Generation of reactive oxygen species accounts for cytotoxicity of an endogenous dopaminergic neurotoxin, (R)-N-methylsalsolinol, to differentiated dopaminergic SH-SY5Y cells

Journal of Neural Transmission

Volumn 105, Issue 4-5, 1998, Pages 397-405

  Minami, C ^a   Deng, Y ^a   Maruyama, W ^b   Takahashi, T ^c   Kawai, M ^a   Nakahara, D ^d   Naoi, M ^a,e  

^a NAGOYA INSTITUTE OF TECHNOLOGY   (Japan)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^c KONAN WOMEN'S UNIVERSITY   (Japan)

^d HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e Institute of Applied Biochemistry   (Japan)

Author keywords

Catechol isoquinolines; Cytotoxicity; Endogenous neurotoxin; Hydroxyl radical; Oxidative phosphorylation; SH SY5Y cells

Indexed keywords

ANTIOXIDANT; CATALASE; DOPAMINE RECEPTOR STIMULATING AGENT; GALLIC ACID PROPYL ESTER; GLUTATHIONE; ISOQUINOLINE DERIVATIVE; NEUROTOXIN; REACTIVE OXYGEN METABOLITE; SALSOLINOL; SELEGILINE; TROMETAMOL;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROTOXICITY; OXIDATION REDUCTION REACTION; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL;

CELL DIFFERENTIATION; CELL SURVIVAL; DOPAMINE; HUMANS; HYDROXYL RADICAL; ISOQUINOLINES; NEUROBLASTOMA; NEUROTOXINS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; SALSOLINE ALKALOIDS; TETRAHYDROISOQUINOLINES; TUMOR CELLS, CULTURED;

EID: 0031928443     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s007020050065     Document Type: Article

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