Growth hormone versus placebo treatment for one year in growth hormone deficient adults: Increase in exercise capacity and normalization of body composition

Clinical Endocrinology

Volumn 45, Issue 6, 1996, Pages 681-688

  Jørgensen, Jens O L ^a   Vahl, Nina ^a   Hansen, Tony B ^b   Thuesen, Leif ^a   Hagen, Claus ^b   Christiansen, Jens S ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; HUMAN GROWTH HORMONE; PLACEBO;

ADULT; ARTICLE; BODY COMPOSITION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; EXERCISE; FEMALE; GROWTH HORMONE DEFICIENCY; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; TREATMENT OUTCOME;

EID: 0030450507     PISSN: 03000664     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2265.1996.8720883.x     Document Type: Article

References (29)

1. Bengtsson, B-Å., Edén, S., Lönn, L., Kvist, H., Stokland, A., Lindstedt, G., Bosaeus, I., Tölli, J., Sjöstrom, L. & Isaksson, O. (1993) Treatment of Adults with growth hormone (GH) deficiency with recombinant human GH. Journal of Clinical Endocrinology and Metabolism, 76, 309-317.
2. Beshyah, S.A., Freemantle, C., Shahi, M., Anyaoku, V., Merson, S., Lynch, S., Skinner, E., Sharp, P., Foale, R. & Johnston, D. (1995a) Replacement treatment with biosynthetic human growth hormone in growth hormone-deficient hypopituitary adults. Clinical Endocrinology, 42, 73-84.
3. Beshyah, S.A., Henderson, A., Niththyanathan, R., Sharp, P., Richmond, W. & Johnston, D.G. (1994) Metabolic abnormalities in growth hormone-deficient adults: II. Carbohydrate tolerance and lipid metabolism. Endocrinology and Metabolism, 1, 173-180.
4. Beshyah, S.A., Shahi, M., Foal, R. & Johnston, D. (1995b) Cardiovascular effects of prolonged growth hormone replacement in adults. Journal of Internal Medicine, 237, 35-42.
5. Binnerts, A., Deurenberg, P., Swart, G.R., Wilson, J.H.P. & Lamberts, S.W.J. (1992) Body composition in growth hormone-deficient adults. American Journal of Clinical Nutrition, 55, 918-23.
6. Caidahl, K., Edén, S. & Bengtsson, B-Å. (1994) Cardiovascular and renal effects of growth hormone. Clinical Endocrinology, 40, 393-400.
7. Cuneo, R.C., Salomon, F., Wiles, C.M., Hesp, R. & Sönksen, P.H. (1991a) Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength. Journal of Applied Physiology, 70, 688-94.
8. Cuneo, R.C., Salomon, F., Wiles, C.M., Hesp, R. & Sonksen, P.H. (1991b) Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance. Journal of Applied Physiology, 70, 695-700.
9. De Boer, H., Blok, G.J., Voerman, H.J., De Vries, P.M.J.M. & Van Der Veen, E.A. (1992) Body composition in adult growth hormone-deficient men, assessed by anthropometry and bioimpedance analysis. Journal of Clinical Endocrinology and Metabolism, 75, 833-7.
10. De Boer, H., Blok, G-J. & Van Der Veen, E. (1995a) Clinical aspects of growth hormone deficiency in adults. Endocrine Reviews, 16, 63-86.
11. De Boer, H., Blok, G.J., Voerman, B., De Vries, P., Popp-Snijders, C., Van Der Veen, E. (1995b) The optimal growth hormone replacement dose in adults derived from bioimpedunce analysis. Journal of Clinical Endocrinology and Metabolism, 80, 2069-2076.
12. Degerblad, M., Almkvist, O., Grunditz, Hall, K., Kaijser, L., Knutsson, E., Ringertz, H. & Thorén, M. (1990) Physical and psychological capabilities during substitution therapy with recombinant growth hormone in adults with growth hormone deficiency. Acta Endocrinologica, 123, 185-193.
13. Durnin, J.V.G.A. & Womersley, J. (1974) Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. British Journal of Nutrition, 32, 77-97.
14. Frystyk, J., Dinesen, B. & Ørskov, H. (1995) Non-competitive time-resolved immunofluorimetric assays for determination of human insulin-like growth factor I and II. Growth Regulation, 5,
15. Hansen, T.B., Vahl, N., Jørgensen, J.O.L. & Christiansen, J.S. (1995) Whole body and regional soft tissue changes in growth hormone deficient adults after one yar of growth hormone treatment: a double blind, randomized, placebo-controlled study. Clinical Endocrinology, 43, 689-696.
16. Hoffman, D.M., O'Sullivan, A.J., Freund, J. & Ho, K.K.Y. (1995) Adults with growth hormone deficiency have abnormal body composition but normal energy metabolism. Journal of Clinical Endocrinology and Metabolism, 80, 72-77.
17. Joørgensen, J.O.L., Moøller, J., Wolthers, T., Vahl, N., Juul, A., Skakkebæk, N.E. & Christiansen, J.S. (1994a) Growth Hormone (GH)-Deficiency in Adults: Clinical Features and Effects of GH Substitution. Journal of Pediatric Endocrinology, 7, 283-293.
18. Jørgensen, J.O.L., Pedersen, S.A., Thuesen, L., Jørgensen, J., Ingemann-Hansen, T., Skakkebæk, N.E. & Christiansen, J.S.C. (1989) Beneficial Effects of growth hormone treatment in GH deficient adults. The Lancet, i, 1221-25.
19. Jærgensen, J.O.L., Pedersen, S.A., Thuesen, L., Jørgensen, J., Møller, J., Müller, J., Skakkebæk, N.E. & Christiansen, J.S. (1991) Long-term growth hormone treatment in growth hormone deficient adults. Acta Endocrinologica, 125, 449-453.
20. Jørgensen, J.O.L., Thuesen, L., Müller, J., Ovesen, P., Skakkebæk, N.E. & Christiansen, J.S. (1994b) Three years growth hormone treatment in growth hormone-deficient adults: near normalization of body composition and physical performance. European Journal of Endocrinology, 130, 224-228.
21. Jørgensen, J.O.L. & Christiansen, J.S. (1995) European approval of adult growth hormone replacement therapy-good news and time for caution. Endocrinology and Metabolism, 2, 1-2.
22. Jørgensen, J.O.L., Vahl, N., Nyholm, B., Juul, A., Müller, J., Møller, N., Schmitz, O., Skakkebæk, N.E. & Christiansen, J.S. (1996) Substrate metabolism and insulin sensitivity following long-term growth hormone (GH) replacement therapy in GH-deficient adults. Endocrinology and Metabolism (in press)
23. Petersen, F.B. (1960) Muscle training by static, concentric and eccentric contractions. Acta Physiologica Scandinavica, 48, 406-416.
24. Rosén, T., Bosaeus, I., Tölli, J., Lindstedt, G. & Bengtsson, B-Å. (1993) Increased body fat mass and decreased extracellular fluid volume in adults with growing hormone deficiency. Clinical Endocrinology, 38, 63-71.
25. Rosen, T., Johannson, G., Hallgren, P., Caidahl, K., Bosaeus, I. & Bengtsson, B-Å. (1994) Beneficial effects of 12 months replacement therapy with recombinant human growth hormone to growth hormone deficient adults. Endocrinology and Metabolism, 1, 55-66.
26. Rutherford, O.M., Beshyah, S.A. & Johnston, D.G. (1994) Quadriceps strength before and after growth hormone replacement in hypopituitary adults: relationship to changes in lean body mass and IGF-I Endocrinology and Metabolism, 1, 41-47.
27. Rutherford, O.M., Beshyah, S.A., Schott, J., Watkins, Y. & Johnston, D.G. (1995) Contractile properties of the quadriceps muscle in growth hormone-deficient hypopituitary adults. Clinical Science, 88, 67-71.
28. Valcavi, R., Gaddi, O., Zini, M., Iavicoli, M., Mellino, U. & Portioli, I. (1995) Cardiac performance and mass in adults with hypopituitarism effects of one year of growth hormone treatment. Journal of Clinical Endocrinology and Metabolism, 80, 659-666.
29. Whitehead, H.M., Boreham, C., McIlrath, E.M., Sheridan, B., Kennedy L., Atkinson, A.B. & Madden, D.R. (1992) Growth hormone treatment of adults with growth hormone deficiency: results of a 13-month placebo controlled cross-over study. Clinical Endocrinology, 36, 45-52.