Amiloride-sensitive Na channels

Current Opinion in Cell Biology

Volumn 10, Issue 4, 1998, Pages 443-449

  Horisberger, Jean Daniel ^a  

^a University of Lausanne Departement de Pharmacologie et de Toxicologie   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; MINERALOCORTICOID; PROTEIN KINASE; PROTEIN SUBUNIT; PROTEINASE; SODIUM CHANNEL; SODIUM ION; UBIQUITIN;

ANIMAL CELL; CHANNEL GATING; DRUG BINDING SITE; ENDOCYTOSIS; EPITHELIUM CELL; HUMAN; HUMAN CELL; NERVE CELL; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; REVIEW; STOICHIOMETRY;

ANIMALIA; MAMMALIA;

EID: 0032145148     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(98)80056-2     Document Type: Article

References (43)

1. Lifton RP. Molecular genetics of human blood pressure variation. Science. 272:1996;676-680.
2. Hummler E, Barker P, Talbot C, Wang Q, Verdumo C, Grubb B, Gatzy J, Burnier M, Horisberger J-D, Beermann F, et al. A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism. Proc Natl Acad Sci USA. 94:1997;11710-11715.
3. Canessa CM, Horisberger J-D, Rossier BC. Functional cloning of the epithelial sodium channel: relation with genes involved in neurodegeneration. Nature. 361:1993;467-470.
4. + channel: a new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett. 318:1993;95-99.
5. Tavernarakis N, Driscoll M. Molecular modeling of mechanotransduction in the nematode Caenorhabditis elegans. Annu Rev Physiol. 59:1997;659-689.
6. Lingueglia E, Champigny G, Lazdunski M, Barbry P. Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature. 378:1995;730-733.
7. Garty H, Palmer LG. Epithelial sodium channels - function, structure, and regulation. Physiol Rev. 77:1997;359-396.
8. Gründer S, Rossier BC. A reappraisal of aldosterone effects on the kidney: new insights provided by epithelial sodium channel cloning. Curr Opin Nephrol Hypertens. 6:1997;35-39.
9. + channels - insights and outlooks. News Physiol Sci. 12:1997;55-61.
10. Waldmann R, Champigny G, Voilley N, Lauritzen I, Lazdunski M. The mammalian degenerin mDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. J Biol Chem. 271:1996;10433-10436.
11. + channel. J Biol Chem. 271:1996;7879-7882.
12. Garcia-Anoveros J, Derfler B, Nevillegolden J, Hyman BT, Corey DP. BNaC1 and BNaC2 constitute at new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci USA. 94:1997;1459-1464.
13. Lingueglia E, Deweille JR, Bassilana F, Heurteaux C, Sakai H, Waldmann R, Lazdunski M. A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem. 272:1997;29778-29783.
14. + channel, expressed in neurons and demonstration of its sensitivity to extracellular pH. See also [15].
15. + channel specific for sensory neurons. of special interest J Biol Chem. 272:1997;20975-20978 The identification of another member of the mammalian degenerin-like channels, which is responsible for a pH-dependent sodium current very similar to that observed in macroscopic current measurement in the dorsal root ganglion sensory neurons in which this current is expressed. Together with [14], the results bring a molecular understanding to pH-mediated signal transduction, which may be at the basis of the transmission of painful stimuli and offer the possibility of novel strategies in the treatment of pain.
16. Adams CM, Anderson MG, Motto DG, Price MP, Johnson WA, Welsh MJ. Ripped pocket and Pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons. of special interest J Cell Biol. 140:1998;143-152 The first identification and characterization of two members of the ENaC/degenerin family in insects.
17. Puoti A, May A, Rossier BC, Horisberger J-D. Novel isoforms of the beta and gamma subunits of the Xenopus epithelial Na channel provide information about the amiloride binding site and extracellular sodium sensing. Proc Natl Acad Sci USA. 94:1997;5949-5954.
18. + channel subunits. Am J Physiol Cell Physiol. 41:1997;C270-C277.
19. Canessa CM, Schild L, Buell G, Thorens B, Gautshi Y, Horisberger J-D, Rossier BC. The amiloride-sensitive epithelial sodium channel is made of three homologous subunits. Nature. 367:1994;463-467.
20. Palmer LG. Epithelial Na channels. Why all the subunits? J Gen Physiol. 109:1997;675-676.
21. Schild L, Schneeberger E, Gautschi I, Firsov D. Identification of amino acid residues in the α, β and γ subunits of the epithelial sodium channel (ENaC) involved in amiloride block and ion permeation. of special interest J Gen Physiol. 109:1997;15-26 The first solid evidence for the parts of the ENaC protein involved in the channel pore and amiloride binding site. The data also show very clearly that each subunit participates in these structural elements. See also [22].
22. McNicholas CM, Canessa CM. Diversity of channels generated by different combinations of epithelial sodium channel subunits. of special interest J Gen Physiol. 109:1997;681-692 This paper outlines careful physiological analysis of channels made of two subunits α and β or α and γ. The results largely confirm the conclusion of [2], and bring a first indication that the ENaC channel is made of an even number of subunits.
23. Palmer LG, Andersen OS. Interactions of amiloride and small monovalent cations with the epithelial sodium channel. Inferences about the nature of the channel pore. Biophys J. 55:1989;779-787.
24. Chang SS, Grunder S, Hanukoglu A, Rosler A, Mathew PM, Hanukoglu I, Schild L, Lu Y, Shimkets RA, Nelsonwilliams C, et al. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoadosteronism type 1. Nat Genet. 12:1996;248-253.
25. Grunder S, Firsov D, Chang SS, Jaeger NF, Gautschi I, Schild L, Lifton RP, Rossier BC. A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel. of special interest EMBO J. 16:1997;899-907 This paper describes the first identification of a domain involved in the control of the channel gating.
26. Adams CM, Snyder PM, Welsh MJ. Interactions between subunits of the human epithelial sodium channel. J Biol Chem. 272:1997;27295-27300.
27. MacKinnon R. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature. 350:1991;232-235.
28. Snyder PM, Cheng C, Prince LS, Rogers JC, Welsh MJ. Electrophysiological and biochemical evidence that deg/ENaC cation channels are composed of nine subunits. J Biol Chem. 273:1998;681-684.
29. Firsov D, Gautschi I, Merillat AM, Rossier BC, Schild L. The heterotetrameric architecture of the epithelial sodium channel (ENaC). of outstanding interest EMBO J. 17:1998;344-352 This study of the channel subunit stoichiometry is exemplary for the use of three different strategies (quantitative cell-surface expression, MacKinnon approach and concatemeric constructs) to address this difficult problem and for the careful control of the underlying hypothesis needed to interpret the results.
30. Coscoy S, Lingueglia E, Lazdunski M, Barbry P. The FMRF amide activated sodium channel is a tetramer. J Biol Chem. 273:1998;8317-8322.
31. May A, Puoti A, Gaeggeler H-P, Horisberger J-D, Rossier BC. Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel alpha subunit in A6 renal cells. of special interest J Am Soc Nephrol. 8:1997;1813-1822 This is the first demonstration of an early translational control of the epithelial sodium channel alpha subunit by a mineralocorticoid hormone.
32. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR Jr, Ulick S, Milora RV, Finding JW, et al. Liddle's syndrome: heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell. 79:1994;407-414.
33. Firsov D, Schild L, Gautschi I, Merillat AM, Schneeberger E, Rossier BC. Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome - a quantitative approach. Proc Natl Acad Sci USAs. 93:1996;15370-15375.
34. + channel deleted in Liddles syndrome. EMBO J. 15:1996;2371-2380.
35. + channel (ENaC). Am J Physiol Cell Physiol. 41:1997;C1871-C1880.
36. Staub O, Gautschi I, Ishikawa T, Breitschopf K, Ciechanover A, Schild L, Rotin D. Regulation of stability and function of the epithelial Na channel (ENaC) by ubiquitination. of special interest EMBO J. 16:1997;6325-6336 Together with [34,35], this work provides solid evidence for the role of unbiquitination by Nedd4 in the control of the ENaC protein biological halflife and shows the involvement of two intracellular domains, one in the carboxyl terminus for Nedd4 binding and one in the amino terminus for the ubiquitination site.
37. Shimkets RA, Lifton RP, Canessa CM. The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis. of special interest J Biol Chem. 272:1997;25537-25541 The first evidence for the involvement of clathrin-mediated endocytosis in the control of channel physiological half-life and surface density.
38. Vallet V, Gaeggeler H-P, Chraibi A, Horisberger J-D, Rossier BC. An epithelial serine protease activates the amiloride-sensitive sodium channel. of special interest Nature. 389:1997;607-610 Together with [40], this paper constitutes the first description of the direct activation of an ion channel by an extracellular protease and the molecular identification of this protease in kidney cells. This new process could apply to other members of the gene family.
39. Jovov B, Wills NK, Donaldson PJ, Lewis SA. Vectorial secretion of a kallikrein-like enzyme by cultured renal cells. I. General properties. Am J Physiol. 259:1990;C869-C882.
40. Chraibi A, Vallet V, Firsov D, Kharoubi-Hess S, Horisberger J-D. Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocyte. J Gen Physiol. 111:1998;1-12.
41. Shimkets RA, Lifton RP, Canessa CM. Phosphorylation of the epithelial sodium channel: effects of kinases and hormones. Proc Natl Acad Sci USA. 95:1997;3301-3305.
42. + reabsorption in A6 cells. Am J Physiol. 43:1998;F300-F314.
43. + in rat cortical collecting tubule. J Physiol (Lond). 509:1998;151-162.