Apoptosis of central and peripheral neurons can be prevented with cyclin-dependent kinase/mitogen-activated protein kinase inhibitors

Journal of Neurochemistry

Volumn 70, Issue 4, 1998, Pages 1401-1410

  Maas Jr , James W ^a,c   Horstmann, Sonja ^b   Borasio, Gian Domenico ^b   Anneser, Johanna M H ^b   Shooter, Eric M ^a   Kahle, Philipp J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Apoptosis; c Jun kinase; Cyclin dependent kinase; Olomoucine; Retinal ganglion; Roscovitine

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; BUTYROLACTONE; CYCLIN DEPENDENT KINASE INHIBITOR; ENZYME INHIBITOR; ISOOLOMOUCINE; NEUROTROPHIC FACTOR; OLOMOUCINE; PURINE DERIVATIVE; ROSCOVITINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CENTRAL NERVOUS SYSTEM; CHICK EMBRYO; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; NERVE CELL NECROSIS; NONHUMAN; ONCOGENE C JUN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; RETINA GANGLION CELL;

EID: 0031906033     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1998.70041401.x     Document Type: Article

References (43)

1. Arends M. J. and Wyllie A. H. (1991) Apoptosis: mechanisms and roles in pathology. Int. Rev. Exp. Pathol. 32, 223-254.
2. Barres B. A., Silverstein B. E., Corey D. P., and Chun L. L. (1988) Immunological, morphological, and electrophysiological variation among retinal ganglion cells purified by panning. Neuron 1, 791-803.
3. Cuenda A., Rouse J., Doza Y. N., Meier R., Cohen P., Gallagher T. F., Young P. R., and Lee J. C. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett. 364, 229-233.
4. Estus S., Zaks W. J., Freeman R. S., Gruda M., Bravo R., and Johnson E. M. Jr. (1994) Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis. J. Cell Biol. 127, 1717-1727.
5. Freeman R. S., Estus S., and Johnson E. M. Jr. (1994) Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 12, 343-355.
6. Gupta S., Barrett T., Whitmarsh A. J., Cavanagh J., Sluss H. K., Dérijard B., and Davis R. J. (1996) Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 15, 2760-2770.
7. Ham J., Babij C., Whitfield J., Pfarr C. M., Lallemand D., Yaniv M., and Rubin L. L. (1995) A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14, 927-939.
8. Hamburger V. and Hamilton H. L. (1951) A series of normal stages in the development of the chick embryo. J. Morphol. 88, 49-92.
9. Heintz N. (1993) Cell death and the cell cycle: a relationship between transformation and neurodegeneration? Trends Biochem. Sci. 18, 157-159.
10. Herber B., Truss M., Beato M., and Müller R. (1994) Inducible regulatory elements in the human cyclin D1 promoter. Oncogene 9, 2105-2107.
11. Herdegen T., Skene P., and Bähr M. (1997) The c-Jun transcription factor - bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci. 20, 227-231.
12. Hilberg F., Aguzzi A., Howells N., and Wagner E. F. (1993) c-jun is essential for normal mouse development and hepatogenesis. Nature 365, 179-181.
13. Hughes S. M., Lillien L. E., Raff M. C., Rohrer H., and Sendtner M. (1988) Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture. Nature 335, 70-73.
14. Johnson R. S., van Lingen B., Papaioannou V. E., and Spiegelman B. M. (1993) A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 7, 1309-1317.
15. Jones K. H. and Senft J. A. (1985) An improved method to determine cell viability by simultaneous staining with fluorescein diacetate-propidium iodide. J. Histochem. Cytochem. 33, 77-79.
16. Kahle P. J., Verity A. N., Meyer-Franke A., Twiss J. L., and Shooter E. M. (1996) NGF induces neurite outgrowth and nuclear translocation of ERKs despite inhibition of ERK activity. Soc. Neurosci. Abstr. 22, 556.
17. Kahle P. J., Shooter E. M., Johnson R. M., and Verity A. N. (1997) Phosphatidylcholine-specific phospholipase inhibitor D609 differentially affects MAP kinases and immediate-early genes in PC12 cells. Cell. Signal. (in press).
18. Karin M., Liu Z., and Zandi E. (1997) AP-1 function and regulation. Curr Opin. Cell Biol. 9, 240-246.
19. Kitagawa M., Okabe T., Ogino H., Matsumoto H., Suzuki-Takahashi I., Kokubo T., Higashi H., Saitoh S., Taya Y., Yasuda H., Ohba Y., Nishimura S., Tanaka N., and Okuyama A. (1993) Butyrolactone I, a selective inhibitor of cdk2 and cdc2 kinase. Oncoeene 8, 2425-2432.
20. Kranenburg O., van der Eb A. J., and Zantema A. (1996) Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J. 15, 46-54.
21. Kummer J. L., Rao P. K. and Heidenreich K. A. (1997) Apoptosis induced by withdrawal of trophic factors is mediated by p38 mitogen-activated protein kinase. J. Biol. Chem. 272, 20490-20494.
22. Lahti J. M., Xiang J., Heath L. S., Campana D., and Kidd V. J. (1995) PITSLRE protein kinase activity is associated with apoptosis. Mol. Cell. Biol. 15, 1-11.
23. Lindsay R. M., Thoenen H., and Barde Y. A. (1985) Placode and neural crest-derived sensory neurons are responsive at early developmental stages to brain-derived neurotrophic factor. Dev. Biol. 112, 319-328.
24. Markus M. A., Kahle P. J., Winkler A., Horstmann S., Anneser J. M. H., and Borasio G. D. (1997) Survival-promoting activity of inhibitors of cyclin-dependent kinases on primary neurons correlates with inhibition of c-Jun kinase-1. Neurobiol. Dis. 4, 122-133.
25. Matsushime H., Quelle D. E., Shurtleff S. A. Shibuya M., Sherr C. J., and Kato J. Y. (1994) D-type cyclin-dependent kinase activity in mammalian cells. Mol. Cell. Biol. 14, 2066-2076.
26. Meijer L., Borgne A., Mulner O., Chong J. P., Blow J. J., Inagaki N., Inagaki M., Delcros J. G., and Moulinoux J. P. (1997) Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5. Eur. J. Biochem. 243, 527-536.
27. Mesner P. W., Epting C. L., Hegarty J. L., and Green S. H. (1995) A timetable of events during programmed cell death induced by trophic factor withdrawal from neuronal PC12 cells. J. Neurosci. 15, 7357-7366.
28. Meyer-Franke A., Kaplan M. R., Pfrieger F. W., and Barres B. A. (1995) Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron 15, 805-819.
29. Meyerson M. and Harlow E. (1994) Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol. Cell. Biol. 14, 2077-2086.
30. Minden A., Lin A., Smeal T., Dérijard B., Cobb M., Davis R., and Karin M. (1994) c-Jun N-terminal phosphorylation correlates with activation of the JNK subgroup but not the ERK subgroup of mitogen-activated protein kinases. Mol. Cell. Biol. 14, 6683-6688.
31. Nikolic M., Dudek H., Kwon Y. T., Ramos Y. F., and Tsai L. H. (1996) The cdk5/p35 kinase is essential for neunte outgrowth during neuronal differentiation. Genes Dev. 10, 816-825.
32. Oppenheim R. W. (1991) Cell death during development of the nervous system. Annu. Rev. Neurosci. 14, 453-501.
33. Oppenheim R. W., Prevette D., Tytell M., and Homma S. (1990) Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes. Dev. Biol. 138, 104-113.
34. Park D. S., Farinelli S. E., and Greene L. A. (1996) Inhibitors of cyclin-dependent kinases promote survival of post-mitotic neuronally differentiated PC12 cells and sympathetic neurons. J. Biol. Chem. 271, 8161-8169.
35. Pigino G., Paglini G., Ulloa L., Avila J., and Caceres A. (1997) Analysis of the expression, distribution and function of cyclin dependent kinase 5 (cdk5) in developing cerebellar macroneurons. J. Cell Sci. 110, 257-270.
36. Roffler-Tarlov S., Brown J. J., Tarlov E., Stolarov J., Chapman D. L., Alexiou M., and Papaioannou V. E. (1996) Programmed cell death in the absence of c-Fos and c-Jun. Development 122, 1-9.
37. Segal R. A., and Greenberg M. E. (1996) Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 19, 463-489.
38. Vesely J., Havlicek L., Strnad M., Blow J. J., Donella-Deana A., Pinna L., Letham D. S., Kato J., Detivaud L., Leclerc S., and Meijer L. (1994) Inhibition of cyclin-dependent kinases by purine analogues. Eur. J. Biochem. 224, 771-786.
39. Virdee K., Bannister A. J., Hunt S. P., and Tolkovsky A. M. (1997) Comparison between the timing of JNK activation, c-Jun phosphorylation, and onset of death commitment in sympathetic neurones. J. Neurochem. 69, 550-561.
40. Walker P. R. and Sikorska M. (1994) Endonuclease activities, chromatin structure, and DNA degradation in apoptosis. Biochem. Cell Biol. 72, 615-623.
41. Wu B.-Y., Fodor E. J. B., Edwards R. H., and Rutter W. J. (1989) Nerve growth factor induces the proto-oncogene c-jun in PC12 cells. J. Biol. Chem. 264, 9000-9003.
42. Xia Z., Dickens M., Raingeaud J., Davis R. J., and Greenberg M. E. (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331.
43. Xiang J., Lahti J. M., and Kidd V. J. (1994) 2-Aminopurine overrides a late telophase delay created by ectopic expression of the PITSLREβ1 protein kinase. Biochem. Biophys. Res. Commun. 199, 1167-1173.