Sequence requirements for removal of tRNA by an isolated human immunodeficiency virus type 1 RNase H domain

Journal of Virology

Volumn 72, Issue 8, 1998, Pages 6805-6812

  Smith, Christine M ^a   Leon, Oscar ^b   Smith, Jeffrey S ^a,c   Roth, Monica J ^a  

^a University of Medicine and Dentistry   (United States)

^b UNIVERSIDAD AUSTRAL DE CHILE   (Chile)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; DNA; HISTIDINE; MANGANESE; PURINE; RIBONUCLEASE H; RIBONUCLEOTIDE; RNA; TRANSFER RNA; VIRUS RNA;

ARTICLE; DNA RNA HYBRIDIZATION; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; RNA SEQUENCE; VIRUS REPLICATION;

EID: 0031902993     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.8.6805-6812.1998     Document Type: Article

References (41)

1. Arts, E. J., and S. F. Le Grice. 1998. Interaction of retroviral reverse transcriptase with template-primer duplex during replication. Prog. Nucleic Acid Res. Mol. Biol. 58:339-393.
2. Baltimore, D. 1970. RNA-dependent DNA polymerase in virions of RNA tumor viruses. Nature 226:1209-1211.
3. Berkower, I., J. Leis, and J. Hurwitz. 1973. Isolation and characterization of an endonuclease from Escherichia coli specific for ribonuclcic acid in ribonucleic acid-deoxyribonucleic acid hybrid structures. J. Biol. Chem. 248: 5914-5921.
4. Champoux, J. J., E. Gilboa, and D. Baltimore. 1984. Mechanism of RNA primer removal by the RNase H activity of avian myeloblastosis virus reverse transcriptase. J. Virol. 49:686-691.
5. Federoff, O. Y., M. Salazar, and B. R. Reid. 1996. Structural variation among retroviral primer-DNA junctions: solution of the HIV-1 (-)-strand Okazaki fragment r(gcca)d(GCAGTGGC). Biochemistry 35:11070-11080.
6. Ghosh, M., P. S. Jacques, D. W. Rodgers, M. Ottman, J. Darlix, and S. F. LeGrice. 1996. Alterations in the primer grip of p66 HIV-1 reverse transcriptase and their consequences for primer utilization. Biochemistry 35: 8553-8562.
7. Guo, J., W. Wu, Z. Y. Yuan, K. Post, R. J. Crouch, and J. G. Levin. 1995. Defects in primer-template binding, processive DNA synthesis, and RNase H activity associated with chimeric reverse transcriptases having the murine leukemia virus polymerase domain joined to the Escherichia coli RNase H. Biochemistry 34:5018-5029.
8. Hong, T., K. Drlica, A. Pinter, and E. Murphy. 1991. Circular DNA of human immunodeficiency virus: analysis of circle junction nucleotide sequences. J. Virol. 65:551-555.
9. Jurriaans, S., A. D. Ronde, J. Dekker, J. Goudsmit, and M. Cornellissen. 1992. Analysis of human immunodeficiency virus type 1 LTR-LTR junctions in peripheral blood mononuclear cells of infected individuals. J. Gen. Virol. 73:1537-1541.
10. Met. J. Virol. 71:207-217.
11. Kang, S. M., J. K. Wakefield, and C. D. Morrow. 1996. Mutations in both the U5 region and the primer-binding site influence the selection of the tRNA used for the initiation of HIV-1 reverse transcription. Virology 222:401-104.
12. Kulkosky, J., R. A. Katz, and A. M. Skalka. 1990. Terminal nucleotides of the preintegrative linear form of HIV-1 DNA deduced from the sequence of circular DNA junctions. J. Acquired Immune Defic. Syndr. 3:852.
13. Metzger, W., T. Hermann, O. Schatz, S. F. J. LeGrice, and H. Heumann. 1993. Hydroxyl radical footprint analysis of human immunodeficiency virus reverse transcriptase-template primer complexes. Proc. Natl. Acad. Sci. USA 90:5909-5913.
14. Omer, C. A., and A. J. Faras. 1982. Mechanism of release of the avian retrovirus tRNA Trp primer molecule from viral DNA by rihonuclease H during reverse transcription. Cell 30:797-805.
15. Palaniappan, C., M. Wisniewski, P. S. Jacques, S. F. LeGrice, P. J. Fay, and R. A. Bambara. 1997. Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function. J. Biol. Chem. 272: 11157-11164.
16. Pauza, C. D. 1990. Two bases are deleted from the termini of HIV-1 linear DNA during integrative recombination. Virology 179:886-889.
17. Powell, M. D., M. Ghosh, P. S. Jacques, K. J. Howard, S. F. LeGrice, and J. G. Levin. 1997. Alanine-scanning mutations in the "primer grip" of p66 HIV-1 reverse transcriptase result in selective loss of RNA priming activity. J. Biol. Chem. 272:13262-13269.
18. Pullen, K. A., L. K. Ishimoto, and J. J. Champoux. 1992. Incomplete removal of the RNA primer for minus-strand DNA synthesis by human immunodeficiency virus type 1 reverse transcriptase. J. Virol. 66:367-373.
19. Rausch, J. W., and S. F. J. LeGrice. 1997. Substituting a conserved residue of the ribonuclease H domain alters substrate hydrolysis by retroviral reverse transcriptase. J. Biol. Chem. 272:8602-8610.
20. Repaske, R., J. W. Hartley, M. F. Kavlick, R. R. O'Neill, and J. B. Austin. 1989. Inhibition of RNase H activity and viral replication by single mutations in the 3' region of Moloney murine leukemia virus reverse transcriptase. J. Virol. 63:1460-1464.
21. Resnick, R., C. A. Omer, and A. J. Faras. 1984. Involvement of retrovirus reverse transcriptase-associated RNase H in the initiation of strong-stop (+) DNA synthesis and the generation of the long terminal repeat. J. Virol 51: 813-821.
22. Lys primer-binding site of human immunodeficiency virus type 1 identify essential regions for reverse transcription. J. Virol. 65:4555-4564.
23. Salazar, M., J. J. Champoux, and B. R. Reid. 1993. Sugar conformations at hybrid duplex junctions in HIV-1 and Okazaki fragments. Biochemistry 32: 739-744.
24. Schatz, O., F. V. Cromme, F. Gruninger-Leitch, and S. F. J. LeGrice. 1989. Point mutations in conserved amino acid residues within the C-terminal domain of HIV-1 reverse transcriptase specifically repress RNase H function. FEBS Lett. 237:311-314.
25. Schatz, O., J. Mous, and S. F. J. LeGrice. 1990. HIV-1 RT-associated ribonuclease H displays both endonuclease and 3′-5′ exonuclease activity. EMBO J. 9:1171-1176.
26. Schultz, S. J., and J. J. Champoux. 1996. RNase H domain of Moloney murinc leukemia virus reverse transcriptase retains activity but requires the polymerase domain for specificity. J. Virol. 70:8630-8638.
27. Schultz, S. J., S. H. Whiting, and J. J. Champoux. 1995. Cleavage specificities of Moloney murine leukemia virus RNase H implicated in the second strand transfer during reverse transcription. J. Biol. Chem. 270:24135-24145.
28. Pro mediated by M-MuLV and HIV-1 reverse transcriptases. Virology 229:437-446.
29. Smith, J. S., K. Gritsman, and M. J. Roth. 1994. Contributions of DNA polymerase subdomains to the RNase H activity of HIV-1 reverse transcriptase. J. Virol. 68:5721-5729.
30. Smith, J. S., S. Kim, and M. J. Roth. 1990. Analysis of long terminal repeat circle junctions of human immunodeficiency virus type 1. J. Virol. 64:6286-6290.
31. Smith, J. S., and M. J. Roth. 1993. Purification and characterization of an active human immunodeficiency virus type 1 RNase H domain. J. Virol. 67: 4037-4049.
32. Lys3. J. Biol. Chem. 267:15071-15079.
33. Tanese, N., and S. P. Goff. 1988. Domain structure of Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activities. Proc. Natl. Acad. Sci. USA 85:1777-1781.
34. Tisdale, M., T. Schulze, B. A. Larder, and K. Moelling. 1991. Mutations within RNase H domain of HIV-1 reverse transcriptase abolish virus infectivity. J. Gen. Virol. 72:59-66.
35. Wakefield, J. K., and C. D. Morrow. 1996. Mutations within the primer binding site of the human immunodeficiency virus type 1 define sequence requirements essential for reverse transcription. Virology 220:290-298.
36. Wakefield, J. K., H. Rhim, and C. D. Morrow. 1994. Minimal sequence requirements of a functional human immunodeficiency virus type 1 primer binding site. J. Virol. 68:1605-1614.
37. Whitcomb, J. M., B. A. Ortiz-Conde, and S. H. Hughes. 1995. Replication of avian leukosis viruses with mutations at the primer binding site: use of alternative tRNAs as primers. J. Virol. 69:6228-6238.
38. Wohrl, B. M., B. Ehresman, G. Keith, and S. F. LeGrice. 1993. Nuclease footprinting of human immunodeficiency virus/tRNA(Lys-3) complex. J. Biol. Chem. 268:13617-13624.
39. Wohrl, B. M., M. M. Georgiadis, A. Telesnitsky, W. A. Hendrickson, and S. F. LeGrice. 1995. Footprint analysis of replicating murine leukemia virus reverse transcriptase. Science 267:96-99.
40. Wohrl, B. M., C. Tantillo, E. Arnold, and S. F. LeGrice. 1995. An expanded model of replicating human immunodeficiency virus reverse transcriptase. Biochemistry 34:5343-5356.
41. Zhan, X., and R. J. Crouch. 1997. The isolated RNase H domain of murine leukemia virus reverse transcriptase. Retention of activity with concomitant loss of specificity. J. Biol. Chem. 272:22023-22029.