Distinct multisite synergistic interactions determine substrate specificities of human chymase and rat chymase-1 for angiotensin II formation and degradation

Journal of Biological Chemistry

Volumn 272, Issue 5, 1997, Pages 2963-2968

  Sanker, Subramaniam ^a   Chandrasekharan, Unnikrishnan M ^a   Wilk, Dennis ^a   Glynias, Manuel J ^a   Karnik, Sadashiva S ^a   Husain, Ahsan ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; CHYMASE;

ANIMAL CELL; ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT;

AMINO ACID SEQUENCE; ANGIOTENSIN II; ANIMALS; BINDING SITES; CHYMASES; HEART VENTRICLES; HUMANS; KINETICS; MAST CELLS; MYOCARDIUM; OLIGOPEPTIDES; RATS; REGRESSION ANALYSIS; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

ANIMALIA; FELIS CATUS;

EID: 0031025002     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.5.2963     Document Type: Article

References (22)

1. Brain, S. D., and Williams, T. J. (1988) Nature 335, 73-75
2. Woodbury, R. G., Miller, H. R., Huntley, J. F., Newlanda, G. F., Palliser, A. C., and Wakelin, D. (1984) Nature 312, 450-452
3. Le Trong, H., Neurath, H., and Woodbury, R. G. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 364-367
4. Caughey, G. H., Leidig, F., Viro, N. F., and Nadel, J. A. (1988) J. Pharmacol. Exp. Ther. 244, 133-137
5. Urata, H., Kinoshita, A., Misono, K. S., Bumpus, F. M., and Husain, A. (1990) J. Biol. Chem. 265, 22348-22357
6. Benditt, E. P., and Arase, M. (1959) J. Exp. Med. 110, 451-460
7. Chandrasekharan, U. M., Sanker, S., Glynias, M. J., Karnik, S. S., and Husain, A. (1996) Science 271, 502-505
8. Itoh, H., Murakumo, Y., Tomita, M., Ide, H., Kobayashi, T., Maruyama, H., Horii, Y., and Nawa, Y. (1996) Biochem. J. 314, 923-929
9. Urata, H., Boehm, K. D., Philip, A., Kinoshita, A., Gabrovsek, J., Bumpus, F. M., and Husain, A. (1993) J. Clin. Invest. 91, 1269-1281
10. Hoit, B. D., Shao, Y., Kinoshita, A., Gabel, M., Husain, A., and Walsh, R. A. (1995) J. Clin. Invest. 95, 1519-1527
11. Powers, J. C., Tanaka, T., Harper, J. W., Minematsu, Y., Barker, L., Lincoln, D., Crumley, K. V., Fraki, J. E., Schechter, N. M., Lazarus, G. G., Nakajima, K., Nakashino, K., Neurath, H., and Woodbury, R. G. (1985) Biochemistry 24, 2048-2058
12. Kinoshita, A., Urata, H., Bumpus, F. M., and Husain, A. (1991) J. Biol. Chem. 266, 19192-19197
13. Wells, J. A. (1990) Biochemistry 29, 8509-8517
14. Polgar, L. (1989) Mechanisms of Protease Action, pp. 87-122, CRC Press, Boca Raton, FL
15. Fersht, A. R. (1985) Enzyme Structure and Mechanism, 2nd Ed., pp. 311-344. W. H. Freeman, New York
16. Coombs, G. S., Dang, A. T., Madison, E. L., and Corey, D. R. (1996) J. Biol. Chem. 271, 4461-4467
17. Schellenberger, V., Braune, K., Hofmann, H., and Jakubke, H. (1991) Eur. J. Biochem. 199, 623-636
18. Gron, H., and Breddam, K. (1992) Biochemistry 31, 8967-8971
19. Schellenberger, V., Turck, C. W., and Rutter, W. J. (1994) Biochemistry 33, 4251-4257
20. Bastos, M., Maeji, N. J., and Abeles, R. H. (1995) Proc. Natl Acad. Sci. U. S. A. 92, 6738-6742
21. Schechter, I., and Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-162
22. Stein, R. L., Viscarello, B. R., and Wildonger, R. A. (1984) J. Am. Chem. Soc. 106, 796-798