[18F]Fluoroalkyl analogues of the potent 5-HT(1A) antagonist WAY 100635: Radiosyntheses and in vivo evaluation

Nuclear Medicine and Biology

Volumn 23, Issue 4, 1996, Pages 487-490

  Wilson, Alan A ^a   DaSilva, Jean N ^a   Houle, Sylvain ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

5 HT1A; Fluorine 18; Positron emission tomography

Indexed keywords

8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; FLUORINE 18; KETANSERIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RITANSERIN; SEROTONIN ANTAGONIST; SULPIRIDE; DIAGNOSTIC AGENT; FLUORINE; N (2 (4 (2 (2' FLUOROETHOXY)PHENYL) 1 PIPERAZINYL)ETHYL) N (2 PYRIDINYL)CYCLOHEXANE CARBOXAMIDE; N (2 (4 (2 (3' FLUOROPROPOXY)PHENYL) 1 PIPERAZINYL)ETHYL) N (2 PYRIDNYL)CYCLOHEXANE CARBOXAMIDE; N-(2-(4-(2-(2'-FLUOROETHOXY)PHENYL)-1-PIPERAZINYL)ETHYL)-N-(2-PYRIDINYL)CYCLOHEXANE CARBOXAMIDE; N-(2-(4-(2-(3'-FLUOROPROPOXY)PHENYL)-1-PIPERAZINYL)ETHYL)-N-(2-PYRIDNYL)CYCLOHEXANE CARBOXAMIDE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SEROTONIN 1 RECEPTOR; SEROTONIN RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; POSITRON EMISSION TOMOGRAPHY; RAT; ANIMAL; CHEMISTRY; DRUG EFFECT; ISOTOPE LABELING; MALE; METABOLISM; METHODOLOGY; RADIOCHEMISTRY; SPRAGUE DAWLEY RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TISSUE DISTRIBUTION;

ANIMALS; FLUORINE RADIOISOTOPES; ISOTOPE LABELING; MALE; PIPERIDINES; PYRIDINES; RADIOCHEMISTRY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION;

EID: 0030131582     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/0969-8051(96)00026-1     Document Type: Article

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