A novel concept for the combinatorial synthesis of peptide nucleic acids

Nucleosides and Nucleotides

Volumn 17, Issue 9-11, 1998, Pages 1667-1670

  Dömling, Alexander ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b Morphochem AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE NUCLEIC ACID;

CONFERENCE PAPER; DRUG DNA BINDING; DRUG SYNTHESIS; GENE THERAPY;

EID: 0031759313     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319808004699     Document Type: Conference Paper

References (37)

1. Gmelin, R., Z. physiol. CA., 1959, 316, 164; Gmelin, R., Acta Chem. Scand., 1961, 15, 1188.
2. Gmelin, R., Z. physiol. CA., 1959, 316, 164; Gmelin, R., Acta Chem. Scand., 1961, 15, 1188.
3. Dewar, J. H., Shaw, G., J. Chem. Soc., 1962, 583; Kjaer, A., Knudsen, A., Larsen, P. O., Acta Chem. Scand., 1961, 15, 1193; Shvachkin, Yu. P., Azarova, M. T., Zh. Obshch. Khim., 1964, 34, 407; Martinez, A. P., Lee, W. W., J. Org. Chem., 1965, 30, 317-318; Lidak, M. Yu, Paégle, R. A., Plata, M. G., Shvachkin, Yu. P., Chem. Heterocycl. Comp., 1971, 494-498.
4. Dewar, J. H., Shaw, G., J. Chem. Soc., 1962, 583; Kjaer, A., Knudsen, A., Larsen, P. O., Acta Chem. Scand., 1961, 15, 1193; Shvachkin, Yu. P., Azarova, M. T., Zh. Obshch. Khim., 1964, 34, 407; Martinez, A. P., Lee, W. W., J. Org. Chem., 1965, 30, 317-318; Lidak, M. Yu, Paégle, R. A., Plata, M. G., Shvachkin, Yu. P., Chem. Heterocycl. Comp., 1971, 494-498.
5. Dewar, J. H., Shaw, G., J. Chem. Soc., 1962, 583; Kjaer, A., Knudsen, A., Larsen, P. O., Acta Chem. Scand., 1961, 15, 1193; Shvachkin, Yu. P., Azarova, M. T., Zh. Obshch. Khim., 1964, 34, 407; Martinez, A. P., Lee, W. W., J. Org. Chem., 1965, 30, 317-318; Lidak, M. Yu, Paégle, R. A., Plata, M. G., Shvachkin, Yu. P., Chem. Heterocycl. Comp., 1971, 494-498.
6. Dewar, J. H., Shaw, G., J. Chem. Soc., 1962, 583; Kjaer, A., Knudsen, A., Larsen, P. O., Acta Chem. Scand., 1961, 15, 1193; Shvachkin, Yu. P., Azarova, M. T., Zh. Obshch. Khim., 1964, 34, 407; Martinez, A. P., Lee, W. W., J. Org. Chem., 1965, 30, 317-318; Lidak, M. Yu, Paégle, R. A., Plata, M. G., Shvachkin, Yu. P., Chem. Heterocycl. Comp., 1971, 494-498.
7. Dewar, J. H., Shaw, G., J. Chem. Soc., 1962, 583; Kjaer, A., Knudsen, A., Larsen, P. O., Acta Chem. Scand., 1961, 15, 1193; Shvachkin, Yu. P., Azarova, M. T., Zh. Obshch. Khim., 1964, 34, 407; Martinez, A. P., Lee, W. W., J. Org. Chem., 1965, 30, 317-318; Lidak, M. Yu, Paégle, R. A., Plata, M. G., Shvachkin, Yu. P., Chem. Heterocycl. Comp., 1971, 494-498.
8. Shvachkin, Y. P., Smirnova, A. P., Ermak, N. M., Z. Obsh. Khim., 1995, 65, 1230-1230.
9. Shvachkin, Yu P., Mishin, G. P., Korshunova, G. A., Russian Chem. Rev., 1982, 51, 178-188.
10. De Koning, H., Pandit, U. K., Rec., 1971, 91, 1069-1080; Takemoto, K., Tahara, H., Yamada, A., Inaki, Y., Ueda, N., Makr. Chem., 1973, 169, 327-331.
11. De Koning, H., Pandit, U. K., Rec., 1971, 91, 1069-1080; Takemoto, K., Tahara, H., Yamada, A., Inaki, Y., Ueda, N., Makr. Chem., 1973, 169, 327-331.
12. P.C.Zamecnik, M.L.Stephenson, Proc. Natl. Acad. Sci. U.S.A., 1978, 75, 280.
13. Nielsen, P. E., Egholm, M., Berg, R. H., Buchardt, O., Science, 1991, 254, 1497-1500.
14. Hydrup, B., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 5-23.
15. Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W., Corey, D. R., Nature Biotech., 1996, 14, 615-619; Wang, J., Palecek, E., Nielsen, P. E., Rivas, G., Cai, X., Shiraishi, H., Dontha, N., Luo, D., Fabias, P. A. M., J. Am. Chem. Soc., 1996, 118, 7667-7670; Thiede, C., Bayerdörffer, E., Blasczyk, R., Wittig, B., Neubauer, A., Nucl. Acid. Res., 1996, 24, 983-984; Koppelhus, U., Zachar, V., Nielsen, P. E., Liu, X., Eugen-Olsen, J., Ebbesen, P., Nucl. Acid Res., 1997, 25, 2167-2173; Weiler, J., Gausepohl, H., Hauser, N., Jensen, O. N., Hoheisel, J. D., Nucl. Acid Res., 1997, 25, 2792-2799.
16. Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W., Corey, D. R., Nature Biotech., 1996, 14, 615-619; Wang, J., Palecek, E., Nielsen, P. E., Rivas, G., Cai, X., Shiraishi, H., Dontha, N., Luo, D., Fabias, P. A. M., J. Am. Chem. Soc., 1996, 118, 7667-7670; Thiede, C., Bayerdörffer, E., Blasczyk, R., Wittig, B., Neubauer, A., Nucl. Acid. Res., 1996, 24, 983-984; Koppelhus, U., Zachar, V., Nielsen, P. E., Liu, X., Eugen-Olsen, J., Ebbesen, P., Nucl. Acid Res., 1997, 25, 2167-2173; Weiler, J., Gausepohl, H., Hauser, N., Jensen, O. N., Hoheisel, J. D., Nucl. Acid Res., 1997, 25, 2792-2799.
17. Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W., Corey, D. R., Nature Biotech., 1996, 14, 615-619; Wang, J., Palecek, E., Nielsen, P. E., Rivas, G., Cai, X., Shiraishi, H., Dontha, N., Luo, D., Fabias, P. A. M., J. Am. Chem. Soc., 1996, 118, 7667-7670; Thiede, C., Bayerdörffer, E., Blasczyk, R., Wittig, B., Neubauer, A., Nucl. Acid. Res., 1996, 24, 983-984; Koppelhus, U., Zachar, V., Nielsen, P. E., Liu, X., Eugen-Olsen, J., Ebbesen, P., Nucl. Acid Res., 1997, 25, 2167-2173; Weiler, J., Gausepohl, H., Hauser, N., Jensen, O. N., Hoheisel, J. D., Nucl. Acid Res., 1997, 25, 2792-2799.
18. Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W., Corey, D. R., Nature Biotech., 1996, 14, 615-619; Wang, J., Palecek, E., Nielsen, P. E., Rivas, G., Cai, X., Shiraishi, H., Dontha, N., Luo, D., Fabias, P. A. M., J. Am. Chem. Soc., 1996, 118, 7667-7670; Thiede, C., Bayerdörffer, E., Blasczyk, R., Wittig, B., Neubauer, A., Nucl. Acid. Res., 1996, 24, 983-984; Koppelhus, U., Zachar, V., Nielsen, P. E., Liu, X., Eugen-Olsen, J., Ebbesen, P., Nucl. Acid Res., 1997, 25, 2167-2173; Weiler, J., Gausepohl, H., Hauser, N., Jensen, O. N., Hoheisel, J. D., Nucl. Acid Res., 1997, 25, 2792-2799.
19. Norton, J. C., Piatyszek, M. A., Wright, W. E., Shay, J. W., Corey, D. R., Nature Biotech., 1996, 14, 615-619; Wang, J., Palecek, E., Nielsen, P. E., Rivas, G., Cai, X., Shiraishi, H., Dontha, N., Luo, D., Fabias, P. A. M., J. Am. Chem. Soc., 1996, 118, 7667-7670; Thiede, C., Bayerdörffer, E., Blasczyk, R., Wittig, B., Neubauer, A., Nucl. Acid. Res., 1996, 24, 983-984; Koppelhus, U., Zachar, V., Nielsen, P. E., Liu, X., Eugen-Olsen, J., Ebbesen, P., Nucl. Acid Res., 1997, 25, 2167-2173; Weiler, J., Gausepohl, H., Hauser, N., Jensen, O. N., Hoheisel, J. D., Nucl. Acid Res., 1997, 25, 2792-2799.
20. Hamilton, S. E., Iyer, M., Norton, J. C., Corey, D. R., Bioorg. & Med. Chem. Lett., 1996, 6, 2897-2900.
21. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
22. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
23. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
24. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
25. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
26. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
27. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
28. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
29. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
30. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
31. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
32. Hyrup, B., Egholm, M., Buchardt, O., Nielsen, P. E., Bioorg. & Med. Chem. Lett., 1996, 6, 1083-1088; Umemiya, H., Kagechika, H., Hashimoto, Y., Shudo, K., Nucleot. & Nucleos., 1996, 15, 465-475; van der Laan, A., Strömberg, R., van Boom, J. H., Kuyi-Yeheskiely, E., Efimov, V. A., Chakhmakhcheva, O., G., Tetrahedron Lett., 1996, 37, 7857-7860: Gangamani, B. P., Kumar, V. A., Ganesh, K. N., Tetrahedron, 1996, 52, 15017-15030; Fujii, M., Yoshida, K., Hidaka, J., Ohtsu, T., Bioorg. & Med. Chem. Lett., 1997, 7, 637-640; Jordan, S., Schwemler, C., Koch, W., Kretschmer, A., Schwenner, E., Stropp, U., Mielke, B., Bioorg. & Med. Chem. Lett., 1997, 7, 681-686; ibidem 687-690; Goodnow, R. A., Tam, S., Pruess, D. L., McComas, W. W., Tetrahedron Lett., 1997, 38, 3199-3202; Altmann, K. H., Chiesi, C. S., García-Echevaerría, C., Bioorg. & Med. Chem. Lett., 1997, 7, 1119-1122; ibidem 1123-1126; Howarth, N. M., Wakelin, L. P. G., J. Org. Chem., 1997, 62, 5441-5450; Tsantrizos, Y. S., Lunetta, J. F., Boyd, M., Fader, L. D., Wilson, M.-C., J. Org. Chem., 1997, 62, 5451-5457.
33. Merrifield, R. B., J. Am. Chem. Soc., 1963, 85, 2149.
34. Ugi, I., Dömling, A.,. Hörl, W., Endeavour, 1994, 18, 115.
35. Ugi, I., Dömling, A., Combinatorial Chemistry and High Throughput Screening., 1998, 1 in press.
36. Dömling, A., Barrère, M., Richter, W., Lindhorst, T., Starnecker, M., Combinatorial Chemistry and High Throughput Screening. 1998, 1 submitted.
37. Dömling, A., unpublished.