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Volumn 8, Issue 6, 1996, Pages 815-821

Cell cycle control of replication initiation in eukaryotes

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE;

EID: 0030561285     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(96)80082-2     Document Type: Article
Times cited : (46)

References (67)
  • 2
    • 0029079350 scopus 로고
    • The origin recognition complex in silencing, cell cycle progression and DNA replication
    • of outstanding interest. This paper describes the cloning of the S. cerevisiae ORC5 gene. Multiple tandem origins suppressed the plasmid-maintenance defect of orc5-1 and orc2-1 mutants. ORC2 and ORC5 interact genetically with members of the MCM/P1 family (CDC46, CDC47 and CDC54) and with CDC6, CDC7 and CDC14 (which encodes a putative phosphatase involve in DNA replication.
    • Loo S, Fox CA, Rine J, Kobayashi R, Stillman B, Bell S. The origin recognition complex in silencing, cell cycle progression and DNA replication. of outstanding interest Mol Biol Cell. 6:1995;741-756 This paper describes the cloning of the S. cerevisiae ORC5 gene. Multiple tandem origins suppressed the plasmid-maintenance defect of orc5-1 and orc2-1 mutants. ORC2 and ORC5 interact genetically with members of the MCM/P1 family (CDC46, CDC47 and CDC54) and with CDC6, CDC7 and CDC14 (which encodes a putative phosphatase involve in DNA replication.
    • (1995) Mol Biol Cell , vol.6 , pp. 741-756
    • Loo, S.1    Fox, C.A.2    Rine, J.3    Kobayashi, R.4    Stillman, B.5    Bell, S.6
  • 3
    • 0028897908 scopus 로고
    • The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication
    • of special interest. orc2-1 and orc5-1 temperature-sensitive mutants show decreased replication initiation at ARS1, as measured by two-dimensional gel analysis. This paper also describes mutants in ORC5 that are defective in silencing, but not in replication, suggesting independent roles for ORC in both processes.
    • Fox CA, Loo S, Dillin A, Rine J. The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication. of special interest Genes Dev. 9:1995;911-924 orc2-1 and orc5-1 temperature-sensitive mutants show decreased replication initiation at ARS1, as measured by two-dimensional gel analysis. This paper also describes mutants in ORC5 that are defective in silencing, but not in replication, suggesting independent roles for ORC in both processes.
    • (1995) Genes Dev , vol.9 , pp. 911-924
    • Fox, C.A.1    Loo, S.2    Dillin, A.3    Rine, J.4
  • 4
    • 0029048775 scopus 로고
    • ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome
    • of special interest. orc5-1 cells accumulate in S phase at the restrictive temperature and CDC6 is multicopy suppressor of this effect. Co-immunoprecipitation of ORC5 and Cdc6 expressed in baculovirus indicates a physical interaction between these proteins.
    • Liang C, Weinreich M, Stillman B. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. of special interest Cell. 81:1995;667-676 orc5-1 cells accumulate in S phase at the restrictive temperature and CDC6 is multicopy suppressor of this effect. Co-immunoprecipitation of ORC5 and Cdc6 expressed in baculovirus indicates a physical interaction between these proteins.
    • (1995) Cell , vol.81 , pp. 667-676
    • Liang, C.1    Weinreich, M.2    Stillman, B.3
  • 5
    • 0028832366 scopus 로고
    • The multidomain structure of Orc1p reveals similary to regulators of DNA replication and transcriptional silencing
    • Bell SP, Mitchell J, Leber J, Kobayashi R, Stillman B. The multidomain structure of Orc1p reveals similary to regulators of DNA replication and transcriptional silencing. Cell. 83:1995;563-568.
    • (1995) Cell , vol.83 , pp. 563-568
    • Bell, S.P.1    Mitchell, J.2    Leber, J.3    Kobayashi, R.4    Stillman, B.5
  • 6
    • 0029586090 scopus 로고
    • Conserved initiator proteins in eukaryotes
    • of special interest. Using a PCR strategy, these authors have cloned ORC1 genes from the budding yeast Kluyveromyces lactis, the fission yeast. S. pombe and human cells. They also cloned ORC2 from Arabidopsis thaliana, Caenorhabditis elegans and human cells, suggesting that ORC subunits are conserved throughout eukaryotes.
    • Gavin KA, Hidaka M, Stillman B. Conserved initiator proteins in eukaryotes. of special interest Science. 270:1995;1667-1671 Using a PCR strategy, these authors have cloned ORC1 genes from the budding yeast Kluyveromyces lactis, the fission yeast. S. pombe and human cells. They also cloned ORC2 from Arabidopsis thaliana, Caenorhabditis elegans and human cells, suggesting that ORC subunits are conserved throughout eukaryotes.
    • (1995) Science , vol.270 , pp. 1667-1671
    • Gavin, K.A.1    Hidaka, M.2    Stillman, B.3
  • 7
    • 0029597854 scopus 로고
    • A Drosophila homolog of the yeast origin recognition complex
    • of outstanding interest. The D. melanogaster (Dm) ORC2 and ORC5 genes have been cloned. A six-subunit protein complex, containing the DmORC2 and DmORC5 proteins, has been fractionated from embryo nuclear extracts. Molecular weights of the DmORC components are similar to those of the S. cerevisiae ORC subunits.
    • Gossen M, Pak DTS, Hansen SK, Acharya JK, Botchan MR. A Drosophila homolog of the yeast origin recognition complex. of outstanding interest Science. 270:1995;1674-1677 The D. melanogaster (Dm) ORC2 and ORC5 genes have been cloned. A six-subunit protein complex, containing the DmORC2 and DmORC5 proteins, has been fractionated from embryo nuclear extracts. Molecular weights of the DmORC components are similar to those of the S. cerevisiae ORC subunits.
    • (1995) Science , vol.270 , pp. 1674-1677
    • Gossen, M.1    Pak, D.T.S.2    Hansen, S.K.3    Acharya, J.K.4    Botchan, M.R.5
  • 8
    • 0029583658 scopus 로고
    • Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex
    • Muzi-Falconi M, Kelly TJ. Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex. Proc Natl Acad Sci USA. 92:1995;12475-12479.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12475-12479
    • Muzi-Falconi, M.1    Kelly, T.J.2
  • 9
    • 0030053520 scopus 로고    scopus 로고
    • Role for a Xenopus Orc2-related protein in controlling DNA replication
    • of outstanding interest. This paper describes the cloning of the Xenopus Orc2 gene. Indirect immunofluorescence studies in Xenopus egg extracts show that Orc2 binds to chromatin before DNA replication starts. Replication initiation is prevented when Orc2 is removed from egg extracts with specific antibodies, suggesting that Orc2 plays a key role in replication initiation.
    • Carpenter PB, Mueller PR, Dunphy WG. Role for a Xenopus Orc2-related protein in controlling DNA replication. of outstanding interest Nature. 379:1996;357-360 This paper describes the cloning of the Xenopus Orc2 gene. Indirect immunofluorescence studies in Xenopus egg extracts show that Orc2 binds to chromatin before DNA replication starts. Replication initiation is prevented when Orc2 is removed from egg extracts with specific antibodies, suggesting that Orc2 plays a key role in replication initiation.
    • (1996) Nature , vol.379 , pp. 357-360
    • Carpenter, P.B.1    Mueller, P.R.2    Dunphy, W.G.3
  • 10
    • 0030054354 scopus 로고    scopus 로고
    • Interaction of cdc2 and cdc18 with a fission yeast orc2-like protein
    • of outstanding interest. A two-hybrid screen identified S. pombe Orc2 (Orp2) as a Cdc2-interacting factor. Recombinant Orp2 associates with Cdc2 and Cdc18 in fission yeast lysates. These findings suggest that Cdc2 controls DNA replication by interacting with replication origins.
    • Leatherwood J, Lopezgirona A, Russell P. Interaction of cdc2 and cdc18 with a fission yeast orc2-like protein. of outstanding interest Nature. 379:1996;360-363 A two-hybrid screen identified S. pombe Orc2 (Orp2) as a Cdc2-interacting factor. Recombinant Orp2 associates with Cdc2 and Cdc18 in fission yeast lysates. These findings suggest that Cdc2 controls DNA replication by interacting with replication origins.
    • (1996) Nature , vol.379 , pp. 360-363
    • Leatherwood, J.1    Lopezgirona, A.2    Russell, P.3
  • 11
    • 0030044864 scopus 로고    scopus 로고
    • Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L
    • Takahara K, Bong M, Brevard R, Eddy RL, Haley LL, Saint SJ, Shows TB, Hoffman GG, Greenspan DS. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. Genomics. 31:1996;119-122.
    • (1996) Genomics , vol.31 , pp. 119-122
    • Takahara, K.1    Bong, M.2    Brevard, R.3    Eddy, R.L.4    Haley, L.L.5    Saint, S.J.6    Shows, T.B.7    Hoffman, G.G.8    Greenspan, D.S.9
  • 12
    • 0030592518 scopus 로고    scopus 로고
    • Interaction between the origin recognition complex and the replication licensing system in Xenopus
    • Orc1 antibodies also removes Orc2. This treatment prevents replication initiation from occurring and Mcm3 from binding to chromatin, although RLF is still active. The results also demonstrate a requirements for the sequential assembly of Orc1 and then Mcm3 onto chromatin. of outstanding interest
    • Rowles A, Chong JPJ, Brown L, Howell M, Evan GI, Blow JJ. Interaction between the origin recognition complex and the replication licensing system in Xenopus. of outstanding interest Cell. 1996; The authors describe the cloning of the Xenopus Orc1 gene and the purification of the Xenopus ORC complex. Immunodepletion of Orc1 from egg extracts with anti-Orc1 antibodies also removes Orc2. This treatment prevents replication initiation from occurring and Mcm3 from binding to chromatin, although RLF is still active. The results also demonstrate a requirements for the sequential assembly of Orc1 and then Mcm3 onto chromatin.
    • (1996) Cell
    • Rowles, A.1    Chong, J.P.J.2    Brown, L.3    Howell, M.4    Evan, G.I.5    Blow, J.J.6
  • 13
    • 0029610435 scopus 로고
    • Overview of the regulation of S phase in Xenopus egg extracts
    • Chevalier S, Chartrain I, Philippe M, Ford CC. Overview of the regulation of S phase in Xenopus egg extracts. Biochimie. 77:1995;808-816.
    • (1995) Biochimie , vol.77 , pp. 808-816
    • Chevalier, S.1    Chartrain, I.2    Philippe, M.3    Ford, C.C.4
  • 14
    • 0011928274 scopus 로고    scopus 로고
    • The DNA replication licensing system
    • in press
    • Thommes P, Blow JJ. The DNA replication licensing system. Cancer Surveys. 1996;. in press.
    • (1996) Cancer Surveys
    • Thommes, P.1    Blow, J.J.2
  • 15
    • 0029445205 scopus 로고
    • Stepwise assembly of initiation-complexes at budding yeast replication origins during the cell-cycle
    • Suppl
    • Diffley JFX, Cocker JH, Dowell SJ, Harwood J, Rowley A. Stepwise assembly of initiation-complexes at budding yeast replication origins during the cell-cycle. J Cell Sci. 19:1995;67-72. Suppl.
    • (1995) J Cell Sci , vol.19 , pp. 67-72
    • Diffley, J.F.X.1    Cocker, J.H.2    Dowell, S.J.3    Harwood, J.4    Rowley, A.5
  • 16
    • 0028972375 scopus 로고
    • P65(Cdc18) plays a major role controlling the initiation of DNA replication in fission yeast
    • 1→S-phase transition. Expression of cdc18 is required for replication initiation to occur and cdc18 overexpression induces repeated rounds of DNA replication without an intervening mitosis. This suggests that Cdc18 is rate-limiting for S-phase entry and that its degradation prevents replication in a single cell cycle.
    • 1→S-phase transition. Expression of cdc18 is required for replication initiation to occur and cdc18 overexpression induces repeated rounds of DNA replication without an intervening mitosis. This suggests that Cdc18 is rate-limiting for S-phase entry and that its degradation prevents replication in a single cell cycle.
    • (1995) Cell , vol.83 , pp. 397-405
    • Nishitani, H.1    Nurse, P.2
  • 17
    • 0029864759 scopus 로고    scopus 로고
    • Cdc18(+) regulates initiation of DNA replication in Schizosaccharomyces pombe
    • of outstanding interest. See annotation [16].
    • Muzi-Falconi M, Brown GW, Kelly TJ. Cdc18(+) regulates initiation of DNA replication in Schizosaccharomyces pombe. of outstanding interest Proc Natl Acad Sci USA. 93:1996;1566-1570 See annotation [16].
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 1566-1570
    • Muzi-Falconi, M.1    Brown, G.W.2    Kelly, T.J.3
  • 18
    • 0029082391 scopus 로고
    • Cdc6 is an unstable protein whose de novo synthesis in G(1) is important for the onset of S phase and for preventing a reductional anaphase in the budding yeast Saccharomyces cerevisiae
    • 1 phase are defective for entry into S phase.
    • 1 phase are defective for entry into S phase.
    • (1995) EMBO J , vol.14 , pp. 3788-3799
    • Piatti, S.1    Lengauer, C.2    Nasmyth, K.3
  • 19
    • 0030030623 scopus 로고    scopus 로고
    • An essential role for the cdc6 protein in forming the pre-replicative complexes of budding yeast
    • ts strain causes the loss of the prereplicative complex. This suggests that Cdc6, which is necessary for origin firing in vivo, is also a component of the pre-replicative complex.
    • ts strain causes the loss of the prereplicative complex. This suggests that Cdc6, which is necessary for origin firing in vivo, is also a component of the pre-replicative complex.
    • (1996) Nature , vol.379 , pp. 180-182
    • Cocker, J.H.1    Piatti, S.2    Santocanale, C.3    Nasmyth, K.4    Diffley, J.F.X.5
  • 20
    • 0027978640 scopus 로고
    • Interaction of Dbf4, the Cdc7 protein-kinase requlatory subunit, with yeast replication origins in vivo
    • Dowell SJ, Romanowski P, Diffley JFX. Interaction of Dbf4, the Cdc7 protein-kinase requlatory subunit, with yeast replication origins in vivo. Science. 265:1994;1243-1246.
    • (1994) Science , vol.265 , pp. 1243-1246
    • Dowell, S.J.1    Romanowski, P.2    Diffley, J.F.X.3
  • 21
    • 0027192941 scopus 로고
    • Cell cycle regulation of the yeast Cdc7 protein-kinase by association with the Dbf4 protein
    • Jackson AL, Pahl PMB, Harrison K, Rosamond J, Sclafani RA. Cell cycle regulation of the yeast Cdc7 protein-kinase by association with the Dbf4 protein. Mol Cell Biol. 13:1993;2899-2908.
    • (1993) Mol Cell Biol , vol.13 , pp. 2899-2908
    • Jackson, A.L.1    Pahl, P.M.B.2    Harrison, K.3    Rosamond, J.4    Sclafani, R.A.5
  • 22
    • 0028979307 scopus 로고
    • Hsk1(+), a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae Cdc7, is required for chromosomal replication
    • Masai H, Miyake T, Arai K. Hsk1(+), a Schizosaccharomyces pombe gene related to Saccharomyces cerevisiae Cdc7, is required for chromosomal replication. EMBO J. 14:1995;3094-3104.
    • (1995) EMBO J , vol.14 , pp. 3094-3104
    • Masai, H.1    Miyake, T.2    Arai, K.3
  • 23
    • 0029670238 scopus 로고    scopus 로고
    • The role of MCM/P1 proteins in the licensing of DNA replication
    • Chong JPJ, Thsmmes P, Blow JJ. The role of MCM/P1 proteins in the licensing of DNA replication. Trends Biochem Sci. 21:1996;102-106.
    • (1996) Trends Biochem Sci , vol.21 , pp. 102-106
    • Chong, J.P.J.1    Thsmmes, P.2    Blow, J.J.3
  • 25
    • 0028989339 scopus 로고
    • Purification of an Mcm-containing complex as a component of the DNA replication licensing system
    • 1 phase and is displaced as replication occurs.
    • 1 phase and is displaced as replication occurs.
    • (1995) Nature , vol.375 , pp. 418-421
    • Chong, J.P.J.1    Mahbubani, M.H.2    Khoo, C.-Y.3    Blow, J.J.4
  • 26
    • 0029000522 scopus 로고
    • Identification of the yeast MCM3-related protein as a component of Xenopus DNA replication licensing factor
    • 2 phase, Xenopus egg extracts identified the Mcm3 protein. Removal of these proteins from egg extracts with specific antibodies prevents replication initiation. Recombinant Mcm3 cannot cross an intact nuclear envelope.
    • 2 phase, Xenopus egg extracts identified the Mcm3 protein. Removal of these proteins from egg extracts with specific antibodies prevents replication initiation. Recombinant Mcm3 cannot cross an intact nuclear envelope.
    • (1995) Cell , vol.81 , pp. 601-609
    • Kubota, Y.1    Mimura, S.2    Nishimoto, S.3    Takisawa, H.4    Nojima, H.5
  • 27
    • 0029036901 scopus 로고
    • MCM3 complex required for cell cycle regulation of DNA replication in verterbrate cells
    • of outstanding interest. Having cloned the gene encoding Xenopus Mcm3, these authors show that anti-Mcm3 antibodies remove Mcm2, Mcm3 and Mcm5 from Xenopus egg extracts. This treatment prevents DNA replication from occurring. Native Mcm3 could apparently cross the nuclear envelope, as nuclei assembled in a Mcm3-depleted extract became competent to replicate following transfer to underpleted extract.
    • Madine MA, Khoo C-Y, Mills AD, Laskey RA. MCM3 complex required for cell cycle regulation of DNA replication in verterbrate cells. of outstanding interest Nature. 375:1995;421-424 Having cloned the gene encoding Xenopus Mcm3, these authors show that anti-Mcm3 antibodies remove Mcm2, Mcm3 and Mcm5 from Xenopus egg extracts. This treatment prevents DNA replication from occurring. Native Mcm3 could apparently cross the nuclear envelope, as nuclei assembled in a Mcm3-depleted extract became competent to replicate following transfer to underpleted extract.
    • (1995) Nature , vol.375 , pp. 421-424
    • Madine, M.A.1    Khoo, C.-Y.2    Mills, A.D.3    Laskey, R.A.4
  • 29
    • 0029058498 scopus 로고
    • Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: Physical interaction between P1(MCM3) and CDC46 proteins
    • Kimura H, Takizawa N, Nozaki N, Sugimoto K. Molecular cloning of cDNA encoding mouse Cdc21 and CDC46 homologs and characterization of the products: physical interaction between P1(MCM3) and CDC46 proteins. Nucleic Acids Res. 23:1995;2097-2104.
    • (1995) Nucleic Acids Res , vol.23 , pp. 2097-2104
    • Kimura, H.1    Takizawa, N.2    Nozaki, N.3    Sugimoto, K.4
  • 30
    • 0029053298 scopus 로고
    • A human homologue of the yeast replication protein Cdc21: Interactions with other Mcm proteins
    • Musahl C, Schulte D, Burkhart R, Knippers R. A human homologue of the yeast replication protein Cdc21: interactions with other Mcm proteins. Eur J Biochem. 230:1995;1096-1101.
    • (1995) Eur J Biochem , vol.230 , pp. 1096-1101
    • Musahl, C.1    Schulte, D.2    Burkhart, R.3    Knippers, R.4
  • 31
    • 0028969165 scopus 로고
    • Expression, phosphorylation and nuclear localization of the human P1 protein, a homolog of the yeast Mcm3 replication protein
    • Schulte D, Burkhart R, Musahl C, Hu B, Schlatterer C, Hameister H, Knippers R. Expression, phosphorylation and nuclear localization of the human P1 protein, a homolog of the yeast Mcm3 replication protein. J Cell Sci. 108:1995;1381-1389.
    • (1995) J Cell Sci , vol.108 , pp. 1381-1389
    • Schulte, D.1    Burkhart, R.2    Musahl, C.3    Hu, B.4    Schlatterer, C.5    Hameister, H.6    Knippers, R.7
  • 32
    • 0030066302 scopus 로고    scopus 로고
    • Properties of the human nuclear protein p85Mcm - Expression, nuclear localization and interaction with other Mcm proteins
    • Schulte D, Richter A, Burkhart R, Musahl C, Knippers R. Properties of the human nuclear protein p85Mcm - expression, nuclear localization and interaction with other Mcm proteins. Eur J Biochem. 235:1996;144-151.
    • (1996) Eur J Biochem , vol.235 , pp. 144-151
    • Schulte, D.1    Richter, A.2    Burkhart, R.3    Musahl, C.4    Knippers, R.5
  • 34
    • 0028012867 scopus 로고
    • A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division
    • Todorov IT, Pepperkok R, Philipova RN, Kearsey SE, Ansorge W, Werner D. A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division. J Cell Sci. 107:1994;253-265.
    • (1994) J Cell Sci , vol.107 , pp. 253-265
    • Todorov, I.T.1    Pepperkok, R.2    Philipova, R.N.3    Kearsey, S.E.4    Ansorge, W.5    Werner, D.6
  • 35
    • 0028074229 scopus 로고
    • DNA polymerase alpha associated protein P1, murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period
    • Kimura H, Nozaki N, Sugimoto K. DNA polymerase alpha associated protein P1, murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period. EMBO J. 13:1994;4311-4320.
    • (1994) EMBO J , vol.13 , pp. 4311-4320
    • Kimura, H.1    Nozaki, N.2    Sugimoto, K.3
  • 36
    • 0029074364 scopus 로고
    • BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication
    • 1 and early S phase. They also show that BM28 hyperphosphorylation correlates with its displacement from chromatin.
    • 1 and early S phase. They also show that BM28 hyperphosphorylation correlates with its displacement from chromatin.
    • (1995) J Cell Biol , vol.129 , pp. 1433-1445
    • Todorov, I.T.1    Attaran, A.2    Kearsey, S.E.3
  • 37
    • 0030043371 scopus 로고    scopus 로고
    • Human replication proteins Hcdc21, Hcdc46 and P1mcm3 bind chromatin uniformly before S phase and are displaced locally during DNA replication
    • of special interest. Using confocal microscopy in human cells, these authors report that the nuclear localization of MCM/P1 proteins does not correlate with foci of ongoing DNA synthesis, but that sites of bound MCM/P1 proteins are the ones with unreplicated DNA.
    • Krude T, Musahl C, Laskey RA, Knippers R. Human replication proteins Hcdc21, Hcdc46 and P1mcm3 bind chromatin uniformly before S phase and are displaced locally during DNA replication. of special interest J Cell Sci. 109:1996;309-318 Using confocal microscopy in human cells, these authors report that the nuclear localization of MCM/P1 proteins does not correlate with foci of ongoing DNA synthesis, but that sites of bound MCM/P1 proteins are the ones with unreplicated DNA.
    • (1996) J Cell Sci , vol.109 , pp. 309-318
    • Krude, T.1    Musahl, C.2    Laskey, R.A.3    Knippers, R.4
  • 38
    • 0028939041 scopus 로고
    • A murine replication protein accumulates temporarily in the heterochromatic regions of nuclei prior to initiation of DNA replication
    • of special interest. In synchronized mouse cells, Mcm3 is a nuclear protein throughout interphase. Mcm3 accumulates in the heterochromatic regions of the chromosomes before the formation of replication foci.
    • Starborg M, Brundell E, Gell K, Larsson C, White I, Daneholt B, Höog C. A murine replication protein accumulates temporarily in the heterochromatic regions of nuclei prior to initiation of DNA replication. of special interest J Cell Sci. 108:1995;927-934 In synchronized mouse cells, Mcm3 is a nuclear protein throughout interphase. Mcm3 accumulates in the heterochromatic regions of the chromosomes before the formation of replication foci.
    • (1995) J Cell Sci , vol.108 , pp. 927-934
    • Starborg, M.1    Brundell, E.2    Gell, K.3    Larsson, C.4    White, I.5    Daneholt, B.6    Höog, C.7
  • 39
    • 0029968413 scopus 로고    scopus 로고
    • Chromatin binding, nuclear localization and phosphorylation of Xenopus Cdc21 are cell cycle dependent and associated with the control of initiation of DNA replication
    • of outstanding interest. Xenopus Cdc21 (Mcm4) is localized with chromatin before nuclear envelope formation and is displaced as DNA replication proceeds. After mitosis, Cdc21 is underphosphorylated; it becomes partially phosphorylated during S phase and is hyperphosphorylated at the beginning of mitosis, possibly as a substrate of the kinase MPF.
    • Coue M, Kearsey SE, Mechali M. Chromatin binding, nuclear localization and phosphorylation of Xenopus Cdc21 are cell cycle dependent and associated with the control of initiation of DNA replication. of outstanding interest EMBO J. 15:1996;1085-1097 Xenopus Cdc21 (Mcm4) is localized with chromatin before nuclear envelope formation and is displaced as DNA replication proceeds. After mitosis, Cdc21 is underphosphorylated; it becomes partially phosphorylated during S phase and is hyperphosphorylated at the beginning of mitosis, possibly as a substrate of the kinase MPF.
    • (1996) EMBO J , vol.15 , pp. 1085-1097
    • Coue, M.1    Kearsey, S.E.2    Mechali, M.3
  • 41
    • 0029362933 scopus 로고
    • DNA replication. Almost licensed
    • Ford C, Chevalier S. DNA replication. Almost licensed. Curr Biol. 5:1995;1009-1012.
    • (1995) Curr Biol , vol.5 , pp. 1009-1012
    • Ford, C.1    Chevalier, S.2
  • 42
    • 0028845639 scopus 로고
    • Cyclin-dependent kinase regulation
    • Lees E. Cyclin-dependent kinase regulation. Curr Opin Cell Biol. 7:1995;773-780.
    • (1995) Curr Opin Cell Biol , vol.7 , pp. 773-780
    • Lees, E.1
  • 43
    • 0028114987 scopus 로고
    • The B-type cyclin kinase inhibitor p40(Sic1) controls the G1 to S transition in Saccharomyces cerevisiae
    • Schwob E, Bohm T, Mendenhall MD, Nasmyth K. The B-type cyclin kinase inhibitor p40(Sic1) controls the G1 to S transition in Saccharomyces cerevisiae. Cell. 79:1994;233-244.
    • (1994) Cell , vol.79 , pp. 233-244
    • Schwob, E.1    Bohm, T.2    Mendenhall, M.D.3    Nasmyth, K.4
  • 44
    • 0030022048 scopus 로고    scopus 로고
    • B-type cyclins regulate G(1) progression in fission yeast in opposition to the p25(Rum1) Cdk inhibitor
    • 1 cyclin. In cells that lack Cig2, however, both Cig1 and Cdc13 are able to promote Cdc2 kinase activity. Rum 1 inhibits both Cdc2-Cig2 and Cdc2-Cdc13 kinase activity in vitro.
    • 1 cyclin. In cells that lack Cig2, however, both Cig1 and Cdc13 are able to promote Cdc2 kinase activity. Rum 1 inhibits both Cdc2-Cig2 and Cdc2-Cdc13 kinase activity in vitro.
    • (1996) EMBO J , vol.15 , pp. 839-849
    • Martin-Castellanos, C.1    Labib, K.2    Moreno, S.3
  • 45
    • 0029670828 scopus 로고    scopus 로고
    • A single fission yeast mitotic cyclin-B p34(Cdc2) kinase promotes both S-phase and mitosis in the absence of G(1) cyclins
    • 1 phase. The kinase activity associated with Cdc13 builds up during interphase, being maximal at the end of mitosis. In the absence of Cig2, Cdc2-Cdc13 can promote S-phase entry.
    • 1 phase. The kinase activity associated with Cdc13 builds up during interphase, being maximal at the end of mitosis. In the absence of Cig2, Cdc2-Cdc13 can promote S-phase entry.
    • (1996) EMBO J , vol.15 , pp. 850-860
    • Fisher, D.L.1    Nurse, P.2
  • 47
    • 0029416996 scopus 로고
    • P25(Rum1) orders S phase and mitosis by acting as an inhibitor of the p34(Cdc2) mitotic kinase
    • Correabordes J, Nurse P. p25(Rum1) orders S phase and mitosis by acting as an inhibitor of the p34(Cdc2) mitotic kinase. Cell. 83:1995;1001-1009.
    • (1995) Cell , vol.83 , pp. 1001-1009
    • Correabordes, J.1    Nurse, P.2
  • 48
    • 0029035302 scopus 로고
    • Cyclin A associated kinase activity is rate limiting for entrance into S phase and is negatively regulated in G(1) by p27(Kip1)
    • 1 phase.
    • 1 phase.
    • (1995) Mol Cell Biol , vol.15 , pp. 4347-4352
    • Resnitzky, D.1    Hengst, L.2    Reed, S.I.3
  • 49
    • 0029024332 scopus 로고
    • Overexpression of human cyclin A advances entry into S phase
    • of outstanding interest. of special interest. See annotation [48].
    • of outstanding interest Rosenberg AR, Zindy F, Ledeist F, Mouly H, Metezeau P, Brechot C, Lamas E. Overexpression of human cyclin A advances entry into S phase. of special interest Oncogene. 10:1995;1501-1509 See annotation [48].
    • (1995) Oncogene , vol.10 , pp. 1501-1509
    • Rosenberg, A.R.1    Zindy, F.2    Ledeist, F.3    Mouly, H.4    Metezeau, P.5    Brechot, C.6    Lamas, E.7
  • 51
    • 0027742184 scopus 로고
    • Distinct roles for cyclin-dependent kinases in cell cycle control
    • Van den Heuvel S, Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science. 262:1993;2050-2054.
    • (1993) Science , vol.262 , pp. 2050-2054
    • Van Den Heuvel, S.1    Harlow, E.2
  • 52
    • 0029926060 scopus 로고    scopus 로고
    • Differential effects of Cdk2 and Cdk3 on the control of Rb and E2f function during G(1) exit
    • Hofmann F, Livingston DM. Differential effects of Cdk2 and Cdk3 on the control of Rb and E2f function during G(1) exit. Genes Dev. 10:1996;851-861.
    • (1996) Genes Dev , vol.10 , pp. 851-861
    • Hofmann, F.1    Livingston, D.M.2
  • 53
    • 0029015715 scopus 로고
    • Both cdc2 and cdk2 promote S phase initiation in Xenopus egg extracts
    • Suc1 beads, cannot support DNA replication. Under those conditions, Cdk2 could restimulate DNA replication. In Cdk2-depleted extracts, which contain endogenous Cdc2, DNA replication could be restimulated by both newly translated Cdk2 and newly translated Cdc2.
    • Suc1 beads, cannot support DNA replication. Under those conditions, Cdk2 could restimulate DNA replication. In Cdk2-depleted extracts, which contain endogenous Cdc2, DNA replication could be restimulated by both newly translated Cdk2 and newly translated Cdc2.
    • (1995) J Cell Sci , vol.108 , pp. 1831-1841
    • Chevalier, S.1    Tassan, J.P.2    Cox, R.3    Philippe, M.4    Ford, C.5
  • 54
    • 0029125622 scopus 로고
    • Early events in DNA replications require cyclin E and are blocked by p21(Cip1)
    • Cip1 also inhibited DNA replication in egg extracts. Under those conditions, DNA replication can be restimulated with recombinant cyclin E.
    • Cip1 also inhibited DNA replication in egg extracts. Under those conditions, DNA replication can be restimulated with recombinant cyclin E.
    • (1995) J Cell Biol , vol.130 , pp. 755-769
    • Jackson, P.K.1    Chevalier, S.2    Philippe, M.3    Kirschner, M.W.4
  • 55
    • 0029891988 scopus 로고    scopus 로고
    • Both cyclin A and cyclin E have S phase promoting factor (SPF) activity in Xenopus egg extracts
    • of special interest. Baculovirus Cdk2-cyclin E, Cdk2-cyclin A and Cdc2-cyclin A, but not Cdc2-cyclin B, protein kinase complexes can individually restimulate DNA replication in egg extracts that are affinity depleted of Cdks. Low levels of cyclin A dependent kinase activity allow DNA replication to occur, whereas high kinase activity drives the extract into mitosis.
    • Strausfeld UP, Howell M, Descombes P, Chevalier S, Rempel R, Adamczewski J, Maller JL, Hunt T, Blow JJ. Both cyclin A and cyclin E have S phase promoting factor (SPF) activity in Xenopus egg extracts. of special interest J Cell Sci. 109:1996;1555-1563 Baculovirus Cdk2-cyclin E, Cdk2-cyclin A and Cdc2-cyclin A, but not Cdc2-cyclin B, protein kinase complexes can individually restimulate DNA replication in egg extracts that are affinity depleted of Cdks. Low levels of cyclin A dependent kinase activity allow DNA replication to occur, whereas high kinase activity drives the extract into mitosis.
    • (1996) J Cell Sci , vol.109 , pp. 1555-1563
    • Strausfeld, U.P.1    Howell, M.2    Descombes, P.3    Chevalier, S.4    Rempel, R.5    Adamczewski, J.6    Maller, J.L.7    Hunt, T.8    Blow, J.J.9
  • 56
    • 0028920140 scopus 로고
    • Maternal Xenopus Cdk2-cyclin E complexes function during meiotic and early embryonic cell cycles that lack a G1 phase
    • of special interest. See annotation [57].
    • Rempel RE, Sleight SB, Maller JL. Maternal Xenopus Cdk2-cyclin E complexes function during meiotic and early embryonic cell cycles that lack a G1 phase. of special interest J Biol Chem. 270:1995;6843-6855 See annotation [57].
    • (1995) J Biol Chem , vol.270 , pp. 6843-6855
    • Rempel, R.E.1    Sleight, S.B.2    Maller, J.L.3
  • 57
    • 0029891396 scopus 로고    scopus 로고
    • Xenopus cyclin E, a nuclear phosphoprotein, accumulates when oocytes gain the ability to initiate DNA replication
    • of special interest. Together with [56], this paper describes the cloning of three Xenopus cyclin E cDNAs. Cyclin E is a nuclear stable protein in Xenopus egg extracts and its phosphorylation is dependent upon Cdk2 kinase activity.
    • Chevalier S, Couturier A, Chartrain I, Le Guellec R, Beckhelling C, Le Guellec K, Philippe M, Ford CC. Xenopus cyclin E, a nuclear phosphoprotein, accumulates when oocytes gain the ability to initiate DNA replication. of special interest J Cell Sci. 109:1996;1173-1184 Together with [56], this paper describes the cloning of three Xenopus cyclin E cDNAs. Cyclin E is a nuclear stable protein in Xenopus egg extracts and its phosphorylation is dependent upon Cdk2 kinase activity.
    • (1996) J Cell Sci , vol.109 , pp. 1173-1184
    • Chevalier, S.1    Couturier, A.2    Chartrain, I.3    Le Guellec, R.4    Beckhelling, C.5    Le Guellec, K.6    Philippe, M.7    Ford, C.C.8
  • 58
    • 0030061451 scopus 로고    scopus 로고
    • Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity
    • Guadagno TM, Newport JW. Cdk2 kinase is required for entry into mitosis as a positive regulator of Cdc2-cyclin B kinase activity. Cell. 84:1996;73-82.
    • (1996) Cell , vol.84 , pp. 73-82
    • Guadagno, T.M.1    Newport, J.W.2
  • 59
    • 0028980273 scopus 로고
    • P19(Skp1) and p45(Skp2) are essential elements of the cyclin A-Cdk2 S phase kinase
    • Skp2 is co-injected. It is not known, however, whether this protein affects DNA replication independently or via its interaction with Cdk2-cyclin A.
    • Skp2 is co-injected. It is not known, however, whether this protein affects DNA replication independently or via its interaction with Cdk2-cyclin A.
    • (1995) Cell , vol.82 , pp. 915-925
    • Zhang, H.1    Kobayashi, R.2    Galaktionov, K.3    Beach, D.4
  • 60
    • 0025924452 scopus 로고
    • Involvement of p34cdc2 in establishing the dependency of S phase on mitosis
    • Broek D, Bartlett R, Crawford K, Nurse P. Involvement of p34cdc2 in establishing the dependency of S phase on mitosis. Nature. 349:1991;388-393.
    • (1991) Nature , vol.349 , pp. 388-393
    • Broek, D.1    Bartlett, R.2    Crawford, K.3    Nurse, P.4
  • 61
    • 0028059299 scopus 로고
    • Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex
    • Hayles J, Fisher D, Woollard A, Nurse P. Temporal order of S phase and mitosis in fission yeast is determined by the state of the p34cdc2-mitotic B cyclin complex. Cell. 78:1994;813-822.
    • (1994) Cell , vol.78 , pp. 813-822
    • Hayles, J.1    Fisher, D.2    Woollard, A.3    Nurse, P.4
  • 62
    • 0029878078 scopus 로고    scopus 로고
    • Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharmyces pombe
    • of special interest. Overexpression of the Cdk inhibitor Rum1 induced the accumulation of Cdc18 and rescued the lethality of the cdc18 mutant. The authors suggest that mitotic Cdks may inhibit replication initiation by blocking the expression or activity of Cdc18.
    • Jallepalli PV, Kelly TJ. Rum1 and Cdc18 link inhibition of cyclin-dependent kinase to the initiation of DNA replication in Schizosaccharmyces pombe. of special interest Genes Dev. 10:1996;541-552 Overexpression of the Cdk inhibitor Rum1 induced the accumulation of Cdc18 and rescued the lethality of the cdc18 mutant. The authors suggest that mitotic Cdks may inhibit replication initiation by blocking the expression or activity of Cdc18.
    • (1996) Genes Dev , vol.10 , pp. 541-552
    • Jallepalli, P.V.1    Kelly, T.J.2
  • 63
    • 0029410629 scopus 로고
    • S phase promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state
    • Sic1 Cdk inhibitor was sufficient to induce the formation of the prereplication complex at origins.
    • Sic1 Cdk inhibitor was sufficient to induce the formation of the prereplication complex at origins.
    • (1995) Curr Biol , vol.5 , pp. 1257-1269
    • Dahmann, C.1    Diffley, J.F.X.2    Nasmyth, K.A.3
  • 64
    • 0029761435 scopus 로고    scopus 로고
    • Activation of S-phase-promoting CDKs in late G1 defines a 'point of no return' after which Cdc6 synthesis cannot promote DNA replication in yeast
    • 1 phase until anaphase, providing a possible mechanism to inhibit prereplicative complex formation during this period.
    • 1 phase until anaphase, providing a possible mechanism to inhibit prereplicative complex formation during this period.
    • (1996) Genes Dev , vol.10 , pp. 1516-1531
    • Piatti, S.1    Bohm, T.2    Cocker, J.H.3    Diffley, J.F.X.4    Nasmyth, K.5
  • 65
    • 0029013865 scopus 로고
    • Distinct Modes of cyclin E/Cdc2c kinase regulation and S phase control in mitotic endoreduplication cycles of Drosophila embryogenesis
    • Sauer K, Knoblich JA, Richardson H, Lehner CF. Distinct Modes of cyclin E/Cdc2c kinase regulation and S phase control in mitotic endoreduplication cycles of Drosophila embryogenesis. Genes Dev. 9:1995;1327-1339.
    • (1995) Genes Dev , vol.9 , pp. 1327-1339
    • Sauer, K.1    Knoblich, J.A.2    Richardson, H.3    Lehner, C.F.4
  • 66
    • 0029917506 scopus 로고    scopus 로고
    • The yeast Cdc16 and Cdc27 genes restrict DNA replication to once per cell cycle
    • 2-like state and contain high Cdc28-Clb2 kinase activity. The authors suggest that Cdc16 and Cdc27 limit DNA replication to once per cell cycle, by targeting proteolysis of an essential S-phase component.
    • 2-like state and contain high Cdc28-Clb2 kinase activity. The authors suggest that Cdc16 and Cdc27 limit DNA replication to once per cell cycle, by targeting proteolysis of an essential S-phase component.
    • (1996) Cell , vol.85 , pp. 39-48
    • Heichman, K.A.1    Roberts, J.M.2
  • 67
    • 0029051233 scopus 로고
    • Cyclin ubiquitination - The destructive end of mitosis
    • Murray A. Cyclin ubiquitination - the destructive end of mitosis. Cell. 81:1995;149-152.
    • (1995) Cell , vol.81 , pp. 149-152
    • Murray, A.1


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