메뉴 건너뛰기




Volumn 76, Issue 3, 1998, Pages 280-287

A novel concept in mucosal adjuvanticity: The CTA1-DD adjuvant is a B cell-targeted fusion protein that incorporates the enzymatically active cholera toxin A1 subunit

Author keywords

ADP ribosylation; Cholera toxin; Costimulation; Mucosal; Targeted adjuvants

Indexed keywords

CHOLERA TOXIN; IMMUNOLOGICAL ADJUVANT;

EID: 0031815672     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1711.1998.00750.x     Document Type: Article
Times cited : (40)

References (47)
  • 2
    • 0026579998 scopus 로고
    • The mucosal immune system: From fundamental concepts to vaccine development
    • McGhee JR, Mestecky J, Dertzbaugh MT et al. The mucosal immune system: From fundamental concepts to vaccine development. Vaccine 1992; 10: 75-88.
    • (1992) Vaccine , vol.10 , pp. 75-88
    • McGhee, J.R.1    Mestecky, J.2    Dertzbaugh, M.T.3
  • 3
    • 0010687078 scopus 로고    scopus 로고
    • A molecular approach to the construction of an effective mucosal vaccine adjuvant. Studies based on cholera toxin ADP-ribosylation and cell targeting
    • Kagnoff MF, Kiyono H (eds) Academic Press
    • Lycke N. A molecular approach to the construction of an effective mucosal vaccine adjuvant. Studies based on cholera toxin ADP-ribosylation and cell targeting. In: Kagnoff MF, Kiyono H (eds) Essentials of Mucosal Immunology. Academic Press, 1996; 563-80.
    • (1996) Essentials of Mucosal Immunology , pp. 563-580
    • Lycke, N.1
  • 4
    • 0002160869 scopus 로고
    • Mucosal adjuvants
    • Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JR, Bienenstock J (eds) Academic Press
    • Elson CO, Dertzbaugh MT. Mucosal adjuvants. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JR, Bienenstock J (eds) Handbook of Mucosal Immunology. Academic Press, 1994; 391-402.
    • (1994) Handbook of Mucosal Immunology. , pp. 391-402
    • Elson, C.O.1    Dertzbaugh, M.T.2
  • 5
    • 0343773445 scopus 로고    scopus 로고
    • IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease
    • Röcken M, Racke M, Shevach EM. IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today 1996; 17: 225-31.
    • (1996) Immunol. Today , vol.17 , pp. 225-231
    • Röcken, M.1    Racke, M.2    Shevach, E.M.3
  • 6
    • 0002000895 scopus 로고
    • Oral tolerance and regulation of immunity to dietary antigens
    • Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JP, Bienenstock J (eds) Academic Press
    • Mowat A. Oral tolerance and regulation of immunity to dietary antigens. In: Ogra PL, Mestecky J, Lamm ME, Strober W, McGhee JP, Bienenstock J (eds) Handbook of Mucosal Immunology. Academic Press, 1994; 185.
    • (1994) Handbook of Mucosal Immunology , pp. 185
    • Mowat, A.1
  • 7
    • 0002044169 scopus 로고    scopus 로고
    • Oral tolerance: Immunologic mechanisms and treatment of autoimmune diseases
    • Kagnoff MF, Kiyono H (eds) Academic Press
    • Weiner HL. Oral tolerance: Immunologic mechanisms and treatment of autoimmune diseases. In: Kagnoff MF, Kiyono H (eds) Essentials of Mucosal Immunology. Academic Press, 1996; 555-61.
    • (1996) Essentials of Mucosal Immunology. , pp. 555-561
    • Weiner, H.L.1
  • 8
    • 0025806703 scopus 로고
    • Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route
    • Mowat AM, Donachie AM, Reid G, Jarrett O. Immune-stimulating complexes containing Quil A and protein antigen prime class I MHC-restricted T lymphocytes in vivo and are immunogenic by the oral route. Immunology 1991; 72: 317-22.
    • (1991) Immunology , vol.72 , pp. 317-322
    • Mowat, A.M.1    Donachie, A.M.2    Reid, G.3    Jarrett, O.4
  • 9
    • 0025834747 scopus 로고
    • Biodegradable and biocompatible poly (DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies
    • Eldridge JH, Staas JK, Meulbroek JA, Tice TR, Gilley RM. Biodegradable and biocompatible poly (DL-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies. Infect. Immun. 1991; 59: 2978-86.
    • (1991) Infect. Immun. , vol.59 , pp. 2978-2986
    • Eldridge, J.H.1    Staas, J.K.2    Meulbroek, J.A.3    Tice, T.R.4    Gilley, R.M.5
  • 10
    • 2642676876 scopus 로고    scopus 로고
    • Lack of local suppression in orally tolerant CD8 deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa
    • Grdic D, Hörnquist E, Kjerrulf M, Lycke N. Lack of local suppression in orally tolerant CD8 deficient mice reveals a critical regulatory role of CD8+ T cells in the normal gut mucosa. J. Immunol. 1998; 160: 754-62.
    • (1998) J. Immunol. , vol.160 , pp. 754-762
    • Grdic, D.1    Hörnquist, E.2    Kjerrulf, M.3    Lycke, N.4
  • 11
    • 0021681145 scopus 로고
    • Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen
    • Elson CO, Ealding W. Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated protein antigen. J. Immunol. 1984; 133: 2892-7.
    • (1984) J. Immunol. , vol.133 , pp. 2892-2897
    • Elson, C.O.1    Ealding, W.2
  • 12
    • 0029161099 scopus 로고
    • The three-dimensional crystal structure of cholera toxin
    • Zhang RG, Scott DL, Westbrook ML et al. The three-dimensional crystal structure of cholera toxin. J. Mol. Biol. 1995; 251: 563-73.
    • (1995) J. Mol. Biol. , vol.251 , pp. 563-573
    • Zhang, R.G.1    Scott, D.L.2    Westbrook, M.L.3
  • 13
    • 0027942083 scopus 로고
    • Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis
    • Pizza M, Domenighini M, Hol W et al. Probing the structure-activity relationship of Escherichia coli LT-A by site-directed mutagenesis. Mol. Microbiol. 1994; 14: 51-60.
    • (1994) Mol. Microbiol. , vol.14 , pp. 51-60
    • Pizza, M.1    Domenighini, M.2    Hol, W.3
  • 14
    • 0026458260 scopus 로고
    • Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin
    • Spangler BD. Structure and function of cholera toxin and the related Escherichia coli heat-labile enterotoxin. Microbiol. Rev. 1992; 56: 622-47.
    • (1992) Microbiol. Rev. , vol.56 , pp. 622-647
    • Spangler, B.D.1
  • 16
    • 19144364760 scopus 로고    scopus 로고
    • Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin
    • Takahashi I, Marinaro M, Kiyono H et al. Mechanisms for mucosal immunogenicity and adjuvancy of Escherichia coli labile enterotoxin. J. Infect. Dis. 1996; 173: 627-35.
    • (1996) J. Infect. Dis. , vol.173 , pp. 627-635
    • Takahashi, I.1    Marinaro, M.2    Kiyono, H.3
  • 17
    • 0030940814 scopus 로고    scopus 로고
    • Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin
    • Douce G, Fontana M, Pizza M, Rappuoli R, Dougan G. Intranasal immunogenicity and adjuvanticity of site-directed mutant derivatives of cholera toxin. Infect. Immun. 1997; 65: 2821-8.
    • (1997) Infect. Immun. , vol.65 , pp. 2821-2828
    • Douce, G.1    Fontana, M.2    Pizza, M.3    Rappuoli, R.4    Dougan, G.5
  • 18
    • 0027174854 scopus 로고
    • Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin
    • Sixma TK, Kalk KH, van Zanten BA et al. Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin. J. Mol. Biol. 1993; 230: 890-918.
    • (1993) J. Mol. Biol. , vol.230 , pp. 890-918
    • Sixma, T.K.1    Kalk, K.H.2    Van Zanten, B.A.3
  • 19
    • 0019293278 scopus 로고
    • Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin
    • Dallas WS, Falkow S. Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin. Nature 1980; 288: 499-501.
    • (1980) Nature , vol.288 , pp. 499-501
    • Dallas, W.S.1    Falkow, S.2
  • 20
    • 0030030530 scopus 로고    scopus 로고
    • Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: Receptor binding is essential and induces differential modulation of lymphocyte subsets
    • Nashar TO, Webb HM, Eaglestone S, Williams NA, Hirst TR. Potent immunogenicity of the B subunits of Escherichia coli heat-labile enterotoxin: Receptor binding is essential and induces differential modulation of lymphocyte subsets. Proc. Natl Acad. Sci. USA 1996; 93: 226-30.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 226-230
    • Nashar, T.O.1    Webb, H.M.2    Eaglestone, S.3    Williams, N.A.4    Hirst, T.R.5
  • 21
    • 0029094081 scopus 로고
    • Analysis of the second messenger systems involved in the synergistic effect of cholera toxin and interleukin-4 on B cell isotype-switching
    • Lycke N. Analysis of the second messenger systems involved in the synergistic effect of cholera toxin and interleukin-4 on B cell isotype-switching. Adv. Exp. Med. Biol. 1995; 15-20.
    • (1995) Adv. Exp. Med. Biol. , pp. 15-20
    • Lycke, N.1
  • 23
    • 0030820364 scopus 로고    scopus 로고
    • Interferon-γ deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance
    • Kjerrulf M, Grdic D, Ekman L et al. Interferon-γ deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance. Immunology 1997; 92: 60-8.
    • (1997) Immunology , vol.92 , pp. 60-68
    • Kjerrulf, M.1    Grdic, D.2    Ekman, L.3
  • 24
    • 0030023828 scopus 로고    scopus 로고
    • CD8-deficient mice exhibit augmented mucosal immune responses and intact adjuvant effect of cholera toxin
    • Hörnquist E, Grdic D, Mak T, Lycke N. CD8-deficient mice exhibit augmented mucosal immune responses and intact adjuvant effect of cholera toxin. Immunology 1996; 87: 220-9.
    • (1996) Immunology , vol.87 , pp. 220-229
    • Hörnquist, E.1    Grdic, D.2    Mak, T.3    Lycke, N.4
  • 25
    • 0031569528 scopus 로고    scopus 로고
    • A genetically engineered non-toxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit
    • Ågren L, Ekman L, Löwenadler B, Lycke N. A genetically engineered non-toxic vaccine adjuvant that combines B cell targeting with immunomodulation by cholera toxin A1 subunit. J. Immunol. 1997; 158: 3936-46.
    • (1997) J. Immunol. , vol.158 , pp. 3936-3946
    • Ågren, L.1    Ekman, L.2    Löwenadler, B.3    Lycke, N.4
  • 27
    • 0026699224 scopus 로고
    • The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity
    • Lycke N, Tsuji T, Holmgren J. The adjuvant effect of Vibrio cholerae and Escherichia coli heat-labile enterotoxins is linked to their ADP-ribosyltransferase activity. Eur. J. Immunol. 1992; 22: 2277-81.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 2277-2281
    • Lycke, N.1    Tsuji, T.2    Holmgren, J.3
  • 28
    • 0024322169 scopus 로고
    • Cholera toxin as a mucosal adjuvant: Glutaraldehyde treatment dissociates adjuvanticity from toxicity
    • Liang X, Lamm ME, Nedrud JG. Cholera toxin as a mucosal adjuvant: Glutaraldehyde treatment dissociates adjuvanticity from toxicity. J. Immunol. 1989; 143: 484-90.
    • (1989) J. Immunol. , vol.143 , pp. 484-490
    • Liang, X.1    Lamm, M.E.2    Nedrud, J.G.3
  • 29
    • 0021058990 scopus 로고
    • New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development
    • Levine MM, Kaper JB, Black RE, Clemens ML. New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development. Microbiol. Rev. 1983; 47: 510-50.
    • (1983) Microbiol. Rev. , vol.47 , pp. 510-550
    • Levine, M.M.1    Kaper, J.B.2    Black, R.E.3    Clemens, M.L.4
  • 30
    • 0027488503 scopus 로고
    • The interaction between different domains of staphylococcal protein A and human polyclonal IgG, IgA, IgM and F (ab′)2: Separation of affinity from specificity
    • Ljungberg UK, Jansson B, Niss U et al. The interaction between different domains of staphylococcal protein A and human polyclonal IgG, IgA, IgM and F (ab′)2: Separation of affinity from specificity. Mol. Immunol. 1993; 30: 1279-85.
    • (1993) Mol. Immunol. , vol.30 , pp. 1279-1285
    • Ljungberg, U.K.1    Jansson, B.2    Niss, U.3
  • 31
    • 0028141008 scopus 로고
    • Fusion proteins with heterologous T helper epitopes. Recombinant E. coli heat-stable enterotoxin proteins
    • Löwenadler B, Lycke N. Fusion proteins with heterologous T helper epitopes. Recombinant E. coli heat-stable enterotoxin proteins. Intern. Rev. Immunol. 1994; 11: 103-11.
    • (1994) Intern. Rev. Immunol. , vol.11 , pp. 103-111
    • Lycke N, L.B.1
  • 32
    • 0028113922 scopus 로고
    • A quantitative analysis of antigen-presenting cell function; activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing co-stimulation
    • Cassell DJ, Schwartz RH. A quantitative analysis of antigen-presenting cell function; activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing co-stimulation. J. Exp. Med. 1994; 180: 1829-40.
    • (1994) J. Exp. Med. , vol.180 , pp. 1829-1840
    • Cassell, D.J.1    Schwartz, R.H.2
  • 33
    • 0029157151 scopus 로고
    • B lymphocytes can be competent antigen presenting cells for priming CD4+ T cells to protein antigens in vivo
    • Constant S, Schweitzer N, West J, Ranney P, Bottomly K. B lymphocytes can be competent antigen presenting cells for priming CD4+ T cells to protein antigens in vivo. J. Immunol. 1995; 155: 3734-41.
    • (1995) J. Immunol. , vol.155 , pp. 3734-3741
    • Constant, S.1    Schweitzer, N.2    West, J.3    Ranney, P.4    Bottomly, K.5
  • 34
    • 0029862687 scopus 로고    scopus 로고
    • B cells solicit their own help from T cells
    • Stockinger B, Zal T, Zal A, Gray D. B cells solicit their own help from T cells. J. Exp. Med. 1996; 183: 891-9.
    • (1996) J. Exp. Med. , vol.183 , pp. 891-899
    • Stockinger, B.1    Zal, T.2    Zal, A.3    Gray, D.4
  • 35
    • 0031296660 scopus 로고    scopus 로고
    • The mucosal adjuvanticity of cholera toxin involves enhancement of co-stimulatory activity by selective up-regulation of B7.2 expression
    • Cong Y, Weaver C, Elson C. The mucosal adjuvanticity of cholera toxin involves enhancement of co-stimulatory activity by selective up-regulation of B7.2 expression. J. Immunol. 1997; 159: 5301.
    • (1997) J. Immunol. , vol.159 , pp. 5301
    • Cong, Y.1    Weaver, C.2    Elson, C.3
  • 36
    • 0029041926 scopus 로고
    • cAmp-independent effects of cholera toxin on B cell activation, Iii. Cholera toxin a subunit-mediated ADP-ribosylation acts synergistically with ionomycin or IL-4 to induce B cell proliferation
    • Francis ML, Okazaki I, Moss J et al. cAmp-independent effects of cholera toxin on B cell activation, Iii. Cholera toxin a subunit-mediated ADP-ribosylation acts synergistically with ionomycin or IL-4 to induce B cell proliferation. J. Immunol. 1995; 154: 4956-64.
    • (1995) J. Immunol. , vol.154 , pp. 4956-4964
    • Francis, M.L.1    Okazaki, I.2    Moss, J.3
  • 37
    • 0028985871 scopus 로고
    • Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity
    • Dickinson BL, Clements JD. Dissociation of Escherichia coli heat-labile enterotoxin adjuvanticity from ADP-ribosyltransferase activity. Infect. Immun. 1995; 63: 1617-23.
    • (1995) Infect. Immun. , vol.63 , pp. 1617-1623
    • Dickinson, B.L.1    Clements, J.D.2
  • 38
    • 0028918767 scopus 로고
    • Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants
    • Douce G, Turcotte C, Cropley I et al. Mutants of Escherichia coli heat-labile toxin lacking ADP-ribosyltransferase activity act as nontoxic, mucosal adjuvants. Proc. Natl Acad. Sci. USA 1995; 92: 1644-8.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 1644-1648
    • Douce, G.1    Turcotte, C.2    Cropley, I.3
  • 39
    • 0029805948 scopus 로고    scopus 로고
    • Mutants of the Escherichia coli heat-labile enterotoxin with reduced ADP-ribosylation activity or no activity retain the immunogenic properties of the native holotoxin
    • de Haan L, Verweij WR, Feil IK et al. Mutants of the Escherichia coli heat-labile enterotoxin with reduced ADP-ribosylation activity or no activity retain the immunogenic properties of the native holotoxin. Infect. Immun. 1996; 64: 5413-16.
    • (1996) Infect. Immun. , vol.64 , pp. 5413-5416
    • De Haan, L.1    Verweij, W.R.2    Feil, I.K.3
  • 40
    • 0007205169 scopus 로고    scopus 로고
    • A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity
    • Yamamoto S, Kiyono H, Yamamoto M et al. A nontoxic mutant of cholera toxin elicits Th2-type responses for enhanced mucosal immunity. Proc. Natl Acad. Sci. USA 1997; 94; 5267-72.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 5267-5272
    • Yamamoto, S.1    Kiyono, H.2    Yamamoto, M.3
  • 41
    • 0030902280 scopus 로고    scopus 로고
    • Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrhea-genicity but retain adjuvanticity
    • Yamamoto S, Takeda Y, Yamamoto M et al. Mutants in the ADP-ribosyltransferase cleft of cholera toxin lack diarrhea-genicity but retain adjuvanticity. J. Exp. Med. 1997; 185: 1203-10.
    • (1997) J. Exp. Med. , vol.185 , pp. 1203-1210
    • Yamamoto, S.1    Takeda, Y.2    Yamamoto, M.3
  • 42
    • 0026005836 scopus 로고
    • Site-specific mutagenesis of the catalytic subunit of cholera toxin: Substituting lysine for arginine 7 causes loss of activity
    • Burnette WN, Mar VL, Platler BW et al. Site-specific mutagenesis of the catalytic subunit of cholera toxin: Substituting lysine for arginine 7 causes loss of activity. Infect. Immun. 1991; 59: 4266-70.
    • (1991) Infect. Immun. , vol.59 , pp. 4266-4270
    • Burnette, W.N.1    Mar, V.L.2    Platler, B.W.3
  • 43
    • 0028128355 scopus 로고
    • Role of trypsin-like cleavage at arginine 192 in the enzymatic and cytotonic activities of Escherichia coli heat-labile enterotoxin
    • Grant CC, Messer RJ, Cieplak W Jr. Role of trypsin-like cleavage at arginine 192 in the enzymatic and cytotonic activities of Escherichia coli heat-labile enterotoxin. Infect. Immun. 1994; 62: 4270-8.
    • (1994) Infect. Immun. , vol.62 , pp. 4270-4278
    • Grant, C.C.1    Messer, R.J.2    Cieplak Jr., W.3
  • 44
    • 0029852233 scopus 로고    scopus 로고
    • Mutations in the a subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin
    • Magagnoli C, Manetti R, Fontana MR et al. Mutations in the A subunit affect yield, stability, and protease sensitivity of nontoxic derivatives of heat-labile enterotoxin. Infect. Immun. 1996; 64: 5434-8.
    • (1996) Infect. Immun. , vol.64 , pp. 5434-5438
    • Magagnoli, C.1    Manetti, R.2    Fontana, M.R.3
  • 45
    • 0027396382 scopus 로고
    • Induction of mucosal immunity by intranasal application of a streptococcal surface protein antigen with the cholera toxin B subunit
    • Wu HY, Russell MW. Induction of mucosal immunity by intranasal application of a streptococcal surface protein antigen with the cholera toxin B subunit. Infect. Immun. 1993; 61: 314-20.
    • (1993) Infect. Immun. , vol.61 , pp. 314-320
    • Wu, H.Y.1    Russell, M.W.2
  • 46
    • 0029036648 scopus 로고
    • Mucosal immunization with bacterial protein antigen genetically coupled to cholera toxin A2/B subunits
    • Hajishengallis G, Hollingshead SK, Koga T, Russell MW. Mucosal immunization with bacterial protein antigen genetically coupled to cholera toxin A2/B subunits. J. Immunol. 1995; 154: 4322-32.
    • (1995) J. Immunol. , vol.154 , pp. 4322-4332
    • Hajishengallis, G.1    Hollingshead, S.K.2    Koga, T.3    Russell, M.W.4
  • 47
    • 0025991211 scopus 로고
    • Host defence against cholera toxin is strongly CD4+ T cell dependent
    • Hörnquist E, Goldschmidt TJ, Holmdahl R, Lycke N. Host defence against cholera toxin is strongly CD4+ T cell dependent. Infect. Immun. 1991; 59: 3630-8.
    • (1991) Infect. Immun. , vol.59 , pp. 3630-3638
    • Hörnquist, E.1    Goldschmidt, T.J.2    Holmdahl, R.3    Lycke, N.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.