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Volumn 274, Issue 2 37-2, 1998, Pages

Insulin acutely suppresses glucose production by both peripheral and hepatic effects in normal dogs

Author keywords

Free fatty acids; Glucagon; Gluconeogenic precursors; Glucose turnover; Portal peripheral insulin gradient

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN;

EID: 0031937665     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1998.274.2.e346     Document Type: Article
Times cited : (23)

References (30)
  • 1
    • 0025297310 scopus 로고
    • Peripheral effects of insulin dominate suppression of fasting hepatic glucose production
    • Endocrinol. Metab. 21
    • Ader, M., and R. N. Bergman. Peripheral effects of insulin dominate suppression of fasting hepatic glucose production. Am. J. Physiol. 258 (Endocrinol. Metab. 21): E1020-E1032, 1990.
    • (1990) Am. J. Physiol. , vol.258
    • Ader, M.1    Bergman, R.N.2
  • 2
    • 0017902265 scopus 로고
    • The reliability of rates of glucose appearance in vivo calculated from constant tracer infusion
    • Allsop, J. R., R. R. Wolfe, and J. F. Burke. The reliability of rates of glucose appearance in vivo calculated from constant tracer infusion. Biochem. J. 172: 407-416, 1978.
    • (1978) Biochem. J. , vol.172 , pp. 407-416
    • Allsop, J.R.1    Wolfe, R.R.2    Burke, J.F.3
  • 3
    • 2642593735 scopus 로고
    • Extrapancreatic effects of somatostatin infusion to increase glucose clearance
    • Endocrinol. Metab. 10
    • Bergman, R. N., M. Ader, D. T. Finegood, and G. Pacini. Extrapancreatic effects of somatostatin infusion to increase glucose clearance. Am. J. Physiol. 247 (Endocrinol. Metab. 10): E370-E379, 1984.
    • (1984) Am. J. Physiol. , vol.247
    • Bergman, R.N.1    Ader, M.2    Finegood, D.T.3    Pacini, G.4
  • 4
    • 0027223164 scopus 로고
    • Quantitation of measurement error with Optimal Segments: Basis for adaptive time course smoothing
    • Endocrinol. Metab. 27
    • Bradley, D. C., G. M. Steil, and R. N. Bergman. Quantitation of measurement error with Optimal Segments: basis for adaptive time course smoothing. Am. J. Physiol. 264 (Endocrinol. Metab. 27): E902-E911, 1993.
    • (1993) Am. J. Physiol. , vol.264
    • Bradley, D.C.1    Steil, G.M.2    Bergman, R.N.3
  • 5
    • 0028276676 scopus 로고
    • Insulin regulation of renal glucose metabolism in conscious dogs
    • Cersosimo, E., R. L. Judd, and J. M. Miles. Insulin regulation of renal glucose metabolism in conscious dogs. J. Clin. Invest. 93: 2584-2589, 1994.
    • (1994) J. Clin. Invest. , vol.93 , pp. 2584-2589
    • Cersosimo, E.1    Judd, R.L.2    Miles, J.M.3
  • 6
    • 0017172025 scopus 로고
    • The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog
    • Cherrington, A. D., J. L. Chiasson, J. E. Liljenquist, A. S. Jennings, U. Keller, and W. W. Lacy. The role of insulin and glucagon in the regulation of basal glucose production in the postabsorptive dog. J. Clin. Invest. 58: 1407-1418, 1976.
    • (1976) J. Clin. Invest. , vol.58 , pp. 1407-1418
    • Cherrington, A.D.1    Chiasson, J.L.2    Liljenquist, J.E.3    Jennings, A.S.4    Keller, U.5    Lacy, W.W.6
  • 8
    • 0024265025 scopus 로고
    • Modelling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps
    • Finegood, D. T., R. N. Bergman, and M. Vranic. Modelling error and apparent isotope discrimination confound estimation of endogenous glucose production during euglycemic glucose clamps. Diabetes 37: 1025-1034, 1988.
    • (1988) Diabetes , vol.37 , pp. 1025-1034
    • Finegood, D.T.1    Bergman, R.N.2    Vranic, M.3
  • 9
    • 0029981609 scopus 로고    scopus 로고
    • A moderate decline in specific activity does not lead to an underestimation of hepatic glucose production during a glucose clamp
    • Fisher, S. J., Z. Q. Shi, H. L. A. Lickley, S. Efendic, M. Vranic, and A. Giacca. A moderate decline in specific activity does not lead to an underestimation of hepatic glucose production during a glucose clamp. Metabolism 45: 587-593, 1996.
    • (1996) Metabolism , vol.45 , pp. 587-593
    • Fisher, S.J.1    Shi, Z.Q.2    Lickley, H.L.A.3    Efendic, S.4    Vranic, M.5    Giacca, A.6
  • 10
    • 0026644792 scopus 로고
    • Metabolic effects of suppression of nonesterified fatty acid levels with Acipimox in obese NIDDM subjects
    • Fulcher, G. R., M. Walker, C. Catalano, L. Agius, and K. G. M. M. Alberti. Metabolic effects of suppression of nonesterified fatty acid levels with Acipimox in obese NIDDM subjects. Diabetes 41: 1400-1408, 1992.
    • (1992) Diabetes , vol.41 , pp. 1400-1408
    • Fulcher, G.R.1    Walker, M.2    Catalano, C.3    Agius, L.4    Alberti, K.G.M.M.5
  • 11
    • 0031046709 scopus 로고    scopus 로고
    • Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs. Role of glucagon
    • Giacca, A., S. J. Fisher, R. H. McCall, Z. Q. Shi, and M. Vranic. Direct and indirect effects of insulin in suppressing glucose production in depancreatized dogs. Role of glucagon. Endocrinology 138: 999-1007, 1997.
    • (1997) Endocrinology , vol.138 , pp. 999-1007
    • Giacca, A.1    Fisher, S.J.2    McCall, R.H.3    Shi, Z.Q.4    Vranic, M.5
  • 12
    • 0026443620 scopus 로고
    • Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs
    • Giacca, A., S. J. Fisher, Z. Q. Shi, R. Gupta, L. Lickley, and M. Vranic. Importance of peripheral insulin levels for insulin-induced suppression of glucose production in depancreatized dogs. J. Clin. Invest. 90: 1769-1777, 1992.
    • (1992) J. Clin. Invest. , vol.90 , pp. 1769-1777
    • Giacca, A.1    Fisher, S.J.2    Shi, Z.Q.3    Gupta, R.4    Lickley, L.5    Vranic, M.6
  • 13
    • 0023518532 scopus 로고
    • Effects of somatatostatin on nonesterified fatty acid levels modifies glucose homeostasis during fasting
    • Endocrinol. Metab. 16
    • Hendrick, G. K., R. T. Frizzell, and A. D. Cherrington. Effects of somatatostatin on nonesterified fatty acid levels modifies glucose homeostasis during fasting. Am. J. Physiol 253 (Endocrinol. Metab. 16): E443-E452, 1987.
    • (1987) Am. J. Physiol , vol.253
    • Hendrick, G.K.1    Frizzell, R.T.2    Cherrington, A.D.3
  • 14
    • 0029620621 scopus 로고
    • Labeled glucose infusate technique in clamp studies. Is precise matching of glucose specific activity important?
    • Hother-Nielsen, O., J. E. Henriksen, P. Staehr, and H. Beck-Nielsen. Labeled glucose infusate technique in clamp studies. Is precise matching of glucose specific activity important? Endocrinol. Metab. Clin. North Am. 2: 275-287, 1995.
    • (1995) Endocrinol. Metab. Clin. North Am. , vol.2 , pp. 275-287
    • Hother-Nielsen, O.1    Henriksen, J.E.2    Staehr, P.3    Beck-Nielsen, H.4
  • 16
    • 0030975131 scopus 로고    scopus 로고
    • Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans
    • Lewis, G. F., M. Vranic, P. Harley, and A. Giacca. Fatty acids mediate the acute extrahepatic effects of insulin on hepatic glucose production in humans. Diabetes 46: 1111-1119, 1997.
    • (1997) Diabetes , vol.46 , pp. 1111-1119
    • Lewis, G.F.1    Vranic, M.2    Harley, P.3    Giacca, A.4
  • 17
    • 0029936779 scopus 로고    scopus 로고
    • Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans
    • Lewis, G. F., B. Zinman, Y. Groenewoud, M. Vranic, and A. Giacca. Hepatic glucose production is regulated both by direct hepatic and extrahepatic effects of insulin in humans. Diabetes 45: 454-462, 1996.
    • (1996) Diabetes , vol.45 , pp. 454-462
    • Lewis, G.F.1    Zinman, B.2    Groenewoud, Y.3    Vranic, M.4    Giacca, A.5
  • 18
    • 0020666381 scopus 로고
    • A microfluorometric method for the determination of free fatty acids in plasma
    • Miles, J., R. Glasscock, J. Aikens, J. Gerich, and M. Raymond. A microfluorometric method for the determination of free fatty acids in plasma. J. Lipid Res. 24: 96-99, 1983.
    • (1983) J. Lipid Res. , vol.24 , pp. 96-99
    • Miles, J.1    Glasscock, R.2    Aikens, J.3    Gerich, J.4    Raymond, M.5
  • 19
    • 8044254591 scopus 로고    scopus 로고
    • Portal effect of insulin to lower HGO requires hyperglucagonemia
    • Mittelman, S., G. Steil, and K. Rebrin. Portal effect of insulin to lower HGO requires hyperglucagonemia (Abstract). Diabetes Suppl. 2: 166A, 1996.
    • (1996) Diabetes Suppl. , vol.2
    • Mittelman, S.1    Steil, G.2    Rebrin, K.3
  • 20
    • 0025761375 scopus 로고
    • Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration
    • Myers, S. R., O. P. McGuinness, D. W. Neal, and A. D. Cherrington. Intraportal glucose delivery alters the relationship between net hepatic glucose uptake and the insulin concentration. J. Clin. Invest. 87: 930-939, 1991.
    • (1991) J. Clin. Invest. , vol.87 , pp. 930-939
    • Myers, S.R.1    McGuinness, O.P.2    Neal, D.W.3    Cherrington, A.D.4
  • 22
    • 0023546855 scopus 로고
    • Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects
    • Prager, R., P. Wallace, and J. M. Olefsky. Direct and indirect effects of insulin to inhibit hepatic glucose output in obese subjects. Diabetes 36: 607-611, 1987.
    • (1987) Diabetes , vol.36 , pp. 607-611
    • Prager, R.1    Wallace, P.2    Olefsky, J.M.3
  • 23
    • 0028825129 scopus 로고
    • Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin
    • Rebrin, K., G. M. Steil, L. Getty, and R. N. Bergman. Free fatty acid as a link in the regulation of hepatic glucose output by peripheral insulin. Diabetes 44: 1038-1045, 1995.
    • (1995) Diabetes , vol.44 , pp. 1038-1045
    • Rebrin, K.1    Steil, G.M.2    Getty, L.3    Bergman, R.N.4
  • 24
    • 0029861999 scopus 로고    scopus 로고
    • Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs
    • Rebrin, K., G. M. Steil, S. D. Mittelman, and R. N. Bergman. Causal linkage between insulin suppression of lipolysis and suppression of liver glucose output in dogs. J. Clin. Invest. 98: 741-749, 1996.
    • (1996) J. Clin. Invest. , vol.98 , pp. 741-749
    • Rebrin, K.1    Steil, G.M.2    Mittelman, S.D.3    Bergman, R.N.4
  • 25
    • 0025764186 scopus 로고
    • Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dependent) diabetes mellitus
    • Saloranta, C., A. Franssila-Kallunki, A. Ekstrand, M. R. Taskinen, and L. Groop. Modulation of hepatic glucose production by non-esterified fatty acids in type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34: 409-415, 1991.
    • (1991) Diabetologia , vol.34 , pp. 409-415
    • Saloranta, C.1    Franssila-Kallunki, A.2    Ekstrand, A.3    Taskinen, M.R.4    Groop, L.5
  • 27
    • 0029969117 scopus 로고    scopus 로고
    • A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog
    • Sindelar, D. K., J. H. Balcom, C. A. Chu, D. W. Neal, and A. D. Cherrington. A comparison of the effects of selective increases in peripheral or portal insulin on hepatic glucose production in the conscious dog. Diabetes 45: 1594-1604, 1996.
    • (1996) Diabetes , vol.45 , pp. 1594-1604
    • Sindelar, D.K.1    Balcom, J.H.2    Chu, C.A.3    Neal, D.W.4    Cherrington, A.D.5
  • 28
    • 0030969441 scopus 로고    scopus 로고
    • The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog
    • Sindelar, D. K., C. A. Chu, M. Rohlie, D. W. Neal, L. L. Swift, and A. D. Cherrington. The role of fatty acids in mediating the effects of peripheral insulin on hepatic glucose production in the conscious dog. Diabetes 46: 187-196, 1997.
    • (1997) Diabetes , vol.46 , pp. 187-196
    • Sindelar, D.K.1    Chu, C.A.2    Rohlie, M.3    Neal, D.W.4    Swift, L.L.5    Cherrington, A.D.6
  • 29
    • 26744452637 scopus 로고    scopus 로고
    • The interaction between increments in peripheral and portal vein insulin in regulating hepatic glucose production
    • Sindelar, D. K., C. An Chu, A. Venkatakrishnan, P. Venson, and A. D. Cherrington. The interaction between increments in peripheral and portal vein insulin in regulating hepatic glucose production (Abstract). Diabetes 45, Suppl. 2: 167A, 1996.
    • (1996) Diabetes , vol.45 , Issue.2 SUPPL.
    • Sindelar, D.K.1    An Chu, C.2    Venkatakrishnan, A.3    Venson, P.4    Cherrington, A.D.5


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