Interferon-γ receptor-deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance

Immunology

Volumn 92, Issue 1, 1997, Pages 60-68

  Kjerrulf, M ^a   Grdic, D ^a   Ekman, L ^a   Schon K ^a   Vajdy, M ^a   Lycke, N Y ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLERA TOXIN; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOLOGICAL ADJUVANT; INTERFERON RECEPTOR; INTERLEUKIN 10; INTERLEUKIN 4; KEYHOLE LIMPET HEMOCYANIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CONTROLLED STUDY; GENE TARGETING; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; INTESTINE EPITHELIUM CELL; INTESTINE LOOP; INTRAPERITONEAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LAMINA PROPRIA; MESENTERY LYMPH NODE; MOUSE; MUCOSAL IMMUNITY; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SPLEEN CELL; T LYMPHOCYTE; TRANSCYTOSIS;

EID: 0030820364     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.1997.00312.x     Document Type: Article

References (53)

1. BAO S., GOLDSTONE S. & HUBAND A.J. (1993) Localization of IFN-γ and IL-6 mRNA in murine intestine by in situ hybridization. Immunology 80, 666.
2. BRETT F., MOWAT A., FARQUHARSON M. et al. (1992) The distribution of immunoreactive interferon-γ-containing cells in normal human tissues. Immunology 77, 515.
3. BREESE E., BRAEGGER C., CORRIGAN C., WALKER-SMITH J. & MACDONALD T. (1993) Interleukin-2- and interferon-γ-secreting T cells in normal and diseased human intestinal mucosa. Immunology 78, 127.
4. HÖRNQUIST E., GRDIC D., MAK T. & LYCKE N. (1996) CD8-deficient mice exhibit augmented mucosal immune responses and intact adjuvant effect of cholera toxin. Immunology 87, 220.
5. QUIDING M., NORDSTRÖM I., KILANDER A. et al. (1991) Intestinal immune responses in humans. Oral cholera vaccination induces strong intestinal antibody responses and interferon-γ production and evokes local immunological memory. J Clin Invest 88, 143.
6. RAMARATHINAM L., SHABAN R., NEISEL D. & KIMPEL G. (1991) IFN-γ production by gut-associated lymphoid tissue and spleen following oral immunization. Microb Pathog 11, 347.
7. YAMAMOTO S., RUSS F., TEIXEIRA H., CONRADT P. & KAUFMANN S. (1993) Listeria monocytogenes-induced gamma interferon secretion by intraepithelial γ/δ T lymphocytes. Infect Immun 61, 2154.
8. GOES N., SIMS T., URMSON J. et al. (1995) Disturbed MHC regulation in the IFN-γ knockout mouse. J Immunol 155, 4559.
9. COLGAN S., PARKOS C., MATTHEWS J. et al. (1994) Interferon-γ induces a cell surface phenotype switch on T84 intestinal epithelial cells. Am J Physiol 267, C402.
10. YOUNGMAN K., FIOCCHI C. & KAETZEL C. (1994) Inhibition of IFN-γ activity in supernatants from stimulated human intestinal mononuclear cells prevents up-regulation of the polymeric Ig receptor in an intestinal epithelial cell line. J Immunol 153, 675.
11. SOLLID L., KVALE D., BRANDTZAEG P., MARKUSSEN G. & THORSBY E. (1987) Interferon-γ enhances expression of secretory component, the epithelial cell receptor for polymeric immunoglobulins. J Immunol 138, 4303.
12. MADARA J. & STAFFORD J. (1989) Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest 83, 724.
13. HOLMGREN J., FRYKLUND J. & LARSSON H. (1989) Gamma interferon mediated downregulation of electrolyte secretion by intestinal epithelial cells: a local immune mechanism? Scand J Immunol 30, 499.
14. VAJDY M., KOSCO-VILBOIS M., KOPF M., KÖHLER G. & LYCKE N. (1995) Impaired mucosal immune responses in interleukin 4-targeted mice. J Exp Med 181, 41.
15. KOPF M., LE GROS G., BACHMANN M. et al. (1993) Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362, 245.
16. TRINCHIERI G. & SCOTT P. (1994) The role of interleukin 12 in the immune response, disease and therapy. Immunol Today 15, 460.
17. SCOTT P. (1991) IFN-γ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J Immunol 147, 3149.
18. MCKNIGHT A., ZIMMER G., FOGELMAN I., WOLF S. & ABBAS A. (1994) Effects of IL-12 on helper T cell-dependent immune responses in vivo. J Immunol 152, 2172.
19. SCHIJNS V.E.C.J., HAAGMANS B.L. & HORZINEK M.C. (1995) IL-12 stimulates an antiviral type I cytokine response but lacks adjuvant activity in IFN-γ-receptor-deficient mice. J Immunol 155, 2525.
20. RHINER S.L. & SEDER R.A. (1995) T helper cell differentiation in immune response. Curr Opin Immunol 7, 360.
21. FLESH I.E.A., HESS J.H., HUANG S. et al. (1995) Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon y and tumor necrosis factor α. J Exp Med 181, 1615.
22. WANG Z., REINER S.L., ZHENG S., DALTON D. & LOCKSLEY R.M. (1994) CD4 + effector cells default to the Th2 pathway in interferon-γ deficient mice infected with Leishmania major. J Exp Med 179, 1367.
23. HSIEH C.-S., MACATONIA S.E., O'GARRA A. & MURPHY K.M. (1995) T cell genetic background determines default T helper phenotype development in vitro. J Exp Med 181, 713.
24. SWIHART K., FRUTH U., MESSMER N. et al. (1995) Mice from a genetically resistant background lacking interferon y receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4 + T cell response. J Exp Med 181, 961.
25. ZHANG Z. & MICHAEL G.M. (1990) Orally inducible immune unresponsiveness is abrogated by IFN-γ treatment. J Immunol 144, 4163.
26. HUANG S., HENDRIKS W., ALTHAGE A. et al. (1993) Immune responses in mice that lack the interferon-γ receptor. Science 259, 1742.
27. LYCKE N. & DEFRANCOIS L. (1996) Isolation of mouse small intestinal intraepitrial lymphocytes, Peyer's patch and lamina propria. In: Current Protocols in Immunology (ed. J. Coligan), p.3.19.6. John Wiley & Sons Inc., Washington.
28. HÖRNQVIST E., GOLDSCHMIDT T., HOLMDAHL R. & LYCKE N. (1991) Host defence against cholera toxin is strongly CD4 + T cell dependent. Infect Immun 59, 3630.
29. LYCKE N. & COICO R. (1996) Measurement of immunoglobulin synthesis using the ELISPOT assay. In: Current Protocols in Immunology (ed. J. Coligan), p.7.14.1. John Wiley & Sons Inc., Washington.
30. ELSON C.O., EALDING W. & LEFKOWITZ J. (1984) A lavage technique allowing repeated measurement of IgA antibody in mouse intestinal secretions. J Immunol Methods 67, 101.
31. LANGE S. & HOLMGREN J. (1978) Protective antitoxic cholera immunity in mice: influence of route and number of immunizations and mode of action of protective antibodies. Acta Pathol Microbiol Scand Sect C 86, 145.
32. LYCKE N. & HOLMGREN J. (1986) Strong adjuvant properties of cholera toxin on gut mucosal immune responses to orally presented antigens. Immunology 39, 301.
33. STROBER W. & EHRHARDT R.O. (1994) Regulation of IgA B cell development. In: Handbook of Mucosal Immunology (ed. W. Strober), p. 159. Academic Press Inc., San Diego, CA.
34. LEBMAN D. & COFFMAN R.L. (1986) Interleukin-4 causes isotype switching to IgE in T cell stimulated clonal B cell cultures. J Exp Med 168, 853.
35. HÖRNQVIST E., EKMAN L., GRDIC D., SCHÖN K. & LYCKE N. (1995) Paradoxical IgA immunity in CD4-deficient mice. Lack of cholera toxin-specific protective immunity despite normal gut mucosal IgA differentiation. J Immunol 155, 2877.
36. COLGAN S., RESNICK M., PARKOS C. et al. (1994) IL-4 directly modulates function of a model human intestinal epithelium. J Immunol 153, 2122.
37. BASCHIERI S., LEES R., LUSSOW A. & ROBSON MACDONALD H. (1993) Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines. Eur J Immunol 23, 2661.
38. MCMENAMIN C. & HOLT P. (1993) The natural immune responses to inhaled soluble protein antigen involves major histocompatibility complex (MHC) class I-restricted CD4 + T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production. J Exp Med 178, 889.
39. HOYNE G. & THOMAS W. (1995) T-cell responses to orally administered antigens. Study of the kinetics of lymphokine production after single and multiple feeding. Immunology 84, 304.
40. MARTH T., STROBER W. & KELSALL B. (1996) High dose oral tolerance in ovalbumin TCR-transgenic mice. Systemic neutralization of IL-12 augments TGF-β secretion and T cell apoptosis. J Immunol 157, 2348.
41. BURSTEIN H., SHEA M. & ABBAS A. (1992) Aqueous antigens induce in vivo tolerance selectively in IL-2- and IFN-γ-producing (Th1) cells. J Immunol 148, 3687.
42. LAMONT A.G., MOWAT A. & PARROTT D. (1989) Priming of systemic and local delayed-type hypersensitivity responses by feeding low doses of ovalbumin to mice. Immunology 66, 595.
43. CHEN Y., INOBE J. & WEINER H.L. (1995) Induction of oral tolerance to myelin basic protein in CD8-depleted mice: Both CD4 + and CD8 + cells mediate active suppression. J Immunol 155, 910.
44. -/- mice. FASEB J 10, Abstract nr 167.
45. ELSON C. & EALDING W. (1984) Cholera toxin feeding did not induce oral tolerance in mice and abrogated oral tolerance to an unrelated antigen. J Immunol 133, 2892.
46. LYCKE N., BROMANDER A., EKMAN L. et al. (1995) The use of knock-out mice in studies of induction and regulation of gut mucosal immunity. Mucosal Immunol Update 3, 1.
47. GARSIDE P., STEEL M., WORTHEY E.A. et al. (1995) T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction. J Immunol 154, 5649.
48. COYLE A., TSUYUKI S., BERTRAND C. et al. (1996) Mice lacking the IFN-γ receptor have an impaired ability to resolve a lung eosinophilic inflammatory response associated with a prolonged capacity of T cells to exhibit a Th2 cytokine profile. J Immunol 156, 2680.
49. VANCOTT J., PASCUAL D., CHATFIELD S. et al. (1995) The host response to mucosal vaccines in the context of targeted gene knockout mice. Mucosal Immunol Update 3, 3.
50. DIGHE A., CAMPBELL D., HSIEH C.-S. et al. (1995) Tissue-specific targeting of cytokine unresponsiveness in transgenic mice. Immunity 3, 657.
51. CEBRA J.J. & SHROFF K.E. (1994) Peyer's patches as inductive sites for IgA commitment. In: Handbook of Mucosal Immunology (eds. P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. McGhee & J. Bienenstock), p. 151. Academic Press Inc., San Diego, CA.
52. KELSALL B. & STROBER W. (1995) Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch. J Exp Med 183, 237.
53. KVALE D., BRANDTZAEG P. & LOVHAUG D. (1988) Up-regulation of the expression of secretory component and HLA molecules in a human colonic cell line by TNF-α and IFN-γ. Scand J Immunol 28, 351.