-
1
-
-
11944267365
-
Antisense oligonucleotides: A new therapeutic principle
-
E. UHLMANN and A. PEYMAN, Antisense oligonucleotides: A new therapeutic principle, Chem. Rev. 90, 543-584 (1990).
-
(1990)
Chem. Rev.
, vol.90
, pp. 543-584
-
-
Uhlmann, E.1
Peyman, A.2
-
2
-
-
85022440392
-
Synthesis of oligonucleotide analogues with modified backbones
-
R. S. VARMA, Synthesis of oligonucleotide analogues with modified backbones, Synlett , 621-637 (1993).
-
(1993)
Synlett
, pp. 621-637
-
-
Varma, R.S.1
-
5
-
-
0002037211
-
Carbohydrate Modifications in Antisense Research
-
Am. Chem. Soc., Washington D.C.
-
Y. S. SANGHVI and P. D. COOK, Carbohydrate Modifications in Antisense Research, ACS Symp. Ser. 580, Am. Chem. Soc., Washington D.C. (1994).
-
(1994)
ACS Symp. Ser.
, vol.580
-
-
Sanghvi, Y.S.1
Cook, P.D.2
-
6
-
-
0345706517
-
Antisense oligonucleotides
-
A. DE MESMAEKER, R. HANER, P. MARTIN and H. E. MOSER, Antisense oligonucleotides, Acc. Chem. Res. 28, 366-374 (1995).
-
(1995)
Acc. Chem. Res.
, vol.28
, pp. 366-374
-
-
De Mesmaeker, A.1
Haner, R.2
Martin, P.3
Moser, H.E.4
-
8
-
-
0345164206
-
Antisense oligonucleotides
-
B. A. TEICHER, ed.. Humana Press, Totowa, NJ
-
S. T. CROOKE, Antisense oligonucleotides, pp. 299-366 in Cancer Therapeutics: Experimental and Clinical Agents, (B. A. TEICHER, ed.). Humana Press, Totowa, NJ (1996).
-
(1996)
Cancer Therapeutics: Experimental and Clinical Agents
, pp. 299-366
-
-
Crooke, S.T.1
-
10
-
-
0041582974
-
Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
-
P. C. ZAMECNIK and M. L. STEPHENSON, Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide, Proc. Natl. Acad. Sci. U.S.A. 75, 280-284 (1978).
-
(1978)
Proc. Natl. Acad. Sci. U.S.A.
, vol.75
, pp. 280-284
-
-
Zamecnik, P.C.1
Stephenson, M.L.2
-
11
-
-
0005772676
-
Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide
-
M. L. STEPHENSON and P. C. ZAMECNIK, Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide, Proc. Natl. Acad. Sci. U.S.A. 75, 285-288 (1978).
-
(1978)
Proc. Natl. Acad. Sci. U.S.A.
, vol.75
, pp. 285-288
-
-
Stephenson, M.L.1
Zamecnik, P.C.2
-
12
-
-
0001674585
-
Designer antisense oligonucleotides: Conjugation chemistry and functionality placement
-
S. T. CROOKE and B. LEBLEU, eds.. CRC Press, Boca Raton, FL
-
M. MANOHARAN, Designer antisense oligonucleotides: conjugation chemistry and functionality placement, pp. 303-349 in Antisense Research and Applications, (S. T. CROOKE and B. LEBLEU, eds.). CRC Press, Boca Raton, FL (1993).
-
(1993)
Antisense Research and Applications
, pp. 303-349
-
-
Manoharan, M.1
-
13
-
-
0029093853
-
Backbone modifications in oligonucleotides and peptide nucleic acid systems
-
A. DE MESMAEKER, K.-H. ALTMANN, A. WALDNER and S. WENDEBORN, Backbone modifications in oligonucleotides and peptide nucleic acid systems, Curr. Opin. Struct. Biol. 5, 343-355 (1995).
-
(1995)
Curr. Opin. Struct. Biol.
, vol.5
, pp. 343-355
-
-
De Mesmaeker, A.1
Altmann, K.-H.2
Waldner, A.3
Wendeborn, S.4
-
14
-
-
0030727765
-
The ups and downs of nucleic acid duplex stability: Structure-stability studies on chemically modified DNA:RNA duplexes
-
S. M. FREIER and K-H. ALTMANN, The ups and downs of nucleic acid duplex stability: Structure-stability studies on chemically modified DNA:RNA duplexes, Nucleic Acids Res. 25, 4429-4443 (1997).
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 4429-4443
-
-
Freier, S.M.1
Altmann, K.-H.2
-
15
-
-
0027246678
-
Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines
-
R. W. WAGNER, M. D. MATTEUCCI, G. J. LEWIS, A. J. GUTIERREZ, C. MOULDS and B. C. FRÖHLER, Antisense gene inhibition by oligonucleotides containing C-5 propyne pyrimidines, Science 260, 1510-1513 (1993).
-
(1993)
Science
, vol.260
, pp. 1510-1513
-
-
Wagner, R.W.1
Matteucci, M.D.2
Lewis, G.J.3
Gutierrez, A.J.4
Moulds, C.5
Fröhler, B.C.6
-
16
-
-
12644268252
-
Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo
-
B. P. MONIA, H. SASMOR, J. F. JOHNSTON, S. M. FREIER, E. A. LESNIK, M. MÜLLER, T. GEIGER, K-H. ALTMANN, H. MOSER and D. FABBRO, Sequence-specific antitumor activity of a phosphorothioate oligodeoxyribonucleotide targeted to human C-raf kinase supports an antisense mechanism of action in vivo, Proc. Natl. Acad. Sci. U.S.A. 93, 15481-15484 (1996).
-
(1996)
Proc. Natl. Acad. Sci. U.S.A.
, vol.93
, pp. 15481-15484
-
-
Monia, B.P.1
Sasmor, H.2
Johnston, J.F.3
Freier, S.M.4
Lesnik, E.A.5
Müller, M.6
Geiger, T.7
Altmann, K.-H.8
Moser, H.9
Fabbro, D.10
-
17
-
-
0031010177
-
2′-O-(2-Methyoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level by formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells
-
B. F. BAKER, S. S. LOT, T. P. CONDON, S. CHENG-FLOURNEY, E. A. LESNIK, H. M. SASMOR and C. F. BENNETT, 2′-O-(2-Methyoxy)ethyl-modified anti-intercellular adhesion molecule 1 (ICAM-1) oligonucleotides selectively increase the ICAM-1 mRNA level by formation of the ICAM-1 translation initiation complex in human umbilical vein endothelial cells, J. Biol. Chem. 272, 11994-12000 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 11994-12000
-
-
Baker, B.F.1
Lot, S.S.2
Condon, T.P.3
Cheng-Flourney, S.4
Lesnik, E.A.5
Sasmor, H.M.6
Bennett, C.F.7
-
18
-
-
0029099305
-
A new access to 2′-O-alkylated ribonucleosides and properties of 2′-O-alkylated oligoribonucleotides
-
P. MARTIN, A new access to 2′-O-alkylated ribonucleosides and properties of 2′-O-alkylated oligoribonucleotides, Helv. Chim. Acta 78, 486-504 (1995).
-
(1995)
Helv. Chim. Acta
, vol.78
, pp. 486-504
-
-
Martin, P.1
-
19
-
-
18844455464
-
Second generation of antisense oligonucleotides: From nuclease resistance to biological efficacy in animals
-
K-H. ALTMANN, N. M. DEAN, D. FABBRO, S. M. FREIER, T. GEIGER, R. HANER, D. HÜSKEN, P. MARTIN, B. P. MONIA, M. MÜLLER, F. NATT, P. NICKLIN, J. PHILLIPS, U. PIELES, H. SASMOR and H. E. MOSER, Second generation of antisense oligonucleotides: from nuclease resistance to biological efficacy in animals, Chimia 50, 168-176 (1996).
-
(1996)
Chimia
, vol.50
, pp. 168-176
-
-
Altmann, K.-H.1
Dean, N.M.2
Fabbro, D.3
Freier, S.M.4
Geiger, T.5
Haner, R.6
Hüsken, D.7
Martin, P.8
Monia, B.P.9
Müller, M.10
Natt, F.11
Nicklin, P.12
Phillips, J.13
Pieles, U.14
Sasmor, H.15
Moser, H.E.16
-
20
-
-
0029791763
-
Second-generation antisense oligonucleotides: Structure-activity relationships and the design of improved signal-transduction inhibitors
-
K-H. ALTMANN, D. FABBRO, N. M. DEAN, T. GEIGER, P. MONIA, M. MÜLLER and P. NICKLIN, Second-generation antisense oligonucleotides: structure-activity relationships and the design of improved signal-transduction inhibitors, Biochem. Soc. Trans. 24, 630-637 (1996).
-
(1996)
Biochem. Soc. Trans.
, vol.24
, pp. 630-637
-
-
Altmann, K.-H.1
Fabbro, D.2
Dean, N.M.3
Geiger, T.4
Monia, P.5
Müller, M.6
Nicklin, P.7
-
21
-
-
0030463954
-
2′-O-Aminopropyl ribonucleotides: A zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides
-
R. H. GRIFFEY, B. P. MONIA, L. L. CUMMINS, S. FREIER, M. J. GREIG, C. J. GUINOSSO, E. A. LESNIK, S. M. MANALILI, V. MOHAN, S. OWENS, B. R. ROSS, H. SASMOR, E. WANCEWICZ, K. WEILER, P. D. WHEELER and P. D. COOK, 2′-O-Aminopropyl ribonucleotides: a zwitterionic modification that enhances the exonuclease resistance and biological activity of antisense oligonucleotides, J. Med. Chem. 39, 5100-5109 (1996).
-
(1996)
J. Med. Chem.
, vol.39
, pp. 5100-5109
-
-
Griffey, R.H.1
Monia, B.P.2
Cummins, L.L.3
Freier, S.4
Greig, M.J.5
Guinosso, C.J.6
Lesnik, E.A.7
Manalili, S.M.8
Mohan, V.9
Owens, S.10
Ross, B.R.11
Sasmor, H.12
Wancewicz, E.13
Weiler, K.14
Wheeler, P.D.15
Cook, P.D.16
-
22
-
-
0028177581
-
Oligodeoxyribonucleotide N3′ → P5′ phosphoramidates: Synthesis and hybridization properties
-
S. M. GRYAZNOV and J. K. CHEN, Oligodeoxyribonucleotide N3′ → P5′ phosphoramidates: Synthesis and hybridization properties, J. Am. Chem. Soc. 116, 3143-3144 (1994).
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 3143-3144
-
-
Gryaznov, S.M.1
Chen, J.K.2
-
23
-
-
0028983405
-
Oligonucleotide N3′ → P5′ phosphoramidates
-
S. M. GRYAZNOV, D. H. LLOYD, J-K. CHEN, R. G. SCHULTZ, L. A. DEDIONISIO, L. RATMEYER and W. D. WILSON, Oligonucleotide N3′ → P5′ phosphoramidates, Proc. Natl. Acad. Sci. U.S.A. 92, 5798-5802 (1995).
-
(1995)
Proc. Natl. Acad. Sci. U.S.A.
, vol.92
, pp. 5798-5802
-
-
Gryaznov, S.M.1
Lloyd, D.H.2
Chen, J.-K.3
Schultz, R.G.4
Dedionisio, L.A.5
Ratmeyer, L.6
Wilson, W.D.7
-
24
-
-
0021891882
-
Nucleoside phosphorothioates
-
F. ECKSTEIN, Nucleoside phosphorothioates, Ann. Rev. Biochem. 54, 367-402 (1985).
-
(1985)
Ann. Rev. Biochem.
, vol.54
, pp. 367-402
-
-
Eckstein, F.1
-
25
-
-
0027474318
-
Phosphorodithioate DNA as a potential therapeutic drug
-
W. S. MARSHALL and M. H. CARUTHERS, Phosphorodithioate DNA as a potential therapeutic drug, Science 259, 1564-1570 (1993).
-
(1993)
Science
, vol.259
, pp. 1564-1570
-
-
Marshall, W.S.1
Caruthers, M.H.2
-
26
-
-
0000140697
-
Developing antisense oligonucleotides from laboratory to clinical trials
-
D. E. SZYMKOWSKI, Developing antisense oligonucleotides from laboratory to clinical trials, Drug Discov. Today 1, 415-428 (1996).
-
(1996)
Drug Discov. Today
, vol.1
, pp. 415-428
-
-
Szymkowski, D.E.1
-
27
-
-
0031027349
-
In vivo studies with antisense oligonucleotides
-
S. AKHTAR and S. AGRAWAL, In vivo studies with antisense oligonucleotides, Trends Pharmacol. Sci. 18, 12-19 (1997).
-
(1997)
Trends Pharmacol. Sci.
, vol.18
, pp. 12-19
-
-
Akhtar, S.1
Agrawal, S.2
-
28
-
-
0030951966
-
Antisense '97: A roundtable on the state of the industry
-
Antisense '97: A roundtable on the state of the industry, Feature article in Nature Biotechn. 15, 519-524 (1997).
-
(1997)
Feature Article in Nature Biotechn.
, vol.15
, pp. 519-524
-
-
-
29
-
-
0344733946
-
Antisense Medicinal Chemistry
-
ed. S. T. CROOKE, Springer, New York, NY. in press
-
P. D. COOK., Antisense Medicinal Chemistry. In Protocols in Experimental Pharmacology, ed. S. T. CROOKE, Springer, New York, NY. 1997 (in press).
-
(1997)
Protocols in Experimental Pharmacology
-
-
Cook, P.D.1
-
30
-
-
0029071029
-
Enzymatic synthesis of stereoregular (all Rp) oligonucleotide phosphorothioate and its properties
-
J. TANG, A. ROSKEY, Y. LI and S. AGRAWAL, Enzymatic synthesis of stereoregular (all Rp) oligonucleotide phosphorothioate and its properties, Nucleosides & Nucleotides 14, 985-990 (1995).
-
(1995)
Nucleosides & Nucleotides
, vol.14
, pp. 985-990
-
-
Tang, J.1
Roskey, A.2
Li, Y.3
Agrawal, S.4
-
31
-
-
0029609588
-
Diastereomers of nucleoside 3′-O-2-Thio-1,3,2-oxathia(selenaphospholanes): Building blocks for stereocontrolled synthesis of oligo(nucleoside phosphorothioate)s
-
W. J. STEC, A. GRAJKOWSKI, A. KOBYLANSKA, B. KARWOWSKI, M. KOZIOLKIEWICZ, K. MISIURA, A. OKRUSZEK, A. WILK, P. GUGA and M. BOCZKOWSKA, Diastereomers of nucleoside 3′-O-(2-Thio-1,3,2-oxathia(selenaphospholanes): Building blocks for stereocontrolled synthesis of oligo(nucleoside phosphorothioate)s, J. Am. Chem. Soc. 117, 12019-12029 (1995).
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 12019-12029
-
-
Stec, W.J.1
Grajkowski, A.2
Kobylanska, A.3
Karwowski, B.4
Koziolkiewicz, M.5
Misiura, K.6
Okruszek, A.7
Wilk, A.8
Guga, P.9
Boczkowska, M.10
-
32
-
-
0029984257
-
Influence of a thiophosphate linkage on the duplex stability - Does Sp configuration always lead to higher stability than Rp?
-
H. KANEHARA, T. WADA, M. MIZUGUCHI and K. MAKINO, Influence of a thiophosphate linkage on the duplex stability - does Sp configuration always lead to higher stability than Rp?, Nucleosides & Nucleotides 15, 1169-1178 (1996).
-
(1996)
Nucleosides & Nucleotides
, vol.15
, pp. 1169-1178
-
-
Kanehara, H.1
Wada, T.2
Mizuguchi, M.3
Makino, K.4
-
33
-
-
0030980028
-
Stability of stereoregular oligo(nucleoside phosphorothioate)s
-
M. KOZIOLKIEWICZ, M. WOJCIK, A. KOBYLANSKA, B. KARWOWSKI, B. REBOWSKA, P. GUGA and W. J. STEC. Stability of stereoregular oligo(nucleoside phosphorothioate)s pp. 43-48 in Human Plasma: Diastereoselectivity of plasma 3′-exonuclease. Antisense & Nucleic Acid Drug Development, vol. 7 (1997).
-
(1997)
Human Plasma: Diastereoselectivity of Plasma 3′-exonuclease. Antisense & Nucleic Acid Drug Development
, vol.7
, pp. 43-48
-
-
Koziolkiewicz, M.1
Wojcik, M.2
Kobylanska, A.3
Karwowski, B.4
Rebowska, B.5
Guga, P.6
Stec, W.J.7
-
34
-
-
0030990479
-
A stereoselective synthesis of dinucleotide phosphorothioates, using chiral indol-oxazaphosphorine intermediates
-
J. C. WANG and G. JUST, A stereoselective synthesis of dinucleotide phosphorothioates, using chiral indol-oxazaphosphorine intermediates, Tetrahedron Lett. 38, 3797-3800 (1997).
-
(1997)
Tetrahedron Lett.
, vol.38
, pp. 3797-3800
-
-
Wang, J.C.1
Just, G.2
-
35
-
-
0000876636
-
Measurement of macromolecular binding using electrospray mass spectrometry. Determination of dissociation constants for oligonucleotide-serum albumin complexes
-
M. J. GREIG, H. GAUS, L. L. CUMMINS, H. SASMOR and R. H. GRIFFEY, Measurement of macromolecular binding using electrospray mass spectrometry. Determination of dissociation constants for oligonucleotide-serum albumin complexes, J. Am. Chem. Soc. 117, 10765-10766 (1995).
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 10765-10766
-
-
Greig, M.J.1
Gaus, H.2
Cummins, L.L.3
Sasmor, H.4
Griffey, R.H.5
-
36
-
-
12644302203
-
Pharmacokinetic properties of several novel oligonucleotide analogs in mice
-
S. T. CROOKE, M. J. GRAHAM, J. E. ZUCKERMAN, D. BROOKS, B. S. CONKLIN, L. L. CUMMINS, M. J. GREIG, C. J. GUINOSSO, D. KORNBRUST, M. MANOHARAN, H. M. SASMOR, T. SCHLEICH, K. L. TIVEL and R. H. GRIFFEY, Pharmacokinetic properties of several novel oligonucleotide analogs in mice, J. Pharm. Expr. Therap. 277, 923-937 (1996).
-
(1996)
J. Pharm. Expr. Therap.
, vol.277
, pp. 923-937
-
-
Crooke, S.T.1
Graham, M.J.2
Zuckerman, J.E.3
Brooks, D.4
Conklin, B.S.5
Cummins, L.L.6
Greig, M.J.7
Guinosso, C.J.8
Kornbrust, D.9
Manoharan, M.10
Sasmor, H.M.11
Schleich, T.12
Tivel, K.L.13
Griffey, R.H.14
-
37
-
-
0029100397
-
Absorption, tissue distribution and in vivo stability in rats of a hybrid anti-sense oligonucleotide following oral administration
-
S. AGRAWAL, X. ZHANG, Z. LU, H. ZHAO, J. M. TAMBURIN, J. YAN, H. CAI, R. B. DIASIO, I. HABUS, Z. JIANG, R. P. IYER, D. YU and R. ZHANG, Absorption, tissue distribution and in vivo stability in rats of a hybrid anti-sense oligonucleotide following oral administration, Biochem. Pharm. 50, 571-576 (1995).
-
(1995)
Biochem. Pharm.
, vol.50
, pp. 571-576
-
-
Agrawal, S.1
Zhang, X.2
Lu, Z.3
Zhao, H.4
Tamburin, J.M.5
Yan, J.6
Cai, H.7
Diasio, R.B.8
Habus, I.9
Jiang, Z.10
Iyer, R.P.11
Yu, D.12
Zhang, R.13
-
38
-
-
33749282063
-
Targeting RNA with conformationally restricted oligonucleotides
-
P. HERDEWIJN, Targeting RNA with conformationally restricted oligonucleotides, Liebigs Ann. 1337-1348 (1996).
-
(1996)
Liebigs Ann.
, pp. 1337-1348
-
-
Herdewijn, P.1
-
39
-
-
0000117791
-
Structural aspects of nucleic acid analogs and antisense oligonucleotides
-
M. EGLI, Structural aspects of nucleic acid analogs and antisense oligonucleotides, Angew. Chem. Int. Ed. Engl. 35, 1894-1909 (1996).
-
(1996)
Angew. Chem. Int. Ed. Engl.
, vol.35
, pp. 1894-1909
-
-
Egli, M.1
-
40
-
-
0029077840
-
Characterization of fully 2′-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity
-
L. L. CUMMINS, S. R. OWENS, M. L. RISEN, E. A. LESNIK, S. M. FREIER, D. McGEE, C. J. GUINOSSO and P. D. COOK, Characterization of fully 2′-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity, Nucleic Acids Res. 23, 2019-2024 (1995).
-
(1995)
Nucleic Acids Res.
, vol.23
, pp. 2019-2024
-
-
Cummins, L.L.1
Owens, S.R.2
Risen, M.L.3
Lesnik, E.A.4
Freier, S.M.5
McGee, D.6
Guinosso, C.J.7
Cook, P.D.8
-
41
-
-
0027204049
-
Oligodeoxynucleotides containing 2′-O-modified adenosine: Synthesis and effects on stability of DNA:RNA duplexes
-
E. A. LESNIK, C. J. GUINOSSO, A. M. KAWASAKI, H. SASMOR, M. ZOUNES, L. L. CUMMINS, D. J. ECKER, P. D. COOK and S. M. FREIER, Oligodeoxynucleotides containing 2′-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes, Biochemistry 32, 7832-7838 (1993).
-
(1993)
Biochemistry
, vol.32
, pp. 7832-7838
-
-
Lesnik, E.A.1
Guinosso, C.J.2
Kawasaki, A.M.3
Sasmor, H.4
Zounes, M.5
Cummins, L.L.6
Ecker, D.J.7
Cook, P.D.8
Freier, S.M.9
-
42
-
-
0027479864
-
Uniformly modified 2′-deoxy-2′-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets
-
A. M. KAWASAKI, M. D. CASPER, S. M. FREIER, E. A. LESNIK, M. C. ZOUNES, L. L. CUMMINS, C. GONZALEZ and P. D. COOK, Uniformly modified 2′-deoxy-2′-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets, J Med. Chem. 36, 831-841 (1993).
-
(1993)
J Med. Chem.
, vol.36
, pp. 831-841
-
-
Kawasaki, A.M.1
Casper, M.D.2
Freier, S.M.3
Lesnik, E.A.4
Zounes, M.C.5
Cummins, L.L.6
Gonzalez, C.7
Cook, P.D.8
-
43
-
-
0030038280
-
Oligo-2′-fluoro-2′-deoxynucleotide N3′ → P5′ phosphoramidates: Synthesis and properties
-
R. G. SCHULTZ and S. M. GRYAZNOV, Oligo-2′-fluoro-2′-deoxynucleotide N3′ → P5′ phosphoramidates: synthesis and properties, Nucleic Acids Res. 24, 2966-2973 (1996).
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 2966-2973
-
-
Schultz, R.G.1
Gryaznov, S.M.2
-
44
-
-
0028968912
-
Site and mechanism of anti-sense inhibition by C-5 propyne oligonucleotides
-
C. MOULDS, J. G. LEWIS, B. C. FROEHLER, D. GRANT, T. HUANG, J. F. MILLIGAN, M. D. MATTEUCCI and R. W. WAGNER, Site and mechanism of anti-sense inhibition by C-5 propyne oligonucleotides, Biochemistry 34, 5044-5053 (1995).
-
(1995)
Biochemistry
, vol.34
, pp. 5044-5053
-
-
Moulds, C.1
Lewis, J.G.2
Froehler, B.C.3
Grant, D.4
Huang, T.5
Milligan, J.F.6
Matteucci, M.D.7
Wagner, R.W.8
-
45
-
-
0031019342
-
Binding affinity and specificity of Escherichia coli RNase H1: Impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids
-
W. F. LIMA and S. T. CROOKE, Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids, Biochemistry 36, 5004-5019 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 5004-5019
-
-
Lima, W.F.1
Crooke, S.T.2
-
46
-
-
0030849094
-
The influence of antisense oligonucleotide-induced RNA structure on E. coli RNase H1 activity
-
W. F. LIMA, V. MOHAN and S. T. CROOKE, The influence of antisense oligonucleotide-induced RNA structure on E. coli RNase H1 activity, J. Biol. Chem. 272, 18191-18199 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18191-18199
-
-
Lima, W.F.1
Mohan, V.2
Crooke, S.T.3
-
47
-
-
0030872852
-
RNase H-independent antisense activity of oligonucleotide N3′ → P5′ phosphoramidates
-
O. HEIDENREICH, S. GRYAZNOV and M. NERENBERG, RNase H-independent antisense activity of oligonucleotide N3′ → P5′ phosphoramidates, Nucleic Acids Res. 25, 776-780 (1997).
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 776-780
-
-
Heidenreich, O.1
Gryaznov, S.2
Nerenberg, M.3
-
48
-
-
0026332351
-
Medicinal chemistry of antisense oligonucleotides - Future opportunities
-
P. D. COOK, Medicinal chemistry of antisense oligonucleotides - future opportunities, Anti-Cancer Drug Design 6, 585-607 (1991).
-
(1991)
Anti-Cancer Drug Design
, vol.6
, pp. 585-607
-
-
Cook, P.D.1
-
49
-
-
0003098462
-
Medicinal chemistry strategies for antisense research
-
S. T. CROOKE and B. LEBLEU, eds.. CRC Press, Boca Raton, FL
-
P. D. COOK, Medicinal chemistry strategies for antisense research, pp. 149-187 in Antisense Research and Applications, (S. T. CROOKE and B. LEBLEU, eds.). CRC Press, Boca Raton, FL (1993).
-
(1993)
Antisense Research and Applications
, pp. 149-187
-
-
Cook, P.D.1
-
50
-
-
0027168725
-
Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression
-
B. P. MONIA, E. A. LESNIK, C. GONZALEZ, W. F. LIMA, D. MCGEE, C. J. GUINOSSO, A. M. KAWASAKI, P. D. COOK and S. M. FREIER, Evaluation of 2′-modified oligonucleotides containing 2′-deoxy gaps as antisense inhibitors of gene expression, J. Biol. Chem. 268, 14514-14522 (1993).
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 14514-14522
-
-
Monia, B.P.1
Lesnik, E.A.2
Gonzalez, C.3
Lima, W.F.4
Mcgee, D.5
Guinosso, C.J.6
Kawasaki, A.M.7
Cook, P.D.8
Freier, S.M.9
-
51
-
-
0030807543
-
Evaluation of antisense sequences directed against the bcl-2 mRNA reveals a novel oligonucleotide targeting the coding region as potent inducer of apoptosis in small cell lung cancer
-
A. ZIEGLER, G. LUEDKE, D. FABBRO, K.-H. ALTMANN, R. A. STAHEL and U. ZANGEMEISTER-WITTKE, Evaluation of antisense sequences directed against the bcl-2 mRNA reveals a novel oligonucleotide targeting the coding region as potent inducer of apoptosis in small cell lung cancer, J. Natl. Cancer Inst. 89, 1027-1036 (1997).
-
(1997)
J. Natl. Cancer Inst.
, vol.89
, pp. 1027-1036
-
-
Ziegler, A.1
Luedke, G.2
Fabbro, D.3
Altmann, K.-H.4
Stahel, R.A.5
Zangemeister-Wittke, U.6
-
52
-
-
0002796803
-
Pharmacology of antisense therapeutic agents
-
S. AGRAWAL, ed.. Humana Press, Totowa, NJ
-
C. F. BENNETT, N. DEAN, D. J. ECKER and B. P. MONIA, Pharmacology of antisense therapeutic agents, pp. 13-46 in Methods in Molecular Medicine: Antisense Therapeutics, (S. AGRAWAL, ed.). Humana Press, Totowa, NJ (1996).
-
(1996)
Methods in Molecular Medicine: Antisense Therapeutics
, pp. 13-46
-
-
Bennett, C.F.1
Dean, N.2
Ecker, D.J.3
Monia, B.P.4
-
53
-
-
0030906533
-
Crystal structures of oligodeoxyribonucleotides containing 6′-α-methyl and 6′-α-hydroxy carbocyclic thymidines
-
S. PORMANN, K.-H. ALTMANN, N. REYNES and M. EGLI, Crystal structures of oligodeoxyribonucleotides containing 6′-α-methyl and 6′-α-hydroxy carbocyclic thymidines, J. Am. Chem. Soc. 119, 2396-2403 (1997).
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 2396-2403
-
-
Pormann, S.1
Altmann, K.-H.2
Reynes, N.3
Egli, M.4
-
54
-
-
0000831957
-
Crystal structure of a parallel-stranded duplex of a deoxycytidylyl-(3′-5′)-deoxycytidine analogue containing intranucleosidyl C(3′)-C(5′) ethylene bridges
-
M. EGLI, P. LUBINI, M. BOLLI, M. DOBLER and C. LEUMANN, Crystal structure of a parallel-stranded duplex of a deoxycytidylyl-(3′-5′)-deoxycytidine analogue containing intranucleosidyl C(3′)-C(5′) ethylene bridges, J. Am. Chem. Soc. 115, 5855-5856 (1993).
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 5855-5856
-
-
Egli, M.1
Lubini, P.2
Bolli, M.3
Dobler, M.4
Leumann, C.5
-
55
-
-
75449117197
-
A parallel-stranded double helix at atomic resolution
-
R. H. SARMA and M. H. SARMA, eds. Adenine Press, Schenectady, NY
-
P. LUBINI and M. EGLI, A parallel-stranded double helix at atomic resolution, pp. 155-175 in Structural Biology: The State of the Art Proceedings of the Eighth Conversation, State University of New York, Albany, NY 1993. Vol. 2. (R. H. SARMA and M. H. SARMA, eds). Adenine Press, Schenectady, NY (1994).
-
(1994)
Structural Biology: The State of the Art Proceedings of the Eighth Conversation, State University of New York, Albany, NY 1993
, vol.2
, pp. 155-175
-
-
Lubini, P.1
Egli, M.2
-
56
-
-
0000970139
-
Crystal structure of a dimethylene sulfone linked ribodinucleotide analog
-
A. L. ROUGHTON, S. PORTMANN, S. A. BENNER and M. EGLI, Crystal structure of a dimethylene sulfone linked ribodinucleotide analog, J. Am. Chem. Soc. 117, 7249-7250 (1995).
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 7249-7250
-
-
Roughton, A.L.1
Portmann, S.2
Benner, S.A.3
Egli, M.4
-
57
-
-
0032554065
-
Consequences of replacing the DNA 3′-oxygen by an amino group: High-resolution crystal structure of a fully modified N3′ → P5′ phosphoramidate DNA dodecamer duplex
-
V. TERESHKO, S. GRYAZNOV and M. EGLI, Consequences of replacing the DNA 3′-oxygen by an amino group: High-resolution crystal structure of a fully modified N3′ → P5′ phosphoramidate DNA dodecamer duplex, J. Am. Chem. Soc. 120, 269-283 (1998).
-
(1998)
J. Am. Chem. Soc.
, vol.120
, pp. 269-283
-
-
Tereshko, V.1
Gryaznov, S.2
Egli, M.3
-
58
-
-
0029021044
-
Synthesis of 5′-C-methyl-D-allo-& L-talo-ribonucleoside 3′-O-phosphoramidates & their incorporation into hammerhead ribozymes
-
L. BEIGELMAN, A. KARPEISKY and U. USMAN, Synthesis of 5′-C-methyl-D-allo-& L-talo-ribonucleoside 3′-O-phosphoramidates & their incorporation into hammerhead ribozymes, Nucleosides & Nucleotides 14, 901-905 (1995).
-
(1995)
Nucleosides & Nucleotides
, vol.14
, pp. 901-905
-
-
Beigelman, L.1
Karpeisky, A.2
Usman, U.3
-
59
-
-
0028500180
-
Stabilizing effects of the RNA 2′-substituent: Crystal structure of an oligodeoxynucleotide duplex containing 2′-O-methylated adenosines
-
P. LUBINI, W. ZÜRCHER and M. EGLI, Stabilizing effects of the RNA 2′-substituent: crystal structure of an oligodeoxynucleotide duplex containing 2′-O-methylated adenosines, Chem. & Biol. 1, 39-45 (1994).
-
(1994)
Chem. & Biol.
, vol.1
, pp. 39-45
-
-
Lubini, P.1
Zürcher, W.2
Egli, M.3
-
60
-
-
0029999204
-
Synthesis and structure of 1-deoxy-1-phenyl-β-D-ribofuranose and its incorporation into oligonucleotides
-
J. MATULIC-ADAMIC, L. BEIGELMAN, S. PORTMANN, M. EGLI and N. USMAN, Synthesis and structure of 1-deoxy-1-phenyl-β-D-ribofuranose and its incorporation into oligonucleotides, J. Org. Chem. 61, 3909-3911 (1996).
-
(1996)
J. Org. Chem.
, vol.61
, pp. 3909-3911
-
-
Matulic-Adamic, J.1
Beigelman, L.2
Portmann, S.3
Egli, M.4
Usman, N.5
-
61
-
-
0029956116
-
RNA hydration: A detailed look
-
M. EGLI, S. PORTMANN and N. USMAN, RNA hydration: A detailed look, Biochemistry 35, 8489-8494 (1996).
-
(1996)
Biochemistry
, vol.35
, pp. 8489-8494
-
-
Egli, M.1
Portmann, S.2
Usman, N.3
-
62
-
-
0027299690
-
Conformational influence of the ribose 2′-hydroxyl group: Crystal structures of DNA-RNA chimeric duplexes
-
M. EGLI, N. USMAN and A. RICH, Conformational influence of the ribose 2′-hydroxyl group: Crystal structures of DNA-RNA chimeric duplexes, Biochemistry 32, 3221-3237 (1993).
-
(1993)
Biochemistry
, vol.32
, pp. 3221-3237
-
-
Egli, M.1
Usman, N.2
Rich, A.3
-
63
-
-
0028350664
-
A single 2′-hydroxyl group converts B-DNA to A-DNA. Crystal structure of the DNA-RNA chimeric decamer d(CCGGC)r(G)d(CCGG) with a novel intermolecular G•C base-paired quadruplet
-
C. BAN, B. RAMAKRISHNAN and M. SUNDARALINGAM, A single 2′-hydroxyl group converts B-DNA to A-DNA. Crystal structure of the DNA-RNA chimeric decamer d(CCGGC)r(G)d(CCGG) with a novel intermolecular G•C base-paired quadruplet, J. Mol. Biol. 236, 275-285 (1994).
-
(1994)
J. Mol. Biol.
, vol.236
, pp. 275-285
-
-
Ban, C.1
Ramakrishnan, B.2
Sundaralingam, M.3
-
64
-
-
0030572981
-
The structure of an RNA/DNA hybrid: A substrate of the ribonuclease activity of HIV-1 reverse transcriptase
-
N. C. HORTON and B. C. FINZEL, The structure of an RNA/DNA hybrid: A substrate of the ribonuclease activity of HIV-1 reverse transcriptase, J. Mol. Biol. 264, 521-533 (1996).
-
(1996)
J. Mol. Biol.
, vol.264
, pp. 521-533
-
-
Horton, N.C.1
Finzel, B.C.2
-
65
-
-
0343387237
-
Crystallization and preliminary X-ray diffraction analysis of double-helical RNA octamers
-
M. EGLI, S. PORTMANN, D. TRACZ, C. WORKMAN and N. USMAN, Crystallization and preliminary X-ray diffraction analysis of double-helical RNA octamers, Acta Cryst. D 51, 1065-1070 (1995).
-
(1995)
Acta Cryst. D
, vol.51
, pp. 1065-1070
-
-
Egli, M.1
Portmann, S.2
Tracz, D.3
Workman, C.4
Usman, N.5
-
66
-
-
0029051383
-
The crystal structure of r(CCCCGGGG) in two distinct lattices
-
S. PORTMANN, N. USMAN and M. EGLI, The crystal structure of r(CCCCGGGG) in two distinct lattices, Biochemistry 34, 7569-7575 (1995).
-
(1995)
Biochemistry
, vol.34
, pp. 7569-7575
-
-
Portmann, S.1
Usman, N.2
Egli, M.3
-
67
-
-
0026206788
-
Sparse matrix sampling: A screening method for crystallization of proteins
-
J. JANCARIK and S-H. KIM, Sparse matrix sampling: a screening method for crystallization of proteins, J. Appl. Crystallogr. 24, 409-411 (1991).
-
(1991)
J. Appl. Crystallogr.
, vol.24
, pp. 409-411
-
-
Jancarik, J.1
Kim, S.-H.2
-
68
-
-
0029115376
-
Rapid crystallization of chemically synthesized "hammerhead" RNAs using a "double-screening" procedure
-
W. G. SCOTT, J. T. FINCH, R. GRENFELL, J. FOGG, T. SMITH, M. J. GAIT and A. KLUG, Rapid crystallization of chemically synthesized "hammerhead" RNAs using a "double-screening" procedure, J. Mol. Biol. 250, 327-332 (1995).
-
(1995)
J. Mol. Biol.
, vol.250
, pp. 327-332
-
-
Scott, W.G.1
Finch, J.T.2
Grenfell, R.3
Fogg, J.4
Smith, T.5
Gait, M.J.6
Klug, A.7
-
69
-
-
0030132944
-
A highly efficient 24-condition matrix for the crystallization of nucleic acid fragments
-
I. BERGER, C.-H. KANG, N. SINHA, M. WOLTERS and A. RICH, A highly efficient 24-condition matrix for the crystallization of nucleic acid fragments, Acta Crystallogr. D 52, 465-468 (1996).
-
(1996)
Acta Crystallogr. D
, vol.52
, pp. 465-468
-
-
Berger, I.1
Kang, C.-H.2
Sinha, N.3
Wolters, M.4
Rich, A.5
-
70
-
-
0018787717
-
Protein crystallization using incomplete factorial experiments
-
C. W. CARTER, JR and C. W. CARTER, Protein crystallization using incomplete factorial experiments, J. Biol. Chem. 254, 12219-12223 (1979).
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 12219-12223
-
-
Carter C.W., Jr.1
Carter, C.W.2
-
71
-
-
0027237520
-
Crystallization of ribozymes and small RNA motifs by a sparse matrix approach
-
J. A. DOUDNA, C. GROSSHANS, A. GOODING and C. E. KUNDROT, Crystallization of ribozymes and small RNA motifs by a sparse matrix approach, Proc. Natl. Acad. Sci. U.S.A. 90, 7829-7833 (1993).
-
(1993)
Proc. Natl. Acad. Sci. U.S.A.
, vol.90
, pp. 7829-7833
-
-
Doudna, J.A.1
Grosshans, C.2
Gooding, A.3
Kundrot, C.E.4
-
72
-
-
0027974580
-
Use of low-molecular-weight polyethylene glycol in the crystallization of RNA oligomers
-
K. J. BAEYENS, J. JANCARIK and S. R. HOLBROOK, Use of low-molecular-weight polyethylene glycol in the crystallization of RNA oligomers, Acta Cryst. D 50, 764-767 (1994).
-
(1994)
Acta Cryst. D
, vol.50
, pp. 764-767
-
-
Baeyens, K.J.1
Jancarik, J.2
Holbrook, S.R.3
-
73
-
-
0028969142
-
The evaluation of 2′- and 6′-substituted carbocyclic nucleosides as building blocks for antisense oligonucleotides
-
K-H. ALTMANN, M. O. BÉVIERRE, A. DE MESMAEKER and H. E. MOSER, The evaluation of 2′- and 6′-substituted carbocyclic nucleosides as building blocks for antisense oligonucleotides, Biorg. Med. Chem. Lett. 5, 431-436 (1995).
-
(1995)
Biorg. Med. Chem. Lett.
, vol.5
, pp. 431-436
-
-
Altmann, K.-H.1
Bévierre, M.O.2
De Mesmaeker, A.3
Moser, H.E.4
-
74
-
-
0019843568
-
Structure of a B-DNA dodecamer. III. Geometry of hydration
-
H. R. DREW and R. E. DICKERSON, Structure of a B-DNA dodecamer. III. Geometry of hydration, J. Mol. Biol. 151, 535-556 (1981).
-
(1981)
J. Mol. Biol.
, vol.151
, pp. 535-556
-
-
Drew, H.R.1
Dickerson, R.E.2
-
75
-
-
0020692923
-
Ordered water structure around a B-DNA dodecamer. A quantitative study
-
M. L. KOPKA, A. V. FRATINI, H. R. DREW and R. E. DICKERSON, Ordered water structure around a B-DNA dodecamer. A quantitative study, J. Mol. Biol. 163, 129-146 (1983).
-
(1983)
J. Mol. Biol.
, vol.163
, pp. 129-146
-
-
Kopka, M.L.1
Fratini, A.V.2
Drew, H.R.3
Dickerson, R.E.4
-
76
-
-
0029670086
-
An oligodeoxyribonucleotide N3′ → P5′ phosphoramidate duplex forms an A-type helix in solution
-
D. DING, S. M. GRYAZNOV, D. H. LLOYD, S. CHANDRASEKARAN, S. YAO, L. RATMEYER, Y. PAN and W. D. WILSON, An oligodeoxyribonucleotide N3′ → P5′ phosphoramidate duplex forms an A-type helix in solution, Nucleic Acids Res. 24, 354-360 (1996).
-
(1996)
Nucleic Acids Res.
, vol.24
, pp. 354-360
-
-
Ding, D.1
Gryaznov, S.M.2
Lloyd, D.H.3
Chandrasekaran, S.4
Yao, S.5
Ratmeyer, L.6
Pan, Y.7
Wilson, W.D.8
-
77
-
-
84988109905
-
Antisense oligonucleotides with alternating phosphodiester-"amide-3" linkages
-
J. LEBRETON, A. WALDNER, C. LESUEUR and A. DE MESMAEKER, Antisense oligonucleotides with alternating phosphodiester-"amide-3" linkages, Synlett 137(140), (1994).
-
(1994)
Synlett
, vol.137
, Issue.140
-
-
Lebreton, J.1
Waldner, A.2
Lesueur, C.3
De Mesmaeker, A.4
-
78
-
-
33748217097
-
Amides as a new type of backbone modification in oligonucleotides
-
A. DE MESMAEKER, A. WALDNER, J. LEBRETON, P. N. HOFFMAN, V. FRITSCH, R. M. WOLF and S. M. FREIER, Amides as a new type of backbone modification in oligonucleotides, Angew. Chem. Int. Ed. Engl. 33, 226-229 (1994).
-
(1994)
Angew. Chem. Int. Ed. Engl.
, vol.33
, pp. 226-229
-
-
De Mesmaeker, A.1
Waldner, A.2
Lebreton, J.3
Hoffman, P.N.4
Fritsch, V.5
Wolf, R.M.6
Freier, S.M.7
-
79
-
-
0026683445
-
Oligonucleosides-Synthesis of a novel methylhydroxylamine-linked nucleoside dimer and its incorporation into antisense sequences
-
J.-J. VASSEUR, F. DEBART, Y. S. SANGHVI and P. D. COOK, Oligonucleosides-Synthesis of a novel methylhydroxylamine-linked nucleoside dimer and its incorporation into antisense sequences, J. Am. Chem. Soc. 114, 4006-4007 (1992).
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 4006-4007
-
-
Vasseur, J.-J.1
Debart, F.2
Sanghvi, Y.S.3
Cook, P.D.4
-
80
-
-
0030053079
-
Oligonucleotide mimics for antisense therapeutics: Solution phase and automated solid-support synthesis of MMI linked oligomers
-
F. MORVAN, Y. S. SANGHVI, M. PREBOST, J-J. VASSEUR and L. BELLON, Oligonucleotide mimics for antisense therapeutics: Solution phase and automated solid-support synthesis of MMI linked oligomers, J. Am. Chem. Soc. 118, 255-256 (1996).
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 255-256
-
-
Morvan, F.1
Sanghvi, Y.S.2
Prebost, M.3
Vasseur, J.-J.4
Bellon, L.5
-
81
-
-
0026341239
-
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
-
P. E. NIELSEN, M. EGHOLM, R. H. BERG and O. BUCHARDT, Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide, Science 254, 1497-1500 (1991).
-
(1991)
Science
, vol.254
, pp. 1497-1500
-
-
Nielsen, P.E.1
Egholm, M.2
Berg, R.H.3
Buchardt, O.4
-
82
-
-
0027364174
-
PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules
-
M. EGHOLM, O. BUCHARDT, L. CHRISTENSEN, C. BEHRENS, S. M. FREIER, D. A. DRIVER, R. H. BERG, S. K. KIM, B. NORDEN and P. E. NIELSEN, PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules, Nature 365, 566-568 (1993).
-
(1993)
Nature
, vol.365
, pp. 566-568
-
-
Egholm, M.1
Buchardt, O.2
Christensen, L.3
Behrens, C.4
Freier, S.M.5
Driver, D.A.6
Berg, R.H.7
Kim, S.K.8
Norden, B.9
Nielsen, P.E.10
-
83
-
-
0028038592
-
Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone
-
P. E. NIELSEN, M. EGHOLM and O. BUCHARDT, Peptide nucleic acid (PNA). A DNA mimic with a peptide backbone, Bioconjugate Chem. 5, 3-7 (1994).
-
(1994)
Bioconjugate Chem.
, vol.5
, pp. 3-7
-
-
Nielsen, P.E.1
Egholm, M.2
Buchardt, O.3
-
84
-
-
0030969949
-
Morpholino and phosphorothioate antisense oligomers compared in cell-free and in-cell systems
-
J. SUMMERTON, D. STEIN, S. B. HUANG, P. MATTHEWS, S. WELLER and M. PARTRIDGE, Morpholino and phosphorothioate antisense oligomers compared in cell-free and in-cell systems, Antisense Nucleic Acid Drug Dev. 7, 63-70 (1997).
-
(1997)
Antisense Nucleic Acid Drug Dev.
, vol.7
, pp. 63-70
-
-
Summerton, J.1
Stein, D.2
Huang, S.B.3
Matthews, P.4
Weller, S.5
Partridge, M.6
-
85
-
-
0028858581
-
Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance
-
L. BEIGELMAN, J. A. MCSWIGGEN, K. G. DRAPER, C. GONZALEZ, K. JENSEN, A. M. KARPEISKY, A. S. MODAK, J. MATULIC-ADAMIC, A. B. DIRENZO, P. HAEBERLI, D. SWEEDLER, D. TRACZ, S. GRIMM, F. E. WINCOTT, V. G. THACKRAY and N. USMAN, Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance, J. Biol. Chem. 270, 25702-25708 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 25702-25708
-
-
Beigelman, L.1
Mcswiggen, J.A.2
Draper, K.G.3
Gonzalez, C.4
Jensen, K.5
Karpeisky, A.M.6
Modak, A.S.7
Matulic-Adamic, J.8
Direnzo, A.B.9
Haeberli, P.10
Sweedler, D.11
Tracz, D.12
Grimm, S.13
Wincott, F.E.14
Thackray, V.G.15
Usman, N.16
-
86
-
-
0027197574
-
Oligonucleotide-directed triple-helix formation
-
J.-S. SUN and C. HÉLÈNE, Oligonucleotide-directed triple-helix formation, Curr. Opin. Struct. Biol. 3, 345-356 (1993).
-
(1993)
Curr. Opin. Struct. Biol.
, vol.3
, pp. 345-356
-
-
Sun, J.-S.1
Hélène, C.2
-
87
-
-
0031183804
-
Isolation and characterization of 2-fluoro, 2-amino, and 2-fluoro/amino-modified RNA ligands to human IFN-gamma that inhibit receptor binding
-
M. F. KUBIK, T. FITZWATER, S. R. WATSON and D. M. TASSET, Isolation and characterization of 2-fluoro, 2-amino, and 2-fluoro/amino-modified RNA ligands to human IFN-gamma that inhibit receptor binding, J. Immunol. 159, 259-267 (1997).
-
(1997)
J. Immunol.
, vol.159
, pp. 259-267
-
-
Kubik, M.F.1
Fitzwater, T.2
Watson, S.R.3
Tasset, D.M.4
-
88
-
-
0031037029
-
Structural RNA mimetics: N3′ → P5′ phosphoramidate DNA analogs of HIV-1 RRE and TAR RNA form A-type helices that bind specifically to Rev and Tat-related pep tides
-
C. T. RIGL, D. H. LLOYD, D. S. TSOU, S. GRYAZNOV and W. D. WILSON, Structural RNA mimetics: N3′ → P5′ phosphoramidate DNA analogs of HIV-1 RRE and TAR RNA form A-type helices that bind specifically to Rev and Tat-related pep tides, Biochemistry 36, 650-659 (1997).
-
(1997)
Biochemistry
, vol.36
, pp. 650-659
-
-
Rigl, C.T.1
Lloyd, D.H.2
Tsou, D.S.3
Gryaznov, S.4
Wilson, W.D.5
|