Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulation

Molecular Microbiology

Volumn 21, Issue 1, 1996, Pages 171-179

  Grant, Chris M ^a   Collinson, Lindsay P ^a   Roe, Jung Hye ^b   Dawes, Ian W ^a  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE REDUCTASE;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; MUTANT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSCRIPTION REGULATION; YEAST;

EID: 0030016469     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1996.6351340.x     Document Type: Article

References (51)

1. Alonso-Moraga, A., Bocanegra, A., Torres, J.M., Lopez-Barea, J., and Pueyo, C. (1987) Glutathione status and sensitivity to GSH-reacting compounds of Escherichia coli strains deficient in glutathione metabolism and/or catalase activity. Mol Cell Biochem 73: 61-68.
2. Apontoweil, P., and Berends, W. (1975) Isolation and characterization of glutathione-deficient mutants of Escherichia coli K12. Biochem Biophys Acta 399: 10-22.
3. Berben, G., Dumont, J., Gilliquet, V., Bolle, P.-A., and Hillger, F. (1991) The YDp plasmids: a uniform set of vectors bearing versatile gene disruption cassettes for Saccharomyces cerevisiae. Yeast 7: 475-477.
4. Casalone, E., Di Ilio, C., Federici, G., and Polsinelli, M. (1988) Glutathione and glutathione metabolizing enzymes in yeasts. Antonie van Leeuwenhoek 54: 367-375.
5. Christianson, T.W., Sikorski, R.S., Dante, M., Shero, J.H., and Mieter, P. (1992) Multifunctional yeast high-copy-number shuttle vectors. Gene 110: 119-122.
6. Collinson, L.P., and Dawes, I.W. (1992) Inducibilty of the response of yeast cells to peroxide stress. J Gen Microbiol 138: 329-335.
7. Collinson, L.P., and Dawes, I.W. (1995) Isolation, characterisation and overexpression of the yeast gene, GLR1, encoding glutathione reductase. Gene 156: 123-127.
8. Davis, N.K., Greer, S., Jones-Mortimer, M.C., and Perham, R.N. (1982) Isolation and mapping of glutathione reductase-negative mutants of Escherichia coli K12. J Gen Microbiol 128: 1631-1634.
9. Dean, R., and Simpson, J. (1989) Free-radicals: the good, the bad . . . Today's Life Sci 1: 28-34.
10. Demple, B. (1991) Regulation of bacterial oxidative stress genes. Annu Rev Genet 25: 315-337.
11. Douglas, K.T. (1987) Mechanisms of action of glutathione-dependent enzymes. In Advances in Enzymology. Meister, A. (ed.). New York: John Wiley and Sons Inc., pp. 103-167.
12. Estrela, J.M., and Pallardo, F.V. (1990) Role of glutathione in the regulation of protein synthesis and degradation in eukaryotes. In Glutathione: Metabolism and Physiological Functions, Vina, J. (ed.). Boca Raton: CRC Press, pp. 177-185.
13. Farr, S.B., and Kogoma, T. (1991) Oxidative stress responses in Escherichia coli and Salmonella typhimurium. Microbiol Rev 55: 561-585.
14. Flattery-O'Brien, J., Collinson, L.P., and Dawes, I.W. (1993) Saccharomyces cerevisiae has an inducible response to menadione which differs to that to hydrogen peroxide. J Gen Microbiol 139: 501-507.
15. Galiazzo, F., and Labbe-Bois, R. (1993) Regulation of Cu, Zn-and Mn-superoxide dismutase transcription in Saccharomyces cerevisiae. FEBS Letts 315: 197-200.
16. Geitz, D., St. Jean, A., Woods, R.A., and Schiestl, R.H. (1992) Improved method for high efficiency transformation of intact yeast cells. Nucl Acids Res. 20: 1425.
17. Grant, C.M., MacIver, F.H., and Dawes, I.W. (1996) Glutathione is an essential metabolite required for resistance to oxidative stress in the yeast Saccharomyces cerevisiae. Curr Genet 29: 511-515.
18. 2 and gamma radiation. J Bacteriol 168: 1026-1029.
19. Griffith, O.W., and Meister, A. (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulphoximine (S-n-butyl homocysteine sulphoximine). J Biol Chem 254: 7558-7560.
20. Guarente, L. (1983) Yeast promoters and IacZ fusions designed to study expression of cloned genes in yeast. Meth Enzymol 101: 181-191.
21. Halliwell, B. (1991) Reactive oxygen species in living systems: source, biochemistry, and role in human disease. Am J Med 91:3C-14S-3C-38S.
22. Halliwell, B., and Gutteridge, J.M.C. (1989) Free Radicals in Biology and Medicine. 2nd edn. Oxford: Oxford University Press.
23. Harshman, K.D., Moye-Rowley, W.S., and Parker, C.S. (1988) Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar AP-1 that is distinct to GCN4. Cell 53: 321-330.
24. Jain, A., Martensson, J., Einar, E., Auld, P.A.M., and Meister, A. (1991) Glutathione deficiency leads to mitochondrial damage in brain. Proc Natl Acad Sci USA 88: 1913-1917.
25. Jamieson, D.J. (1992) Saccharomyces cerevisiae has distinct adaptive responses to both hydrogen peroxide and menadione. J Bacteriol 174: 6678-6681.
26. Jamieson, D.J. (1995) The effect of oxidative stress on Saccharomyces cerevisiae. Redox Report 1: 89-95.
27. Jamieson, D.J., Rivers, S.L., and Stephen, D.W.S. (1994) Analysis of Saccharomyces cerevisiae proteins induced by peroxide and Superoxide stress. Microbiology 140: 3277-3283.
28. Kistler, M., Summer, K.H., and Eckardt, F. (1986) Isolation of glutathione-dependent mutants of the yeast Saccharomyces cerevisiae. Mutat Res 173: 117-120.
29. Kuge, S., and Jones, N. (1994) YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides. EMBO J 13: 655-664.
30. Kullick, I., and Storz, G. (1994) Transcriptional regulators of the oxidative stress response in prokaryotes and eukaryotes. Redox Report 1: 23-29.
31. Larsson, A. (1990) Heredity disorders in glutathione metabolism. In Glutathione: Metabolism and Physiological Functions. Vina, J. (ed.). Boca Raton: CRC Press Inc., pp. 359-366.
32. Lee, F.J., and Hassan, H.M. (1985) Biosynthesis of superoxide dismutase in Saccharomyces cerevisiae: effects of paraquat and copper. J Free Rad Biol Med 1: 319-325.
33. López-Barea, J., Bárcena, J.A., Bocanegra, J.A., Florindo, J., García-Alfonso, C., López-Ruiz, A., Martínez-Galisteo, E., and Peinado, J. (1990) Structure, mechanism, functions, and regulatory properties of glutathione reductase. In Glutathione: Metabolism and Physiological Functions, Vina, J. (ed.). Boca Raton: CRC Press Inc., pp. 105-116.
34. Marchler, G., Schüller, C., Adam, G., and Ruis, H. (1993) A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J 12: 1997-2003.
35. Martensson, J., Jain, A., Stole, E., Frayer, W., Auld, P.A.M., and Meister, A. (1991) Inhibition of glutathione synthesis in the newborn rat: a model for endogenously produced oxidative stress. Proc Natl Acad Sci USA 88: 9360-9364.
36. Meister, A. (1988) Glutathione metabolism and its selective modification. J Biol Chem 263: 17205-17208.
37. Meister, A., and Anderson, M.E. (1983) Glutathione. Annu Rev Biochem 52: 711-760.
38. Mikaelian, I., and Sergent, A. (1992) A general and fast method to generate multiple site directed mutations. Nucl Acids Res 20: 376.
39. Myers, A.M., Tzagoloff, A., Kinney, D.M., and Lusty, C.J. (1986) Yeast shuttle vectors with multiple cloning sites for construction of IacZ fusions. Gene 45: 299-310.
40. Ohtake, Y., and Yabuuchi, S. (1991) Molecular cloning of the γ-glutamylcysteine synthetase gene of Saccharomyces cerevisiae. Yeast 7: 953-961.
41. Philips, J.P., and Hilliker, A.J. (1990) Genetic analysis of oxygen defense mechanisms in Drosophila melanogaster. Adv Genet 28: 43-64.
42. Scandalios, J.G. (1990) Response of plant antioxidant defense genes. Adv Genet 28: 2-35.
43. Schmitt, M.E., Brown, T.A., and Trumpower, B.L. (1990) A rapid and simple method for preparation of RNA from Saccharomyces cerevisiae. Nucl Acids Res 18: 3091-3092.
44. Schnell, N., Krems, B., and Entian, K.-D. (1992) The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, a c-jun homologue, is involved in oxygen metabolism. Curr Genet 21: 269-273.
45. Sies, H. (1993) Strategies of antioxidant defense. Eur J Biochem 215: 213-219.
46. Stephen, D.W.S., Rivers, S.L., and Jamieson, D.J. (1995) The role of the YAP1 and YAP2 genes in the regulation of the adaptive oxidative stress responses of Saccharomyces cerevisiae. Mol Microbiol 16: 415-423.
47. Tietze, F. (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione. Anal Biochem 27: 502-506.
48. Toda, T., Shimanuki, M., and Yanagida, M. (1991) Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases. Genes Dev 5: 60-73.
49. Tuggle, C.K., and Fuchs, J.A. (1985) Glutathione reductase is not required for maintenance of reduced glutathione in Escherichia coli K-12. J Bacteriol 162: 448-450.
50. Wemmie, J.A., Szczypka, M.S., Thiele, D.J., and Moye-Rowley, W.S. (1994) Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1. J Biol Chem 269: 32592-32597.
51. Wu, A., and Moye-Rowley, W.S. (1994) GSH1, which encodes glutamylcysteine synthetase, is a target gene for yAP-1 transcriptional regulation. Mol Cell Biol 14: 5832-5839.