In vivo SPECT imaging of 5-HT(1A) receptors with [123I]p-MPPI in nonhuman primates

Synapse

Volumn 24, Issue 3, 1996, Pages 273-281

  Kung, Hank F ^a,b   Frederick, Dana ^a   Kim, Hee Joung ^a   McElgin, William ^a   Kung, Mei Ping ^a   Mu, Mu ^a   Mozley, P David ^a   Vessotskie, Janet M ^a   Stevenson, D Andrew ^a   Kushner, Steven A ^a   Zhuang, Zhi Ping ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE   (United States)

Author keywords

Antagonists; Hippocampus; Serotonin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; IODINE 123; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ARTICLE; BRAIN REGION; CENTRAL NERVOUS SYSTEM FUNCTION; CONTROLLED STUDY; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; NONHUMAN; NORMAL HUMAN; PRIMATE; PRIORITY JOURNAL; RECEPTOR DENSITY; SEROTONIN RELEASE; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY;

AMINOPYRIDINES; ANIMALS; AUTORADIOGRAPHY; BRAIN; BRAIN CHEMISTRY; IODINE RADIOISOTOPES; LIGANDS; MACACA FASCICULARIS; MAGNETIC RESONANCE IMAGING; PIPERAZINES; RECEPTORS, SEROTONIN; TISSUE DISTRIBUTION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 10544244582     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199611)24:3<273::AID-SYN10>3.0.CO;2-Y     Document Type: Article

References (41)

1. 1A receptors. Pharmacol. Biochem. Behav.
2. 2A receptor messenger-RNAs in human hippocampus using a reverse-transcriptase polymerase chain-reaction (RT-PCR) technique and their correlation with binding-site densities and age. Neurosci. Lett., 178:85-89.
3. 1A receptors. J. Med. Chem., 36:1509-1510.
4. Cross, A.J., Slater, P., Perry, E.K., and Perry, R.H. (1988) An autoradiographic analysis of serotonin receptors in human temporal cortex: changes in Alzheimer's-type dementia. Neurochem. Int., 13:89-96.
5. De Vivo, M., and Maayani, S. (1988) 5-HT receptors coupled to adenylate cyclase. In: The Serotonin Receptors. E. Sanders-Bush, ed. The Humana Press, Clifton, NJ, pp. 141-179.
6. 1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol. Sci., 14:441-448.
7. 1A antagonist BMY-7378, NAN-190 and (-)-propranolol on serotonergic dorsal raphe unit-activity in behaving cats. J. Pharmacol. Exp. Ther., 270:1359-1366.
8. 1A receptor. Biochemistry, 33:4283-4290.
9. 1A serotonin agonists and antagonists. Drug Dev. Res., 26:251-274.
10. 1A receptors in rat brain membranes. Eur. J. Pharmacol., 288:173-186.
11. 1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. Eur. J. Pharmacol., 211:211-219.
12. Hoyer, D., Clarke, D.E., Fozard, J.R., Hartig, P.R., Martin, G.R., Mylecharane, E.J., Saxena, P.R., and Humphrey, P.P.A. (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacological Rev., 46:157-203.
13. 1A receptors in rat brain. Eur. J. Pharmacol., 271:515-523.
14. 1A autoreceptors of the dorsal and median raphe nuclei. J. Pharmacol. Exp. Ther., 269:1268-1279.
15. 1A receptor antagonist: p-MPPI. Life Sci., 55:1459-1462.
16. 2 receptor imaging agent. J. Nucl. Med., 31:648-654.
17. 1A receptors in rat brain. Synapse, 18:359-366.
18. 125I]p-MPPI (4-(2′-methoxy-phenyl)-1-[2′-(n-2″-pyridinyl)-p-iodobenzamido] -ethyl-piperazine) as a new selective imaging radioligand of serotonin-1A sites in rat brain. In vitro binding and autoradiographic studies. J. Pharmacol. Exp. Ther., 272:429-437.
19. 3H]WAY 100635 in the mouse. Eur. J. Pharmacol., 271:505-514.
20. Lowry, O.H., Rosebrough, N.J., Farr, A.L., and Randall, R.J. (1951) Protein measurement with folin phenol reagent. J. Biol. Chem., 193:265-275.
21. Lucki, I., Singh, A., and Kreiss, D.S. (1994) Antidepressant-like behavioral-effects of serotonin receptor agonists. Neurosci. Biobehav. Rev., 18:85-95.
22. Macpherson, G.A. (1983) A practical computer-based approach to the analysis of radioligand binding experiments. Comput. Programs Biomed., 17:107-114.
23. A1 receptor systems in rat hippocampal membranes. J. Pharmacol. Exp. Ther., 263:1275-1284.
24. 1A receptors with positron emission tomography. Life Sci., 55:PL403-PL407.
25. Meltzer, H.Y., and Maes, M. (1994) Effect of pindolol on the 1-5-HTP-induced increase in plasma prolactin and cortisol concentrations in man. Psychopharmacology, 114:635-643.
26. 1A receptor-mediated effects of antidepressants [review]. Prog. Neuropsychopharmacol. Biol. Psychiatry, 17:1-19.
27. Pazos, A., Cortes, R., and Palacios, J.M. (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. II. Serotonin-2 receptors. Brain Res., 346:231-249.
28. 1A receptor of 1-aryl-4-[(1-tetralin)alkyl]piperazines. 2. J. Med. Chem., 38:942-949.
29. 1A receptors in vivo [abstr]. J. Nucl. Med., 36:58P.
30. 1A serotonin antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine with reduced alpha 1-adrenergic affinity. J. Med. Chem., 34:2633-2638.
31. Ritter, J.M., and Jones, T. (1995) PET: a symposium highlighting its clinical and pharmacological potential. Trends Pharmacol. Sci., 16:117-119.
32. Robson, L., Gower, A.J., Kendall, D.A., and Marsden, C.A. (1993) Age-related behavioral, neurochemical and radioligand binding changes in the central 5-HT system of Sprague-Dawley rats. Psychopharmacology, 113:274-281.
33. 1A receptors. Brain Res., 532:191-196.
34. Sedvall, G., Farde, L., Persson, A., and Wiesel, F.-A. (1986) Imaging of neurotransmitter receptors in the living human brain. Arch. Gen. Psychiatry, 43:995-1005.
35. Stahl, S. (1994) Is serotonin receptor down-regulation linked to the mechanism of action of antidepressant drugs? Psychopharmacol. Bull., 30:39-43.
36. 1A receptor activation in vivo. Life Sci., 56:PL163-PL168.
37. Weiland, G.A., and Molinoff, P.B. (1981) Quantitative analysis of drug-receptor interaction: I. Determination of kinetics and equilibrium properties. Life Sci., 29:313-330.
38. 1A receptor agonist, 8-OH-DPAT? Eur. J. Pharmacol., 193:253-256.
39. 1A receptor ligand. J. Med. Chem., 36:3161-3165.
40. 1A ligands. J. Med. Chem., 37:4572-4575.
41. 1A ligand. J. Med. Chem., 37:1406-1407.