Identification of receptors and Smad proteins involved in activin signalling in a human epidermal keratinocyte cell line

Genes to Cells

Volumn 3, Issue 2, 1998, Pages 125-134

  Shimizu, Akira ^a,b,c   Kato, Mitsuyasu ^a,b   Nakao, Atsuhito ^d   Imamura, Takeshi ^a,b   Ten Dijke, Peter ^d   Heldin, Carl Henrik ^d   Kawabata, Masahiro ^a,b   Shimada, Shinji ^c   Miyazono, Kohei ^a,b  

^a CANCER INSTITUTE   (Japan)

^b CANCER CHEMOTHERAPY CENTER   (Japan)

^c UNIVERSITY OF YAMANASHI   (Japan)

^d LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN A; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; EMBRYO; EPIDERMIS; GROWTH REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; XENOPUS;

ACTIVIN RECEPTORS; ACTIVINS; ANIMALS; CELLS, CULTURED; COS CELLS; DNA-BINDING PROTEINS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; INHIBINS; KERATINOCYTES; PHOSPHORYLATION; PRECIPITIN TESTS; RECEPTORS, GROWTH FACTOR; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANS-ACTIVATORS; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031855590     PISSN: 13569597     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2443.1998.00174.x     Document Type: Article

References (58)

1. Attisano, L., Wrana, J.L., Cheifetz, S. & Massagué, J. (1992) Novel activin receptors: Distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors. Cell 68, 97-108.
2. Attisano, L., Wrana, J.L., Montalvo, E. & Massagué, J. (1996) Activation of signalling by the activin receptor complex. Mol. Cell. Biol. 16, 1066-1073.
3. Baker, J.C. & Harland, R.M. (1996) A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev. 10, 1880-1889.
4. Boukamp, P., Petrusevska, R.T., Breitkreutz, D., Hornung, J., Markham, A. & Fusenig, N.E. (1988) Normal keratmization in a spontaneously immortalized human keratinocyte cell line. J. Cell Biol. 106, 761-771.
5. Candia, A.F., Watabe, T., Hawley, S.H.B., et al. (1997) Cellular interpretation of multiple TGF-β signals: intracellular antagonism between activin/BVg1 and BMP-2/4 signaling mediated by Smads. Development 124, 4467-4480.
6. Cárcamo, J., Weis, F.M.B., Ventura, F., et al. (1994) Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor β and activin. Mol. Cell. Biol. 14, 3810-3821.
7. Chen, Y., Bhushan, A. & Vale, W (1997) Smad8 mediates the signaling of the receptor serine kinase. Proc. Natl. Acad. Sci. USA 94, 12938-12943.
8. Choi, Y. & Fuchs, E. (1990) TGF-β and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells. Cell Regulation 1, 791-809.
9. Derynck, R. & Zhang, Y (1996) Intracellular signalling: The Mad way to do it. Curr. Biol. 6, 1226-1229.
10. ten Dijke, P., Ichijo, H., Franzén, P., et al. (1993) Activin receptor-like kinases; A novel subclass of cell-surface receptors with predicted serine/threonine kinase activity. Oncogene 8, 2879-2887.
11. ten Dijke, P., Miyazono, K. & Heldin, C.-H. (1996) Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Curr. Opin. Cell Biol. 8, 139-145.
12. ten Dijke, P., Yamashita, H., Ichijo, H., et al. (1994) Characterization of type I receptors for transforming growth factor-β and activin. Science 264, 101-104.
13. Ebner, R., Chen, R.-H., Shum, L., et al (1993) Cloning of a type I TGF-β receptor and its effect on TGF-β binding to the type II receptor. Science 260, 1344-1348.
14. E subunit gene. Biochem. Biophys. Res. Commun. 228, 669-674.
15. Frank, S., Madlener, M. & Werner, S. (1996) Transforming growth factors β1, β2, and β3 and their receptors are differentially regulated during normal and impaired wound healing. J. Biol. Chem. 271, 10188-10193.
16. Fuchs, E. (1990) Epidermal differentiation: the bare essentials. J. Cell Biol. 111, 2807-2814.
17. Graff, J.M., Bansal, A. & Melton, D.A. (1996) Xenopus Mad proteins transduce distinct subsets of signals for the TGFβ superfamily. Cell 85, 479-487.
18. Hahn, S.A., Schutte, M., Shamsul-Hoque, A.T.M., et al. (1996) DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271, 350-353.
19. Heldin, C.-H., Miyazono, K. & ten Dijke, P (1997) TGF-β signalling from cell membrane to nucleus through Smad proteins. Nature 390, 465-471.
20. Hoodless, P.A., Haerry, T., Abdollah, S., et al. (1996) MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85, 489-500.
21. C chain. Biochem. Biophys. Res. Commun. 206, 608-613.
22. Hübner, G., Hu, Q., Smola, H. & Werner, S. (1996) Strong induction of activin expression after injury suggests an important role of activin in wound repair. Dev. Biol. 173, 490-498.
23. Ichijo, H., Yamashita, H., ten Dijke, P., Eto, Y., Heldin, C.-H. & Miyazono, K. (1993) Characterization of in vivo phosphorylation of activin type II receptor. Biochem. Biophys. Res. Commun. 194, 1508-1514.
24. Kato, M., Ishizaki, A., Hellman, U., et al. (1995) A human keratinocyte cell line produces two autocrine growth inhibitors, transforming growth factor-β and insulin-like growth factor binding protein-6, in a calcium- and cell density-dependent manner. J. Biol. Chem. 270, 12373-12379.
25. Kingsley, D.M. (1994) The TGF-β superfamily: new members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8, 133-146.
26. Lagna, G., Hata, A., Hemmati-Brivanlou, A. & Massagué, J. (1996) Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways. Nature 383, 832-836.
27. Levine, J.H., Moses, H.L., Gold, L.I. & Nanney, L.B. (1993) Spatial and temporal patterns of immunoreactive transforming growth factor β1, β2, and β3 during excisional wound repair. Am. J. Pathol. 143, 368-380.
28. Ling, N., Ying, S.-Y, Ueno, N., et al. (1986) Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin. Nature 321, 779-782.
29. Macías-Silva, M., Abdollah, S., Hoodless, P.A., Pirone, R., Attisano, L. & Wrana, J.L. (1996) MADR2 is a substrate of the TGFβ receptor and its phosphorylation is required for nuclear accumulation and signaling. Cell 87, 1215-1224.
30. Massagué, J. (1996) TGFβ signaling: Receptors, transducers, and mad proteins. Cell 85, 947-950.
31. Mathews, L.S. (1994) Activin receptors and cellular signaling by the receptor serine kinase family. Endocrine Rev. 15, 310-325.
32. Mathews, L.S. & Vale, W.W. (1991) Expression cloning of an activin receptor, a predicted transmembrane serine kinase. Cell 65, 973-982.
33. Mathews, L.S., Vale, W.W. & Kintner, C.R. (1992) Cloning of a second type of activin receptor and functional characterization in Xenopus embryos. Science 255, 1702-1705.
34. Matzuk, M.M., Kumar, T.R. & Bradley, A. (1995a) Different phenotypes for mice deficient in either activins or activin receptor type II. Nature 374, 356-360.
35. Matzuk, M.M., Kumar, T.R., Vassalli, A., et al. (1995b) Functional analysis of activins during mammalian development. Nature 374, 354-356.
36. Matzuk, M.M., Lu, N., Vogel, H., Sellheyer, K., Roop, D.R. & Bradley, A. (1995c) Multiple defects and perinatal death in mice deficient in follistatin. Nature 374, 360-363.
37. McCarthy, S.A. & Bicknell, R. (1993) Inhibition of vascular endothelial cell growth by activin-A. J. BioL Chem. 268, 23066-23071.
38. A chain. Proc. Natl. Acad. Sci. USA 85, 2434-2438.
39. Nagamine, T., Imamura, T., Ishidou, Y., et al. (1997) Activin A and other TGF-β superfamily members acting via activin receptors may regulate bone formation during fracture healing in rats. J. Orthopaed. Res., in press.
40. Nakao, A., Imamura, T., Souchelnytskyi, S., et al. (1997b) TGF-β receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 16, 5353-5362.
41. Nakao, A., Röijer, E., Imamura, T., et al. (1997a) Identification of Smad2, a human MAD-related protein in the TGF-β signaling pathway. J. Biol. Chem. 272, 2896-2900.
42. Oda, S., Nishimatsu, S., Murakami, K. & Ueno, N. (1995) Molecular cloning and functional analysis of a new activin β subunit: a dorsal mesoderm-inducing activity in Xenopus. Biochem. Biophys. Res. Commun. 210, 581-588.
43. Schmid, P., Cox, D., Bilbe, G., et al. (1993) TGF-βs and TGF-β type II receptor in human epidermis: differential expression in acute and chronic skin wounds. J. PathoL 171, 191-197.
44. Schmitt, J., Jenkins, G., Gilbert, N.A., Copeland, N.G., Pohl, J. & Schrewe, H. (1996) Structure, chromosomal localization, and expression analysis of the mouse inhibin/activin βC (Inhbc) gene. Genomics 32, 358-366.
45. Seishima, M., Nojiri, M., Akiyama, T., et al. (1996) Expression of activin A in human keratinocytes at early stages of cultivation. FEBS Lett. 398, 120-124.
46. Shipley, G.D., Pittelkow, M.R., Wille, J.J., Scott, R.E. & Moses, H.L. (1986) Reversible inhibition of normal prokeratinocyte proliferation by type β transforming growth factor-growth inhibitor in serum-free medium. Cancer Res. 46, 2068-2071.
47. Smith, J.C., Price, B.M.J., Van Nimmen, K. & Huylebroeck, D. (1990) Identification of potent Xenopus mesoderm-inducing factor as a homologue of activin A. Nature 345, 729-731.
48. Suzuki, A., Chang, C., Yingling, J.M., Wang, X.-F. & HemmatiBrivanlou, A. (1997) Smad5 induces ventral fates in Xenopus embryo. Dev. Biol. 184, 402-405.
49. Tsuchida, K., Mathews, L.S. & Vale, WW (1993) Cloning and characterization of a transmembrane serine kinase that acts as an activin type I receptor. Proc. Natl. Acad. Sci. USA 90, 11242-11246.
50. Vale, W., Rivier, J., Vaughan, J., et al. (1986) Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature 321, 776-779.
51. Vassalli, A., Matzuk, M.M., Gardner, H.A., Lee, K.F. & Jaenisch, R. (1994) Activin/inhibin βB subunit gene disruption leads to defects in eyelid development and female reproduction. Genes Dev. 8, 414-427.
52. Wataya-Kaneda, M., Hashimoto, K., Kato, M., Miyazono, K. & Yoshikawa, K. (1994) Differential localization of TGF-β-precursor isotypes in normal human skin. J. Dermatol. Sci. 8, 38-44.
53. Willis, S.A., Zimmerman, C.M., Li, L.I. & Mathews, L.S. (1996) Formation and activation by phosphorylation of activin receptor complexes. Mol. Endocrinol. 10, 367-379.
54. Wu, R.-Y, Zhang, Y, Feng, X.-Y & Derynck, R. (1997) Heteromeric and homomeric interactions correlate with signaling activity and functional cooperativity of Smad3 and Smad4/DPC4. Mol. Cell. Biol. 17, 2521-2528.
55. Yamaguchi, K., Shirakabe, K., Shibuya, H., et al. (1995) Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 270, 2008-2011.
56. Yasuda, H., Mine, T., Shibata, H., et al (1993) Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes.J. Clin. Invest. 92, 1491-1496.
57. Zhang, Y., Feng, X.-H., Wu, R.-Y. & Derynck, R. (1996) Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383, 168-172.
58. Zhang, Y, Musci, T. & Derynck, R. (1997) The tumor suppressor Smad4/DPC4 as a central mediator of Smad function. Curr. Biol. 7, 270-276.