Genes and environment in the etiology of colorectal cancer

Seminars in Cancer Biology

Volumn 8, Issue 4, 1998, Pages 285-298

  Gertig, Dorota M ^a,b,c   Hunter, David J ^a,b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c HARVARD CENTER FOR CANCER PREVENTION   (United States)

Author keywords

Colorectal cancer; Environment; Genetics

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACETYLSALICYLIC ACID; ACYLTRANSFERASE; APOLIPOPROTEIN E; CARCINOGEN; CYTOCHROME P450; GLUTATHIONE TRANSFERASE; TRACE ELEMENT;

ALCOHOL CONSUMPTION; CIGARETTE SMOKING; COLORECTAL CANCER; DIET; DNA REPAIR; ENVIRONMENTAL FACTOR; ENZYME POLYMORPHISM; EXERCISE; FAT INTAKE; FITNESS; FRUIT; GENE MUTATION; HUMAN; MEAT; REVIEW; RISK FACTOR; VEGETABLE;

EID: 0031771057     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1006/scbi.1998.0078     Document Type: Article

References (144)

1. 1. Potter J (1992) Reconciling the epidemiology, physiology, and molecular biology of colon cancer. JAMA 268:1573-1576
2. 2. Giovannucci E, Willett WC (1994) Dietary factors and risk of colon cancer. Ann Med 26:443-452
3. 3. Vogelstein B, Fearon ER, Hamilton SR et al (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319:525-532
4. 4. Fearon ER, Vogelstein B (1990) A genetic model for colorectal tumorigenesis. Cell 61:759-767
5. 5. Lynch HT, Smyrk T (1996) Hereditary nonpolyposis colorectal cancer (Lynch syndrome). Cancer 78:1149-1167
6. 6. Liu B, Nicolaides NC, Markowitz S et al (1995) Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability. Nature Genetics 9:48-55
7. 7. Perera FP, Mooney LA, Dickey CP et al (1996) Molecular epidemiology in environmental carcinogenesis. Environ Health Persp 104:441-443
8. 8. Raunio H, Husgafvel-Pursiainen K, Anttila S, Hietanen E, Hirvonen A (1995) Diagnosis of polymorphisms in carcinogen-activating and inactivating enzymes and cancer susceptibility - a review. Gene 159:113-121
9. 9. Murray CJ, Lopez AD (1996) Global Health Statistics: a Compendium of Incidence, Prevalence and Mortality Estimates for over 200 Conditions. World Health Organization
10. 10. Potter JD, Slattery ML, Bostick RM, Gapstur SM (1993) Colon cancer: a review of the epidemiology. Epidemiol Rev 15:499-545
11. 11. Haenszel W (1961) Cancer mortality among the foreign-born in the United States. J Natl Cancer Inst 26:37-132
12. 12. McMichael AJ, McCall MG, Hartshorne JM, Woodings TL (1980) Patterns of gastrointestinal cancer in European migrants to Australia: the role of dietary change. Int J Cancer 25:431-437
13. 13. Potter J (1996) Nutrition and colorectal cancer. Cancer Causes Control 7:127-146
14. 14. Haenszel W, Berg JW, Segi M, Kurihara M, Locke FB (1973) Large bowel cancer in Hawaiian Japanese. JNCI 51:1765-1779
15. 15. Manousos O, Day NE, Trichopoulos D, Gerovassilis F, Tzonou A, Polychronopoulou A (1983) Diet and colorectal cancer: a case-control study in Greece. Int J Cancer 32:1-5
16. 16. La Vecchia C, Negri E, DeCarli A et al (1988) A case-control study of diet and colorectal cancer in Northern Italy. Int J Cancer 41:492-498
17. 17. Young TB, Wolf DA (1988) Case-control study of proximal and distal colon cancer and diet in Wisconsin. Int J Cancer 42:167-175
18. 18. Lee HP, Gourley L, Duffy SW, Esteve J, Lee J, Day NE (1989) Colorectal cancer and diet in an Asian population: a case-control study among Singapore Chinese. Int J Cancer 43:1007-1016
19. 19. Benito E, Obrador A, Stiggelbout A et al (1990) A population-based case-control study of colorectal cancer in Majorca. Int J Cancer 45:69-76
20. 20. Gerhardsson M, Floderus B, Norell SE (1988) Physical activity and colon cancer risk. Int J Epidemiol 17:743-746
21. 21. Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Willett WC (1994) Intake of fat, meat, and fiber in relation to risk of colon cancer in men. Cancer Res 54:2390-2397
22. 22. Willett WC, Stampfer MJ, Colditz GA, Rosner B, Speizer FE (1990) Relation of meat, fat and fiber intake to the risk of colon cancer in a prospective study among women. New Engl J Med 323:1664-1672
23. 23. Phillips RL, Snowdon DA (1983) Association of meat and coffee use with cancers of the large bowel, breast and prostate among Seventh-day Adventists: preliminary results. Cancer Res (suppl) 43:2403-23085
24. 24. Garland C, Shekelle RE, Barrett-Connor E, Criqui MH, Rossof AH, Paul O (1985) Dietary vitamin D and calcium and risk of colorectal cancer: a 19-year prospective study in men. Lancet 1:307-309
25. 25. Thun MJ, Calle EE, Namboodiri MM et al (1992) Risk factors for fatal colon cancer in a large prospective study. J Natl Cancer Inst 84:1491-1500
26. 26. Reddy BS (1981) Diet and excretion of bile acids. Cancer Res 41:3766-3768
27. 27. Sugimura T (1986) Past, present and future of mutagens in cooked foods. Env Health Persp 67:5-10
28. 28. Bogen K (1994) Cancer potencies of heterocyclic amines found in cooked foods. Fd Chem Toxic 32:505-515
29. 29. Nagao M, Ushijima T, Wakabayashi K et al (1994) Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods. Cancer 74:1063-1069
30. 30. Ito N, Hasegawa R, Sano M et al (1991) A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis 12:1503-1506
31. 31. Gold L, Slone T, Manley N, Ames B (1994) Heterocyclic amines formed by cooking food: comparison of bioassay results with other chemicals in the Carcinogenic Potency Database. Cancer Lett 83:21-29
32. 32. Lang N, Butler M, Massengill J et al (1994) Rapid metabolic phenotypes for acetyltransferase and cytochrome p4501A2 and putative exposure to food-borne heterocyclic amines increase the risk for colorectal cancer or polyps. Cancer Epidemiol, Biomark Prevent 3:675-682
33. 33. Roberts-Thomson IC, Ryan P, Khoo KK, Hart WJ, McMichael AJ, Butler RN (1996) Diet, acetylator phenotype, and risk of colorectal neoplasia. Lancet 347:1372-1374
34. 34. Chen J, Stampfer MJ, Hough H et al (in press) A prospective study of N-Acetyltransferase genotype, red meat intake and risk of colorectal cancer. Cancer Res
35. 35. Byrne C, Sinha R, Platz EA et al (1998) Predictors of dietary heterocyclic amine intake in three prospective cohorts. Cancer Epidemiol, Biomark Prevent 7:523-529
36. 36. Trock B, Lanza E, Greenwald P (1990) Dietary fiber, vegetables, and colon cancer: critical review and meta-analyses of the epidemiologic evidence. JNCI 82:650-661
37. 37. Martinez I, Torres R, Frias Z et al (1981) Factors associated with adenocarcinoma of the large bowel in Puerto Rico. Rev Latinoam Oncol Clin 13:13-20
38. 38. Miller AB, Howe GR, Jain M, Craib KJ, Harrison L. (1983) Food items and food groups as risk factors in a case-control study of diet and colorectal cancer. Int J Cancer 32:155-161
39. 39. Graham S, Dayal H, Swanson M, Mittelman A, Wilkinson G (1988) Diet in the epidemiology of cancer of the colon and rectum. JNCI 61:709-714
40. 40. Wargovich MJ, Eng VW, Newmark HL, Bruce WR (1983) Calcium ameliorates the toxic effect of deoxycholic acid on colonic epithelium. Carcinogenesis 4:1205-1207
41. 41. Buset M, Lipkin M, Winaver S, Swaroop S, Friedman E (1986) Inhibition of human colonic epithelial cell proliferation in vivo and in vitro by calcium. Cancer Res 46:5426-5430
42. 42. Sitrin MD, Halline AG, Abrahams C, Brasitus TA (1991) Dietary calcium and vitamin D modulate 1,2-dimethylhydrazine-induced colonic carcinogenesis in the rat. Cancer Res 51:5608-5613
43. 43. Cross HS, Pavelka M, Slavik J, Peterlik M (1992) Growth control of human colon cancer cells by vitamin D and calcium in vitro. J Natl Cancer Inst 84:1355-1357
44. 44. Martinez ME, Giovannucci EL, Colditz GA et al (1996) Calcium, vitamin D, and the occurrence of colorectal cancer among women. J Natl Cancer Inst 88:1375-1382
45. 45. Longnecker MP, Martin-Moreno JM, Knekt P et al (1992) Serum α-tocopherol concentration in relation to subsequent colorectal cancer: pooled data from five cohorts. J Natl Cancer Inst 84:430-435
46. 46. Knekt P, Aromaa A, Maatela J et al (1988) Serum vitamin E and risk of cancer among Finnish men during a 10-year follow-up. Am J Epidemiol 127:28-41
47. 47. Bostick RM, Potter JD, McKenzie DR, Sellers TA et al (1993) Reduced risk of colon cancer with high intake of vitamin E: the Iowa Women's Health Study. Cancer Res 53:4230-4237
48. 48. Greenberg ER, Baron JA, Tosteson TD et al (1994) A clinical trial of antioxidant vitamins to prevent colorectal adenoma. N Engl J Med 331:141-147
49. 49. Mason JB (1994) Folate and colonic carcinogenesis: searching for a mechanistic understanding. J Nutr Biochem 5:170-175
50. 50. Blount BC, Ames BN (1995) DNA damage in folate deficiency. Baillieres Clin Haematol 8:461-478
51. 51. Goelz SE, Vogelstein B, Hamilton SR, Feinberg AP (1985) Hypomethylation of DNA from benign and malignant human colon neoplasms. Science 228:187-190
52. 52. Feinberg AP, Gehrke CW, Kuo KC, Ehrlich M (1988) Reduced genomic 5-methyl cytosine content in human colonic neoplasia. Cancer Res 48:1159-1161
53. 53. Wainfan E, Dizik M, Stender M, Christman JK (1989) Rapid appearance of hypomethylated DNA in liver of rats fed cancer-promoting, methyl-deficient diets. Cancer Res 49:4094-4097
54. 54. Cravo ML, Mason JB, Dayal Y et al (1992) Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats. Cancer Res 52:5002-5006
55. 55. Dizik M, Christman JK, Wainfan E (1991) Alterations in expression and methylation of specific genes in livers of rats fed a cancer promoting methyl-deficient diet. Carcinogenesis 12:1307-1312
56. 56. Freudenheim JL, Graham S, Marshall JR, Haughey BP, Cholewinski S, Wilkinson G (1991) Folate intake and carcinogenesis of the colon and rectum. Int J Epidemiol 20:368-374
57. 57. Giovannucci E, Rimm EB, Ascherio A, Stampfer MJ, Colditz GA, Willett WC (1995) Alcohol, low-methionine-low-folate diets, and risk of colon cancer in men. J Natl Cancer Inst 87:265-273
58. 58. Glynn SA, Albanes D, Pietinen P et al (1996) Colorectal cancer and folate status: a nested case-control study among smokers. Cancer Epidemiol, Biomark Prevent 5:487-494
59. 59. Terry M, Neugut AI (1998) Cigarette smoking and the colorectal adenoma-carcinoma sequence: a hypothesis to explain the paradox. Am J Epidemiol 147:903-910
60. 60. Olsen J, Kronborg O (1993) Coffee, tobacco and alcohol as risk factors for cancer and adenoma of the large intestine. Int J Epidemiol 22:398-402
61. 61. Giovannucci E, Rimm EB, Stampfer MJ et al (1994) A prospective study of cigarette smoking and risk of colorectal adenoma and colorectal cancer in U.S. men. J Natl Cancer Inst 86:183-191
62. 62. Wu AH, Paganini-Hill A, Ross RK, Henderson BE (1987) Alcohol, physical activity and other risk factors for colorectal cancer. Br J Cancer 55:687-694
63. 63. Sandler RS, Sandler DP, Comstock GW, Helsing KJ, Shore DL (1988) Cigarette smoking and the risk of colorectal cancer in women. J Natl Cancer Inst 80:1329-1333
64. 64. Choi S, Kahyo H (1991) Effect of cigarette smoking and alcohol consumption in the etiology of cancers of the digestive tract. Int J Cancer 49:381-386
65. 65. Nyren O, Bergstrom R, Nystrom L et al (1996) Smoking and colorectal cancer: a 20-year follow-up study of Swedish construction workers. J Natl Cancer Inst 88:1302-1307
66. 66. Gapstur S, Potter J, Folsom A (1994) Alcohol consumption and colon and rectal cancer in postmenopausal women. Int J Epidemiol 23:50-57
67. 67. Klatsky A, Armstrong M, Friedman G, Hiatt R (1988) The relations of alcoholic beverage use to colon and rectal cancer. Am J Epidemiol 128:1007-1015
68. 68. Hirayama T (1989) Association between alcohol consumption and cancer of the sigmoid colon: observations from a Japanese cohort study. Lancet 334:725-727
69. 69. Gordon T, Kannel WB (1984) Drinking and mortality: the Framingham Study. Am J Epidemiol 120:97-107
70. 70. Longnecker M, Orza M, Adams M, Vioque J, Chalmers T (1990) A meta-analysis of alcoholic beverage consumption in relation to risk of colorectal cancer. Cancer Causes Control 1:59-68
71. 71. Schreinmachers DM, Everson RB (1994) Aspirin use and lung, colon and breast cancer incidence in a prospective study. Epidemiology 5:138-146
72. 72. Giovannucci E, Rimm EB, Stampfer MJ, Colditz GA, Ascherio A, Willett WC (1994) Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Int Med 121:241-246
73. 73. Marcus AJ (1995) Aspirin as prophylaxis against colorectal cancer. N Engl J Med 333:656-658
74. 74. Colditz GA, Cannuscio CC, Frazier AL (1997) Physical activity and reduced risk of colon cancer. Cancer Causes Control 8:649-667
75. 75. McMichael AJ, Potter JD (1980) Reproduction, endogenous and exogenous sex hormones, and colon cancer: a review and hypothesis. J Natl Cancer Inst 65:1201-1207
76. 76. Grodstein F, Martinez E, Platz EA et al (1998) Postmenopausal hormone use and risk of colorectal cancer and adenoma. Ann Inter Med 128:705-712
77. 77. Calle EE, Miracle-McMahill HL, Thun MJ, Heath CW (1995) Estrogen replacement therapy and risk of fatal colon cancer in a prospective cohort of postmenopausal women. J Natl Cancer Inst 87:517-523
78. 78. Kampman E, Potter JD, Slattery ML, Caan BJ, Edwards S (1997) Hormone replacement therapy, reproductive history and colon cancer: a multi-center, case-control study in the United States. Cancer Causes Control 8:146-158
79. 79. Newcomb PA, Storer BE (1995) Postmenopausal hormone use and risk of large-bowel cancer. J Natl Cancer Inst 87:1067-1071
80. 80. Aaltonen LA, Salovaara R, Kristo P et al (1998) Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med 338:1481-1487
81. 81. Bellacosa A, Genuardi M, Anti M, Viel A, Ponz de Leon M (1996) Hereditary nonpolyposis colorectal cancer: review of clinical, molecular genetics, and counseling aspects. Am J Med Genet 62:353-364
82. 82. Bodmer WF, Bailey CJ, Bodmer J et al (1987) Localization of the gene for familial adenomatous polyposis on chromosome 5. Nature 328:614-616
83. 83. Modrich P (1991) Mechanisms and biological effects of mismatch repair. Ann Rev Genet 25:229-253
84. 84. Leach F, Nicolaides N, Papadopoulos N et al (1993) Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75:1215-1225
85. 85. Bronner C, Baker S, Morrison P et al (1994) Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368:258-261
86. 86. Nicolaides N, Papadopoulos N, Liu B et al (1994) Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 371:75-80
87. 87. Fishel R, Lescoe MK, Rao MR et al (1994) The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 77:167
88. 88. Ionov Y, Peinado M, Malkhosyan S, Shibata D, Perucho M (1993) Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363:558-561
89. 89. Thibodeau SN, Bren G, Schaid D (1993) Microsatellite instability in cancer of the proximal colon. Science 260:816-819
90. 90. Loeb LA (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51:3075-3079
91. 91. Khoury MJ, Beaty TH, Cohen BH (1993) Fundamentals of Genetic Epidemiology. Oxford University Press, New York
92. 92. Vineis P (1997) Molecular epidemiology: low-dose carcinogens and genetic susceptibility. Int J Cancer 71:1-3
93. 93. Taioli E, Zocchetti C, Garte S (1998) Models of interaction between metabolic genes and environmental exposure in cancer susceptibility. Environ Health Persp 106:67-70
94. 94. Caporaso N, Landi MT, Vineis P (1991) Relevance of metabolic polymorphisms to human carcinogenesis: evaluation of epidemiologic evidence. Pharmacogenetics 1:4-19
95. 95. Vineis P, McMichael A (1996) Interplay between heterocyclic amines in cooked meat and metabolic phenotype in the etiology of colon cancer. Cancer Causes Control 7:479-486
96. 96. Turesky R, Lang N, Butler M, Teitel C, Kadlubar F (1991) Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon. Carcinogenesis 12:1839-1845
97. 97. Hunter D (1997) Methodological issues in the use of biological markers in cancer epidemiology:Cohort studies. In Application of Biomarkers in Cancer Epidemiology (Toniolo P, Buffetta P, Shuker D, Rothman N, Hulka B, Pearce N, eds) pp. 39-46. Oxford University Press, London
98. 98. Rothman KJ (1986) Modern Epidemiology. Little, Brown and Company, Boston/Toronto
99. 99. Peto R, Pike MC, Armitage P et al (1976) Design and analysis of randomized clinical trials requiring prolonged observation of each patient; I Introduction and design. Br J Cancer 35:1-39
100. 100. Ma J, Stampfer MJ, Giovannucci E et al (1997) Methylenetetrahydrofolate reductase polymorphism, dietary interactions and risk of colorectal cancer. Cancer Res 57:1098-1102
101. 101. van der Put NMJ, Steegers-Theunissen RPM, Frosst P et al (1995) Mutated methylenetetrahydrofolate reductase as a risk factor for spina bifida. Lancet 346:1070-1071
102. 102. Rosenblatt DS (1995) Inherited disorders of folate transport and metabolism, in: The metabolic and molecular basis of inherited disease (Scriver CR, Beaudert AL, Sly WS, Valle D, eds). McGraw-Hill, New York
103. 103. Stampfer MJ, Malinow MR, Willett WC et al (1992) A prospective study of plasma homocysteine and risk of myocardial infarction in US physicians. JAMA 268:877-881
104. 104. Verhoef P, Stampfer MJ (1995) Prospective studies of homocysteine and cardiovascular disease. Nutrition Rev 53:283-288
105. 105. Chen J, Giovannucci E, Kelsey K et al (1996) A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Res 56:4862-4864
106. 106. Ma J, Stampfer MJ, Christensen B et al (1998) A polymorphism of methionine synthase gene: a link to risk of colorectal cancer. Am J Epidemiol (Suppl) 147:S65
107. 107. Bell DA, Stephens EA, Castranio T et al (1995) Polyadenylation polymorphism in the acetyltransferase 1 Gene (NAT1) increases risk of colorectal cancer. Cancer Res 55:3537-3542
108. 108. Hickman D, Sim E (1991) N-Acetyltransferase polymorphism. Comparison of phenotype and genotype in humans. Biochem Pharmacol 42:1007-1014
109. 109. Cascorbi I, Drakoulis N, Brockmoller J, Maurer A, Sperling K, Roots I (1995) Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity. Am J Human Genet 57:581-592
110. 110. Brockmoller J, Cascorbi I, Kerb R, Roots I (1996) Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res 56:3915-3925
111. 111. Probst-Hensch N, Haile RW, Ingles SA et al (1995) Acetylation polymorphism and prevalence of colorectal adenomas. Cancer Res 55:2017-2020
112. 112. Vatsis K, Weber W, Bell D et al (1995) Nomenclature for N-acetyltransferases. Pharmacogenetics 5:1-17
113. 113. Kadlubar FF, Butler MA, Kaderlik KR, Chou H-C, Lang NP (1992) Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis. Environ Health Persp 98:69-74
114. 114. Ketterer B (1988) Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mutat Res 202:343-361
115. 115. Mannervik B, Awasthi YC, Board PG et al (1992) Nomenclature for human glutathione transferases. Biochem J 282:305-308
116. 116. Pemble S, Schroeder KR, Spencer SR et al (1994) Human glutathione S-transferase O (GSTT1):cDNA cloning and the characterization of a genetic polymorphism. Biochem J 300:271-276
117. 117. Seidegard J, Vorachek WR, Pero RW, Pearson WR (1988) Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc Natl Acad Sci 85:7293-7297
118. 118. Bell DA, Thompson CL, Taylor J et al (1992) Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: application to glutathione transferase μ. Environ Health Persp 98:113-117
119. 119. Katoh T, Nagata N, Kuroda Y et al (1996) Glutathione S-transferase M1 (GSTM1) and T1(GSTT1) genetic polymorphism and susceptibility to gastric and colorectal adenocarcinoma. Carcinogenesis 17:1855-1859
120. 120. Deakin M, Elder J, Hendrickse C et al (1996) Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interactions with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis 17:881-884
121. 121. Chenevix-Trench G, Young J, Coggan M, Board P (1995) Glutathione S-transferase M1 and T1 polymorphisms: susceptibility to colon cancer and age of onset. Carcinogenesis 16:1655-1657
122. 122. van Poppel G, Verhagen H, van't Veer P, van Bladeren PJ (1993) Markers for cytogenetic damage in smokers: associations with plasma antioxidants and glutathione S-transferase M. Cancer Epidemiol, Biomark Prevent 2:441-447
123. 123. Wiencke JK, Pemble S, Ketterer B, Kelsey KT (1995) Gene deletion of glutathione S-transferase θ: correlation with induced genetic damage and potential role in endogenous mutagenesis. Cancer Epidemiol, Biomark Prevent 4:253-259
124. 124. Yu M, Ross RK, Chan KK et al (1995) Glutathione S-transferase M1 genotype affects aminobiphenyl-hemoglobin adduct levels in white, black and asian smokers and non-smokers. Cancer Epidemiol, Biomark Prevent 4:861-864
125. 125. Zhong S, Wyllie AH, Barnes D, Wolf CR, Spurr NK (1993) Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis 14:1821-1824
126. 126. Gertig DM, Stampfer MJ, Haiman C, Hennekens CH, Kelsey K, Hunter DJ (In press) Glutathione S-transferase GSTM1 and GSTT1 polymorphisms and colorectal cancer risk; a prospective study. Cancer Epidemiol, Biomark Prevent
127. 127. Strange RC, Matharoo B, Faulder GC et al (1991) The human glutathione S-transferases: a case-control study of the incidence of the GST1 0 phenotype in patients with adenocarcinoma. Carcinogenesis 12:25-28
128. 128. Pelkonen O, Nebert DW (1982) Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis. Pharmacol Rev 34:189-222
129. 129. Hayashi S, Watanabe J, Nakachi K, Kawajiri K (1991) Genetic linkage of lung cancer-associated Msp1 polymorphism with amino acid replacement in the heme binding region of the human cytochrome P4501A1 gene. J Biochem 110:407-411
130. 130. Cascorbi I, Brockmoller J, Roots I (1996) A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. Cancer Res 5:4965-4969
131. 131. Kawajiri K, Nakachi K, Imai K, Yoshii A, Shinoda N, Watanabe J (1990) Identification of genetically high risk individuals to lung cancer by DNA polymorphisms of the cytochrome P450IA1 gene. FEBS Lett 263:131-133
132. 132. Cosma G, Crofts F, Taioli E, Toniolo P, Garte SJ (1993) The relationship between genotype and function of the human CYP1A1 gene. J Toxicol Environ Health 40:309-316
133. 133. Sivaraman L, Leatham MP, Yee J, Wilkens LR, Lau AF, Le Marchand L (1994) CYP1A1 genetic polymorphisms and in situ colorectal cancer. Cancer Res 54:3692-3695
134. 134. Herz J, Willnow TE (1995) Lipoprotein and receptor interactions in vivo. Curr Opin Lipidol 6:97-103
135. 135. Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S (1993) Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 342:697-699
136. 136. Kervinen K, Sodervik H, Makela J et al (1996) Is the development of adenoma and carcinoma in proximal colon related to apolipoprotein E phenotype? Gastroenterology 110:1785-1790
137. 137. Ilett KF, David BM, Detchon P, Castleden WM, Kwa R (1987) Acetylation phenotype in colorectal carcinoma. Cancer Res 47:1466-1469
138. 138. Wohlebb JC, Hunter CF, Blass B, Kadlubar FF, Chu DZJ, Lang NP (1990) Aromatic amine acetyltransferase as a marker for colorectal cancer: environmental and demographic associations. Int J Cancer 46:22-30
139. 139. Ladero J, Gonzalez J, Benitez J et al (1991) Acetylator polymorphism in human colorectal cancer. Cancer Res 51:2098-2100
140. 140. Oda Y, Tanaka M, Nakanishi I (1994) Relation between the occurrence of K-ras gene point mutations and genotypes of polymorphic N-acetyltransferase in human colorectal carcinomas. Carcinogenesis 15:1365-1369
141. 141. Shibuta K, Nakashima T, Abe M et al (1994) Molecular genotyping for N-acetylation polymorphism in Japanese patients with colorectal cancer. Cancer 74:3108-3112
142. 142. Aragaki CC, Greenland S, Probst-Hensch N, Haile RW (1997) Hierarchical modeling of gene-environment interactions: estimating NAT2 * genotype-specific dietary effects on adenomatous polyps. Cancer Epidemiol, Biomark Prevent 6:307-314
143. 143. Hubbard AL, Moyes C, Wyllie AH, Smith CA, Harrison DJ (1998) N-acetyl transferase 1: two polymorphisms in coding sequence identified in colorectal cancer patients. Br J Cancer 77:913-916
144. 144. Ilyas M, Tomlinson IPM (1996) Genetic pathways in colorectal cancer. Histopathol 28:389-399