Computer-assisted quantitation of enhancing lesions in multiple sclerosis: Correlation with clinical classification

American Journal of Neuroradiology

Volumn 18, Issue 4, 1997, Pages 705-710

  Miki, Yukio ^a   Grossman, Robert I ^a   Udupa, Jayaram K ^a   Samarasekera, Supun ^a   Van Buchem, Mark A ^a   Cooney, Brian S ^a   Pollack, Stuart N ^a   Kolson, Dennis L ^a   Constantinescu, Christian ^a   Polansky, Marcia ^b   Mannon, Lois J ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

Brain, magnetic resonance; Brain, measurements; Computers; Sclerosis, multiple

Indexed keywords

ADULT; ARTICLE; BRAIN SIZE; CLINICAL ARTICLE; CLINICAL TRIAL; COMPUTER ASSISTED DIAGNOSIS; DISEASE COURSE; DISEASE DURATION; FEMALE; HUMAN; IMAGE QUALITY; MALE; MULTIPLE SCLEROSIS; NUCLEAR MAGNETIC RESONANCE IMAGING; PROGNOSIS;

ADULT; BRAIN; CHRONIC DISEASE; CONTRAST MEDIA; DISABILITY EVALUATION; DISEASE PROGRESSION; FEMALE; FOLLOW-UP STUDIES; FUZZY LOGIC; HUMANS; IMAGE ENHANCEMENT; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PROSPECTIVE STUDIES; RECURRENCE; REMISSION, SPONTANEOUS; SOFTWARE;

EID: 18844476424     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (44)

1. Grossman RI, Gonzalez SF, Atlas SW, Galetta S, Silberberg DH. Multiple sclerosis: gadolinium enhancement in MR imaging. Radiology 1986;161:721-725
2. Horowitz AL, Kaplan RD, Grewe G, White RT, Salberg LM. The ovoid lesion: a new MR observation in patients with multiple sclerosis. AJNR Am J Neuroradiol 1989;10:303-305
3. Nesbit GM, Forbes GS, Scheithauer BW, Okazaki H, Rodriguez M. Multiple sclerosis: histopathologic and MR and/or CT correlation in 37 cases at biopsy and three cases at autopsy. Radiology 1991;180:467-474
4. Gean MA, Vezina LG, Marton KI, et al. Abnormal corpus callosum: a sensitive and specific indicator of multiple sclerosis. Radiology 1991;180:215-221
5. Miller DH, Barkhof F, Nauta JJ. Gadolinium enhancement increases the sensitivity of MRI in detecting disease activity in multiple sclerosis. Brain 1993;116:1077-1094
6. Harris JO, Frank JA, Patronas N, McFarlin DE, McFarland HF. Serial gadolinium-enhanced magnetic resonance imaging scans in patients with early, relapsing-remitting multiple sclerosis: implications for clinical trials and natural history. Ann Neurol 1991; 29:548-555
7. Barkhof F, Hommes OR, Scheltens P, Valk J. Quantitative MRI changes in gadolinium-DTPA enhancement after high-dose intravenous methylprednisolone in multiple sclerosis. Neurology 1991; 41:1219-1222
8. Capra R, Marciano N, Vignolo LA, Chiesa A, Gasparotti R. Gadolinium-pentetic acid magnetic resonance imaging in patients with relapsing remitting multiple sclerosis. Arch Neurol 1992;49:687-689
9. Wiebe S, Lee DH, Karlik SJ, et al. Serial cranial and spinal cord magnetic resonance imaging in multiple sclerosis. Ann Neurol 1992;32:643-650
10. Thompson AJ, Miller D, Youl B, et al. Serial gadolinium-enhanced MRI in relapsing/remitting multiple sclerosis of varying disease duration. Neurology 1992;42:60-63
11. McFarland HF, Frank JA, Albert PS, et al. Using gadolinium-enhanced magnetic resonance imaging lesions to monitor disease activity in multiple sclerosis. Ann Neurol 1992;32:758-766
12. Barkhof F, Scheltens P, Frequin ST, et al. Relapsing-remitting multiple sclerosis: sequential enhanced MR imaging vs clinical findings in determining disease activity. AJR Am J Roentgenol 1992;159:1041-1047
13. Nauta JJ, Thompson AJ, Barkhof F, Miller DH. Magnetic resonance imaging in monitoring the treatment of multiple sclerosis patients: statistical power of parallel-groups and crossover designs. J Neurol Sci 1994;122:6-14
14. Kapouleas I. Automatic detection of white matter lesions in magnetic resonance brain images. Comput Methods Programs Biomed 1990;1:17-35
15. Cline HE, Lorensen WE, Kikinis R, Jolesz F. Three-dimensional segmentation of MR images of the head using probability and connectivity. J Comput Assist Tomogr 1990;14:1037-1045
16. Wicks DA, Tofts PS, Miller DH, et al. Volume measurement of multiple sclerosis lesions with magnetic resonance images: a preliminary study. Neuroradiology 1992;34:475-479
17. Filippi M, Horsfield MA, Tofts PS, Barkhof F, Thompson AJ, Miller DH. Quantitative assessment of MRI lesion load in monitoring the evolution of multiple sclerosis. Brain 1995;118:1601-1612
18. Kamber M, Shinghal R. Model-based 3-D segmentation of multiple sclerosis lesions in magnetic resonance brain images. IEEE Trans Med Imaging 1995;14:442-453
19. Broderick JP, Narayan S, Gaskill M, Dhawan AP, Khoury J. Volumetric measurement of multifocal brain lesions: implications for treatment trials of vascular dementia and multiple sclerosis. J Neuroimaging 1996;6:36-43
20. Johnston B, Atkins MS, Mackiewich B, Anderson M. Segmentation of multiple sclerosis lesions in intensity corrected multispectral MRI. IEEE Trans Med Imaging 1996;15:154-169
21. Udupa JK, Wei L, Samarasekera S, Miki Y, van Buchern MA, Grossman RI. Multiple sclerosis lesion quantification using fuzzy connectedness principles. IEEE Trans Med Imaging (in press)
22. Smith ME, Stone LA, Albert PS, et al. Clinical worsening in multiple sclerosis is associated with increased frequency and area of gadopentetate dimeglumine-enhancing magnetic resonance im-aging lesions. Ann Neurol 1993;33:480-489
23. Frank JA, Stone LA, Smith ME, Albert PS, Maloni H, McFarland HF. Serial contrast-enhanced magnetic resonance imaging in patients with early relapsing-remitting multiple sclerosis: implications for treatment trials. Ann Neurol 1994;36:S86-S90
24. Poser CM, Paty DW, Scheinberg L, et al. New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;13:227-231
25. Kurtzke JF. Rating neurological impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 1983;33: 1444-1452
26. Udupa JK, Samarasekera S. Fuzzy connectedness and object definition: theory, algorithms and applications in image segmentation. Graph Models Image Processing 1996;58:246-261
27. Samarasekera S, Udupa JK, Miki Y, Wei L, Grossman RI. A new computer-assisted method for the quantification of enhancing lesions in multiple sclerosis. J Comput Assist Tomogr 1997;21: 145-151
28. Katz D, Taubenberger JK, Cannella B, McFarlin DE, Raine CS, McFarland HF. Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis. Ann Neurol 1993;34:661-669
29. Grossman RI, Braffman BH, Brorson JR, Goldberg HI, Silberberg DH, Gonzalez SF. Multiple sclerosis: serial study of gadolinium-enhanced MR imaging. Radiology 1988;169:117-122
30. Miller DH, Rudge P, Johnson G, et al. Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis. Brain 1988; 111:927-939
31. Kermode AG, Thompson AJ, Tofts P, et al. Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis: pathogenetic and clinical implications. Brain 1990;113:1477-1489
32. Bastianello S, Pozzilli C, Bernardi S, et al. Serial study of gadolinium-DTPA MRI enhancement in multiple sclerosis. Neurology 1990;40:591-595
33. Thompson AJ, Kermode AG, Wicks D, et al. Major differences in the dynamics of primary and secondary progressive multiple sclerosis. Ann Neurol 1991;29:53-62
34. Capra R, Marciano N, Cotti CV, et al. Immunological and gadolinium-DTPA MRI evaluation of relapsing remitting multiple sclerosis. Acta Neurol Scand 1992;86:342-345
35. Miller DH, Thompson AJ, Morrissey SP, et al. High dose steroids in acute relapses of multiple sclerosis: MRI evidence for a possible mechanism of therapeutic effect. J Neurol Neurosurg Psychiatry 1992;55:450-453
36. Goodkin DE, Ross JS, Medendorp SV, Konecsni J, Rudick RA. Magnetic resonance imaging lesion enlargement in multiple sclerosis: disease-related activity, chance occurrence, or measurement artifact? Arch Neurol 1992;49:261-263
37. Mattioli F, Cappa SF, Cominelli C, Capra R, Marcianoc N, Gasparotti R. Serial study of neuropsychological performance and gadolinium-enhanced MRI in MS. Acta Neurol Scand 1993;87:465-468
38. Bastianello S, Pozzilli C, D'Andrea F, et al. A controlled trial of mitoxantrone in multiple sclerosis: serial MRI evaluation at one year. Can J Neurol Sci 1994;21:266-270
39. Barkhof F, Tas MW, Frequin ST, et al. Limited duration of the effect of methylprednisolone on changes on MRI in multiple sclerosis. Neuroradiology 1994;36:382-387
40. Kidd D, Thompson AJ, Kendall BE, Miller DH, McDonald WI. Benign form of multiple sclerosis: MRI evidence for less frequent and less inflammatory disease activity. J Neurol Neurosurg Psychiatry 1994;57:1070-1072
41. Guttmann CRG, Ahn SS, Hsu L, Kikinis R, Jolesz FA. The evolution of multiple sclerosis lesions on serial MR. AJHR Am J Neuroradiol 1995;16:1481-1491
42. Grossman RI, Yousem DM. White matter diseases. In: Thrall JH, ed. Neuroradiology: The Requisites. St Louis, Mo: Mosby; 1994: 201-224
43. Khoury SJ, Guttmann CR, Orav EJ, et al. Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden. Neurology 1994;44:2120-2124
44. Confavreux C, Aimard G, Devic M. Course and prognosis of multiple sclerosis assessed by the computerized data processing of 349 patients. Brain 1980;103:281-300