High throughput on-bead monitoring of solid phase reactions by diffuse reflectance infrared fourier transform spectroscopy (DRIFTS)

Tetrahedron Letters

Volumn 38, Issue 16, 1997, Pages 2821-2824

  Chan, Tin Yau ^a   Chen, Ru ^a   Sofia, Michael J ^a   Smith, Brian C ^b   Glennon, Dennis ^c  

^a Transcell Technologies Inc   (United States)

^b Spectros Instruments Inc   (United States)

^c Midac Corp   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOSACCHARIDE;

ARTICLE; AUTOMATION; DRUG MONITORING; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; TECHNIQUE;

EID: 0030914640     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)00496-6     Document Type: Article

References (23)

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6. (c) Shapiro, M.J.; Kumaravel, G., Petter, R.C., Beveridge, R. Tetrahedron Lett. 1996, 37, 4671-4674.
7. (a) Fitch, W.L.; Detre, G.; Holmes, C.P.; Shoolery, J.N.; Keifer, P.A. J.Org. Chem. 1994, 59, 7955-7956.
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13. (c) Hauske, J.R.; Dorff, P. Tetrahedron Lett. 1995, 36, 1589-1592.
14. (a) Yan, B.; Kumaravel, G.; Anjaria, H.; Wu, A.; Petter, R.C.; Jewell, Jr., C.F.; Wareing, J.R. J. Org. Chem. 1995, 60, 5736-5738.
15. (b) Yan, B.; Fell, J.B.; Kumaravel, G. J. Org. Chem. 1996, 61, 7467-7472.
16. Gremlich, H.-U.; Berets, S.L. Appl. Spec. 1996, 50, 532-536.
17. Gosselin, F.; Di Renzo, M.; Ellis, T.H.; Lubell, W.D. J. Org. Chem. 1996, 61, 7980-7981.
18. Smith, B.C. Foundamentals of Fourier Transform Infrared Spectroscopy; CRC Press: Boca Raton, 1996.
19. (a) Pike Technologies, 2919 Commerce Park Drive, Madison, WI 53719.
20. (b) Spectros Insturments, Inc., 175 North Street, Shrewsbury, MA 01545
21. -1 and were smoothed with a second degree six point Savitsky-Golay algorithm on a Midac Prospect FT-IR spectrophotometer equipped with a Spectros Instruments Diffuse Reflectance Accessory. Alignment and background were obtained once at the beginning with an empty sample cup.
22. NovaBiochem HL is a polystyrene resin with amino terminals. NovaBiochem TG is a polyehtylene glycol grafted polystyrene resin with amino terminals
23. NovaBiochem TGR is a polyethylene glycol grafted polystyrene resin modified with a Rink linker.