Altered Peptide Ligands Trigger Perforin- Rather than Fas-Dependent Cell Lysis

Journal of Immunology

Volumn 159, Issue 9, 1997, Pages 4165-4170

  Bachmann, Martin F ^a,c   Ohteki, Toshiaki ^a   Faienza, Kim McKall ^a   Zakarian, Arsen ^a   Kägi, David ^a,b   Speiser, Daniel E ^a   Ohashi, Pamela S ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b AMGEN INSTITUTE   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; FAS LIGAND; FASL PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; PERFORIN; PORE FORMING CYTOTOXIC PROTEIN;

ANIMAL; ARTICLE; CELL DEATH; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; GENETICS; IMMUNOLOGY; MOUSE; TRANSGENIC MOUSE;

ANIMALS; ANTIGENS, CD95; CELL DEATH; CYTOTOXICITY, IMMUNOLOGIC; FAS LIGAND PROTEIN; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; PORE FORMING CYTOTOXIC PROTEINS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0031280040     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Kägi, D., F. Vignaux, B. Ledermann, K. Bürki, V. Depraetere, S. Nagata, H. Hengartner, and P. Golstein. 1994. Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity. Science 265:528.
2. Lowin, B., M. Hahne, C. Mattman, and J. Tschopp. 1994. Cytolytic T cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature 370:650.
3. Walsh, C. M., M. Matloubian, C. C. Liu, R. Ueda, C. G. Kurahara, J. L. Christensen, M. T. Huang, J. D. Young, R. Ahmed, and W. R. Clark. 1994. Immune function in mice lacking the perforin gene. Proc. Natl. Acad. Sci. 91:10854.
4. Kägi, D., B. Ledermann, K. Bürki, P. Seiler, B. Odermatt, K. J. Olsen, E. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31.
5. Kägi, D., P. Seiler, J. Pavlovic, K. Bürki, R. M. Zinkernagel, and H. Hengartner. 1995. The roles of perforin-and Fas-dependent cytotoxocity against cytopathic and non-cytopathic viruses. Eur. J. Immunol 25:3256.
6. Ehl, S., U. Hoffmann-Rohrer, S. Nagata, H. Hengartner, and R. M. Zinkernagel. 1996. Different susceptibility of cytotoxic T cells to CD95 (Fas/Apo-1) ligand-mediated cell death after activation in vitro versus in vivo. J. Immunol. 156:2357.
7. Watanabe-Fukunaga, R., C. I. Brannan, N. G. Copeland, N. A. Jenkins, and S. Nagata. 1992. Lymphoroliferative disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356:314.
8. Suda, T., T. Takahashi, P. Golstein, and S. Nagata. 1993. Molecular cloning and expression of the fas ligand, a novel member of the tumor necrosis factor family. Cell 75:1169.
9. Lynch, D. H., M. L. Watson, M. R. Alderson, P. R. Baum, R. E. Miller, T. Tough, M. Gibson, T. Davis-Smith, C. A. Smith, K. Hunter, D. Bhat, W. Din, R. G. Goodwin, and M. F. Seldin. 1994. The mouse Fas-ligand gene is mutated in gld mice and is part of a TNF family gene cluster. Immunity 1:131.
10. Takahashi, T., M. Tanaka, C. I. Brannan, N. A. Jenkins, N. G. Copeland, T. Suda, and S. Nagata. 1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76:969.
11. Nagata, S., and P. Golstein. 1995. The fas death factor. Science 267:1449.
12. Russell, J. H., B. Rush, C. Weaver, and R. Wang. 1993. Mature T cells of autoimmune lpr/lpr mice have a defect in antigen-stimulated suicide. Proc. Natl. Acad. Sci. 90:4409.
13. Singer, G. G., and A. K. Abbas. 1994. The Fas-antigen is involved in peripheral but not thymic deletion of T lymphocytes in T cell receptor transgenic mice. Immunity 1:365.
14. Griffith, T. S., T. Brunner, S. M. Fletcher, D. R. Green, and T. A. Ferguson. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270:1158.
15. Bellgrau, D., D. Gold, H. Selawry, J. Moore, A. Franzusoff, and R. C. Duke. 1995. A role of CD95 ligand in preventing graft rejection. Nature 377:630.
16. Baker, M. B., R. L. Riley, E. R. Podack, and R. B. Levy. 1997. Graft-versus-host disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin function. Proc. Natl. Acad. Sci. USA 94:1366.
17. Hahne, M., D. Rimoldi, M. Schröter. P. Romero, M. Schreier, L. E. French, P. Schneider, T. Bornand, A. Fontana, D. Lienard, J.-C. Cerrotini, and J. Tschopp. 1996. Melanoma cell expression of Fas (Apo-1/CD95) ligand: implications for tumor immune escape. Science 274:1363.
18. + T cells by a self-derived peptide. Nature 378:295.
19. Brossart, P., and M. J. Bevan. 1996. Selective activation of Fas/Fas ligand-mediated cytotoxicity by a self peptide. J. Exp. Med. 183:2449.
20. d-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative. J. Exp. Med. 185:629.
21. Jameson, S. C., K. A. Hogquist, and M. J. Bevan. 1995. Positive selection of thymocytes. Annu. Rev. Immunol. 13:93.
22. Ohashi, P. S. 1996. T cell selection and autoimmunity: flexibility and tuning. Curr. Opin. Immunol. 8:808.
23. Pircher, H. P., K. Bürki, R. Lang, H. Hengartner, and R. M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342:559.
24. + thymocytes in vitro does not require dedicated antigen presenting cells. Eur. J. Immunol. 23:669.
25. Bachmann, M. F. 1997. Evaluation of lymphocytic choriomeningitis virus-specific cytotoxic T cell responses. In Immunology Methods Manual. I. Lefkowitz, ed. Academic Press, New York, pp. 1921-1933.
26. Sebzda, E., T. M. Kündig, C. T. Thomson, K. Aoki, S. Y. Mak, J. P. Mayer, T. Zamborelli, S. G. Nathenson, and P. S. Ohashi. 1996. Mature T cell reactivity altered by peptide agonist that induces positive selection. J. Exp. Med. 183:1093.
27. Alexander, J., K. Snoke, J. Ruppert, J. Sidney, M. Wall, S. Southwood, C. Oseroff, T. Arrhenius, F. C. Gaeta, and S. M. Colon. 1993. Functional consequences of engagement of the T cell receptor by low affinity ligands. J. Immunol. 150:1.
28. Jameson, S. C., F. R. Carbone, and M. J. Bevan. 1993. Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells. J. Exp. Med. 177:1541.
29. Bertoletti, A., A. Sette, F. V. Chisari, A. Penna, M. Levrero, C. M. De, F. Fiaccadori, and C. Ferrari. 1994. Natural variants of cytotoxic epitopes are T cell receptor antagonists for anti-viral cytotoxic T cells. Nature 369:407.
30. Moskophidis, D., F. Lechner, H. P. Pircher, and R. M. Zinkernagel. 1993. Virus persistence in acutely infected immunocompetent mice by exhaustion of antiviral cytotoxic effector T cells. Nature 362:758.
31. Trenn, G., H. Takayama, and M. V. Sitkovsky. 1987. Exocytosis of cytolytic granules may not be required for target cell lysis by cytotoxic T-lymphocytes. Nature 330:72.
32. Ostergaard, H. L., K. P. Kane, M. F. Mescher, and W. R. Clark. 1987. Cytotoxic T lymphocyte mediated lysis without release of serine esterase. Nature 330:71.
33. Evavold, B. D., J. Sloan-Lancaster, and P. M. Allen. 1993. Tickling the TCR: selective T-cell functions stimulated by altered peptide ligands. Immunol. Today 14:602.
34. Bachmann, M. F., E. Sebzda, T. M. Kündig, A. Shahinian, D. Speiser, T. W. Mak, and P. S. Ohashi. 1996. T cell responses are governed by avidity and costimulatory thresholds. Eur. J. Immunol. 26:2017.
35. Bachmann, M. F., A. Oxenius, D. E. Speiser, S. Mariathasan, H. Hengartner, R. M. Zinkernagel, and P. S. Ohashi. 1997. Peptide induced TCR-down regulation on naive T cell predicts agonist/partial agonist properties and strictly correlates with T cell activation. Eur. J. Immunol. In press.