Therapeutic potential of the neurotrophins and neurotrophin-CNTF combinations in peripheral neuropathies and motor neuron diseases

CIBA Foundation Symposia

Volumn , Issue 196, 1996, Pages 39-53

  Lindsay, Ronald M ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; NERVE GROWTH FACTOR; NERVE PROTEIN; NEUROTROPHIN 3;

ANIMAL; CYTOLOGY; DRUG EFFECT; DRUG POTENTIATION; HUMAN; MOTONEURON; MOTOR NEURON DISEASE; REVIEW; SENSORY NERVE CELL; SPINAL CORD;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; DRUG SYNERGISM; HUMANS; MOTOR NEURON DISEASE; MOTOR NEURONS; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS, AFFERENT; NEUROTROPHIN 3; SPINAL CORD;

EID: 0030330387     PISSN: 03005208     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (41)

1. Acheson A, Lindsay RM 1994 Diverse roles of neurotrophic factors in health and disease. Semin Neurosci 6:333-341
2. Albers KM, Wright DE, Davis BM 1994 Overexpression of nerve growth factor in epidermis of transgenic mice causes hypertrophy of the peripheral nervous system. J Neurosci 14:1422-1432
3. Cliffer KD, Helgren ME, Cavnor CC, DiStefano PS, Wiegand SJ, Lindsay RM 1994 NT-3 attenuates reduction in H-reflex produced by pyridoxine toxicity to large primary afferent neurons in rats. Soc Neurosci Abstr 20:455
4. Crowley C, Spencer SD, Nishimura MC et al 1994 Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76:1001-1011
5. DiStefano PS, Friedman B, Radziejewski C et al 1992 The neurotrophins BDNF, NT-3, and NGF display distinct patterns of retrograde axonal transport in peripheral and central neurons. Neuron 8:983-993
6. Ernfors P, Lee K-F, Kucera J, Jaenisch R 1994 Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77:503-512
7. Gaese F, Kolbeck R, Barde Y-A 1994 Sensory ganglia require neurotrophin-3 early in development. Development 120:1613-1619
8. Glass DJ, Yancopoulos GD 1993 The neurotrophins and their receptors. Trends Cell Biol 3:262-267
9. Hagg T 1994 Neurotrophins (BDNF, NT-3, NT-4) prevent death of axotomized adult rat substantia nigra neurons. Soc Neurosci Abstr 20:193
10. Hagg T, Varon S 1993 Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. Proc Natl Acad Sci USA 90:6315-6319
11. Hagg T, Quon D, Higaki J, Varon S 1992 Ciliary neurotrophic factor prevents neuronal degeneration and promotes low-affinity NGF receptor expression on the adult rat CNS. Neuron 8:145-158
12. Hefti F, Hartikka JA, Montero CN, Junard EO 1988 Role of nerve growth factor in the central nervous system. In: Ferrendelli JA, Collins RC, Johnson EM (eds) Neurobiology of amino acids, peptides and trophic factors. Kluwer Academic, Nonvell, MA
13. Helgren ME, Torrento K, DiStefano PS, Curtis R, Lindsay RM, Wiegand SJ 1994 NT-3 attenuates proprioceptive deficits in the adult rat with a large fiber neuropathy. Soc Neurosci Abstr 20:455
14. Henderson CE, Camu W, Mettling C et al 1993 Neurotrophins promote motor neuron survival and are present in embryonic limb bud. Nature 363:266-270
15. Henderson CE, Phillips HS, Pollock RA et al 1994 GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science 266:1062-1064
16. Hohn A, Leibrock J, Bailey K, Barde Y-A 1990 Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344:339-341
17. Hory-Lee R, Russell M, Lindsay RM, Frank E 1993 Neurotrophin 3 supports the survival of developing muscle sensory neurons in culture. Proc Natl Acad Sei USA 90:2613-2617
18. Ikeda K, Wong V, Holmlund TH et al 1994 Histometric effects of ciliary neurotrophic factor in wobbler mouse motor neuron disease. Ann Neurol 37:47-54
19. Ikeda K, Klinkosz B, Greene T et al 1995 Effects of brain-derived neurotrophic factor on motor dysfunction in Wobbler mouse motor neuron disease. Ann Neurol 37:505-511
20. Ip NY, Yancopoulos GD 1992 Ciliary neurotrophic factor and its receptor complex. Prog Growth Factor Res 4:139-155
21. Kato AC, Lindsay RM 1994 Overlapping and additive effects of neurotrophins and CNTF on cultured human spinal cord neurons. Exp Neurol 130:196-201
22. Klein R, Silos-Santiago I, Smeyne RJ et al 1994 Disruption of the neurotrophin-3 receptor gene trkC eliminates Ia muscle afferents and results in abnormal movements. Nature 368:249-251
23. Lindsay RM 1992 The role of neurotrophic factors in functional maintenance of mature sensory neurons. In: Scott SA (ed) Sensory neurons. Oxford University Press, Oxford, p 404-420
24. Lindsay RM, Altar CA, Cedarbaum JM, Hyman C, Wiegand SJ 1993 The therapeutic potential of neurotrophic factors in the treatment of Parkinson's disease. Exp Neurol 124:103-118
25. Lindsay RM, Wiegand SJ, Altar CA, DiStefano PS 1994 Neurotrophic factors: from molecule to man. Trends Neurosci 17: 182-190
26. Maisonpierre PC, Belluscio L, Friedman B et al 1990a NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron 5:501-509
27. Maisonpierre PC, Belluscio L, Squinto S et al 1990b Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science 247:1446-1451
28. McMahon SB, Armanini MP, Ling LH, Phillips HS 1994 Expression and coexpression of Trk receptors in subpopulations of adult primary sensory neurons projecting to identified peripheral targets. Neuron 12:1161-1171
29. Mitsumoto H, Ikeda K, Holmlund T et al 1994a The effects of ciliary neurotrophic factor (CNTF) on motor neuron dysfunction in Wobbler mouse motor neuron disease. Ann Neurol 36:142-148
30. Mitsumoto H, Ikeda K, Klinkosz B, Cedarbaum JM, Wong V, Lindsay RM 1994b Arrest of motor neuron disease in Wobbler mice cotreated with CNTF and BDNF. Science 265:1107-1110
31. Montero C, Hefti F 1988 Rescue of lesioned septal cholinergic neurons by nerve growth factor: specificity and requirement for chronic treatment. J Neurosci 8:2986-2999
32. Morse JK, Wiegand SJ, Anderson K et al 1993 Brain-derived neurotrophic factor (BDNF) prevents the degeneration of medial septal cholinergic neurons following fimbria transection. J Neurosci 13:4146-4156
33. Sendtner M, Kreutzberg GW, Thoenen H 1990 Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature 345:440-441
34. Sendtner M, Holtmann B, Kolbeck R, Thoenen H, Barde Y-A 1992a Brain-derived neurotrophic factor prevents the death of motoneurons in newborn rats after nerve section. Nature 360:757-759
35. Sendtner M, Schmalbruch H, Stöckli KA, Carroll P, Kreutzberg GW, Thoenen H 1992b Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature 358:502-504
36. Snider WD, Johnson EM Jr 1989 Neurotrophic molecules. Ann Neurol 26:489-506
37. Stahl N, Yancopoulos GD 1993 The alphas, betas, and kinases of cytokine receptor complexes. Cell 74:587-590
38. Thoenen H, Barde Y-A 1980 Physiology of nerve growth factor. Physiol Rev 60:1284-1335
39. Wong V, Arriaga R, Ip NY, Lindsay RM 1993 The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons. Eur J Neurosci 5:466-474
40. Yan Q, Elliott J, Snider WD 1992 Brain-derived neurotrophic factor rescues spinal motor neurons from axotomy-induced cell death. Nature 360:753-755
41. Yan Q, Matheson C, Lopez OT 1995 In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons. Nature 373:341-344