SCOPUS 정보 검색 플랫폼

Drug Discovery Today

Volumn 3, Issue 6, 1998, Pages 250-256

Novel molecular targets for the treatment of obesity

(4) Strader, Catherine D a Hwa, Joyce J a Van Heek, Margaret a Parker, Eric M a

a MERCK RESEARCH LABORATORIES (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; ALPHA INTERMEDIN; ANTIOBESITY AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BIOGENIC AMINE; BMS 187257; CYCLOHEXYL[4 [2 [2 HYDROXY 3 (4 HYDROXYPHENOXY)PROPYLAMINO]ETHYL]PHENOXYMETHYL]PHOSPHINIC ACID; FR 165914; GALANIN; GR 23118; HEXYLUREA; LEPTIN; LY 357897; MELANOCORTIN; N [1 [4 [[[[4 [(DIMETHYLAMINO)METHYL]CYCLOHEXYL]METHYL]AMINO]IMINOMETHYL]BENZYL] 2 OXO 2 (1 PYRROLIDINYL)ETHYL] ALPHA [(2 NAPHTHALENYLSULFONYL)AMINO]BENZENEPROPANAMIDE; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROGEN; PD 160170; SR 5811A; UNCLASSIFIED DRUG;

APPETITE; CALORIC INTAKE; DRUG EFFECT; DRUG RECEPTOR BINDING; DRUG TARGETING; ENERGY BALANCE; ENERGY EXPENDITURE; HUMAN; NEUROTRANSMISSION; OBESITY; REVIEW; THERMOGENESIS; WEIGHT REDUCTION;

EID: 0031803273 PISSN: 13596446 EISSN: None Source Type: Journal
DOI: 10.1016/S1359-6446(98)01189-1 Document Type: Review

Times cited : (21)

References (64)

1
- 0028139089
- Zhang Y.et al. Nature. 372:1994;425-431.
- (1994) Nature , vol.372 , pp. 425-431
- Zhang, Y.¹

2
- 13344259300
- Chen H.et al. Cell. 84:1996;491-495.
- (1996) Cell , vol.84 , pp. 491-495
- Chen, H.¹

3
- 0030137757
- Phillips M.S.et al. Nat. Genet. 13:1996;18-19.
- (1996) Nat. Genet. , vol.13 , pp. 18-19
- Phillips, M.S.¹

4
- 0029073613
- Halaas J.L.et al. Science. 269:1995;543-546.
- (1995) Science , vol.269 , pp. 543-546
- Halaas, J.L.¹

5
- 0029066265
- Pelleymounter M.A.et al. Science. 269:1995;540-543.
- (1995) Science , vol.269 , pp. 540-543
- Pelleymounter, M.A.¹

6
- 0029048408
- Campfield L.A.et al. Science. 269:1995;546-548.
- (1995) Science , vol.269 , pp. 546-548
- Campfield, L.A.¹

7
- 0031051499
- Mounzih K., Lu R., Chehab F.F. Endocrinology. 128:1997;1190-1193.
- (1997) Endocrinology , vol.128 , pp. 1190-1193
- Mounzih, K.¹ Lu, R.² Chehab, F.F.³

8
- 0344948748
- Hwa J.J.et al. Am. J. Physiol. 8:1997;1202-1209.
- (1997) Am. J. Physiol. , vol.8 , pp. 1202-1209
- Hwa, J.J.¹

9
- 0030866876
- Mistry A.M., Swick A.G., Romsos D.R. J. Nutr. 127:1997;2065-2072.
- (1997) J. Nutr. , vol.127 , pp. 2065-2072
- Mistry, A.M.¹ Swick, A.G.² Romsos, D.R.³

10
- 0030987368
- Zhou Y.T.et al. Proc. Natl. Acad. Sci. U. S. A. 94:1997;6386-6390.
- (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 6386-6390
- Zhou, Y.T.¹

11
- 0030885230
- Shimabukuro M.et al. J. Clin. Invest. 100:1997;1750-1754.
- (1997) J. Clin. Invest. , vol.100 , pp. 1750-1754
- Shimabukuro, M.¹

12
- 0030878110
- Montague C.T.et al. Nature. 387:1997;903-908.
- (1997) Nature , vol.387 , pp. 903-908
- Montague, C.T.¹

13
- 0028845877
- Maffei M.et al. Nat. Med. 1:1995;1155-1161.
- (1995) Nat. Med. , vol.1 , pp. 1155-1161
- Maffei, M.¹

14
- 0028793697
- Frederich R.C.et al. Nat. Med. 1:1995;1311-1314.
- (1995) Nat. Med. , vol.1 , pp. 1311-1314
- Frederich, R.C.¹

15
- 0029020677
- Considine R.V.et al. J. Clin. Invest. 95:1995;2986-2988.
- (1995) J. Clin. Invest. , vol.95 , pp. 2986-2988
- Considine, R.V.¹

16
- 0029885220
- Considine R.V.et al. Diabetes. 19:1996;992-994.
- (1996) Diabetes , vol.19 , pp. 992-994
- Considine, R.V.¹

17
- 0029050937
- Lonnqvist F.et al. Nat. Med. 1:1995;950-953.
- (1995) Nat. Med. , vol.1 , pp. 950-953
- Lonnqvist, F.¹

18
- 0029083859
- Hamilton B.S.et al. Nat. Med. 1:1995;953-956.
- (1995) Nat. Med. , vol.1 , pp. 953-956
- Hamilton, B.S.¹

19
- 0029881125
- Schwartz M.W.et al. Nat. Med. 2:1996;589-593.
- (1996) Nat. Med. , vol.2 , pp. 589-593
- Schwartz, M.W.¹

20
- 0030807358
- Van Heek M.et al. J. Clin. Invest. 99:1997;385-390.
- (1997) J. Clin. Invest. , vol.99 , pp. 385-390
- Van Heek, M.¹

21
- 0030678119
- Boston B.A.et al. Science. 278:1997;1641-1644.
- (1997) Science , vol.278 , pp. 1641-1644
- Boston, B.A.¹

22
- 0030594830
- Caro J.F.et al. Lancet. 348:1996;159-161.
- (1996) Lancet , vol.348 , pp. 159-161
- Caro, J.F.¹

23
- 0029864416
- Banks W.A.et al. Peptides. 17:1996;305-311.
- (1996) Peptides , vol.17 , pp. 305-311
- Banks, W.A.¹

24
- 0026637310
- Stanley B.G.et al. Peptides. 13:1992;581-587.
- (1992) Peptides , vol.13 , pp. 581-587
- Stanley, B.G.¹

25
- 0026022088
- Billington C.J.et al. Am. J. Physiol. 260:1991;R321-R327.
- (1991) Am. J. Physiol. , vol.260
- Billington, C.J.¹

26
- 0028157404
- Akibayashi A.et al. Mol. Brain Res. 21:1994;55-61.
- (1994) Mol. Brain Res. , vol.21 , pp. 55-61
- Akibayashi, A.¹

27
- 0028335412
- Dube M.G.et al. Brain Res. 646:1994;341-344.
- (1994) Brain Res. , vol.646 , pp. 341-344
- Dube, M.G.¹

28
- 0023867209
- Sahu A.et al. Peptides. 9:1988;83-86.
- (1988) Peptides , vol.9 , pp. 83-86
- Sahu, A.¹

29
- 0029098589
- Stephens T.W.et al. Nature. 377:1995;530-532.
- (1995) Nature , vol.377 , pp. 530-532
- Stephens, T.W.¹

30
- 0029804743
- Erickson J.C.et al. Science. 274:1996;1704-1707.
- (1996) Science , vol.274 , pp. 1704-1707
- Erickson, J.C.¹

31
- 0030840674
- Blomqvist A.G., Herzog H. Trends Neurosci. 20:1997;294-298.
- (1997) Trends Neurosci. , vol.20 , pp. 294-298
- Blomqvist, A.G.¹ Herzog, H.²

32
- 15844420659
- Gerald C.et al. Nature. 382:1996;168-171.
- (1996) Nature , vol.382 , pp. 168-171
- Gerald, C.¹

33
- 0030709477
- Schaffhauser A.O.et al. Diabetes. 46:1997;1792-1798.
- (1997) Diabetes , vol.46 , pp. 1792-1798
- Schaffhauser, A.O.¹

34
- 0028917166
- Jacques D.et al. Eur. J. Pharmacol. 278:1995;R3-R5.
- (1995) Eur. J. Pharmacol. , vol.278
- Jacques, D.¹

35
- 8044234377
- O'Shea D.et al. Endocrinology. 138:1997;196-202.
- (1997) Endocrinology , vol.138 , pp. 196-202
- O'Shea, D.¹

36
- 17544395939
- Hipskind P.A.et al. J. Med. Chem. 40:1997;3712-3714.
- (1997) J. Med. Chem. , vol.40 , pp. 3712-3714
- Hipskind, P.A.¹

37
- 0030873083
- Wright J. Drug Discovery Today. 2:1997;19-24.
- (1997) Drug Discovery Today , vol.2 , pp. 19-24
- Wright, J.¹

38
- 0028985762
- Serradeil-Le Gal C.et al. FEBS Lett. 362:1995;192-196.
- (1995) FEBS Lett. , vol.362 , pp. 192-196
- Serradeil-Le Gal, C.¹

39
- 85030332939
- (1996) Patent WO 96/14307
- Peterson, J.M. et al. (1996) Patent WO 96/14307.
- Peterson, J.M.¹

40
- 85030339665
- (1996) US Patent 5,554,621
- Poindexter, G.S. et al. (1996) US Patent 5,554,621.
- Poindexter, G.S.¹

41
- 0029068647
- Daniels A.J.et al. Proc. Natl. Acad. Sci. U. S. A. 92:1995;9067-9071.
- (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 9067-9071
- Daniels, A.J.¹

42
- 85047679082
- Kanatani A.et al. Endocrinology. 137:1996;3177-3182.
- (1996) Endocrinology , vol.137 , pp. 3177-3182
- Kanatani, A.¹

43
- 0001122022
- Criscione L.et al. Soc. Neurosci. Abstr. 23:1997;575.
- (1997) Soc. Neurosci. Abstr. , vol.23 , pp. 575
- Criscione, L.¹

44
- 0030972558
- Mountjoy K.G., Wong J. Mol. Cell. Endocrinol. 128:1997;171-177.
- (1997) Mol. Cell. Endocrinol. , vol.128 , pp. 171-177
- Mountjoy, K.G.¹ Wong, J.²

45
- 0031051101
- Yang Y-K.et al. Mol. Endocrinol. 11:1997;274-280.
- (1997) Mol. Endocrinol. , vol.11 , pp. 274-280
- Yang, Y-K.¹

46
- 0030889192
- Huszar D.et al. Cell. 88:1997;131-141.
- (1997) Cell , vol.88 , pp. 131-141
- Huszar, D.¹

47
- 85042693485
- Seeley R.J.et al. Nature. 390:1997;349.
- (1997) Nature , vol.390 , pp. 349
- Seeley, R.J.¹

48
- 0025513641
- Crawley J.N.et al. J. Neurosci. 10:1990;3695-3700.
- (1990) J. Neurosci. , vol.10 , pp. 3695-3700
- Crawley, J.N.¹

49
- 0028135499
- Akabayashi A.et al. Proc. Natl. Acad. Sci. U. S. A. 91:1994;10375-10379.
- (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 10375-10379
- Akabayashi, A.¹

50
- 0027048799
- Leibowitz S.F., Kim T. Brain Res. 599:1992;148-152.
- (1992) Brain Res. , vol.599 , pp. 148-152
- Leibowitz, S.F.¹ Kim, T.²

51
- 0027938954
- Habert-Ortoli E.et al. Proc. Natl. Acad. Sci. U. S. A. 91:1994;9780-9783.
- (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 9780-9783
- Habert-Ortoli, E.¹

52
- 0030933327
- Howard A.D.et al. FEBS Lett. 405:1997;285-290.
- (1997) FEBS Lett. , vol.405 , pp. 285-290
- Howard, A.D.¹

53
- 0031452562
- Wang S.et al. J. Biol. Chem. 272:1997;31949-31952.
- (1997) J. Biol. Chem. , vol.272 , pp. 31949-31952
- Wang, S.¹

54
- 0027312070
- Wynick D.et al. Proc. Natl. Acad. Sci. U. S. A. 90:1993;4231-4235.
- (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 4231-4235
- Wynick, D.¹

55
- 0021322138
- Nicholls D.G., Locke R.M. Physiol. Rev. 64:1984;1-64.
- (1984) Physiol. Rev. , vol.64 , pp. 1-64
- Nicholls, D.G.¹ Locke, R.M.²

56
- 0031019249
- Fleury C.et al. Nat. Genet. 15:1997;269-272.
- (1997) Nat. Genet. , vol.15 , pp. 269-272
- Fleury, C.¹

57
- 0031560941
- Vidal-Puig A.et al. Biochem. Biophys. Res. Commun. 235:1997;79-82.
- (1997) Biochem. Biophys. Res. Commun. , vol.235 , pp. 79-82
- Vidal-Puig, A.¹

58
- 0344948730
- Arch J.R.et al. Nature. 309:1984;161-165.
- (1984) Nature , vol.309 , pp. 161-165
- Arch, J.R.¹

59
- 0030679641
- Dow R. Exp. Opin. Invest. Drugs. 6:1997;1811-1825.
- (1997) Exp. Opin. Invest. Drugs , vol.6 , pp. 1811-1825
- Dow, R.¹

60
- 0029793561
- Lipworth B.J. Br. J. Clin. Pharmacol. 42:1996;291-300.
- (1996) Br. J. Clin. Pharmacol. , vol.42 , pp. 291-300
- Lipworth, B.J.¹

61
- 0023951785
- Connacher A.A.et al. Br. Med. J. 296:1988;1217-1220.
- (1988) Br. Med. J. , vol.296 , pp. 1217-1220
- Connacher, A.A.¹

62
- 0027080192
- Liggett S.B. Mol. Pharmacol. 42:1992;634-637.
- (1992) Mol. Pharmacol. , vol.42 , pp. 634-637
- Liggett, S.B.¹

63
- 0345380186
- Tecott L.H.et al. Nature. 374:1995;456-542.
- (1995) Nature , vol.374 , pp. 456-542
- Tecott, L.H.¹

64
- 0030610606
- Bos M.et al. J. Med. Chem. 40:1997;2762-2769.
- (1997) J. Med. Chem. , vol.40 , pp. 2762-2769
- Bos, M.¹

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