Mutagenesis analysis of the murine leukemia virus matrix protein: Identification of regions important for membrane localization and intracellular transport

Journal of Virology

Volumn 71, Issue 7, 1997, Pages 5549-5559

  Soneoka, Yuko ^a   Kingsman, Susan M ^a   Kingsman, Alan J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENVELOPE PROTEIN; GAG PROTEIN; MATRIX PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL MEMBRANE; IMMUNOBLOTTING; INTRACELLULAR TRANSPORT; MURINE LEUKEMIA VIRUS; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; VIRUS ASSEMBLY; VIRUS ENVELOPE; VIRUS PARTICLE;

EID: 0030922098     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.71.7.5549-5559.1997     Document Type: Article

References (47)

1. Bigay, J., E. Faurobert, M. Franco, and M. Chabre. 1994. Roles of lipid modifications of transducin subunits in their GDP-dependent association and membrane binding. Biochemistry 33:14081-14090.
2. Denesvre, C., C. Carrington, A. Corbin, Y. Takeuchi, F.-L. Cosset, T. Schulz, M. Sitbon, and P. Sonigo. 1996. TM domain swapping of murine leukemia virus and human T-cell leukemia virus envelopes confers different infectious abilities despite similar incorporation into virions. J. Virol. 70:4380-4386.
3. Dorfman, T., F. Mammano, W. A. Haseltine, and H. G. Göttlinger. 1994. Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein. J. Virol. 68:1689-1696.
4. Dubridge, B. B., H. C. Hsia, P.-M. Leong, J. H. Miller, and M. P. Carlos. 1987. Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system. Mol. Cell. Biol. 7:379-387.
5. Freed, E. O., and M. A. Martin. 1995. Virion incorporation of envelope glycoprotein with long but not short cytoplasmic tails is blocked by specific, single amino acid substitutions in the human immunodeficiency type 1 matrix. J. Virol. 69:1984-1989.
6. Freed, E. O., and M. A. Martin. 1996. Domains of the human immunodeficiency virus type 1 matrix and gp41 cytoplasmic tail required for envelope incorporation into virions. J. Virol. 70:341-351.
7. Garnier, J., D. J. Osguthorpe, and B. Robson. 1978. Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins. J. Mol. Biol. 120:97-120.
8. Gascuel, O., and J. L. Golmard. 1988. A simple method for predicting the secondary structure of globular proteins: implications and accuracy. Comput. Appl. Biosci. 4:357-365.
9. Gebhardt, A., J. V. Bosch, A. Ziemiecki, and R. R. Friis. 1984. Rous sarcoma virus p19 and gp35 can be chemically crosslinked to high molecular weight complexes. J. Mol. Biol. 174:297-317.
10. Goff, S., P. Traktman, and D. Baltimore. 1981. Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase. J. Virol. 38:239-248.
11. Gonzalez, S. A., J. L. Affranchino, H. R. Gelderblom, and A. Burny. 1993. Assembly of the matrix protein of simian immunodeficiency virus into virus-like particles. Virology 194:548-556.
12. Granowitz, C., and S. P. Goff. 1994. Substitution mutations affecting a small region of the Moloney murine leukemia virus MA gag protein block assembly and release of virion particles. Virology 205:336-344.
13. ras to the plasma membrane. Cell 63:133-139.
14. Hansen, M., L. Jelinek, S. Whiting, and E. Barklis. 1990. Transport and assembly of gag proteins into Moloney murine leukemia virus. J. Virol. 64:5306-5316.
15. Hockley, D. J., R. D. Wood, J. P. Jacobs, and A. J. Garrett. 1988. Electron microscopy of human immunodeficiency virus. J. Gen. Virol. 69:2455-2469.
16. Hunter, E. 1994. Macromolecular interactions in the assembly of HIV and other retroviruses. Sem. Virol. 5:71-83.
17. Jones, T. A., G. Blaug, M. Hansen, and E. Barklis. 1990. Assembly of gog-β-galactosidase proteins into retrovirus particles. J. Virol. 64:2265-2279.
18. Jørgensen, E. C. B., F. S. Pedersen, and P. Jørgensen. 1992. Matrix protein of Akv murine leukemia virus: genetic mapping of regions essential for particle formation. J. Virol. 66:4479-4487.
19. Kaplan, A. H., G. Mardon, J. M. Bishop, and H. E. Varmus. 1988. The first seven amino acids encoded by the v-src oncogene act as a myristylation signal: lysine 7 is a critical determinant. Mol. Cell. Biol. 8:2435-2441.
20. Kim, J., T. Shishido, X. Jiang, A. Aderem, and S. McLaughlin. 1994. Phosphorylation, high ionic strength, and calmodulin reverse the binding of MARCKS to phospholipid vesicles. J. Biol. Chem. 269:28214-28219.
21. Markowitz, D., S. Goff, and A. Bank. 1988. A safe packaging line for gene transfer: separating viral genes on two different plasmids. J. Virol. 62:1120-1124.
22. Massiah, M. A., M. R. Starich, C. Paschall, M. F. Summers, A. M. Christensen, and W. I. Sundquist. 1994. Three-dimensional structure of the human immunodeficiency virus type 1 matrix protein. J. Mol. Biol. 244:198-223.
23. Matthews, S., P. Barlow, J. Boyd, G. Barton, R. Russell, H. Mills, M. Cunningham, N. Meyers, N. Burns, N. Clark, S. Kingsman, A. Kingsman, and I. Campbell. 1994. Structural similarity between the p17 matrix protein of HIV-1 and interferon-γ. Nature 370:666-668.
24. McLaughlin, S., and A. Anderem. 1995. The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions. Trends Biochem. Sci. 20:272-276.
25. Milligan, G., M. Parenti, and A. I. Magee. 1995. The dynamic role of palmitoylation in signal transduction. Trends Biochem. Sci. 20:181-186.
26. Novotny, J., and C. Auffray. 1984. A program for prediction of protein secondary structure from nucleotide sequence data: application to histocompatibility antigens. Nucleic Acids Res. 12:243-255.
27. Peitzsch, R. M., and S. McLaughlin. 1993. Binding of acylated peptides and fatty acids to phospholipid vesicles: pertinence to myristoylated peptides. Biochemistry 32:10436-10443.
28. src can direct myristylation and plasma membrane localization when fused to heterologous proteins. Nature 314:374-377.
29. Perez, L. G., G. L. Davis, and E. Hunter. 1987. Mutants of the Rous sarcoma virus envelope glycoprotein that lack the transmembrane anchor and cytoplasmic domains: analysis of intracellular transport and assembly into virions. J. Virol. 61:2981-2988.
30. Ragheb, J. A., and W. F. Anderson. 1994. Uncoupled expression of Moloney murine leukemia virus envelope polypeptides SU and TM: a functional analysis of the role of TM domains in viral entry. J. Virol. 68:3207-3219.
31. Ragheb, J. A., and W. F. Anderson. 1994. pH-independent murine leukemia virus ecotropic envelope-mediated cell fusion: implications for the role of the R peptide and p12E TM in viral entry. J. Virol. 68:3220-3231.
32. Rao, Z., A. S. Belyaev, E. Fry, P. Roy, I. M. Jones, and D. I. Stuart. 1995. Crystal structure of SIV matrix antigen and implications for virus assembly. Nature 378:743-747.
33. gag is essential for virus particle formation by Moloney murine leukemia virus. Proc. Natl. Acad. Sci. USA 83:7246-7250.
34. Rhee, S. S., and E. Hunter. 1991. Amino acid substitutions within the matrix protein of type D retroviruses affect assembly, transport and membrane association of a capsid. EMBO J. 10:535-546.
35. Rost, B., and C. Sander. 1993. Prediction of protein structure at better than 70% accuracy. J. Mol. Biol. 232:584-599.
36. Rost, B., and C. Sander. 1994. Combining evolutionary information and neural networks to predict protein secondary structure. Proteins 19:55-72.
37. Schultz, A. M., L. E. Henderson, and S. Oroszlan. 1988. Fatty acylation of proteins. Annu. Rev. Cell Biol. 4:611-647.
38. gag is excluded from virus assembly and maturation events. J. Virol. 63:2370-2373.
39. Shinnick, T. M., R. A. Lerner, and J. G. Sutcliffe. 1981. Nucleotide sequence of Moloney murine leukemia virus. Nature 293:543-548.
40. Sigal, C. T., W. Zhou, C. A. Buser, S. McLaughlin, and M. D. Resh. 1994. Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids. Proc. Natl. Acad. Sci. USA 91:12253-12257.
41. Soneoka, Y., P. M. Cannon, E. E. Ramsdale, J. C. Griffiths, G. Romano, S. M. Kingsman, and A. J. Kingsman. 1995. A transient three-plasmid expression system for the production of high titer retroviral vectors. Nucleic Acids Res. 23:628-633.
42. Spearman, P., J.-J. Wang, N. VanderHeyden, and L. Ratner. 1994. Identification of human immunodeficiency virus type 1 Gag protein domains essential to membrane binding and particle assembly. J. Virol. 68:3232-3242.
43. Wedegaertner, P. B., P. T. Wilson, and H. R. Bourne. 1995. Lipid modifications of trimeric G proteins. J. Biol. Chem. 270:503-506.
44. Wills, J. W., and R. C. Craven. 1991. Form, function, and use of retroviral Gag proteins. AIDS 5:639-654.
45. Yu, X., X. Yuan, Z. Matsuda, T.-H. Lee, and M. Essex. 1992. The matrix protein of human immunodeficiency virus type 1 is required for incorporation of viral envelope protein into mature virions. J. Virol. 66:4966-4971.
46. Yuan, X., X. Yu, T.-H. Lee, and M. Essex. 1993. Mutations in the N-terminal region of human immunodeficiency virus type 1 matrix protein block intracellular transport of the Gag precursor. J. Virol. 67:6387-6394.
47. Zhou, W., L. J. Parent, J. W. Wills, and M. D. Resh. 1994. Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids. J. Virol. 68:2556-2569.