Synthesis of new building blocks for peptide nucleic acids containing monomers with variations in the backbone

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 6, 1997, Pages 681-686

  Jordan, Stephan ^a   Schwemler, Christoph ^a   Kosch, Winfried ^a,b   Kretschmer, Axel ^a   Schwenner, Eckhardt ^a   Stropp, Udo ^a   Mielke, Burkhard ^a  

^a BAYER AG   (Germany)

^b BIOTEST AG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE NUCLEIC ACID; PYRROLIDINE DERIVATIVE;

ARTICLE; DRUG DEGRADATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; OLIGOMERIZATION;

EID: 0031576881     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)00079-6     Document Type: Article

References (24)

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21. 11 To introduce sarcosine instead of gylcine into compound 21, compound 7 was coupled with H-Sar-OMe in the presence of BOP-C1/Hünigs base followed by ester hydrolysis with NaOH/isopropanol (76% overall yield).
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24. 13 Jordan, S.; Schwemler, C.; Kosch, W.; Kretschmer, A.; Stropp, U.; Schwenner, E.; Mielke, B. submitted.