An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression

Journal of Biological Chemistry

Volumn 271, Issue 38, 1996, Pages 23169-23175

  Saks, Margaret E ^a   Sampson, Jeffrey R ^a   Nowak, Mark W ^a   Kearney, Patrick C ^a   Du, Fangyong ^a   Abelson, John N ^a   Lester, Henry A ^a   Dougherty, Dennis A ^a  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; AMINO ACID TRANSFER RNA LIGASE; GLYCINE TRANSFER RNA; NICOTINIC RECEPTOR; ACETYLCHOLINE; CHOLINERGIC RECEPTOR; GLUTAMINE TRANSFER RNA;

AMINOACYLATION; ANIMAL CELL; ARTICLE; GENE REPRESSION; NONHUMAN; PRIORITY JOURNAL; STOP CODON; SUPPRESSOR GENE; TETRAHYMENA THERMOPHILA; XENOPUS; ACYLATION; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; ELECTRIC CONDUCTIVITY; ENZYME SPECIFICITY; GENETIC ENGINEERING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS; STEREOISOMERISM;

ANIMALIA; TETRAHYMENA; TETRAHYMENA THERMOPHILA;

ACETYLCHOLINE; ACYLATION; AMINO ACIDS; AMINO ACYL-TRNA SYNTHETASES; ANIMALS; BASE SEQUENCE; CODON, NONSENSE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC CONDUCTIVITY; GENETIC ENGINEERING; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; RECEPTORS, CHOLINERGIC; RNA, TRANSFER, GLN; STEREOISOMERISM; SUBSTRATE SPECIFICITY; SUPPRESSION, GENETIC; TETRAHYMENA THERMOPHILA; TRANSCRIPTION, GENETIC;

EID: 0029661426     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.38.23169     Document Type: Article

References (47)

1. Steege, D. A., and Söll, D. G. (1979) Biological Regulation and Development, pp. 433-485, Plenum Press, New York
2. Miller, J. H., Coulondre, C., Schmeissner, U., Schmitz, A., Hofer, M., and Galas, D. (1979) Nonsense Mutations and tRNA Suppressors, pp. 127-132, Academic Press, Inc., New York
3. Coulondre, C., and Miller, J. H. (1977) J. Mol. Biol. 117, 525-575
4. Normanly, J., Masson, J.-M., Kleina, L. G., Abelson, J. and Miller, J. H. (1986) Proc. Natl. Acad. Sci. U. S. A. 83, 6548-6552
5. Normanly, J., Kleina, L. G., Masson, J.-M., Abelson, J., and Miller, J. H. (1990) J. Mol. Biol. 213, 719-726
6. Noren, C. J., Anthony-Cahill, S. J., Griffith, M. C., and Schultz, P. G. (1989) Science 244, 182-188
7. Cornish, V. W., Mendel, D., and Schultz, P. G. (1995) Angew. Chem. Int. Ed. Engl. 34, 621-633
8. Nowak, M. W., Kearney, P. C., Sampson, J. R., Saks, M. E., Labarca, C. G., Silverman, S. K., Zhong, W., Thorson, J., Abelson, J. N., Davidson, N., Schultz, P. G., Dougherty, D. A., and Lester, H. A. (1995) Science 268, 439-442
9. Karlin, A. (1993) Curr. Opin. Neurobiol 3, 299-309
10. Devillers-Thiéry, A., Galzi, J. L., Eiselé, J. L., Bertrand, S., Bertrand, D., and Changeux, J. P. (1993) J. Membrane Biol. 136, 97-112
11. Lester, H. A. (1992) Annu. Rev. Biophys. Biomol. Struct. 21, 267-292
12. Hanyo, N., Kuchino, Y., Nishimura, S., and Beier, H. (1986) EMBO J. 5, 1307-1311
13. Schüll, C., and Beier, H. (1994) Nucleic Acids Res. 22, 1974-1980
14. Saks, M. E., Sampson, J. R., and Abelson, J. N. (1994) Science 263, 191-197
15. McClain, W. H. (1993) J. Mol. Biol. 234, 257-280
16. Giegé, K., Pulisi, J. D., and Florentz, C. (1993) in Prog. Nucleic Acid Res. 45, 129-206
17. Kearney, P. C., Zhong, W., Nowak, N. W., Silverman, S. K., Zhang H., Labarca, C. G., Saks, M. E., Sampson, J. R., Gallivan, J., Abelson, J., Davidson, N., Dougherty, D. A., and Lester, H. A. (1996) Biophys. J. 70, 251 (abstr.)
18. Nowak, N. W., Kearney, P. C., Zhong, W., Silverman, S. K., Labarca, C. G., Saks, M. E., Sampson, J. R., Abelson, J., Davidson, N., Dougherty, D. A. and Lester, H. A. (1996) Biophys. J. 70, 76 (abstr.)
19. Robertson, S. A., Ellman, J. A., and Schultz, P. G. (1991) J. Am. Chem. Soc. 113, 2722-2729
20. Grodberg, J., and Dunn, J. J. (1988) J. Bacteriol. 170, 1245-1253
21. Davanloo, P., Rosenberg, A. H., Dunn, J. J., and Studier, F. W (1984) Proc. Natl. Acad. Sci. U. S. A. 81, 2035-2039
22. Sampson, J. R., and Uhlenbeck, O. C. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 1033-1037
23. England, T. E., Bruce, A. G., and Uhlenbeck, O. C. (1980) Methods Enzymol. 65, 65-74
24. Quick, N. W., and Lester, H. A. (1994) in Ion Channels of Excitable Cells (Narahaski, T., ed) pp. 261-279, Academic Press, Inc., New York
25. Yarus, M. (1982) Science 218, 646-652
26. Hirsh, D. (1971) J. Mol. Biol. 58, 439-458
27. Bjork, G. R. (1995) Prog. Nucleic Acid Res. Mol. Biol. 50, 263-338
28. Hayase, Y., Jahn, M., Rogers, M. J., Sylvers, L. A., Koizumi, M., Inoue, H., Ohtsuka, E., and Söll, D. (1992) EMBO J. 11, 4159-4165
29. Jahn, M., Rogers, M. J., and Söll, D. (1991) Nature 352, 258-260
30. Rould, M. A., Perona, J. J., and Steitz, T. A. (1991) Nature 352, 213-218
31. Rould, M. A., Perona, J. J., Söll, D., and Steitz, T. A. (1989) Science 246, 1135-1142
32. England, T. E., and Uhlenbeck, O. C. (1978) Biochemistry 17, 2069-2076
33. Aylwin, M. L., and White, M. M. (1994) FEES Lett. 349, 99-103
34. Revah, F., Bertrand, D., Galzi, J.-L., Devillers-Thiéry, A., Mulle, C., Hussy, N., Bertrand, S., Ballivet, M., and Changeux, J.-P. (1991) Nature 353, 846-849
35. Labarca, C., Nowak, M. W., Zhang, H., Tang, L., Deshpande, P., and Lester, H. A. (1995) Nature 376, 514-516
36. Filatov, G. N., and White, M. M. (1995) Mol. Pharmacol. 48, 379-384
37. Stapulionis, R., and Deutscher, M. P. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7158-7161
38. Picard, B., le Maire, M., Wegnez, M., and Denis, H. (1980) Eur. Biochem. 109, 359-368
39. Gurevitz, M., and Apirion, D. (1983) Biochemistry 22, 4000-4005
40. Bienz, M., Kubli, E., Kohli, J., de Henau, S., and Grosjean, H. (1980) Nucleic Acids Res. 8, 5169-5178
41. Mattaj, I. W., Coppard, N. J., Brown, R. S., Clark, B. R. C., and De Robertis, E. M. (1987) EMBO 6, 2409-2413
42. Dihanick, M. E., Najarian, D., Clark, R., Gillman, E. C., Martin, N. C., and Hopper, A. K. (1987) Mol. Cell. Biol. 7, 177-184
43. Martin, N. C., and Hopper, A. K. (1982) J. Biol. Chem. 257, 10562-10565
44. Hatfield, D. L., Smith, D. W. E., Lee, B. J., Worland, P. J., and Oroszian, S. (1990) Biochem. Mol. Biol. 25, 71-96
45. Laski, F. A., Belagaje, R., RajBhandary, U. L., and Sharp, P. A. (1982) Proc. Natl. Acad. Sci. U. S. A. 79, 5813-5817
46. Hudziak, R. M., Laski, F. A., RajBhandary, U. L., Sharp, P. A., and Capecchi, M. R. (1982) Cell 31, 137-146
47. Young, J. F., Capecchi, M., Laski, F. A., RajBhandary, U. L., Sharp, P. A., and Palese, P. (1983) Science 221, 873-875