Mob1, an essential yeast gene required for completion of mitosis and maintenance of ploidy

Molecular Biology of the Cell

Volumn 9, Issue 1, 1998, Pages 29-46

  Luca, Francis C ^a   Winey, Mark ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FUNGAL PROTEIN; PHOSPHOPROTEIN; PROTEIN KINASE;

ARTICLE; CONTROLLED STUDY; DIPLOIDY; ENZYME SUBSTRATE; FUNGAL GENETICS; HAPLOIDY; MITOSIS; MITOSIS SPINDLE; NONHUMAN; PLOIDY; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

FUNGI; MYXOGASTRIA; SACCHAROMYCES CEREVISIAE;

EID: 0031909440     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.9.1.29     Document Type: Article

References (77)

1. Anderson, C.W., Baum, P.R., and Gesteland, R.F. (1973). Processing of adenovirus-2 induced proteins. J. Virol, 12, 241-252.
2. Baudin, A., Ozier-Kalogeropoulos, O., Denouel, A., Lacroute, F., and Cullin, C. (1993). A simple and efficient method for direct gene deletion in Sacchoromyces cerevisiae. Nucleic Acids Res. 21, 3329-3330.
3. Baum, P., Yip, C., Goetsch, L., and Byers, B. (1988). A yeast gene essential for regulation of spindle pole body duplication. Mol. Cell Biol. 8, 5386-5397.
4. Brown, T. (1997). Hybridization analysis of DNA blots. In: Current Protocols in Molecular Biology, ed, F.M. Ausubel, R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smoth, and K. Struhl, New York: John Wiley & Sons, Inc., 2.10.1-2.10.16.
5. Chan, C., and Botstein, D. (1993). Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics 135, 677-691.
6. Chevalier, S., and Blow, J.J. (1996). Cell cycle control of replication initiation in eukaryotes. Curr. Opin. Cell Biol. 8, 815-821.
7. Christianson, T.W., Sikorski, R.S., Dante, M., Shero, J.H., and Heiter, P. (1992). Multifunctional yeast high-copy shuttle vectors. Genetics 110, 119-122.
8. Chun, K., and Goebl, M. (1996). The identification of transposontagged mutations in essential genes that affect cell morphology in Saccharomyces cerevisiae. Genetics 142, 39-50.
9. Datta, N., Williams, L., Caldwell, J., Curry, A., Ashcraft, E., and Long, M. (1996). Novel alterations in CDK1/cyclin B1 kinase complex formation occur during the acquisition of a polyloid DNA content. Mol. Biol. Cell 7, 209-223.
10. Doheny, K., Sorger, P., Hyman, A., Tugendreich, S., Spencer, F., and Hieter, P. (1993). Identification of essential components of the S. cerevisiae kinetochore. Cell 73, 761-774.
11. Elledge, S. (1996). Cell cycle checkpoints: preventing an identity crisis. Science 274, 1664-1671.
12. Francisco, L., Wang, W., and Chan, C.S.M. (1994). Type 1 protein phosphatase acts in opposition to JPL1 protein kinase in regulating yeast chromosome segregation. Mol. Cell Biol. 14, 4731-4740.
13. Fromant, M., Blanquet, S., and Plateau, P. (1995). Direct random mutagenesis of gene-sized DNA fragments using polymerase chain reaction. Anal. Biochem. 224, 347-353.
14. Goh, P., and Kilmartin, J. (1993). NDC10: a gene involved in chromosome segregation in Saccharomyces cerevisiae. J. Cell Biol. 121, 503-512.
15. Golemis, E., Gyuris, J., and Brent, R. (1997). Interaction trap/two hybrid system to identify interacting proteins. In: Current Protocols in Molecular Biology, ed. F.M. Ausubel, R. Brent, R.E. Kingston, D. Moore, J.G. Seidman, J.A. Smoth, and K. Struhl, New York: John Wiley & Sons, 13.14.1-13.14.17.
16. Grafi, G., and Larkins, B. (1995). Endoreduplication in maize endosperm: involvement of M phase-promoting factor inhibition and induction of S phase-related kinases. Science 269, 1262-1664.
17. Guthrie, C., and Fink, G. (1991). Guide to yeast genetics and molecular biology. Methods Enzymol. 194, 1-933.
18. Hardwick, K., and Murray, A. (1995). Mad1p, a phosphoprotein component of the spindle assembly checkpoint in budding yeast. J. Cell Biol. 131, 709-720.
19. Hardwick, K., Weiss, E., Luca, F.C., Winey, M., and Murray, A. (1996). Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption. Science 273, 953-956.
20. Hardy, C.F. (1996). Characterization of an essential Orc2p-associated factor that plays a role in DNA replication. Mol. Cell Biol. 16, 1832-1841.
21. Hardy, C.F., and Pautz, A. (1996). A novel role for Cdc5p in DNA replication. Mol. Cell. Biol. 16, 6775-6782.
22. Harlow, E., and Lane, D. (1988). Antibodies: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
23. Hoffman, C.S., and Winston, F. (1987). A ten minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Genetics 57, 267-272.
24. Hoyt, A., He, L., Totis, L., and Saunders, W. (1993). Loss of function of Saccharomyces cerevisiae kinesin-related CIN8 and KIP1 is suppressed by KAR3 motor domain mutations. Genetics 135, 35-44.
25. Hoyt, M.A., and Geiser, J.R. (1997). Genetic analysis of the mitotic spindle. Annu. Rev. Genet. 30, 7-33.
26. Jackson, C.W. (1992). Megakaryocyte endomitosis: a review. Int. J. Cell Cloning 8, 224-226.
27. Johnston, L.H., Eberly, S.L., Chapman, J.W., Araki, H., and Sugino, A. (1990). The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle. Mol. Cell. Biol. 10, 1358-1366.
28. Juang, Y.-L., Huang, J., Peters, J.-M., McLaughlin, M.E., Tai, C.-Y., and Pellman, D. (1997). APC-mediated proteolysis of Ase1 and the morphogenesis of the mitotic spindle. Science 275, 1311-1314.
29. Keng, T., Clark, M.W., Storms, R.K., Fortin, N., Zhong, W., Ouellette, B.F., Barton, A.B., Kaback, D.B., and Bussey, H. (1994). LTE1 of Saccharomyces cerevisiae is a 1435 codon open reading frame that has sequence similarities to guanine nucleotide releasing factors. Yeast 10, 953-958.
30. King, R., Deshaies, R., Peters, J., and Kirschner, M. (1996). How proteolysis drives the cell cycle. Science 274, 1652-1658.
31. Kitada, K., Johnson, A.L., Johnston, L.H., and Sugino, A. (1993). A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5. Mol. Cell. Biol. 13, 4445-4457.
32. Kroll, E.S., Hyland, K.M., Hieter, P., and Li, J.J. (1996). Establishing genetic interactions by a synthetic dosage lethality phenotype. Genetics 143, 95-102.
33. Lauzé, E., Stoelcker, B., Luca, F.C., Weiss, E., Schutz, A., and Winey, M. (1995). Yeast spindle pole duplication gene MPS1 encodes an essential dual specificity protein kinase. EMBO J. 14, 1655-1663.
34. Lech, K., and Brent, R. (1997). Escherichia coli: media preparation and biological tools. In: Current Protocols in Molecular Biology, ed. F.M. Ausubel, R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smoth, and K. Struhl, New York: John Wiley & Sons, 1.1.1-1.1.6.
35. Levine, D., Sanchez, C., Rabinovitch, P., and Reid, B. (1991). Formation of the tetraploid intermediate is associated with the development cells with more than four centrioles in the etastas-simian virus 40 tumor antigen transgenic mouse model of pancreatic cancer. Proc. Natl. Acad. Sci. USA 88, 6427-6431.
36. Liu, H., Krizek, J., and Bretscher, A. (1992). Construction of a GAL1-regulated yeast cDNA expression library and its application to the identification of genes whose overexpression causes lethality in yeast. Genetics 132, 665-673.
37. Luca, F.C., Shibuya, E.K., Dohrmann, C.E., and Ruderman, J.V. (1991). Both cyclin AΔ60 and BΔ97 are stable and arrest cells in M-phase, but only BΔ97 turns on cyclin degradation. EMBO J. 109, 4311-4320.
38. Lunblad, V. (1997). Saccharomyces cerevisiae. In: Current Protocols in Molecular Biology, Chap. 13, ed. F.M. Ausubel, R. Brent, R.E. Kingston, D.D. Moore, J.G. Seidman, J.A. Smoth, and K. Struhl, New York: John Wiley & Sons.
39. McDonald, H.B., and Byers, B. (1997). A proteasome cap subunit required for spindle pole body duplication in yeast. J. Cell Biol. 137, 539-553.
40. Mitchell, D.A., Marshall, T.K., and Deschenes, R.J. (1993). Vectors for the inducible overexpression of glutathione S-transferase fusion proteins in yeast. Yeast 9, 715-723.
41. Molero, G., Yuste-Rojas, M., Montesi, A., Vazquez, A., Nombela, C., and Sanchez, M. (1993). A cdc-like autolytic Saccharomyces cerevisiae mutant altered in budding site selection is complemented by SPO12, a sporulation gene. J. Bacteriol. 175, 6562-6570.
42. Morishita, T., Mitsuzawa, H., Nakafuku, M., Nakamura, S., Hattori, S., and Anraku, Y. (1995). Requirement of Saccharomyces cerevisiae ras for completion of mitosis. Science 270, 1213-1215.
43. Parkes, V., and Johnston, L.H. (1992). SPO12 and SIT4 suppress mutations in DBF2, which encodes a cell cycle protein kinase that is periodically expressed. Nucleic Acids Res. 20, 5617-5623.
44. Paulovich, A.G., Toczyski, D.P., and Hartwell, L.H. (1997). When checkpoints fail. Cell 88, 315-321.
45. Pringle, J.R., and Hartwell, L.H. (1981). The Saccharomyces cerevisiae cell cycle. In: The Molecular Biology of the Yeast Saccharomyces cerevisiae. Life Cycle and Inheritance, ed. J.N. Atrathern, E.W. Jones, and J.R. Braoch, Cold Spring Harbor, NY: Cold Spring Harbor Press, 97-142.
46. Riles, L., Dutchik, J., Baktha, A., McCauley, B., Thayer, E., Leckie, M., Braden, V., Depke, J., and Olson, M. (1993). Physical maps of the six smallest choromosomes of Saccharomyces cerevisiae at a resolution of 2.6 kilobase pairs. Genetics 134, 81-150.
47. Romanowski, P., and Madine, M. (1996). Mechanisms restricting DNA replication to once per cell cycle: MCMs, pre-replicative complexes and kinases. Trends Biochem. Sci. 6, 184-188.
48. Rose, M., and Fink, G. (1987). KAR1, a gene required for function of both intranuclear and extranuclear microtubules in yeast. Cell 48, 1047-1060.
49. Rothstein, R. (1991). Targeting, disruption, replacement and allele rescue: integrative DNA transformation in yeast. Methods Enzymol. 194, 281-301.
50. Ruby, S.W., and Abelson, J. (1991). Pre-mRNA splicing in yeast. Trends Genet. 7, 79-85.
51. Rudner, A.D., and Murray, A.W. (1996). The spindle assembly checkpoint. Curr. Opin. Cell Biol. 8, 773-780.
52. Russell, M., Bradshaw-Rouse, J., Markwardt, D., and Heideman, W. (1993). Changes in gene expression in the Ras/Adenylate cyclase system of Saccharomyces cerevisiae: correlation with cAMP levels and growth arrest. Mol. Biol. Cell 4, 757-765.
53. Saunders, W., Koshland, D., Eshel, D., Gibbons, I., and Hoyt, A. (1995). Saccharomyces cerevisiae kinesin- and dynein-related protein quired for anaphase chromosome segregation. J. Cell Biol. 128, 617-624.
54. Schild, D., Ananthaswamy, H., and Mortimer, R. (1981). An endomitotic effect of a cell cycle mutation of Saccharomyces cerevisiae. Genetics 97, 551-562.
55. Schutz, A.R., Giddings, T.H., Steiner, E., and Winey, M. (1997). The yeast CDC37 gene interacts with MPS1 and is required for proper execution of spindle pole body duplication. J. Cell Biol. 136, 969-982.
56. Schweitzer, B., and Philippsen, P. (1991). CDC15, an essential cell cycle gene in Saccharomyces cerevisiae, encodes a protein kinase domain. Yeast 7, 265-273.
57. Shirayama, M., Matsui, Y., Tanaka, K., and Toh-e, A. (1994a). Isolation of a CDC25 family gene, MS12/LTE1, as a multicopy suppressor of ira1. Yeast 10, 451-461.
58. Shirayama, M., Matsui, Y., and Toh, E.A. (1994b). The yeast TEM1 gene, which encodes a GTP-binding protein, is involved in termination of M phase. Mol. Cell. Biol. 14, 7476-7482.
59. Shirayama, M., Matsui, Y., and Toh-e, A. (1996). Dominant mutant alleles of yeast protein kinase gene CDC15 suppress the lte1 defect in termination of M phase and genetically interact with CDC14. Mol. Gen. Genet. 251, 176-185.
60. Sikorski, R.S., and Boeke, J.D. (1991). In vitro mutagenesis and plasmid shuffling: from cloned gene to mutant yeast. Methods Enzymol. 194, 302-318.
61. Sikorski, R.S., and Heiter, P. (1989). A system of shuttle vectors and yeast host stains for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 222, 19-27.
62. Smith, M.E., Dickinson, J.R., and Wheals, A.E. (1990). Intracellular and extracellular levels of cyclic AMP during the cell cycle of Saccharoyces cervisiae. Yeast 6, 53-60.
63. Spevak, W., Keiper, B.D., Stratowa, C., and Castanon, M.J. (1993). Saccharomyces cerevisiae cdc15 mutants arrested at a late stage in anaphase are rescued by Xenopus cDNAs encoding N-ras or a protein with beta-transducin repeats. Mol. Cell. Biol. 13, 4953-4966.
64. Stewart, E., and Enoch, T. (1996). S-phase and DNA-damage check-points: a tale of two yeasts. Curr. Biol. 8, 781-787.
65. Stillman, B. (1996). Cell cycle control of DNA replication. Science 274, 1659-1663.
66. Studier, W.F., Rosenberg, A.H., Dunn, J.J., and Dubendorff, J.W. (1990). Use of T7 RNA polymerase to direct expression of cloned genes. Annu. Rev. Biochem. 185, 60-89.
67. Surana, U., Amon, A., Dowzer, C., McGrew, J., Byers, B., and Nasmyth, K. (1993). Destruction of the CDC28/CLB mitotic kinase is not required for the metaphase to anaphase transition in budding yeast. EMBO J. 12, 1969-1978.
68. Thomas, J., and Botstein, D. (1986). A gene required for the separation of chromosomes on the spindle apparatus in yeast. Cell 44, 65-76.
69. Tlsty, T.D., Briot, A., Gualberto, A., Hall, I., Hess, S., Hixon, M. D., Romanov, S., Sage, M., and White, A. (1995). Genomic stability and cancer. Mutat. Res. 337, 1-7.
70. Towbin, H., and Gordon, J. (1984). Immunoblotting and dot immunobinding- current status and outlook. J. Immunol. Methods 72, 313-340.
71. Toyn, J.H., and Johnston, L.H. (1994). The Dbf2 and Dbf20 protein kinases of budding yeast are activated after the metaphase to anaphase cell cycle transition. EMBO J. 13, 1103-1113.
72. Wan, J., Xu, H., and Grunstein, M. (1992). CDC14 of Saccharomyces cerevisiae. cloning, sequence analysis, and transcription during the cell cycle. J. Biol. Chem. 267, 11274-11280.
73. Watt, P.M., Loouis, E.J., Borts, R.H., and Hickson, I.D. (1995). SGS1: a eukaryotic homolog of E. coli RecQ that interacts with topoisomerase II in vivo and is required for faithful chromosome segregation. Cell 81, 253-260.
74. Weiss, E., and Winey, M. (1996). The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint. J. Cell Biol. 132, 111-123.
75. Wickner, R.B., Koh, T.J., Crowley, J.C., O'Neil, J., and Kaback, D.B. (1987). Molecular cloning of chromosome IDNA from Saccharomyces revisiae: Isolation of the MAK16 gene and analysis of an adjacent gene essential for growth at low temperatures. Yeast 3, 51-57.
76. Winey, M., Goetsch, L., Baum, P., and Byers, B. (1991). MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication. J. Cell Biol. 114, 745-754.
77. Yeh, E., Skibbens, R., Cheng, J., Salmon, E., and Bloom, K. (1995). Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae. J. Cell Biol. 130, 687-700.