Serum leptin levels and leptin expression in growth hormone (GH)- deficient and healthy adults: Influence of GH treatment, gender, and fasting

Metabolism: Clinical and Experimental

Volumn 47, Issue 12, 1998, Pages 1514-1519

  Kristensen, Kurt ^a   Pedersen, Steen B ^b   Fisker, Sanne ^b   Nørrelund, Helene ^b   Rosenfalck, Anne Mette ^b   Jorgensen J O L ^b   Richelsen, Bjørn ^b  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN GROWTH HORMONE; LEPTIN;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; FEMALE; GROWTH HORMONE DEFICIENCY; HORMONAL REGULATION; HORMONE SUBSTITUTION; HUMAN; LIPOLYSIS; MALE; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; SUBCUTANEOUS FAT; TREATMENT OUTCOME;

EID: 0031673218     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(98)90079-8     Document Type: Article

References (29)

1. Zimmet P, Hodge A, Nicolson M, et al: Serum leptin concentration, obesity, and insulin resistance in Western Samoans: Cross sectional study. BMJ 313:965-969, 1996
2. Havel PJ, Kasim-Karakas S, Dubuc GR, et al: Gender differences in plasma leptin concentrations. Nat Med 2:949-950, 1996 (letter)
3. Wabitsch M, Jensen PB, Blum WF, et al: Insulin and cortisol promote leptin production in cultured human fat cells. Diabetes 45:1435-1438, 1996
4. Miell JP, Englaro P, Blum WF: Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Horm Metab Res 28:704-707, 1996
5. Berneis K, Vosmeer S, Keller U: Effects of glucocorticoids and of growth hormone on serum leptin concentrations in man. Eur J Endocrinol 135:663-665, 1996
6. Masuzaki H, Ogawa Y, Hosoda K, et al: Glucocorticoid regulation of leptin synthesis and secretion in humans: Elevated plasma leptin levels in Cushing's syndrome. J Clin Endocrinol Metab 82:2542-2547, 1997
7. Kolaczynski JW, Nyce MR, Considine RV, et al: Acute and chronic effects of insulin on leptin production in humans: Studies in vivo and in vitro. Diabetes 45:699-701, 1996
8. Malmstrom R, Taskinen MR, Karonen SL, et al: Insulin increases plasma leptin concentrations in normal subjects and patients with NIDDM. Diabetologia 39:993-996, 1996
9. Wabitsch M, Hauner H, Heinze E, et al: The role of growth hormone/insulin-like growth factors in adipocyte differentiation. Metabolism 44:45-49, 1995 (Suppl 4)
10. Ridderstråle M, Tornqvist H: Effects of tyrosine kinase inhibitors on tyrosine phosphorylation and insulin-like effects in response to human growth hormone in isolated rat adipocytes. Endocrinology 133:4650-4656, 1996
11. Ottoson M, Vikmann-Adolfsen K, Enerbæck S, et al: Growth hormone inhibits lipoprotein lipase activity in human adipose tissue. J Clin Endocrinol Metab 80:936-941, 1995
12. Marcus C, Margery V, Kamel A, et al: Effects of growth hormone on lipolysis in humans. Acta Paediatr Suppl 406:54-58, 1994
13. Richelsen B, Pedersen SB, Børglum J, et al: Growth hormone treatment of obese women for 5 wk: Effect on body composition and adipose tissue LPL activity. Am J Physiol 266:E211-E216, 1994 (suppl)
14. Jorgensen JOL, Vahl N, Hansen TB, et al: Growth hormone versus placebo treatment for one year in growth hormone deficient adults: Increase in exercise capacity and normalization of body composition. Clin Endocrinol (Oxf) 45:681-688, 1996
15. Tartaglia LA, Dembski M, Weng X, et al: Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271, 1995
16. Silva C, Lu H, Day RN: Characterization and cloning of STAT 5 from IM-9 cells and its activation by growth hormone. Mol Endocrinol 10:508-518, 1996
17. Zhang Y, Proenca R, Maffei M. et al: Positional cloning of the mouse obese gene and its human homologue [published erratum appears in Nature 374:479, 1995]. Nature 372:425-432, 1994
18. Wong H, Anderson W, Cheng T, et al: Monitoring mRNA expression by polymerase chain reaction: The "primer-dropping" method. Anal Biochem 223:251-258, 1994
19. Saad MF, Damani S, Gingerich RL, et al: Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab 82:579-584, 1997
20. Rosenbaum M, Nicolson M, Hirsch J, et al: Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81:3424-3427, 1996
21. Considine RV, Sinha MK, Heiman ML, et al: Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 334:292-295, 1996
22. Hamilton BS, Paglia D, Kwan AY, et al: Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1:953-956, 1995
23. Montague CT, Prins JB, Sanders L, et al: Depot- and sex-specific differences in human leptin mRNA expression: Implications for the control of regional fat distribution. Diabetes 46:342-347, 1997
24. Fisker S, Vahl N, Hansen TB, et al: Serum leptin is increased in growth hormone-deficient adults: Relationship to body composition and effects of placebo-controlled growth hormone therapy for 1 year. Metabolism 46:812-817, 1997
25. Al-Shoumer KA, Anyaoku V, Richmond W, et al: Elevated leptin concentrations in growth hormone-deficient hypopituitary adults. Clin Endocrinol (Oxf) 47:153-159, 1997
26. Rosen T, Boaseus I, Tolli J, et al: Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency. Clin Endocrinol (Oxf) 38:63-71, 1993
27. Salomon F, Cuneo RC, Hesp R, et al: The effects of treatment with recombinant human growth hormone on body composition and metabolism in adults with growth hormone deficiency. N Engl J Med 321:1797-1803, 1989
28. Andersen PH, Kristensen K, Pedersen SB, et al: Effects of long-term total fasting and insulin on ob gene expression in obese patients. Eur J Endocrinol 137:229-233, 1997
29. Bianda TL, Glatz Y, Boeni-Schnetzler M, et al: Effects of growth hormone (GH) and insulin-like growth factor-I on serum leptin in GH-deficient adults. Diabetologia 40:363-364, 1997 (letter)