A transforming growth factor β type II receptor gene mutation common in sporadic cecum cancer with microsatellite instability

Cancer Research

Volumn 56, Issue 24, 1996, Pages 5620-5623

  Togo, Goichi ^a   Toda, Nobuo ^a   Kanai, Fumihiko ^a   Kato, Naoya ^a   Shiratori, Yasushi ^a   Kishi, Kiyozo ^b   Imazeki, Fumio ^c   Makuuchi, Masatoshi ^a   Omata, Masao ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b SAITAMA CANCER CENTER   (Japan)

^c CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSATELLITE DNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; CECUM CANCER; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; DNA REPAIR; DNA REPLICATION; GENE MUTATION; HEPATOBILIARY SYSTEM CANCER; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; RECEPTOR GENE;

AGED; CECAL NEOPLASMS; COLORECTAL NEOPLASMS; DNA REPLICATION; FEMALE; HUMANS; MALE; MIDDLE AGED; MUTATION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; STOMACH NEOPLASMS;

EID: 0029773770     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Lynch, H. T , Smyrk, T. C., Watson, P , Lanspa, S. J., Lynch, J. F., Lynch, P. M., Cavalieri, R. J., and Boland, C. R Genetics, Natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: an updated review. Gastroenterology, 104: 1535-1549, 1993
2. Leach, F S., Nicolaides, N C., Papadopoulos, N., Liu, B., Jen, J , Parsons, R , Peltomaki, P., Sistonen, P., Aaltonen, L A., Nystrom-Lahti, M N , Guan, X. Y., Zhang, J., Meltzer, P. S., Yu, J. W., Kao, F T., Chen, D J , Cerosaletti, K. M., Fournier, R. E. K., Todd, S., Lewis, T., Leach, R. J , Naylor, S. L , Weissenbach, J., Mecklin, J. P., Jarvinen, H., Petersen, G. M , Hamilton, S. R., Green, J., Jass, J., Watson, P., Lynch, H T., Trent, J. M., Chapelle, A , Kinzler, K. W., and Vogelstein, B. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell, 75: 1215-1225, 1993.
3. Weissenbach, J., Gyapay, G , Dib, C , Virginal, A., Morissette, J , Millaseau, P., Vaysseix, G., and Lathrop, M. A second-generation linkage map of the human genome Nature (Lond.), 359: 794-801, 1992.
4. Aaltonen, L A., Peltomaki, P., Leach, F. S., Sistonen, P., Pylkkanen, L., Mecklin, J. P., Jarvinen, H., Powell, S M., Jen, J., Hamilton, S. R., Petersen, G. M. Kinzler, K. W., Vogelstein, B., and Chapelle, A Clues to the pathogenesis of familial colorectal cancer. Science (Washington DC), 260 812-816, 1993.
5. Strand, M., Prolla, T. A , Liskay, R M., and Petes, T. D. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature (Lond.), 365: 274-276, 1993.
6. Fishel, R , Lescoe, M. K., Rao, M. R., Copeland, N. G., Jenkins, N. A., Garber, J., Kane, M., and Kolodner, R. The human mutator gene homologue MSH2 and its association with hereditary nonpolyposis colon cancer. Cell, 75: 1027-1038, 1993.
7. Bronner, C E , Baker, S M , Morrison, P. T , Warren, G., Smith, L. G., Lescoe, M K , Kane, M., Earabino, C , Lipford, J., Lindblom, A., Tannergard, P., Bollag, R. J., Godwin, A. R , Ward, D C., Nordenskjold, M , Fishel, R , Kolodner, R., and Liskay, R. M. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature (Lond), 368: 258-261, 1994
8. Nicolaides, N. C., Papadopoulos, N., Liu, B., Wei, Y. F., Carter, K C , Ruben, S. M., Rosen, C. A , Haseltein, W. A., Fleischmann, R. D., Fraser, C. M., Adams, M. D., Venter, J C., Dunlop, M. G., Hamilton, S. R , Pertersen, G. M., Chapelle, A., Vogelstein, B , and Kinzler, K. W. Mutation of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (Lond), 371 75-80, 1994
9. Papadopoulos, N., Nicolaides, N C., Liu, B , Parsons, R., Lengauer, C , Palombo, F., D'Arrigo, A., Markowitz, S , Willson, J. K. V , Kinzler, K. W , Jiricny, J., and Vogelstein, B. Mutations of GTBP in genetically unstable cells. Science (Washington DC), 268: 1915-1917, 1995.
10. Markowitz, S , Wang, J., Myeroff, L., Parsons, R , Sun, L., Lutterbaugh, J , Fan, R S , Zborowska, E , Kinzler, K. W , Vogelstein, B., Brattam, M., and Willson, J. K V Inactivation of the type II TGF-β receptor in colon cancer cells with microsatellite instability. Science (Washington DC), 268: 1336-1338, 1995.
11. Lu, S. L., Akiyama, Y , Nagasaki, H , Saiyo, K., and Yuasa, Y. Mutations of the transforming growth factor-β type II receptor gene and genomic instability in hereditary nonpolyposis coloreetal cancer. Biochem. Biophys. Res Commun., 216: 452-457, 1995.
12. Parsons, R , Myerhoff, L L., Liu, B., Willson, J. K V., Markowitz, S D., Kinzler, K. W., and Vogelstein, B. Microsasellite instability and mutations of the transforming growth factor β receptor type II gene in colorectal cancer. Cancer Res , 55: 5548-5550, 1995
13. Lin, H Y., Wang, X F , Ng-Eaton, E., Weinberg, R A , and Lodish, H. F. Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase Cell, 68: 775-785, 1992.
14. Ionov, Y , Peinado, M. A , Malkhosyan, S., Shibata, D., and Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature (Lond), 363: 558-561, 1993.
15. Thibodeau, S N., Bren, G., and Schaid, D. Microsatellite instability in cancer of the proximal colon Science (Washington DC), 260: 816-819, 1993.
16. Kim, H., Jen, J , Vogelstein, B., and Hamilton, S R. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am. J. Pathol., 145, 148-154, 1994.
17. Tada, M., Omata, M., and Ohto, M Analysis of ras gene mutations in human hepatic malignant tumors by polymerase chain reaction and direct sequencing Cancer Res., 50: 1121-1124, 1990.
18. Liu, B , Farrington, S. M. Petersen, G. M., Hamilton, S. R., Parsons, R., Papadopoulos, N., Fujiwara, T., Jen, J., Kinzler, K. W., Willie, A. H., Vogelstein, B., and Dunlop, M. G. Genetic instability occurs in the majority of young patients with colorectal cancers. Nat. Med., 1: 348-352, 1995
19. Mashiyama, S., Sekiya, T., and Hayashi, K. Screening of multiple DNA samples for detection of sequence changes. Technique, 2: 304-306, 1990
20. Massague, J. The transforming growth factor-β family. Annu Rev Cell Biol., 6: 597-641, 1990.
21. Filmus, J., and Kerbel, R K. Development of resistance mechanisms to the growth-inhibitory effects of transforming growth factor-β during tumor progression. Curr. Opin. Oncol , 5: 123-129, 1993.
22. Geiser, A. G., Burmester, J K., Webbink, R., Roberts, A B., and Sporn, M B. Inhibition of growth by transforming growth factor-β following fusion of two nonresponsive human carcinoma cell lines. J Biol Chem., 267: 2588-2593, 1992.
23. Park, K , Kim, A J , Bang, Y. J , Park, J G., Kim, N. K., Roberts, A. B , and Sporn, M. B Genetic changes in the transforming growth factor-β (TGF-β) type II receptor gene in human gastric cancer cells Correlation with sensitivity to growth inhibition by TGF-β. Proc. Natl Acad. Sci USA, 91: 8772-8776, 1994
24. Sun, L , Wu, G , Willson, J. K , Zborowska, E , Yang, J., Rajkarunanayake, I , Wang, J., Gentry, L. E., Wang, X. F , and Brattain, M. G. Expression of transforming growth factor β type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells J. Biol Chem , 269: 26449-26455, 1994
25. Nakashima, H , Inoue, H., Mon, M., Ueo, H., Ikeda, M., and Akiyoshi, T. Microsatellite instability in Japanese gastric cancer Cancer (Phila.), 75 (Suppl.): 1503-1507, 1995.
26. Han, H J , Yanagisawa, A., Kato, Y , Park, J. G., and Nakamura, Y. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Res , 53: 5087-5089, 1993
27. Saito, K., Yeaton, P., Sato, J., Macdonald, G. A , Cherian, S P., and Boland, C. R Genetic mechanisms of tumorigenesis in cholangiocarcinoma and gallbladder carcinoma. Hepatology, 22: 110A, 1995.
28. Myerhoff, L L., Parsons, R., Kim, S. J , Hedrick, L , Cho, K. R., Orth, K., Mathis, M., Kinzler, K. W , Lutterbaugh, J , Park, K , Bang, Y. J., Lee, H. Y , Park, J. G., Lynch, H. T , Roberts, A. B., Vogelstein, B , and Markowitz, S D. A transforming growth factor β receptor type II gene mutation common in colon and gastric but rare in endometrial cancers with microsatellite instability. Cancer Res., 55: 5545-5547, 1995.
29. Mecklin, J. P , and Jarvinen, H J Clinical features of colorectal carcinoma in cancer family syndrome. Dis. Colon Rectum, 29: 160-164, 1986.
30. Lynch, P M., Lynch, H., and Harris, R. E. Hereditary proximal colonic cancer. Dis. Colon Rectum, 20: 661-669, 1977.
31. Borresen, A-L , Lothe, R A , Meling, G. I , Lystad, S., Morrison, P., Lipford, J., Kane, M. F., Rognum, T. O , and Kolodner, R D Somatic mutations in the hMSH2 gene in microsatellite unstable colorectal carcinomas Hum. Mol. Genet , 4: 2065-2072, 1995
32. Liu, B., Nicolaides, N. C , Markowitz, S., Wilson, J. K. V., Parsons, R. E., Jen, J., Papadopoulos, N , Peltomaki, P., Chapelle, A , Hamilton, S R., Kinzler, K. W , and Vogelstein, B. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability Nat. Genet., 9: 48-55, 1995