A reappraisal of aldosterone effects on the kidney: New insights provided by epithelial sodium channel cloning

Current Opinion in Nephrology and Hypertension

Volumn 6, Issue 1, 1997, Pages 35-39

  Gründer, Stefan ^a   Rossier, Bernard C ^a,b  

^a Inst Pharmacologie Toxicologie l'U   (Switzerland)

^b University of Lausanne Departement de Pharmacologie et de Toxicologie   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; SODIUM CHANNEL;

HOMEOSTASIS AND REGULATION; HUMAN; KIDNEY TUBULE; PRIORITY JOURNAL; REVIEW; SODIUM METABOLISM;

ALDOSTERONE; ANIMALS; CLONING, MOLECULAR; EPITHELIAL CELLS; EPITHELIUM; HUMANS; KIDNEY; SODIUM CHANNELS;

EID: 0031046352     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199701000-00007     Document Type: Review

References (50)

1. Rossier BC, Palmer LG: Mechanisms of aldosterone action on sodium and potassium transport. In The Kidney, Physiology and Pathophysiology. Edited by Seldin DW, Giebiesch G. New York: Raven Press; 1992:1373-1409.
2. Palmer LG: Epithelial Na channels: function and diversity. Annu Rev Physiol 1992, 54:51-66.
3. Palmer LG, Frindt G: Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule. Proc Natl Acad Sci USA 1986, 83:2767-2770.
4. Canessa CM, Horisberger JD, Rossier BC: Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 1993, 361:467-470.
5. + channel. FEBS Lett 1993, 318:95-99.
6. + channel is made of three homologous subunits. Nature 1994, 367:463-467.
7. Duc C, Farman N, Canessa CM, Bonvalet J-P, Rossier BC: Cell-specific expression of epithelial sodium channel α, β and γ subunits in aldosterone-responsive epithelia from the rat: localization by insitu hybridization and immunocytochemistry. J Cell Biol 1994, 127:1907-1921.
8. + channel in the apical membrane of the rat inner medullary collecting duct. J Clin Invest 1995, 96:2748-2757.
9. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR Jr, Ulick S, Milora RV, Findling JW et al: Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell 1994, 79:407-414.
10. Hansson JH, Nelsonwilliams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B, Lifton RP: Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndrome. Nat Genet 1995, 11:76-82.
11. Schild L, Canessa CM, Shimkets RA, Gautschi I, Lifton RP, Rossier BC: A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc Natl Acad Sci USA 1995, 92:5699-5703.
12. •] also.
13. Hansson JH, Schild L, Lu Y, Wilson TA, Gautschi I, Shimkets R, Nelson-Williams C, Rossier BC, Lifton RP: A de-novo missense mutation of the b subunit of the epithelial sodium channel causes hypertension and Liddle sydrome, identifying a proline-rich segment critical for regulation of channel activity. Proc Natl Acad Sci USA 1995, 92:11495-11499.
14. Tamura H, Schild L, Enomoto N, Matsui N, Marumo F, Rossier BC, Sasaki S: Liddle disease caused by a missense mutation of β subunit of the epithelial sodium channel gene. J Clin Invest 1996, 97:1780-1784.
15. •].
16. Snyder PM, Price MP, McDonald FJ, Adams CM, Volk KA, Zeiher BG, Stokes JB, Welsh MJ: Mechanism by which Liddle's syndrome mutations increase activity of a human epithelial sodium channel. Cell 1995, 83:969-978. The authors provide evidence that the Liddle's mutations increase the expression of ENaC at the cell surface.
17. Chang SS, Grunder S, Hanukoglu A, Rössler A, Mathew PM, Hanukoglu I, Schild L, Lu Y, Shimkets RA, Nelson-Williams C et al.: Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nat Gene 1996, 12:248-253. The first demonstration that EnaC is involved in pseudohypoaldosteronism, a salt-loosing syndrome. In this study PHA-1, a severe autosomal recessive form of the disease is caused by mutations in the α and β subunit of ENaC.
18. Strautnieks SS, Thompson RJ, Gardiner RM, Chung E: A novel splice-site mutation in the γ subunit of the epihelial sodium channel gene in three pseudohypoaldosteronism type 1 families. Nature Genet 1996, 13:248-250. First evidence that PHA-1 is caused by a mutation in the γ subunit of ENaC.
19. Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R, Rossier BC: Early death due to defective neonatal lung liquid clearance in αENaC-deficient mice. Nature Genet 1996, 12:325-328. The first demonstration in a knock-out mouse model that αENaC subunit is rate-limiting in lung fluid clearance at birth. The lung phenotype is so severe that all animals die within 40 h. The mouse phenotype differs from the predominant renal phenotype observed in human neonates suffering from PHA-1. The difference remains to be understood.
20. Hummler E, Barker P, Beermann F, Verdumo C, Gatzy J, Boucher R, Rossier BC: Genetic rescue of αENaC knockout mouse: establishment of an animal model for pseudohypoaldosteronism (PHA 1) [Abstract A0173]. J Am Soc Nephrol 1996, 7:1281.
21. Garty H: Mechanisms of aldosterone action in tight epithelia. J Membrane Biol 1986, 90:193-205.
22. + channels in the cortical collecting duct by AVP and mineralocorticoids. Kidney Int 1992, 41:255-268.
23. Verrey F: Transcriptional control of sodium transport in tight epithelia by adrenal steroids. J Membrane Biol 1995, 144:93-110.
24. + channel in colon, lung and kidney. Eur J Physiol 1995, 430:299-307. A detailed analysis of expression of α, β, γ subunits in lung and kidney showing differential regulation by mineralo- and glucocorticoid hormones.
25. + channels subunits. Am J Physiol 1996 (in press).
26. Wang Z-M, Yasui M, Celsi G: Differential effects of glucocorticoids and mineralocorticoids on the mRNA expression of colon ion transporters in infant rats. Pediatr Res 1995, 38:164-168.
27. Denault DL, Fejes-Toth G, Naray-Fejes-Toth A: Aldosterone regulation of sodium channel γ-subunit mRNA in cortical collecting duct cells. Am J Physiol 1996, 271 :C423-C428.
28. May A, Puoti A, Gaeggeler H-P, Rossier BC: Effect of aldosterone on mRNA abundance and rate of protein synthesis of the epithelial sodium channel in A6 kidney cell line [Abstract A0190]. J Am Soc Nephrol 1996, 7:1281
29. Pacha J, Frindt G, Antonian L, Silver RB, Palmer LG: Regulation of Na channels of the rat cortical collecting tubule by aldosterone. J Gen Physiol 1993, 102:25-42.
30. Kemendy AE, Kleyman TR, Eaton DC: Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia. Am J Physiol 1992, 263:C825-C837.
31. Garty H, Edelman IS: Amiloride-sensitive trypsinization of apical sodium channels. Analysis of hormonal regulation of sodium transport in toad baldder. J Gen Physiol 1983, 81:785-803.
32. + channels in the amphibian cell line A6 is not altered by mineralocorticoids. Analysis using a new photoactive amiloride analog in combination with anti-amiloride antibodies. J Biol Chem 1989, 264:11995-12000.
33. Benos DJ, Saccomani G, Sariban-Sohraby S: The epithelial sodium channel. Subunit number and location of the amiloride binding site. J Biol Chem 1987, 262:10613-10618.
34. 1-3 protein. J Biol Chem 1992, 267:4759-4765.
35. Sariban-Sohraby S, Fisher RS, Abramow M: Aldosterone-induced and GTP-stimulated methylation of a 90-kDa polypeptide in the apical membrane of A6 epithelia. J Biol Chem 1993, 268:26613-26617.
36. + channel from the epithelial cell line A6. J Biol Chem 1989, 264:20867-20870.
37. Becchetti A, Sariban-Sohrabi S, Eaton DC: Annual Meeting of Experimental Biology 1996. FASEB J 1996.
38. Rokaw MD, Benos DJ, Palevsky PM, Cunningham SA, West ME, Johnson JP: Regulation of a sodium channel-associated G-protein by aldosterone. J Biol Chem 1996, 271:4491-4496.
39. Sariban-Sohraby S, Mies F, Abramow M, Fisher RS: Aldosterone stimulation of GTP hydrolysis in membranes from renal epithelia. Am J Physiol 1995, 268:C557-C562.
40. Fuller PJ, Brennan FE, Burgess JS, Vrity K: Characterization of putative aldosterone-induced protein genes in the rat colon. The Endocrine Society: Program and Abstracts of the 10th International Congress of Endocrinology, June 12-15 San Franciso; 1996:880.
41. Ohara A, Matsunaga H, Eaton DC: G-protein activation inhibits amiloride-blockable highly selective sodium channels in A6 cells. Am J Physiol 1993, 264:C352-C360.
42. o guanine nucleotide-binding protein at variance with what has been proposed by various authors studying a biochemically purified sodium channel (see, for example, [25]).
43. Palmer LG, Frindt G: Amiloride-sensitive Na channels in the rat cortical cortical collecting tubule are activated by GDPβS [Abstract]. FASEB J 1996, 10:A77.
44. •].
45. + channel. J Gen Physiol 1996, 108:49-65.
46. Stutts MJ, Canessa CM, Olsen JC, Hamrick M, Cohn AJ, Rossier BC, Boucher RC: CFTR as a cAMP-dependent regulator of sodium channels. Science 1995, 269:847-850. A demonstration that cystic fibrosis transmembrance regulator is probably closely associated with ENaC and might play a regulatory role (downregulation of ENaC in normal circumstances and upregulation of ENaC in cystic fibrosis). This regulatory role fits well with the name proposed for the cystic fibrosis gene when it was first cloned. The relevance of the findings remains to be established in epithelial cells that are relevant to the pathophysiology of the disease (i.e. airways, colon, pancreas).
47. Berdiev BK, Prat AG, Cantiello HF, Ausiello DA, Fuller CM, Jovov B, Benos DJ, Ismailov I: Regulation of epithelial sodium channels by short actin filaments. J Biol Chem 1996, 271:17704-17710.
48. + channel (αrENaC) mediates its localization at the apical membrane. EMBO J 1994, 13:4440-4450.
49. + channels in A6 renal epithelial cells. J Membr Biol 1995, 147:195-205.
50. + channels in rat CCT IV. Mediation by activation of protein kinase C. Am J Physiol 1996, 270:F371-F376.