Docking and fusion in neurosecretion

Current Opinion in Cell Biology

Volumn 10, Issue 4, 1998, Pages 483-492

  Robinson, Linda J ^a   Martin, Thomas FJ ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; N ETHYLMALEIMIDE; NEUROTRANSMITTER;

CELL FUSION; CELL MEMBRANE TRANSPORT; EXOCYTOSIS; NEUROSECRETION; PRIORITY JOURNAL; REVIEW; SYNAPSE VESICLE;

EID: 0032146628     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(98)80063-X     Document Type: Article

References (74)

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73. Schweizer FE, Dresbach T, DeBello WM, O'Conner V, Augustine GJ, Betz H. Regulation of neurotransmitter release kinetics by NSF. of special interest Science. 79:1998;1203-1206 This study analyzes the effect of peptides representing the D1 domain ??? NSF on neurotransmitter release in squid giant presynaptic terminals. Injection of certain peptides reduces the amount of neurotransmitter ??? and causes a small increase in the number of docked vesicles at active zone as well as a large decrease in the number of vesicles in the nerve terminal.
74. Littleton TJ, Chapman ER, Kreber R, Garment MB, Carlson SD, Ganetzky B. Temperature-sensitive paralytic mutations demonstrate that assembly and disassembly of the SNARE complex are essential steps in neurotransmitter release. of special interest Neuron. 1998; Temperature-sensitive paralytic mutations in Drosophila syntaxin and NS are characterized in this study. Syntaxin mutants at the nonpermissive temperature exhibit blocked synaptic transmission and fail to assemble ??? SNARE complexes. In contrast, mutations in NSF (comatose) also block synaptic transmission at the nonpermissive temperature but accumulate the t-SNARE syntaxin and 7S SNARE complexes on a light membrane ??? that contains SVs. The authors conclude that a cycle of SNARE ??? assembly and disassembly is essential for neurosecretion, and that NSF may be essential to disassemble SNARE complexes after fusion to allow additional cycles of fusion.