical profile in 125 patients. J Pediatrics 1987;111:359-363
12. Sindern E, Haas J, Stark E, Wurster U. Early onset MS under the age of 16: clinical and paraclinical features. Acta Neurol Scand 1992;86:280-284
13. McAlpine D. Multiple sclerosis: a review. Br Med J 1973;2:292-295
14. Noseworthy J, Paty D, Wonnacott T, et al. Multiple sclerosis after age 50. Neurology 1983;33:1537-1544
15. Bye AME, Kendall BE, Wilson J. Multiple sclerosis in childhood. Dev Med Child Neurol 1985,27:215-222
16. Schumacher GA, Beebe GW, Kibler RF, et al. Problems of experimental trials of therapy in multiple sclerosis. Ann N Y Acad Sci 1965;122:552-568
17. Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;13:227-231
18. Paty DW, Oger JJ, Kastrukoff LF, et al. MRI in the diagnosis of MS: a prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT. Neurology 1988; 38:180-185
19. Thorpe JW, Kidd D, Moseley IF, et al. Spinal MRI in patients with suspected multiple sclerosis and negative brain MRI. Brain 1996;119:709-714
20. McDonnell GV, Hawkins SA. Primary progressive multiple sclerosis: a distinct syndrome? Multiple Sclerosis 1996;2:137-141
21. Weinshenker BG. The natural history of multiple sclerosis: a geographically based study, 1: Clinical course and disability. Brain 1989;112:133-146
22. McAlpine D, Compston N. Some aspects of the natural history of disseminated sclerosis. QJM 1952;82:135-167
23. Thompson AJ, Kermode AG, MacManus DG, et al. Patterns of disease activity in multiple sclerosis: clinical and magnetic resonance imaging study. BMJ 1990;300:631-634
24. Thompson AJ, Kermode AG, Wicks D, et al. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol 1991;29:53-62
25. Goodkin DE, Rudick RA, VanderBrug Medendorp S, et al. Low-dose oral methotrexate in chronic progressive multiple sclerosis: analyses of serial MRIs. Neurology 1996;47:1153-1157
26. Ormerod IEC, Bronstein A, Rudge P, et al. Magnetic resonance imaging in clinically isolated lesions of the brain stem. J Neurol Neurosurg Psychiatry 1986;49:737-743
27. Miller DH, Ormerod IE, Rudge P, et al. The early risk of multiple sclerosis following isolated acute syndromes of the brainstem and spinal cord. Ann Neurol 1989;26:635-639
28. Jacobs L, Kinkel PR, Kinkel WR. Impact of nuclear magnetic resonance imaging on the assessment of multiple sclerosis patients. Semin Neurol 1986;6:24-32
29. Campi A, Filippi M, Comi G, et al. Acute transverse myelopathy: spinal and cranial MR study with clinical follow-up. AJNR Am J Neuroradiol 1995;16:115-123
30. Tas MW, Barkhol F, van Walderveen MA, et al. The effect of gadolinium on the sensitivity and specificity of MR in the initial diagnosis of multiple sclerosis. AJNR Am J Neuroradiol 1995;16: 259-264
31. Soderstrom M, Lindqvist M, Hillert J, et al. Optic neuritis: findings on MRI, CSF examination and HLA class II typing in 60 patients and results of a short-term follow-up. J Neurol 1994;241: 391-397
32. Morrissey SP, Miller DH, Kendall BE, et al. The significance of brain magnetic resonance imaging abnormalities at presentation with clinically isolated syndromes suggestive of multiple sclerosis: a 5-year follow-up study. Brain 1993;116:135-146 .
33. Francis DA, Compston DAS, Batchelor JR, McDonald WI. A reassessment of the risk of multiple sclerosis developing in patients with optic neuritis after extended follow up. J Neurol Neurosurg Psychiatry 1987;50:758-765
34. Group TONS. The five-year risk of multiple sclerosis after optic neuritis: experience of the optic neuritis treatment trial. Neurology 1997;49:1404-1413
35. Filippi M, Horsfield MA, Morrissey SP, et al. Quantitative brain MRI lesion load predicts the course of clinically isolated syndromes suggestive of multiple sclerosis. Neurology 1994;44:635-641
36. Kurtzke JF. A new scale for evaluating disability in multiple sclerosis. Neurology 1955;5:580-583
37. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33: 1444-1452
38. Willoughby E, Paty D. Scales for rating impairment in multiple sclerosis: a critique. Neurology 1988;38:1793-1798
39. Noseworthy J, Van der Voort M, Wong C, Ebers G. Interrater variability with the expanded disability status scale (EDSS) and functional systems (FS) in a multiple sclerosis clinical trial. Neurology 1990;1990:971-975
40. Goodkin D, Cookfair D, Wende K, et al. Inter- and intrarater scoring agreement using grades 1.0 to 3.5 of the Kurtzke Expanded Disability Status Scale (EDSS). Neurology 1992;42:859-863
41. Filippi M, Paty DW, Kappos L, et al. Correlations between changes in disability and T2-weighted brain MRI activity in multiple sclerosis: a follow-up study. Neurology 1995;45:255-260
42. Paty DW, Li DK, Group tUMMS, Group atIMSS. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis, II: MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group. Neurology 1993;43:662-667
43. Miki Y, Grossman RI, Udupa JK, et al. Longitudinal analysis of disease burden in relapsing-remitting multiple sclerosis. N Engl J Med (in press)
44. Prineas JW, McDonald WI. Demyelinating diseases. In: Lantos DIGaPI, ed. Greenfield's Neuropathology. London: Arnold; 1997: 813-896
45. Trapp BD, Peterson J, Ransohoff RM, et al. Axonal transection in the lesions of multiple sclerosis. N Engl J Med 1998;338:278-285
46. Bruck W, Schmied M, Suchanek G, et al. Oligodendrocytes in the early course of multiple sclerosis. Ann Neurol 1994;35:65-73
47. Prineas JW, Connell F. Remyelination in multiple sclerosis. Ann Neurol 1979;5:22-31
48. Raine CS, Wu E. Multiple sclerosis: remyelination in acute lesions. J Neuropathol Exp Neurol 1993;52:199-205
49. Prineas JWea. Multiple sclerosis: remyelination of nascent lesions. Ann Neurol 1993;33:137-151
50. Raine CS. Multiple sclerosis: prospects for remyelination. Multiple Sclerosis 1996;2:195-197
51. Nesbit GM, Forbes GS, Scheithauer BW, et al. Multiple sclerosis: histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy. Radiology 1991;180:467-474
52. Brownell B, Hughes JT. The distribution of plaques in the cerebrum in multiple sclerosis. J Neurol Neurosurg Psychiatry 1962;25: 315-320
53. Catalaa I, Grossman RI, Fulton J. Cortical lesions in MS. AJNR Am J Neuroradiol (in press)
54. Miki Y, Grossman RI, Udupa JK, et al. Isolated U-fiber involvement in multiple sclerosis. Neurology (in press)
55. Giang DW, Poduri KR, Eskin TA, et al. Multiple sclerosis masquerading as a mass lesion. Neuroradiology 1992;34:150-154
56. Butler EG, Gilligan BS. Obstructive hydrocephalus caused by multiple sclerosis. Clin Exp Neurol 1989;26:219-223
57. Youl BD, Kermode AG, Thompson AJ, et al. Destructive lesions in demyelinating disease. J Neurol Neurosurg Psychiatry 1991;54: 288-292
58. Matthews WB. Clinical aspects. In: Matthews WB, ed. McAlpine's Multiple Sclerosis. London: Churchill Livingstone; 1991:43-300
59. Jankovic J, Derman H, Armstrong D. Haemorrhagic complications of multiple sclerosis. J Neurol Neurosurg Psychiatry 1980;43: 76-81
60. Abroms IF, Yessayan L, Shillito J, Barlow CF. Spontaneous intracerebral haemorrhage in patients suspected of multiple sclerosis. J Neurol Neurosurg Psychiatry 1971;34:15-162
61. Horowitz AL, Kaplan RD, Grewe G, et al. The ovoid lesion: a new MR observation in patients with multiple sclerosis. AJNR Am J Neuroradiol 1989;10:303-305
62. Gean MA, Vezina LG, Marton KI, et al. Abnormal corpus callosum: a sensitive and specific indicator of multiple sclerosis. Radiology 1991;180:215-221
63. Russo C, Smoker WR, Kubal W. Cortical and subcortical T2 shortening in multiple sclerosis. AJNR Am J Neuroradiol 1997;18: 124-126
64. Drayer BP, Burger P, Hurwitz B, et al. Magnetic resonance imaging in multiple sclerosis: decreased signal in thalamus and putamen. Ann Neurol 1987;22:546-550
65. Drayer BP. Magnetic resonance imaging of multiple sclerosis. Barrow Neurol Inst Q 1987;3:65-73
66. Guttmann CR, Ahn SS, Hsu L, et al. The evolution of multiple sclerosis lesions on serial MR. AJNR Am J Neuroradiol 1995;16: 1481-1491
67. Powell T, Sussman JG, Davies JG. MR imaging in acute multiple sclerosis: ringlike appearance in plaques suggesting the presence of paramagnetic free radicals. AJNR Am J Neuroradiol 1992;13: 1544-1546
68. Dietemann JL, Beigelman C, Rumbach L, et al. Multiple sclerosis and corpus callosum atrophy: relationship of MRI findings to clinical data. Neuroradiology 1988;30:478-480
69. Davie CA, Barker GJ, Webb S, et al. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain 1995;118:1583-1592
70. Losseff NA, Webb SL, O'Riordan JI, et al. Spinal cord atrophy and disability in multiple sclerosis: a new reproducible and sensitive MRI method with potential to monitor disease progression. Brain 1996;119:701-708
71. Losseff NA, Wang L, Lai HM, et al. Progressive cerebral atrophy in multiple sclerosis: a serial MRI study. Brain 1996;119:2009-2019
72. Arnold DL, Matthews PM, Francis G, Antel J. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Reson Med 1990;14:154-159
73. Matthews PM, Francis G, Antel J, Arnold DL. Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis. Neurology 1991;41:1251-1256
74. Van Hecke P, Marchai G, Johannik K, et al. Human brain proton localized NMR spectroscopy in multiple sclerosis. Magn Reson Med 1991;18:199-206
75. Miller DH, Austin SJ, Connelly A, et al. Proton magnetic resonance spectroscopy of an acute and chronic lesion in multiple sclerosis [letter]. Lancet 1991;337:58-59
76. Grossman RI, Lenkinski RE, Ramer KN, et al. MR proton spectroscopy in multiple sclerosis. AJNR Am J of Neuroradiol 1992;13: 1535-1543
77. Husted CA, Goodin DS, Hugg JW, et al. Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging. Ann Neurol 1994;36:157-165
78. Larsson HB, Christiansen P, Jensen M, et al. Localized in vivo proton spectroscopy in the brain of patients with multiple sclerosis. Magn Reson Med 1991;22:23-31
79. Narayana PA, Wolinsky JS, Jackson EF, McCarthy M. Proton MR spectroscopy of gadolinium-enhanced multiple sclerosis plaques. J Magn Reson Imaging 1992;2:263-270
80. Richards TL. Proton MR spectroscopy in multiple sclerosis: value in establishing diagnosis, monitoring progression, and evaluating therapy. AJR Am J Roentgenol 1991;157:1073-1078
81. Wolinsky JS, Narayana PA, Fenstermacher MJ. Proton magnetic resonance spectroscopy in multiple sclerosis. Neurology 1990;40: 1764-1769
82. Narayanan S, Fu L, Pioro E, et al. Imaging of axonal damage in multiple sclerosis: spatial distribution of magnetic resonance imaging lesions. Ann Neurol 1997;41:385-391
83. Arnold DL, Matthews PM, Francis GS, et al. Proton magnetic resonance spectroscopic imaging for metabolic characterization of demyelinating plaques. Ann Neurol 1992;31:235-241
84. Davie CA, Hawkins CP, Barker GJ, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994;117:49-58
85. Matthews PM, Pioro E, Narayanan S, et al. Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy. Brain 1996;119:715-722
86. Uhlenbrock D, Sehlen S. The value of T1-weighted images in the differentiation between MS, white matter lesions, and subcortical arteriosclerotic encephalopathy (SAE). Neuroradiology 1989;31: 203-212
87. Hiehle JF Jr, Grossman RI, Ramer KN, et al. Magnetization transfer effects in MR-detected multiple sclerosis lesions: comparison with gadolinium-enhanced spin-echo images and nonenhanced T1-weighted images. AJNR Am J Neuroradiol 1995;16: 69-77
88. van Walderveen MA, Barkhof F, Hommes OR, et al. Correlating MRI and clinical disease activity in multiple sclerosis: relevance of hypointense lesions on short-TR/short-TE (T1-weighted) spinecho images. Neurology 1995;45:1684-1690
89. Truyen L, van Waesberghe JH, van Walderveen MA, et al. Accumulation of hypointense lesions ("black holes") on T1 spin-echo MRI correlates with disease progression in multiple sclerosis. Neurology 1996;47:1469-1476
90. Fazekas F, Offenbacher H, Fuchs S, et al. Criteria for an increased specificity of MRI interpretation in elderly subjects with suspected multiple sclerosis. Neurology 1988;38:1822-1825
91. Yetkin FZ, Haughton VM, Papke RA, et al. Multiple sclerosis: specificity of MR for diagnosis. Radiology 1991;178:447-451
92. Barkhof F, Filippi M, Miller DH, et al. Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis. Brain 1997;120:2059-2069
93. Offenbacher H, Fazekas F, Schmidt R, et al. Assessment of MRI criteria for a diagnosis of MS. Neurology 1993;43:905-909
94. Awad JA, Spetzler RF, Kodak JA, et al. Incidental lesions noted on magnetic resonance imaging of the brain: prevalence and clinical significance in various age groups. Neurosurgery 1987;20: 222-227
95. Bowen BC, Barker WW, Loewenstein DA, et al. MR signal abnormalities in memory disorder and dementia. AJNR 1990;11: 283-290
96. Fazekas F. Magnetic resonance signal abnormalities in asymptomatic individuals: their incidental and functional correlates. Eur Neurol 1989;29:164-168
97. Grossman RI, Gonzales-Scarano F, Atlas SW, et al. Multiple sclerosis: gadolinium enhancement in MR imaging. Radiology 1986;161:721-725
98. Miller DH, Barkhof F, Nauta JJ. Gadolinium enhancement increases the sensitivity of MRI in detecting disease activity in multiple sclerosis. Brain 1993;116:1077-1094
99. Smith ME, Stone LA, Albert PS, et al. Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance imaging lesions. Ann Neurol 1993;33:480-489
100. McFarland HF, Frank JA, Albert PS, et al. Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis. Ann Neurol 1992;32:758-766
101. Frank JA, Stone LA, Smith ME, et al. Serial contrast-enhanced magnetic resonance imaging in patients with early relapsing-remitting multiple sclerosis: implications for treatment trials. Ann Neurol 1994;36(Suppl):S86-S90
102. Miller DH. The use of MRI in monitoring the treatment of multiple sclerosis (editorial), Ital J Neurol Sci 1996;17:383-384
103. Harris JO, Frank JA, Patronas N, et al. Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: implications for clinical trials and natural history. Ann Neurol 1991;29:548-555
104. Kermode AG, Thompson AJ, Tofts P, et al. Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis: pathogenetic and clinical implications. Brain 1990;113:1477-1489
105. Tofts PS, Kermode AG. Measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging, 1: fundamental concepts. Magn Reson Med 1991;17:357-367
106. Tofts PS, Kermode AG. Blood brain barrier permeability in multiple sclerosis using labelled DTPA with PET, CT and MRI (letter). J Neurol Neurosurg Psychiatry 1989;52:1019-1020
107. Filippi M, Capra R, Campi A, et al. Triple dose of gadolinium-DTPA and delayed MRI in patients with benign multiple sclerosis. J Neurol Neurosurg Psychiatry 1996;60:526-530
108. Kermode AG, Tofts PS, Thompson AJ, et al. Heterogeneity of blood-brain barrier changes in multiple sclerosis: an MRI study with gadolinium-DTPA enhancement. Neurology 1990;40:229-235
109. Filippi M, Campi A, Martinelli V, et al. Comparison of triple dose versus standard dose gadolinium-DTPA for detection of MRI enhancing lesions in patients with primary progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 1995;59:540-544
110. Filippi M, Yousry T, Campi A, et al. Comparison of triple dose versus standard dose gadolinium-DTPA for detection of MRI enhancing lesions in patients with MS. Neurology 1996;46:379-384
111. Silver NC, Good CD, Barker GJ, et al. Sensitivity of contrast enhanced MRI in multiple sclerosis: effects of gadolinium dose, magnetization transfer contrast and delayed imaging. Brain 1997; 120:1149-1161
112. Barratt HJ, Miller D, Rudge P. The site of lesion causing deafness in multiple sclerosis. Scand Audiol 1988;17:67-71
113. Haughton VM, Yetkin FZ, Rao SM, et al. Quantitative MR in the diagnosis of multiple sclerosis. Magn Reson Med 1992;26:71-78
114. Barbosa S, Blumhardt LD, Roberts N, et al. Magnetic resonance relaxation time mapping in multiple sclerosis: normal appearing white matter and the "invisible" lesion load. Magn Reson Imaging 1994;12:33-42
115. Loevner LA, Grossman RI, Cohen JA, et al. Microscopic disease in normal-appearing white matter on conventional MR images in patients with multiple sclerosis: assessment with magnetization-transfer measurements. Radiology 1995;196:511-515
116. Filippi M, Campi A, Dousset V, et al. A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis. Neurology 1995;45:478-482
117. Miki Y, Grossman RI, Udupa JK, et al. Computer-assisted quantitation of enhancing lesions in multiple sclerosis: correlation with clinical classification. AJNR Am J Neuroradiol 1997;18:705-710
118. Ikuta F, Zimmerman HM. Distribution of plaques in seventy autopsy cases of multiple sclerosis in the United States. Neurology 1976;26:26-28
119. Edwards MK, Farlow MR, Stevens JC. Cranial MR in spinal cord MS: diagnosing patients with isolated spinal cord symptoms. AJNR Am J Neuroradiol 1986;7:1003-1005
120. Honig LS, Sheremata WA. Magnetic resonance imaging of spinal cord lesions in multiple sclerosis. J Neurol Neurosurg Psychiatry 1989;52:459-466
121. Tartaglino LM, Friedman DP, Flanders AE, et al. Multiple sclerosis in the spinal cord: MR appearance and correlation with clinical parameters. Radiology 1995;195:725-732
122. Thielen KR, Miller GM. Multiple sclerosis of the spinal cord: magnetic resonance appearance. J Comput Assist Tomogr 1996;20: 434-438
123. Kidd D, Thorpe JW, Thompson AJ, et al. Spinal cord MRI using multi-array coils and fast spin echo. H. Findings in multiple sclerosis. Neurology 1993;43:2632-2637
124. Kidd D, Thorpe JW, Kendall BE, et al. MRI dynamics of brain and spinal cord in progressive multiple sclerosis. J Neurol Neurosurg Psychiatry 1996;60:15-19
125. Thorpe JW, Kidd D, Kendall BE, et al. Spinal cord MRI using multi-array coils and fast spin echo, I: technical aspects and findings in healthy controls. Neurology 1993;43:2625-2631
126. Lycklama a Nijeholt GJ, Barkhof F, Castelijns JA, et al. Comparison of two MR sequences for the detection of multiple sclerosis lesions in the spinal cord. AJNR Am J Neuroradiol 1996;17:1533-1538
127. Finelli DA, Hurst GC, Karaman GC, et al. Use of magnetization transfer for improved contrast on gradient-echo MR images of the cervical spine. Radiology 1994;193:165-171
128. Sze G, Merriam M, Oshio K, Jolesz FA. Fast spin-echo imaging in the evaluation of intradural disease of the spine. AJNR Am J Neuroradiol 1992;13:1383-1392
129. Hittmair K, Mallek R, Prayer D, et al. Spinal cord lesions in patients with multiple sclerosis: comparison of MR pulse sequences. AJNR Am J Neuroradiol 1996;17:1555-1565
130. Stevenson VL, Gawne-Cain ML, Barker GJ, et al. Imaging of the spinal cord and brain in multiple sclerosis: a comparative study between fast FLAIR and fast spin echo. J Neurol 1997;244:119-124
131. Keiper MA, Grossman RI, Brunson JC, Schnall MD. The low sensitivity of fluid-attenuated inversion-recovery MR in the detection of multiple sclerosis of the spinal cord. AJNR Am J Neuroradiol 1997;18:1035-1039
132. Filippi M, Yousry TA, Alkadhi H, et al. Spinal cord MRI in multiple sclerosis with multicoil arrays: a comparison between fast spin echo and fast FLAIR. J Neurol Neurosurg Psychiatry 1996;61:632-635
133. Thorpe JW, Halpin SF, MacManus DG, et al. A comparison between fast and conventional spin-echo in the detection of multiple sclerosis lesions. Neuroradiology 1994;36:388-392
134. Norbash A, Glover G, Enzmann D. Intracerebral lesion contrast with spin-echo and fast spin-echo pulse sequences. Radiology 1992;185:661-665
135. De Coene B, Hajnal JV, Gatehouse P, et al. MR of the brain using fluid-attenuated inversion recovery (FLAIR) pulse sequences. AJNR Am J Neuroradiol 1992;13:1555-1564
136. De Coene B, Hajnal JV, Pennock JM, Bydder GM. MRI of the brain stem using fluid attenuated inversion recivery pulse sequences. Neuroradiology 1993;35:327-331
137. White S, Hajnal J, Young I, Bydder G. Use of fluid-attentuated inversion-recovery pulse sequences for imaging the spinal cord. Magn Reson Med 1992;28:153-162
138. Rydberg JN, Riederer SJ, Rydberg CH, Jack CR. Contrast optimization of fluid-attenuated inversion recovery (FLAIR) imaging. Magn Reson Med 1995;34:868-877
139. Rydberg JN, Hammond CA, Grimm RC, et al. Initial clinical experience in MR imaging of the brain with a fast flid-attenuated inversion-recovery pulse sequence. Radiology 1994;193:173-180
140. Filippi M, Yousry T, Baratti C, et al. Quantitative assessment of MRI lesion load in multiple sclerosis: a comparison of conventional spin-echo with fast fluid-attenuated inversion recovery. Brain 1996;119:1349-1355
141. Rovaris M, Yousry T, Calori G, et al. Sensitivity and reproducibility of fast-FLAIR, FSE, and TGSE sequences for the MRI assessment of brain lesion load in multiple sclerosis: a preliminary study. J Neuroimaging 1997;7:98-102
142. Davie CA, Hawkins CP, Barker GJ, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994;117:49-58
143. Simmons M, Frondoza C, Coyle J. Immunocytochemical localization of N-acetyl aspartate with monoclonal antibodies. Neuroscience 1991;45:37-45
144. Arnold DL, Riess GT, Matthews PM, et al. Use of proton magnetic resonance spectroscopy for monitoring disease progression in multiple sclerosis. Ann Neurol 1994;36:76-82
145. Davies SE, Newcombe J, Williams SR, et al. High resolution proton NMR spectroscopy of multiple sclerosis lesions. J Neurochem 1995;64:742-748
146. Davie CA, Barker GJ, Webb S, et al. Persistent functional deficit in multiple sclerosis and autosomal dominant cerebellar ataxia is associated with axon loss. Brain 1995;118:1583-1592
147. Brenner R, Munro P, Williams S, et al. The proton NMR spectrum in acute ELAE: the significance of the change in the CHO:Cr ratio. Magn Reson Med 1993;29:737-745
148. Posse S, Schuknecht B, Smith ME, et al. Short echo time proton MR spectroscopic imaging. J Comput Assist Tomogr 1993;17:1-14
149. Aasly J, Garseth M, Sonnewald U, et al. Cerebrospinal fluid lactate and glutamine are reduced in multiple sclerosis. Acta Neurol Scand 1997;95:9-12
150. Nicoli F, Vion-Dury J, Confort-Gouny S, et al. Cerebrospinal fluid metabolic profiles in multiple sclerosis and degenerative dementias obtained by high resolution proton magnetic resonance spectroscopy. Comp Rendus Acad Sci (Serie Iii, Sci Vie) 1996;319:623-631
151. Schiepers C, Van Hecke P, Vandenberghe R, et al. Positron emission tomography, magnetic resonance imaging and proton NMR spectroscopy of white matter in multiple sclerosis. Multiple Sclerosis 1997;3:8-17
152. DeStefano N, Matthews P, Antel J, et al. Chemical pathology of acute demyelinating lesions and its correlation with disability. Ann Neurol 1995;38:901-909
153. Gonen O, Arias-Mendoza F, Goelman G. 3D localized in vivo 1H spectroscopy of human brain by using a hybrid of 1D-Hadamard with 2D-chemical shift imaging. Magn Reson Med 1997;37:644-650
154. Wolff SD, Balaban RS. Magnetization transfer contrast (MTC) and tissue water proton relaxation in vivo. Magn Reson Med 1989;10:135-144
155. McGowan JC, Leigh J. Selective saturation in magnetization transfer experiments. Magn Reson Med 1994;32:517-522
156. McGowan JC, Schnall MD, Leigh JS. Magnetization transfer imaging with pulsed off-resonance saturation: Contrast variation with saturation duty cycle. J Magn Reson 1994;4:79-82
157. Hu BS, Conolly SM, Wright GA, et al. Pulsed saturation transfer contrast. Magn Reson Med 1992;26:231-240
158. Pike GB, Hu BS, Glover GY, Enzmann DR. Magnetization transfer time-of-flight magnetic resonance angiography. Magn Reson Med 1992;25:372-379
159. Dousset V, Grossman RI, Ramer KN, et al. Experimental allergic encephalomyelitis and multiple sclerosis: lesion characterization with magnetization transfer imaging. Radiology 1992;182:483-491
160. van Buchem MA, McGowan JC, Kolson DL, et al. Quantitative volumetric magnetization transfer analysis in multiple sclerosis: estimation of macroscopic and microscopic disease burden. Magn Reson Med 1996;36:632-636
161. van Buchem MA, Udupa JK, McGowan JC, et al. Global volumetric estimation of disease burden in multiple sclerosis based on magnetization transfer imaging. AJNR Am J Neuroradiol 1997;18: 1287-1290
162. Lexa FJ, Grossman RI, Rosenquist AC. MR of wallerian degeneration in the feline visual system: characterization by magnetization transfer rate with histopathologic correlation. AJNR Am J Neuroradiol 1994;15:201-212
163. Petrella JR, Grossman RI, McGowan JC, et al. Multiple sclerosis lesions: relationship between MR enhancement pattern and magnetization transfer effect. AJNR Am J Neuroradiol 1996;17:1041-1049
164. Gass A, Barker GJ, Kidd D, et al. Correlation of magnetization transfer ratio with clinical disability in multiple sclerosis. Ann Neurol 1994;36:62-67
165. Poon C, Henkleman M. Practical T2 quantitation for clinical applications. J Magn Reson Imaging 1992;2:541-553
166. Larsson HB, Frederiksen J, Kjaer L, et al. In vivo determination of T1 and T2 in the brain of patients with severe but stable multiple sclerosis. Magn Reson Med 1988;7:43-55
167. Whittall K, MacKay A, Graeb D, et al. In vivo measurement of T2 distributions and water contents in normal human brain. Magn Reson Med 1997;37:34-43
168. Stewart W, MacKay A, Whittall K, et al. Spin-spin relaxation in experimental allergic encephalomyelitis: analysis of CPMG data using a non-linear least squares method and linear inverse theory. Magn Reson Med 1993;29:767-775
169. MacKay A, Whittall K, Adler J, et al. In-vivo visualization of myelin water in brain by magnetic resonance. Magn Reson Med 1994;31:673-677
170. Kidd D, Barker GJ, Tofts PS, et al. The transverse magnetisation decay characteristics of longstanding lesions and normal-appearing white matter in multiple sclerosis. J Neurol 1997;244:125-130
171. Stejskal E, Tanner J. Spin diffusion measurements: spin echoes in the presence of a time-dependent field gradient. J Chem Phys 1965;42:288-292
172. Warach S, Chien D, Li W, et al. Fast magnetic resonance diffusion-weighted imaging of acute human stroke. Neurology 1992;42: 1717-1723
173. Larsson HB, Thomsen C, Frederiksen J, et al. In vivo magnetic resonance diffusion measurement in the brain of patients with multiple sclerosis. Magn Reson Imaging 1992;10:7-12
174. Christiansen P, Gideon P, Thomsen C, et al. Increased water self-diffusion in chronic plaques and in apparently normal white matter in patients with multiple sclerosis. Acta Neurol Scand 1993;87:195-199
175. Horsfield MA, Lai M, Webb SL, et al. Apparent diffusion coefficients in benign and secondary progressive multiple sclerosis by nuclear magnetic resonance. Magn Reson Med 1996;36:393-400
176. Rovaris M, Gawne-Cain ML, Wang L, Miller DH. A comparison of conventional and fast spin-echo sequences for the measurement of lesion load in multiple sclerosis using a semi-automated contour technique. Neuroradiology 1997;39:161-165
177. Wicks DA, Tofts PS, Miller DH, et al. Volume measurement of multiple sclerosis lesions with magnetic resonance images: a preliminary study. Neuroradiology 1992;34:475-479
178. Filippi M, Rovaris M, Campi A, et al. Semi-automated thresholding technique for measuring lesion volumes in multiple sclerosis: effects of the change of the threshold on the computed lesion loads. Acta Neurol Scand 1996;93:30-34
179. Mitchell JR, Karlik SJ, Lee DH, Fenster A. Computer-assisted identification and quantification of multiple sclerosis lesions in MR imaging volumes in the brain. J Magn Reson Imaging 1994;4: 197-208
180. Mitchell JR, Karlik SJ, Lee DH, et al. The variability of manual and computer assisted quantification of multiple sclerosis lesion volumes. Med Phys 1996;23:85-97
181. Mitchell JR, Karlik SJ, Lee DH, et al. Quantification of multiple sclerosis lesion volumes in 1.5 and 0.5 T anisotropically filtered and unfiltered MR exams. Med Phys 1996;23:115-126
182. Jackson EF, Narayana PA, Wolinsky JS, Doyle TJ. Accuracy and reproducibility in volumetric analysis of multiple sclerosis lesions. J Comput Assist Tomogr 1993;17:200-205
183. Broderick JP, Narayan S, Gaskill M, et al. Volumetric measurement of multifocal brain lesions. Implications for treatment trials of vascular dementia and multiple sclerosis. J Neuroimaging 1996; 6:36-43
184. Kikinis R, Shenton M, Jolesz F, et al. Routine quantitative MRI-based analysis of brain and fluid spaces. J Magn Reson Imaging 1992;2:619-629
185. Bedell BJ, Narayana PA, Wolinsky JS. A dual approach for minimizing false lesion classifications on magnetic resonance images. Magn Reson Med 1997;37:94-102
186. Udupa J, Samarasekera S. Fuzzy connectedness and object definition. SPIE Proc 1995;2431:2-11
187. Samarasekera S, Udupa JK, Miki Y, et al. A new computer-assisted method for the quantification of enhancing lesions in multiple sclerosis. J Comput Assist Tomogr 1997;21:145-151
188. Ogawa S, Tank D, Menon R, et al. Intrinsic signal changes accompanying sensory simulation: Functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci USA 1992; 89:5951-5955
189. Gomori J, Grossman R. Mechanisms responsible for the MR appearance and evolution of intracranial hemorrhage. Radiographics 1988;8:427-440
190. Clanet M, Berry I, Boulanouar K. Functional imaging in multiple sclerosis. Int MS J 1997;4:27-32